Cluster 0: contraception dose preferred lifestyle usual abstinence therapy study method acceptable Cluster 1: methods ovulation abstinence contraception periodic symptothermal calendar withdrawal acceptable lifestyle Cluster 2: practice abstinence methods agree ovulation true contraception lifestyle usual symptothermal Cluster 3: contraception lifestyle usual preferred abstinence course acceptable study medication method Cluster 4: transplantation stem allogeneic cell hematopoietic prior undergone autologous patients history Cluster 5: transplantation stem autologous cell hematopoietic patients eligible prior high chemotherapy Cluster 6: sct autologous allogeneic stem cell prior transplant transplantation auto days Cluster 7: transplantation allogeneic prior autologous organ hematopoietic liver patients cell history Cluster 8: hematopoietic stem allogeneic transplant cell hsct transplantation prior previous autologous Cluster 9: hct allogeneic autologous prior patients days post disease relapse cell Cluster 10: marrow transplantation bone stem cell prior allogeneic hematopoietic reserves extensive Cluster 11: transplantation organ history allogenic stem prior including cell major liver Cluster 12: investigational device drug study days treatment participation currently agent trial Cluster 13: month participation study clinical product investigational involved preceding involving medication Cluster 14: trial trials included participation agents investigational duration clinical start days Cluster 15: trial investigational participation clinical agent days drug prior treatment study Cluster 16: participation study investigational clinical involving drug days weeks studies prior Cluster 17: therapeutic weeks study participation drug treatment clinical molecule participated procedures Cluster 18: investigation participated clinical dosing investigational month currently drug prior patients Cluster 19: product participation clinical investigational study weeks days receipt months prior Cluster 20: allergy suspected agent given trial known course sorafenib association investigational Cluster 21: margins positive surgical negative margin excision tumor surgery lumpectomy mastectomy Cluster 22: breast cancer mammogram imaging biopsy erythema surgery suspicious radiation patients Cluster 23: conserving breast surgery mastectomy therapy radiation radiotherapy bcs patients undergo Cluster 24: surgery prior days patients weeks planned definitive undergo breast patient Cluster 25: clinical concerns safety contraindicate study procedures judgment participation condition compliance Cluster 26: provision existing safety pre interfere unstable condition psychiatric medical consent Cluster 27: good health general donor provider medical determined evaluating unstable generally Cluster 28: jeopardize reasonable outlined safety ability receive illness infection concurrent medical Cluster 29: jeopardize safety condition compliance unstable patient subject study investigator medical Cluster 30: understand able consent study informed written participate risks description benefits Cluster 31: form sign consent informed willing able understand specific written appropriately Cluster 32: attorney power durable sign willing dpa consent informed consented understand Cluster 33: voluntarily understand sign informed consent form conducted assessments procedures document Cluster 34: seronegative antibody hiv immunodeficiency human virus depends donor treatment intact Cluster 35: cmv seropositive recipient antiviral infection donor cidofovir ganciclovir foscarnet seronegative Cluster 36: virus hepatitis htlv human lymphotropic hiv antibody immunodeficiency donor hcv Cluster 37: hepatitis hiv known infection active history positive patients viral chronic Cluster 38: cmv cytomegalovirus infection pcr retinitis active herpes viremia positive viral Cluster 39: positive hiv known patients donor test hepatitis subject status excluded Cluster 40: hepatitis chronic infection active acute history known carrier viral hiv Cluster 41: opportunistic infections concurrent infection dosing cmv day previous viral active Cluster 42: hepatitis known positive history patients tests active viral load infection Cluster 43: viral hepatitis active chronic liver symptomatic disease cirrhosis nonviral known Cluster 44: hepatitis indicating virus acute positive chronic test infection result known Cluster 45: transfusions platelet blood red days platelets cell packed prior refractory Cluster 46: rbc red blood hemoglobin transfusions cell dl transfusion receive days Cluster 47: packed red blood transfusion prbc hemoglobin dl cell cells days Cluster 48: evidence disease metastatic radiologic clinical definitive imaging patients time residual Cluster 49: lipase uln serum times institutional registration pancreatitis capmatinib screened institutions Cluster 50: lipase pancreatitis radiologic clinical evidence uln upper limit normal cabozantinib Cluster 51: amylase pancreatitis lipase history increased pancreatic symptoms uln cholecystitis suggestive Cluster 52: containing platinum regimen chemotherapy progression prior therapy cisplatin disease treatment Cluster 53: lenalidomide prior therapy treatment use cycles patients dexamethasone received refractory Cluster 54: induction chemotherapy aml therapy patients refractory intensive consolidation cr regimen Cluster 55: grapefruit seville oranges juice study star containing fruits fruit products Cluster 56: nivolumab predisposition hepatoxicity caution drugs used containing regimen treated hepatotoxicity Cluster 57: irinotecan prior topotecan hypersensitivity topoisomerase regimen containing treatment hydrochloride patients Cluster 58: rituximab containing prior therapy treatment months regimen refractory received dose Cluster 59: calculated creatinine clearance min ml measured serum uln days obtained Cluster 60: creatinine clearance min ml estimated serum uln renal cc measured Cluster 61: creatinine range serum normal min ml clearance outside renal reference Cluster 62: creatinine mg clearance min ml dl serum calculated