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+In adults: serum creatinine =< 1.5 mg/dl or creatinine clearance > 60 ml/min; and in children serum creatinine (Cr) =< age-adjusted normal* Age 12-15 years: 1.2 mg/dl* Age > 15 years: 1.5 mg/dlXx_NEWLINE_xXCreatinine below age-adjusted maximum limits in the table below OR creatinine clearance >= 60 mL/min/1.73 m^2 assessed within seven (7) days prior to the start of therapy* 0.8 mg/dl (patients =< 5 years of age)* 1.0 mg/dl (patients 5 < age =< 10 years of age)* 1.2 mg/dl (patients 10 < age =< 15 years of age)* 1.5 mg/dl (patients > 15 years of age)Xx_NEWLINE_xXAge-adjusted serum creatinine =< 1.5 x normal for age or creatinine clearance or glomerular filtration rate (GFR) >= 60 cc/min/1.73 m^2* Age 1 month to < 6 months: 0.4 mg/dL for males and 0.4 mg/dL for females* Age 6 months to < 1 year: 0.5 mg/dL for males and 0.5 mg/dL for females* Age 1 to < 2 years: 0.6 mg/dL for males and 0.6 mg/dL for females* Age 2 to < 6 years: 0.8 mg/dL for males and 0.8 mg/dL for females* Age 6 to < 10 years: 1.0 mg/dL for males and 1.0 mg/dL for females* Age 10 to < 13 years: 1.2 mg/dL for males and 1.2 mg/dL for females* Age 13 to < 16 years: 1.5 mg/dL for males and 1.4 mg/dL for females* Age >= 16 years: 1.7 mg/dL for males and 1.4 mg/dL for femalesXx_NEWLINE_xXA serum creatinine =< upper limit of normal (ULN) based on age/gender as follows:* Age 1 month to < 6 months: 0.4 for males, 0.4 for females* Age 6 months to < 1 year: 0.5 for males, 0.5 for females* Age 1 to < 2 years: 0.6 for males, 0.6 for females* Age 2 to < 6 years: 0.8 for males, 0.8 for females* Age 6 to < 10 years: 1 for males, 1 for females* Age 10 to < 13 years: 1.2 for males, 1.2 for females* Age 13 to < 16 years: 1.5 for males, 1.4 for females* Age >= 16 years: 1.7 for males, 1.4 for femalesXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73m^2 or a serum creatinine based on age as follows, within 14 days of registration and within 7 days of the start of treatment:* =< 5 years: 0.8 mg/dL* > 5 years but =< 10 years: 1 mg/dL* > 10 years but =< 15 years: 1.2 mg/dL* > 15 years: 1.5 mg/dLXx_NEWLINE_xXCreatinine within normal limits based on age as follows:* Age (years): maximum serum creatinine (mg/dL)** =< 5: 0.8 mg/dL** 5 < age =< 10: 1.0 mg/dL** 10 < age =< 15: 1.2 mg/dL** > 15: 1.5 mg/dLOR creatinine clearance >= 60 mL/min for adults or >= 60 mL/min/1.73m^2 for children with creatinine levels above institutional upper limit of normalXx_NEWLINE_xXSerum creatinine =< 1.5 x the upper limit of normal for age, or calculated creatinine clearance or nuclear glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2* =< 0.6 mg/dL (1 to < 2 years of age)* =< 0.8 mg/dL (2 to < 6 years of age)* =< 1.0 mg/dL (6 to < 10 years of age)* =< 1.2 mg/dL (10 to < 13 years of age)* =< 1.4 mg/dL (females >= 13 years of age)* =< 1.5 mg/dL (males 13 to < 16 years of age)* =< 1.7 mg/dL (males >= 16 years of age)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows:* Age 1 to < 2 years: 0.6 mg/dL* Age 2 to < 6 years: 0.8 mg/dL* Age 6 to < 10 years: 1 mg/dL* Age 10 to < 13 years: 1.2 mg/dL* Age 13 to < 16 years: 1.5 mg/dL (males), 1.4 mg/dL (females)* Age >= 16 years: 1.7 mg/dL (males), 1.4 mg/dL (females)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:* 1 to < 2 years: =< 0.6 mg/dL* 2 to < 6 years: =< 0.8 mg/dL* 6 to < 10 years: =< 1 mg/dL* 10 to < 13 years: =< 1.2 mg/dL* 13 to < 16 years: =< 1.5 mg/dL (males) and =< 1.4 mg/dL (females)* >= 16 years: =< 1.7 mg/dL (males) and =< 1.4 mg/dL (females)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a maximum serum creatinine (mg/dL) based on age/gender as follows:* 1 to < 2 years: 0.6 * 2 to < 6 years: 0.8 * 6 to < 10 years: 1 * 10 to < 13 years: 1.2 * 13 to < 16 years: 1.5 for males, 1.4 for females* >= 16 years: 1.7 for males, 1.4 for femalesXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows:* Age 1 to < 2 years: maximum serum creatinine (mg/dL) 0.6 for males and females* Age 2 to < 6 years: 0.8 for males and females* Age 6 to < 10 years: 1 for males and females* Age 10 to < 13 years: 1.2 for males and females* Age 13 to < 16 years: 1.5 for males and 1.4 for females* Age >= 16 years: 1.7 for males and 1.4 for femalesXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:* Age < 6 months: Maximum serum creatinine (mg/dL): 0.4 for males and females* Age 6 months to < 1 year: Maximum serum creatinine (mg/dL): 0.5 for males and females* Age 1 to < 2 years: Maximum serum creatinine (mg/dL): 0.6 for males and females* Age 2 to < 6 years: Maximum serum creatinine (mg/dL): 0.8 for males and females* Age 6 to < 10 years: Maximum serum creatinine (mg/dL): 1 for males and females* Age 10 to < 13 years: Maximum serum creatinine (mg/dL): 1.2 for males and females* Age 13 to < 16 years: Maximum serum creatinine (mg/dL): 1.5 for males and 1.4 for females* Age >= 16 years: Maximum serum creatinine (mg/dL): 1.7 for males and 1.4 for femalesXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:* Age 1 to < 2 years: maximum serum creatinine 0.6 mg/dL (males and females)* Age 2 to < 6 years: maximum serum creatinine 0.8 mg/dL (males and females)* Age 6 to < 10 years: maximum serum creatinine 1.0 mg/dL (males and females)* Age 10 to < 13 years: maximum serum creatinine 1.2 mg/dL (males and females)* Age 13 to < 16 years: maximum serum creatinine 1.5 mg/dL (males) and 1.4 mg/dL (females)* Age >= 16 years: maximum serum creatinine 1.7 mg/dL (males) and 1.4 mg/dL (females)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:* 3 to < 6 years of age: maximum (max) serum creatinine 0.8 mg/dL (males and females)* 6 to < 10 years of age: max serum creatinine 1 mg/dL (males and females)* 10 to < 13 years of age: max serum creatinine 1.2 mg/dL (males and females)* 13 to < 16 years of age: max serum creatinine 1.5 md/dL (males) and 1.4 md/dL (females)* >= 16 years of age: max serum creatinine 1.7 mg/dL (males) and 1.4 mg/dL (females)** The threshold creatinine values were derived from the Schwartz formula for estimating GFR utilizing child length and stature data published by the Centers for Disease Control and Prevention (CDC)Xx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or a serum creatinine based on age/gender as follows:* 1 to < 2 years: 0.6 mg/dL for males and females* 2 to < 6 years: 0.8 mg/dL for males and females* 6 to < 10 years: 1.0 mg/dL for males and females* 10 to < 13 years: 1.2 mg/dL for males and females* 13 to < 16 years: 1.5 mg/dL for males and 1.4 mg/dL for females* > = 16 years: 1.7 mg/dL for males and 1.4 mg/dL for femalesXx_NEWLINE_xXCreatinine clearance or radioisotope glomerular filtration rate (GFR) > 60 mL/min/1.73 m^2 by either Cockcroft-Gault formula or analysis normal serum creatinine based on age described below:* =< 5 years, 0.8 mg/dL* 5 < age =< 10 years, 1.0 mg/dL* 10 < age =< 15 years, 1.2 mg/dL* > 15 years, 1.5 mg/dLXx_NEWLINE_xX
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