--- a
+++ b/clusters/unpackedclusters/clust_50.txt
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+Human immunodeficiency virus (HIV) negativeXx_NEWLINE_xXPatients with known human immunodeficiency virus (HIV) infection are excludedXx_NEWLINE_xXNo human immunodeficiency virus (HIV) infection; patients with immune dysfunction are at a significantly higher risk of toxicities from intensive immunosuppressive therapiesXx_NEWLINE_xXPatients with known human immunodeficiency virus (HIV) must have a CD4 count > 350 and be on concurrent antiretrovirals; patients with a history of intravenous drug abuse or any behavior associated with an increased risk of HIV infection should be tested for exposure to the HIV virus; an HIV test is not required for entry on this protocol, but is required if the patient is perceived to be at riskXx_NEWLINE_xXPatients must not have any known immune deficiencies; patients with immune deficiency are at increased risk of lethal infections when treated with marrow-suppressive therapy; therefore, known human immunodeficiency virus (HIV) positive patients receiving combination anti-retroviral therapy are excluded from the studyXx_NEWLINE_xXPatients must not be known to be human immunodeficiency virus (HIV)-positiveXx_NEWLINE_xXPROCUREMENT: Patients with active human immunodeficiency virus (HIV) positive at time of procurement (can be pending at the time of blood draw)Xx_NEWLINE_xXPatients with a known active infection, e.g., hepatitis B virus or hepatitis C virus; human immunodeficiency virus (HIV)-positive patients who are otherwise well and who do not have evidence of significant immune compromise are eligibleXx_NEWLINE_xXHuman immunodeficiency virus (HIV) positive patients who are not on retroviral therapy will not be excluded from cohort 1, the normal liver function cohort* HIV positive patients who are not on retroviral therapy will be excluded from cohorts 2-4Xx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patientsXx_NEWLINE_xXPatients that are known to be positive for human immunodeficiency virus (HIV) are not eligible; note: inclusion of HIV positive patients will be considered at a later dateXx_NEWLINE_xXKnown human immunodeficiency virus (HIV) infected patients (HIV testing will not be performed as a part of screening) on combination antiretroviral therapy are eligible for inclusion; the use of zidovudine is not allowedXx_NEWLINE_xXPatients with known human immunodeficiency virus (HIV) infectionXx_NEWLINE_xXPatients must not have known human immunodeficiency virus (HIV) infection or active hepatitis B or C infectionsXx_NEWLINE_xXHuman immunodeficiency virus (HIV)-positive patients on highly active antiretroviral therapy (HAART) are excludedXx_NEWLINE_xXPatients with known human immunodeficiency virus infection are not to be enrolled in the studyXx_NEWLINE_xXPatients with known human immunodeficiency virus (HIV) or hepatitis B or C are excludedXx_NEWLINE_xXPatients known to be positive for human immunodeficiency virus (HIV) are not eligibleXx_NEWLINE_xXIndividuals who are known to be human immunodeficiency virus (HIV) infected are eligible (note: HIV testing is not required for entry into the study)Xx_NEWLINE_xXHuman immunodeficiency virus (HIV) positive patients will be excludedXx_NEWLINE_xXPatients with known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) might be enrolled if the viral load by PCR is undetectable with/without active treatment and absolute lymphocyte count >= 350/ulXx_NEWLINE_xXPatients with human immunodeficiency virus (HIV) infection are ineligibleXx_NEWLINE_xXPatients with human immunodeficiency virus (HIV) are excludedXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive individuals are ineligibleXx_NEWLINE_xXKnown human immunodeficiency virus (HIV)-positive individuals are ineligibleXx_NEWLINE_xXHistory of human immunodeficiency virus (HIV) infectionXx_NEWLINE_xXPatients should be excluded if they have known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXPatients must not have known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)Xx_NEWLINE_xXHuman immunodeficiency virus (HIV) infectionXx_NEWLINE_xXNo known evidence of human immunodeficiency virus (HIV) infectionXx_NEWLINE_xXPatients with known human immunodeficiency virus (HIV), hepatitis B or C infections; testing to prove negative status is not required for enrollment unless it is deemed necessary for usual medical care of the patientXx_NEWLINE_xXPatients with a known history of human immunodeficiency virus (HIV) must have CD4 count >= institutional lower limit of normal within 28 days prior to registrationXx_NEWLINE_xXPatient who are known to be serologically positive for human immunodeficiency virus (HIV)Xx_NEWLINE_xX
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