measured estimated Cluster 63: crcl creatinine min ml clearance calculated serum uln measured renal Cluster 64: creatinine clearance hour urine min ml collection calculated serum measured Cluster 65: creatinine normal age patients clearance grade biopsy renal serum prior Cluster 66: forms medically sexually acceptable willing contraception able women use childbearing Cluster 67: condom intercourse drug males father sexually vasectomized stopping taking child Cluster 68: men wocbp sexually contraception instructed nivolumab azoospermic adhere active women Cluster 69: sexually males contraception effective childbearing potential use active accepted women Cluster 70: methods accepted medically sexually contraception fertile male female partners agree Cluster 71: final contraception method partner sexually effective product childbearing nonsterilized potential Cluster 72: bear beget children agreement sexually able study contraception dose use Cluster 73: cytotoxic chemotherapy prior days therapy weeks treatment received previous cancer Cluster 74: brentuximab vedotin prior treatment bv dose previous bendamustine hypersensitivity received Cluster 75: weeks therapy prior chemotherapy treatment nitrosourea dose cytotoxic mitomycin radiation Cluster 76: antibody monoclonal weeks prior therapy treatment study received chemotherapy days Cluster 77: chemotherapy allowable cancer different prior systemic note study therapy previous Cluster 78: treatments prior previous cancer discontinued patients weeks therapies received systemic Cluster 79: radiotherapy prior days chemotherapy treatment brain received previous cranial dose Cluster 80: obtained registration uln days prior bilirubin creatinine total upper normal Cluster 81: total bilirubin upper limit normal uln age range serum days Cluster 82: conjugated sum unconjugated age bilirubin upper limit normal uln total Cluster 83: bilirubin uln gilbert level enrolled total serum known upper limit Cluster 84: institutional bilirubin upper total uln normal limit level days registration Cluster 85: institutional bilirubin upper normal limit total age direct registration serum Cluster 86: indicated renal creatinine function adequate uln insufficiency upper level limit Cluster 87: bilirubin uln equal conjugated mla institutional needs level transaminases phase Cluster 88: iuln bilirubin total registration direct patients days prior arm cohort Cluster 89: administration institutional upper limit normal uln measured total bilirubin days Cluster 90: creatine phosphokinase ck cpk uln kinase plasma normal upper limit Cluster 91: heart york association new class myocardial infarction unstable failure congestive Cluster 92: class heart association activity york disability ordinary new comfortable physical Cluster 93: heart unstable cardiovascular angina york association new significant infarction myocardial Cluster 94: heart york association infarction iii myocardial new iv class angina Cluster 95: ventricular heart significant fibrillation failure myocardial infarction tachycardia association york Cluster 96: pulmonary hypertension embolism disease severe significant history fibrosis cardiac patients Cluster 97: heart clinically significant history hypertension qt ecg labile cardiac msec Cluster 98: cardiomyopathy restrictive hypertrophic documented causes heart history cardiomegaly treatment significant Cluster 99: qt cardiac heart ventricular coronary history screening block significant left Cluster 100: abnormalities laboratory following cardiac significant ecg baseline history chemistry hematologic Cluster 101: anc neutrophil absolute mm count peripheral randomization weeks cu days Cluster 102: cells platelet mm count marrow bone plasma nucleated plasmacytosis bil Cluster 103: cells neutrophil absolute count mm anc days registration bil prior Cluster 104: neutrophil mm absolute count greater cu days neutrophils hemoglobin inclusion Cluster 105: neutrophil absolute anc count obtained registration days prior mm mcl Cluster 106: urine pregnancy negative test phase serum ii extension hours randomized Cluster 107: brain metastases steroids requiring symptomatic symptoms known control patients require Cluster 108: brain metastasis symptomatic steroids patients uncontrolled requiring escalating doses metastases Cluster 109: leptomeningeal brain metastases disease symptomatic glucocorticoids uncontrolled continue treated require Cluster 110: untreated brain metastases symptomatic known require symptoms control treated meningeal Cluster 111: gog performance status patients grade gynecological oncology refer group appendix Cluster 112: performance status adequate patients better good considered protocol level patient Cluster 113: gog gynecologic oncology group performance status patients protocol priority rare Cluster 114: metastatic disease patients known presence prior therapy patient systemic confirmed Cluster 115: hematologic function adequate renal liver follows defined bm status coagulation Cluster 116: hepatic renal function adequate defined cardiac coagulation baseline pulmonary reference Cluster 117: parameters hematologic adequate transfusional support hepatic renal laboratory defined ongoing Cluster 118: inadequate function renal organ liver marrow bone hematologic hepatic evidenced Cluster 119: hematologic hepatic renal function adequate cardiac coagulation inadequate defined poor Cluster 120: cns metastases subjects symptoms treated nervous eligible central neurologically stable Cluster 121: cns metastases brain nervous central stable patients treated weeks disease Cluster 122: metastases carcinomatous brain meningitis cns nervous central treated participate previously Cluster 123: cns metastasis metastases nervous asymptomatic central treated steroids imaging previously Cluster 124: carcinomatous meningitis nervous metastases central cns known active untreated clinically Cluster 125: nervous central metastases cns known brain active history treated presence Cluster 126: meningeal involvement nervous central carcinomatosis metastases signs cns brain clinical Cluster 127: