Negative serum pregnancy test within 2 weeks prior to registration for women of childbearing potentialXx_NEWLINE_xXNegative serum or urine pregnancy test done =< 7 days prior to registration, for women of childbearing potential onlyXx_NEWLINE_xXSerum pregnancy test for female patients of childbearing potential, =< 72 hours prior to study entry; women of childbearing potential and male participants must practice adequate contraceptionXx_NEWLINE_xXNegative serum pregnancy test for women of childbearing potential within 14 days of study registrationXx_NEWLINE_xXPatients of childbearing potential must have a negative serum pregnancy test and must agree to practice an effective means of birth controlXx_NEWLINE_xXNegative pregnancy test done =< 7 days prior to registration, for women of childbearing potential onlyXx_NEWLINE_xXNegative pregnancy test done =< 7 days prior to registration, for women of childbearing potential onlyXx_NEWLINE_xXWomen of childbearing potential must have a negative serum pregnancy test within 21 days prior to study entryXx_NEWLINE_xXNegative serum pregnancy test done =< 7 days prior to registration only for women determined to be of childbearing potential by their treating physicianXx_NEWLINE_xXWomen of childbearing potential only: negative pregnancy test done =< 7 days prior to registrationXx_NEWLINE_xXPregnancy or lactation at the time of study entry; (Note: pregnancy testing must be performed within 2 weeks prior to randomization according to institutional standards for women of childbearing potential)Xx_NEWLINE_xXNegative serum pregnancy test within 2 weeks prior to registration for women of childbearing potentialXx_NEWLINE_xXNegative urine or serum pregnancy test within 14 days prior to registration for women of childbearing potentialXx_NEWLINE_xXNegative serum pregnancy test within 14 days prior to registration for women of childbearing potentialXx_NEWLINE_xXWomen of childbearing potential must have a negative pregnancy test within 7 days before enrollment; women of childbearing potential include women who have experienced menarche and who have not undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or are not postmenopausal; postmenopause is defined as amenorrhea >= 12 consecutive months; note: women who have been amenorrheic for 12 or more months are still considered to be of childbearing potential if the amenorrhea is possibly due to prior chemotherapy, antiestrogens, ovarian suppression or any other reversible reasonXx_NEWLINE_xXWomen of childbearing potential must have a negative pregnancy test at screening; women of childbearing potential include women who have experienced menarche and who have not undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or are not postmenopausal; postmenopausal is defined as amenorrhea >= 12 consecutive months; note: women who have been amenorrheic for 12 or more months are still considered to be of childbearing potential if the amenorrhea is possibly due to prior chemotherapy, antiestrogens, ovarian suppression or any other reversible reasonXx_NEWLINE_xXWomen of childbearing potential must have a negative pregnancy test within 14 days of registrationXx_NEWLINE_xXWomen of childbearing potential must have a negative serum pregnancy test within 7 days of the first dose of study treatmentXx_NEWLINE_xXWomen of childbearing potential must have a negative serum pregnancy test within 14 days prior to registrationXx_NEWLINE_xXFemale participants who are pregnant or breastfeeding; women of childbearing potential must have a negative urine or serum pregnancy test within 72 hours prior to randomization; all women of childbearing potential must be willing to comply with an acceptable birth control regimen to prevent pregnancy while receiving treatment and for 3 months after treatment is discontinued as determined by the Investigator; post-menopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential; (note: a woman of childbearing potential is one who is biologically capable of becoming pregnant; this includes women who are using contraceptives or whose sexual partners are either sterile or using contraceptives)Xx_NEWLINE_xXNegative serum pregnancy test within 14 days prior to registration for women of childbearing potentialXx_NEWLINE_xXNegative serum pregnancy test =< 7 days prior to registration for women of childbearing potential* NOTE: women will be considered not of childbearing potential if they are surgically sterile (bilateral oophorectomy or hysterectomy) and/or post-menopausal (amenorrheic for at least 12 months)Xx_NEWLINE_xXFemale patients of childbearing potential should have a negative urine or serum pregnancy test within 24 hours prior to receiving the first dose of study medication; if the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be requiredXx_NEWLINE_xXWomen of childbearing potential must have a negative serum pregnancy test within 14 days prior to registration or randomizationXx_NEWLINE_xXWomen of childbearing potential must have a negative pregnancy test at screening; women of childbearing potential include women who have experienced menarche and who have not undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or are not postmenopausal; postmenopause is defined as amenorrhea >= 12 consecutive months; Note: women who have been amenorrheic for 12 or more months are still considered to be of childbearing potential if the amenorrhea is possibly due to prior chemotherapy, antiestrogens, ovarian suppression or any other reversible reasonXx_NEWLINE_xXNegative serum pregnancy test (in women of childbearing potential) =< 14 days prior to Step 2; women of childbearing potential and men who are sexually active must practice adequate contraception while on studyXx_NEWLINE_xXPregnancy or lactation at the time of study entry; (note: pregnancy testing according to institutional standards for women of childbearing potential must be performed within 2 weeks prior to randomization)Xx_NEWLINE_xXNegative (serum or urine) pregnancy test, for women of childbearing potential onlyXx_NEWLINE_xXWomen of childbearing potential must have a negative urine pregnancy test within 7 days prior to initiation of treatment; women will be considered not of childbearing potential if they are surgically sterile (bilateral oophorectomy or hysterectomy) and/or post-menopausal (amenorrheic for at least 12 months)Xx_NEWLINE_xXWomen of childbearing potential must have a negative qualitative serum pregnancy test =< 14 days prior to Step 1 registrationXx_NEWLINE_xXNegative serum pregnancy test within 7 days of treatment initiation with ibrutinib in women of childbearing potential (WOCBP)Xx_NEWLINE_xXPregnancy test (urine or serum beta-human chorionic gonadotropin [HCG]) done within 72 hours before randomization must be negative (for women of childbearing potential only); if urine pregnancy results are positive or cannot be confirmed as negative, a serum pregnancy test will be requiredXx_NEWLINE_xXFor women of childbearing potential, a negative serum pregnancy test within 14 days of registrationXx_NEWLINE_xXNegative serum pregnancy test within 30 days prior to registration for females of childbearing potential.Xx_NEWLINE_xXIf the patient is a woman is of childbearing potential, a serum pregnancy test, obtained within 14 days prior to step 2 registration, must be negative, and, if randomized to receive radiation therapy, the woman must agree to use contraceptionXx_NEWLINE_xXPregnancy or lactation at the time of study registration; (Note: Pregnancy testing according to institutional standards for women of childbearing potential must be performed within 2 weeks prior to study registration)Xx_NEWLINE_xXNegative urine or serum pregnancy test for women of childbearing potential within 7 days prior to study entryXx_NEWLINE_xXAny patients of childbearing potential must have a negative pregnancy testXx_NEWLINE_xXWomen of childbearing age must have a negative serum pregnancy test within 14 days prior to registrationXx_NEWLINE_xX