Total bilirubin =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 x the upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin < 2 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 x institutional upper limit of normal (ULN) obtained =< 21 days prior to registrationXx_NEWLINE_xXTotal serum bilirubin =< 1.5 times upper limit of normal (ULN) (=< grade 1); if total bilirubin is 2 to 3 mg/dL, but direct bilirubin is normal, then the patient will be considered eligibleXx_NEWLINE_xXBilirubin less than or equal to 1.5 x upper limit of normal (ULN) (CTCAE grade 1)Xx_NEWLINE_xXTotal bilirubin =< 5 x upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin < 1.5 x upper limit of normal assessed within seven (7) days prior to the start of therapyXx_NEWLINE_xXBilirubin =< 3.0 x upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXTREATMENT: Bilirubin =< 2 x upper limit of normalXx_NEWLINE_xXBilirubin < 1.5 times institutional upper limit of normal, within 21 days prior to study entryXx_NEWLINE_xXTotal bilirubin =< 1.5 institutional upper limit of normal (ULN)Xx_NEWLINE_xXObtained =< 7 days prior to registration: Total bilirubin =< 1.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXSerum bilirubin > 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 times upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin < 2 x the institutional upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin < 2 x institutional upper limit of normal (ULN) within 14 days prior to registrationXx_NEWLINE_xXTotal bilirubin =< 1.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXBilirubin < 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 within 30 days prior to registration* It is highly recommended but not required that total bilirubin be =< 1.5 upper limit of normalXx_NEWLINE_xXTotal bilirubin =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXBilirubin less than or equal to 1.5 x institutional/laboratory upper limit of normal (ULN)Xx_NEWLINE_xXBilirubin =< 1.5 times upper limit of normalXx_NEWLINE_xXTotal bilirubin =< 1.5 x institutional upper limit of normal (ULN), within 21 days prior to registrationXx_NEWLINE_xXBilirubin =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin > 2 times the upper limit of normalXx_NEWLINE_xXTotal bilirubin =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXBilirubin =< 1.5 upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 x institutional upper limit of normal (IULN) (or =< 2.5 x upper limit of normal [ULN] with Gilbert�s syndrome)Xx_NEWLINE_xXTotal bilirubin =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 times institutional upper limit of normal (ULN)Xx_NEWLINE_xXINCLUSION CRITERIA FOR STRATUM C: Total bilirubin =< 1.5 times institutional upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 � upper limit of normal (ULN) for the laboratory unless resulting from hemolysisXx_NEWLINE_xXTotal bilirubin =< institutional upper limit of normal (ULN) or =< 1.5 X institutional ULN (if the patient has liver metastases)Xx_NEWLINE_xXTotal bilirubin within =< 1.5 times the upper limit of normal (ULN) institutional limitsXx_NEWLINE_xXTotal bilirubin less than or equal to the institution's upper limit of normalXx_NEWLINE_xXTotal bilirubin =< 1.5 x the institutional upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin < 1.5 upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< the upper limit of normal (ULN) within 4 weeks prior to randomizationXx_NEWLINE_xXRECURRENT/ PROGRESSIVE DIPG (STRATUM 1): Total bilirubin =< 1.5 times institutional upper limit of normal (ULN)Xx_NEWLINE_xXNON-PROGRESSED DIPG (STRATUM 2): Total bilirubin =< 1.5 times institutional upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin below normal institutional upper limit of normal (ULN)Xx_NEWLINE_xXBilirubin =< 1.5 x upper limit of normal (ULN), within 14 days prior to registrationXx_NEWLINE_xXTotal bilirubin =< 1.5 times institutional upper limit of normal (ULN)Xx_NEWLINE_xXWithin 28 days prior to administration of study treatment: Total bilirubin =< 1.5 x the institutional upper limit of normal (ULN)Xx_NEWLINE_xXWithin less than or equal to 14 days prior to registration: Total serum bilirubin =< institutional upper limit of normal (ULN)Xx_NEWLINE_xXWithin 28 days prior to administration of therapy: Total bilirubin =< 1.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin =< 1.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXTotal bilirubin < 4 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXBilirubin =< 1.5 upper limit of normal (ULN)Xx_NEWLINE_xX