carcinomatosis leptomeningeal history cns metastases nervous lymphangitic brain central metastasis Cluster 128: metastasis nervous central cns symptomatic known malignancy untreated history active Cluster 129: tumors primary brain cns nervous central patients metastases solid seizures Cluster 130: neurologically stable metastases brain treated cns nervous central steroids corticosteroids Cluster 131: lesions inactive considered cns asymptomatic active treated nervous central small Cluster 132: recist based measurable disease determined site criteria presence radiology patients Cluster 133: radiographically measurable disease evaluable recist presence patients assessable clinically extranodal Cluster 134: judged investigator clinically significant infections treating limits disability institutional intake Cluster 135: provide written informed consent patients willingness participate study participant voluntarily Cluster 136: scientifically compatible judged medically research enrolled drug type medical study Cluster 137: ability written provide informed consent willingness comply judged protocol investigator Cluster 138: aminotransferase times uln alanine alt aspartate ast liver hepatic upper Cluster 139: aminotransferase uln involvement alt ast alanine aspartate liver cancer subjects Cluster 140: alanine aminotransferase alt uln hepatic laboratory days iu involvement unless Cluster 141: aminotransferase aspartate alanine ast alt uln institutional normal unless serum Cluster 142: aspartate aminotransferase ast uln hepatic days times metastases laboratory iu Cluster 143: aminotransferase uln ast alt liver aspartate alanine metastases present metastasis Cluster 144: amino transferase uln alt ast aspartate alanine aminotransferase liver times Cluster 145: iuln aminotransferase ast alt aspartate alanine liver metastases registration days Cluster 146: uln liver alt metastases alanine present aminotransferase metastasis transaminase ast Cluster 147: aminotransferase uln obtained aspartate alanine ast alt registration days prior Cluster 148: radiotherapy weeks prior study dose treatment starting patients received palliative Cluster 149: fields overlap result region radiotherapy radiation prior therapy cancer study Cluster 150: start treatment prior weeks study days therapy chemotherapy radiation investigational Cluster 151: completed prior therapy weeks radiation chemotherapy enrollment radiotherapy study treatment Cluster 152: beam external radiation therapy prior radiotherapy weeks received gy treatment Cluster 153: palliative radiation radiotherapy weeks therapy prior treatment study allowed days Cluster 154: radiotherapy start weeks treatment prior study palliative received therapy radiation Cluster 155: kind immediate palliative requirement surgery including treatment zydelig fanca fap Cluster 156: anticancer therapies currently receiving therapy received chemotherapy weeks radiation start Cluster 157: hsct autologous amg start treatment weeks prior alemtuzumab admission allogeneic Cluster 158: non older males females age pregnant years breastfeeding lactating available Cluster 159: pregnancy test negative serum female screening focbp days prior wocbp Cluster 160: test urine pregnancy negative serum female confirmed days potential positive Cluster 161: pregnancy childbearing female negative test potential serum patients enrollment days Cluster 162: rule females urine pregnancy test childbearing potential feeding blood pregnant Cluster 163: female potential childbearing pregnancy test negative pregnant urine serum feeding Cluster 164: brain metastasis ct mri metastases exclude imaging scan neurological symptoms Cluster 165: sectional cross imaging disease ct metastatic cm scan tumor bone Cluster 166: psa progression bone pcwg prostate disease lesions new defined scan Cluster 167: bone metastases scan disease metastasis metastatic imaging lesions paget skeletal Cluster 168: carcinoma skin cell progressing potentially requires exceptions additional curative basal Cluster 169: additional progressing malignancy requires known active treatment years required past Cluster 170: treatment prior study weeks days patients months allowed dose trc Cluster 171: pregnant patients known included ineligible currently treated time enrollment study Cluster 172: enrollment prior study time weeks days patients months therapy treatment Cluster 173: progressive disease rapidly patients evidence therapy time study months treatment Cluster 174: survival expected months days weeks free greater infection time opinion Cluster 175: patients disease study prior treatment months defined known score days Cluster 176: transplant liver post prior days patients months eligible history time Cluster 177: randomization prior weeks months days therapy treatment date time laboratory Cluster 178: age time years consent enrollment informed diagnosis study months patients Cluster 179: screening prior months days weeks hospitalization positive date therapy time Cluster 180: genders practice birth control willing months time enrollment treatment patients Cluster 181: entry study prior weeks days months patients time therapy received Cluster 182: psa doubling time months psadt values patients calculate measurements dt Cluster 183: moderate cypa strong inducers inhibitors use days dose study prior Cluster 184: tegretol inducers equetro epitol phenytek rifadin dilantin luminal carbatrol provigil Cluster 185: carcinoma skin cell cancer situ basal curative cervical squamous potentially Cluster 186: malignancy cell recurrence deemed years basal free low carcinoma investigator Cluster 187: diagnosed malignancy nonmelanoma residual type undergone resection situ skin carcinoma Cluster 188: malignancy carcinoma cell curative basal low squamous prostate situ resection Cluster 189: confirmed histologically cytologically diagnosis metastatic patients melanoma cancer pathologically carcinoma Cluster 190: pancreatic adenocarcinoma histologically confirmed cytologically metastatic ductal advanced diagnosis patients Cluster 191: exist longer measures curative standard effective palliative unresectable histologically confirmed Cluster 192: colorectal histologically confirmed cytologically metastatic adenocarcinoma cancer unresectable diagnosis patients Cluster 193: mesothelioma pleural malignant peritoneal histologically mpm confirmed pemetrexed cytologically unresectable Cluster 194: anti cancer therapy prior systemic treatment investigational weeks study days Cluster 195: signs symptoms infection weeks cycle day prior treatment study active Cluster 196: therapy herbal cycle week day prior anticancer weeks contraceptives radiotherapy Cluster 197: cycle day prior weeks days therapy treatment investigational chemotherapy anti Cluster 198: therapy days investigational anti neoplastic dose biologic prior agent chemotherapy Cluster 199: days growth acting factor elapsed events infusion adverse xrt therapy Cluster 200: obscure hazardous condition interpretation make underlying opinion frequent events adverse Cluster 201: events adverse biologic extended occurring agent occur known days agents Cluster 202: unresolved toxicity grade previous alopecia therapy ctcae anticancer anti prior Cluster 203: toxicities anticancer therapy previous unresolved recovered ctcae grade alopecia exception Cluster 204: grade enter anticancer toxicities alopecia ctcae therapies recovered related version Cluster 205: toxicity exacerbated reasonably irreversible expected unresolved hearing included ctcae grade Cluster 206: aes events adverse alopecia grade recovered baseline prior anticancer resolved Cluster 207: benefit standard therapy available clinical solid advanced convey metastatic histologically Cluster 208: standard therapy progressed exists advanced intolerant solid metastatic tumors patients Cluster 209: solid histologically cytologically confirmed tumor advanced standard metastatic diagnosis tumors Cluster 210: tumors solid advanced patients malignant metastatic subjects eligible excluded cell Cluster 211: standard therapy advanced refractory solid available metastatic histologically tumors tumor Cluster 212: prevent signing abnormality condition illness psychiatric medical laboratory consent informed Cluster 213: giving consent capable informed written psychiatric patient debilitating medical illness Cluster 214: illness condition medical abnormality laboratory psychiatric prevent participating significant subject Cluster 215: illness psychiatric medical compliance significant consent informed prevents severe mental Cluster 216: comply willing able requirements protocol study procedures instructions subject follow Cluster 217: aspects comply willing able protocol subject informed participant consent participants Cluster 218: logistics feasibility issues prospective comply procedures compliance opinion related able Cluster 219: comply follow inability procedures study examinations able willing medical procedure Cluster 220: hbac glycosylated hemoglobin glucose diabetes measurement met poorly screening intolerance Cluster 221: ac hemoglobin hgb diabetes uncontrolled defined glycosylated hb poorly controlled Cluster 222: glucose fasting mg dl diabetes blood serum mellitus uncontrolled random Cluster 223: mellitus diabetes insulin poorly controlled induced dependent steroid history hbac Cluster 224: glucose mellitus diabetes closely antidiabetic dm monitored adjusted hbac necessary Cluster 225: haemoglobin dl transfused hb glycated hematology hbac haematological platelet anc Cluster 226: hbac ac hemoglobin glucose diabetes glycated mellitus fasting poorly controlled Cluster 227: glucose fasting mmol plasma mg dl fpg hbac diabetes type Cluster 228: allergy known history intolerance patients hypersensitivity reaction products egg gadolinium Cluster 229: hypersensitivity known history reaction patients ingredients products intolerance reactions comparator Cluster 230: hypersensitivity perflutren known drug suspected products study acyclovir definity patients Cluster 231: sensitivity known products components administered allergy derived dosing component ingredients Cluster 232: murine products hypersensitivity containing protein reactions history allergy bovine known Cluster 233: platelets ml days dl consent surgery chemistry documented total study Cluster 234: bilirubin mg dl direct equal unless ml considered total tumor Cluster 235: total bilirubin mg dl serum days equal uln ml enrollment Cluster 236: mol mg dl creatinine serum bilirubin si total function male Cluster 237: bilirubin mg dl serum direct umol patients total days prior Cluster 238: total bilirubin normal direct dl mg age elevated check conjugated Cluster 239: pressure blood hypertension systolic controlled diastolic uncontrolled readings high adequately Cluster 240: bp systolic deemed pressure controlled blood clinically investigator false familial Cluster 241: hypertension uncontrolled controlled mmhg patients poorly medication history pressure severe Cluster 242: pressure blood sbp mmhg dbp systolic diastolic hypertension antihypertensive adjustment Cluster 243: hg pressure mm systolic blood hypertension diastolic uncontrolled despite bp Cluster 244: mmhg pressure despite diastolic management systolic hypertension optimal blood medical Cluster 245: mmhg pressure blood systolic diastolic hypertension controlled uncontrolled defined inadequately Cluster 246: seizures uncontrolled subjects patients history intracranial hypertension increased eligible pressure Cluster 247: percentile height th gender pressure age blood bp hypertension medication Cluster 248: despite hypertension uncontrolled medical optimal arterial management antihypertensive poorly controlled Cluster 249: heart pressure mmhg blood uncontrolled systolic hypertension diastolic myocardial infarction Cluster 250: antihypertensive bp pressure medications blood mmhg change controlled adequately week Cluster 251: bp mmhg diastolic hypertension pressure systolic blood uncontrolled medication despite Cluster 252: autoimmune past years systemic required disease active treatment modifying immunosuppressive Cluster 253: autoimmune requiring immunosuppressive disease active systemic therapy modifying history treatment Cluster 254: malignant disease non treated study tumor systemic preclude active treatment Cluster 255: treatment malignancy required years systemic start evidence subject study past Cluster 256: requiring treatment active infection systemic malignancy acute psoriasis corneal assessments Cluster 257: antifungals antivirals antibiotics infection requiring active acute systemic prior parenteral Cluster 258: microbial anti acceptable infection prophylaxis parenteral infections guidelines agents uncontrolled Cluster 259: gvhd acute chronic active prophylaxis patients systemic treatment overlap grade Cluster 260: infections requiring systemic active antibiotics therapy chronic suppressive maintenance infection Cluster 261: iron overload hemochromatosis parenteral dextran subjects transferrin anemia ferritin known Cluster 262: urinary tract infection uncomplicated uti active requiring antibiotics infections exception Cluster 263: significant infection clinically active requiring antibiotics virals fungals anti systemic Cluster 264: parenteral antibiotics infection requiring active infective requires oral ongoing current Cluster 265: donors hla matched siblings unrelated donor related haploidentical allele drb Cluster 266: hla typing resolution drb donor high unrelated matched allele dqb Cluster 267: dr donor matched hla unrelated loci allele dq antigen related Cluster 268: hla matched leukocyte donor antigen human unrelated related drb sibling Cluster 269: donor age years matched related haploidentical sibling morbidity score yr Cluster 270: resolution match donor typing drb hla dna high unrelated using Cluster 271: matched donor unrelated related hla available donate mismatched allele suitable Cluster 272: sibling donor hla matched identical offspring parent transplant available haploidentical Cluster 273: donors donor marrow blood related meet apheresis unrelated nmdp guidelines Cluster 274: ecog performance status patients equal scale subject patient grade screening Cluster 275: score ecog performance status ipss scale subject patients symptom acceptable Cluster 276: ecog status functional mf performed acceptable patients fascia farber fap Cluster 277: subjects study therapy eligible investigator treatment prior receiving chemotherapy opinion Cluster 278: participant research study received encephalopathy does treatment cell deficits household Cluster 279: receive patients chemotherapy treatment unable planning study eligible therapy plan Cluster 280: elapsed weeks therapy prior days radiation chemotherapy completion minimum dose Cluster 281: participants research study prior eligible treated treatment received malignancy therapy Cluster 282: chemotherapy prior weeks patients treatment systemic dose days regimen study Cluster 283: radiation weeks therapy prior study treatment dose enrollment chemotherapy drug Cluster 284: previously received patients study subjects therapy untreated treatment radiation participated Cluster 285: cgy radiation tbi therapy delivered prior patients centigray ineligible therapeutic Cluster 286: radionuclide treatment dose weeks received study subject participant prior yttrium Cluster 287: initiating prior treatment therapy days study protocol weeks systemic estrogens Cluster 288: received prior therapy patients treatment radiation eligible weeks dose study Cluster 289: dose treatment study radiation days therapy received bone metastasis site Cluster 290: radiation marrow bone therapy prior received weeks pelvis patients hematopoietically Cluster 291: asthma mild history severe persistent chronic moderate requiring inhaled currently Cluster 292: infections uncontrolled active severe conditions acute chronic including systemic clinically Cluster 293: liver disease chronic history significant known clinically active severe evidence Cluster 294: dysfunction organ renal hepatic significant cardiac liver evidence history severe Cluster 295: acute chronic disease pancreatic skin severe infection liver renal infections Cluster 296: cirrhosis liver hepatic known ascites history chronic evidence disease meaningful Cluster 297: decompensated arrhythmia congestive heart failure uncontrolled ejection fraction absence left Cluster 298: threatening maintenance arrhythmias ventricular infarction myocardial ongoing life congestive heart Cluster 299: heart congestive failure symptomatic history chf disease active requiring arrhythmia Cluster 300: threatening stroke cardiovascular arrhythmia unstable infarction myocardial life problems congestive Cluster 301: heart arrhythmias cardiovascular disease class infarction myocardial congestive symptomatic significant Cluster 302: coronary artery disease cardiac symptomatic heart failure congestive myocardial infarction Cluster 303: cardiac heart significant arrhythmia myocardial failure infarction congestive disease clinically Cluster 304: ischemia evidence symptomatic peripheral myocardial ecg cardiac arrhythmia significant muscle Cluster 305: heart nyha controlled abnormalities york association arrhythmia infarction myocardial congestive Cluster 306: transaminase aminotransferase serum glutamic pyruvate oxaloacetic glutamate sgot sgpt institutional Cluster 307: transaminase glutamic serum pyruvic aminotransferase sgpt oxaloacetic sgot upper alt Cluster 308: transaminase aminotransferase serum uln pyruvate glutamic glutamate oxaloacetic sgot sgpt Cluster 309: glutamic oxaloacetic sgot transaminase serum normal upper limit times uln Cluster 310: transaminase aminotransferase serum pyruvate glutamic glutamate oxaloacetic sgot sgpt aspartate Cluster 311: sgot glutamic oxaloacetic transaminase aspartate ast aminotransferase uln serum institutional Cluster 312: glutamic transaminase aminotransferase pyruvic serum uln sgpt alt sgot oxaloacetic Cluster 313: transaminase iuln aminotransferase serum glutamic sgot oxaloacetic glutamate pyruvate sgpt Cluster 314: sgot oxaloacetic glutamic transaminase aspartate aminotransferase ast upper limit normal Cluster 315: transaminase serum sgot pyruvate glutamate glutamic sgpt oxaloacetic normal upper Cluster 316: transaminase aminotransferase serum glutamic oxaloacetic pyruvate sgot glutamate sgpt ast Cluster 317: cancer melanoma situ malignancy cervical skin non second carcinoma years Cluster 318: situ carcinoma cervical cancer years skin basal malignancy melanoma cell Cluster 319: cancer prostate skin malignancy situ melanoma non years cervical carcinoma Cluster 320: carcinoma situ cured cervical skin malignancies ductal melanomatous invasive non Cluster 321: capacity lung supplementary oxygen monoxide dlco carbon expiratory continuous fev Cluster 322: fev expiratory dlco forced monoxide predicted carbon volume capacity second Cluster 323: smoking cigarette prolonged respiratory tested expiratory fev forced predicted dysfunction Cluster 324: forced capacity fvc fev vital expiratory volume predicted second dlco Cluster 325: fev expiratory forced volume second predicted pulmonary obstructive copd function Cluster 326: normalized inr international ratio uln coagulation anticoagulation warfarin anticoagulants blood Cluster 327: anticoagulation therapeutic applies inr aptt normalized ratio thromboplastin activated international Cluster 328: time aptt thromboplastin activated partial inr normalized ratio prothrombin international Cluster 329: prothrombin inr normalized pt ratio international time uln normal seconds Cluster 330: time inr ptt thromboplastin normalized partial ratio international prothrombin pt Cluster 331: inr warfarin heparin normalized ratio international stable ptt time thromboplastin Cluster 332: bowel vomiting nausea inflammatory refractory resection gastrointestinal absorption diseases significant Cluster 333: vomiting nausea preclude absorption bowel refractory significant resection malabsorption adequate Cluster 334: pediatric years patients age old children trials phase adult eligible Cluster 335: old age years donor patients greater time consent male equal Cluster 336: old years patients patient female male adult time donor women Cluster 337: aged female male years subjects patients equal greater inclusive age Cluster 338: males females age years aged older time old consent greater Cluster 339: bowel affecting small stomach significantly malabsorption resection disease gastrointestinal obstruction Cluster 340: alimentation affecting requirement absorption gastrointestinal disease inability oral procedures intravenous Cluster 341: affecting significantly gastrointestinal function malabsorption swallow syndrome unable disease capsules Cluster 342: integrity tract malabsorption gastrointestinal lack physical syndrome upper oral unable Cluster 343: swallow oral able medications patients patient reliably tolerate capsules absorb Cluster 344: oral medications ability swallow unable receive tolerate patients existing record Cluster 345: tolerate inability able unable mri patients ascorbate oral position flexible Cluster 346: claustrophobia severe anxiolytics unresponsive inability history scanning tolerate oral symptomatic Cluster 347: ability medication oral swallow dosage impaired receive patients form solid Cluster 348: tablets swallow ability oral retain difficulty acetate abiraterone patients tolerate Cluster 349: aspirin daily heparin prophylactic anticoagulation molecular weight mg asa low Cluster 350: heparin fondaparinux lmwh warfarin molecular weight derived coumarin low prophylaxis Cluster 351: warfarin low heparin thrombin lmwh inhibitors xa dose therapeutic molecular Cluster 352: heparin low molecular weight warfarin anticoagulation therapeutic aspirin dose anticoagulants Cluster 353: warfarin anticoagulation inr pt receiving patients therapeutic prophylactic dose therapy Cluster 354: bleeding dose heparin molecular weight inr stable carries warfarin low Cluster 355: heparin low flush acetylsalicylic dwelling dose anticoagulation acid needed maintenance Cluster 356: anticoagulation therapeutic receiving patients therapy anticoagulant aspirin require anticoagulants stable Cluster 357: resection surgical patients tumor prior biopsy complete radiation weeks therapy Cluster 358: gross resection total hematuria tumor disease residual hemoptysis patients subtotal Cluster 359: curative intent surgery treatment resection radiation treated disease surgical therapy Cluster 360: consciousness loss attack transient ischemic months history unexplained enrollment subject Cluster 361: ischemic attack transient stroke months history prior day thrombosis tia Cluster 362: attack ischemic transient cerebrovascular accident tia cva history months prior Cluster 363: block degree av atrioventricular second nd rd ventricular ecg type Cluster 364: ventricular atrial tested tachycardia degree old fibrillation block lvef arrhythmias Cluster 365: ventricular fibrillation atrial tachycardia arrhythmia contractions premature flutter uncontrolled controlled Cluster 366: ventricular tachycardia fibrillation history pointes arrhythmia torsades arrhythmias sustained clinically Cluster 367: ventricular atrial heart tachycardia degree fibrillation block lvef arrhythmias old Cluster 368: birth control methods method female use surgically sterile study male Cluster 369: fathering form acceptable medically birth control childbearing child willing potential Cluster 370: barrier birth control study method adequate contraception abstinence agree duration Cluster 371: child bearing birth potential control women use study agree practice Cluster 372: birth control women potential effective men agree reproductive use childbearing Cluster 373: birth control potential childbearing agree pregnancy study use test method Cluster 374: protection partners barrier birth control method willing week childbearing principal Cluster 375: highly effective method birth sexually control women potential childbearing trial Cluster 376: birth control use effective study agree adequate acceptable forms form Cluster 377: write read english able speak understand unable spanish languages ability Cluster 378: speaking english non spanish patients participants caregiver assessments person emr Cluster 379: spanish english speaks speaking reads consent able informed read french Cluster 380: spanish speak english read able patients inability understand caregiver phase Cluster 381: english read understand able speakers ability questions respond unable written Cluster 382: speak read english able understand ability unable fluently patients inability Cluster 383: language english read speak able primary understand unable proficient patient Cluster 384: communicate english able read spanish sensations exablate ability staff inability Cluster 385: speak english able understand comprehend ability patients unable informed consent Cluster 386: fluent english spanish aim phase language speakers inclusion caregiver pcs Cluster 387: condition compromise opinion situation protocol investigator aes underlying medical assessment Cluster 388: safety interfere opinion investigator compromise illness evaluation drug condition dysfunction Cluster 389: unacceptably places toxicities high risk condition opinion medical investigator patient Cluster 390: patient cognitive information compromise complete psychiatric comply study conditions ability Cluster 391: tolerate compromise significant ability patients therapy opinion medical illness illnesses Cluster 392: compromise safety investigator opinion condition abnormality patient medical ability study Cluster 393: performing subject meeting prevent compromise study opinion requirements condition investigator Cluster 394: successful psychological compromise safety opinion unstable participation conditions medical investigator Cluster 395: threatening dysfunction safety compromise outcomes organ life undue illness opinion Cluster 396: objectives compromise opinion investigator condition study medical protocol nonmalignant sponsor Cluster 397: placement days subcutaneous access venous prior major device surgery enrollment Cluster 398: minor placement procedure access surgical excluding vascular biopsy core device Cluster 399: procedures minor surgical placement major days port surgery biopsy waiting Cluster 400: surgery major placement minor access vascular weeks excluding study procedures Cluster 401: metastatic cancer breast patients prior chemotherapy evidence disease received eligible Cluster 402: inflammatory breast cancer tumors including women disease pagets evidenced assessment Cluster 403: neoadjuvant chemotherapy therapy planned received surgery cancer prior breast patients Cluster 404: docetaxel prior treatment chemotherapy cabazitaxel prostate sensitive cancer received metastatic Cluster 405: advanced cancer metastatic breast diagnosis therapy disease prior received solid Cluster 406: protein urine ratio creatinine hour screening urinalysis gram mg proteinuria Cluster 407: upcr protein urine ratio creatinine urinalysis hour cabozantinib mg spot Cluster 408: upc protein urine ratio hour creatinine dipstick proteinuria value assessed Cluster 409: small lung cell cancer non nsclc confirmed sclc carcinoma stage Cluster 410: lung small histologically cell cytologically non cancer confirmed nsclc stage Cluster 411: prednisone corticosteroids equivalent mg day doses dose systemic use chronic Cluster 412: daily equivalent mg prednisone dose corticosteroids chronic corticosteroid steroids doses Cluster 413: mg day prednisone equivalent kg steroid dose corticosteroid gvhd therapy Cluster 414: doxorubicin cumulative mg epirubicin dose anthracycline exposure anthracyclines equivalent prior Cluster 415: corticosteroids exceed intranasal physiological inhaled prednisone equivalent doses immunosuppressive corticosteroid Cluster 416: steroids prednisone mg equivalent day doses systemic topical dose steroid Cluster 417: corticosteroid use systemic prednisone therapy dose chronic mg prior condition Cluster 418: dose prednisone corticosteroids steroids adrenal equivalent insufficiency chronic mg rheumatoid Cluster 419: dexamethasone mg dose day equivalent days daily prior corticosteroid systemic Cluster 420: apply protocol defined exclusion criteria inclusion pregnant nursing lactating details Cluster 421: procurement criteria time inclusion exclusion pending patients cell infection expectancy Cluster 422: apply criteria inclusion additional information contact investigator exclusions unable pembrolizumab Cluster 423: exist additional criteria exclusion inclusion regarding morbid restrictions illness disease Cluster 424: apply exclusion criteria inclusion cohort additional hepatitis chronic infection active Cluster 425: cabozantinib lln phosphorus dose potassium days calcium lower magnesium serum Cluster 426: phosphorus lln lower serum normal limit calcium potassium magnesium supplementation Cluster 427: lln magnesium serum potassium calcium sodium lower lvef fibrinogen institutional Cluster 428: magnesium lower limit normal mg dl supplementation serum level lln Cluster 429: lower normal values calcium magnesium potassium limit lab institution phosphorus Cluster 430: ongoing infection active uncontrolled illness including patients recent grade evidence Cluster 431: invasive carcinoma dcis breast ductal diagnosis situ cancer multicentric biopsy Cluster 432: curative treated prostate intent cancer situ carcinoma surgically negligible ductal Cluster 433: lobular carcinoma situ breast lcis ductal cancer dcis invasive hyperplasia Cluster 434: ductal carcinoma dcis situ breast invasive cancer treated diagnosis history Cluster 435: bladder cancer superficial radiation invasive prior history diagnosis patient tumor Cluster 436: invasive breast cancer bilateral diagnosis prior diagnosed history dcis non Cluster 437: microliter leukocytes mcl fascial farber fap fanconi fancd fancc fanca Cluster 438: prison residing patients zydelig families fap fanconi fancd fancc fanca Cluster 439: patients disease men zydelig fanca fascia farber fap fanconi fancd Cluster 440: feeding breast allowed enrollment active study farber fap fanconi fancd Cluster 441: fertility future interested arm trial screening women fanca farber fap Cluster 442: unmanageable claustrophobia zydelig family farber fap fanconi fancd fancc fanca Cluster 443: ecog patient screen enrolment better ii fanca farber fap fanconi Cluster 444: pills swallow inability unwillingness fall fap fanconi fancd fancc fanca Cluster 445: sarcoidosis syndrome history fcg fascia fap fanconi fancd fancc fanca Cluster 446: void volume residual bladder post ml fanca fap fanconi fancd Cluster 447: survival likely concomitant associated year illness fanca fap fanconi fancd Cluster 448: consecutive women effective months spermicide bearing child mature potential naturally Cluster 449: nursing women pregnant following plan arm trial breastfeeding exclusion participate Cluster 450: nursing excluded pregnant women study patients step following included woman Cluster 451: women pregnant planning nursing participate study eligible breastfeed ineligible donor Cluster 452: ethics nature board committee independent legal review representative procedure approved Cluster 453: irb iec board ethics approved review consent committee informed independent Cluster 454: anticipated expectancy life months greater weeks time lymphodepletion ecog screening Cluster 455: expectancy life greater months equal physician morbid assessed treating determined Cluster 456: estimated expectancy life months greater investigator patients entry treating physician Cluster 457: expectancy life investigator opinion months weeks determined greater judgment assessed Cluster 458: tolerate inability opinion treating procedures investigator imaging physician predispose rapidly Cluster 459: medically fit undergo stable patients physician determined inoperable unstable receive Cluster 460: physician treating determined opinion discretion patients deemed medical judged treatment Cluster 461: past months history years year active sequelae event chemotherapy cerebrovascular Cluster 462: alcohol abuse current drug dependence illicit psychiatric known evidence drugs Cluster 463: dependence alcohol substance abuse drug history active current year past Cluster 464: sample tumor biopsy tissue archival available fresh provide archived testing Cluster 465: tissue excisional newly biopsy obtained core tumor archival sample lesion Cluster 466: analysis tissue tumor biomarker available biopsy results archived provide samples Cluster 467: archival tissue tumor available biopsy fresh provide undergo willing sample Cluster 468: obtained newly specimen inaccessible archived excisional concern biopsy tissue submit Cluster 469: availability tissue tumor archival sample fresh archived ffpe freshly specimen Cluster 470: tissue tumor available biopsy archived research provide fresh testing patients Cluster 471: cm size tumor dimension lesion tumors greatest patients disease greater Cluster 472: cycle major surgery day days weeks prior recent diagnosis minor Cluster 473: major surgery enrollment days weeks prior study month patients undergone Cluster 474: major surgery drug dose study weeks days prior administration trauma Cluster 475: use prior medications days chronic study intermittent day allowed patients Cluster 476: undergone surgery major prior patients weeks debulking hours subjects days Cluster 477: surgery major registration prior days weeks study eligible diagnostic patients Cluster 478: procedure surgical major prior weeks days study day treatment surgery Cluster 479: surgery day major weeks prior study days diagnostic recovered treatment Cluster 480: major surgery days prior dose treatment study immunotherapy patients entering Cluster 481: transurethral turp prostate resection prior prostatic surgery cryotherapy including procedure Cluster 482: surgery major weeks dose prior study subject radiation lenvatinib treatment Cluster 483: scheduled surgery undergo receive patients chemotherapy cancer study patient procedure Cluster 484: start major surgery weeks study treatment prior recovery days complete Cluster 485: isolated palliative intent local lesions surgery acceptable major procedure surgical Cluster 486: brca mutation deleterious germline cancer breast mutations known testing genes Cluster 487: braf mutation ve melanoma clia tumor raf oncogene mutations nras Cluster 488: dated signed informed consent written specific procedures study provision prior Cluster 489: signed form consent informed icf study specific patient approved prior Cluster 490: specific signed informed consent procedures study prior written obtained initiation Cluster 491: procedures obtained informed consent written prior screening signed study specific Cluster 492: performed written related provide obtained procedures informed consent participation ability Cluster 493: procedures provide informed consent written study prior specific screening related Cluster 494: provision consent informed procedures specific written study prior signed participate Cluster 495: performing evaluations authorization procedures obtained written hipaa related protocol screening Cluster 496: provided consent informed written subject study procedures activities participate prior Cluster 497: drug investigational weeks study preceding treatment prior start administration participation Cluster 498: investigational agent weeks treatment study prior dose administration therapy initiation Cluster 499: vaccine prevention infectious therapy non oncology diseases administration ipilimumab dose Cluster 500: drug study administration dose days prior weeks following therapy treatment Cluster 501: cpi treatment weeks cancer initiation past investigational prior received dose Cluster 502: concurrently using antineoplastic approved patient anti neoplastic investigational therapy agent Cluster 503: initiation treatment study prior days weeks therapy investigational drug cancer Cluster 504: medi receipt dose anticancer prior days investigational therapy amp weeks Cluster 505: agent investigational registration days treatment prior therapy protocol registered study Cluster 506: product investigational days medicinal prior received treatment weeks administration study Cluster 507: exhibit ecog eastern cooperative oncology group status performance patients directly Cluster 508: mri ct scan disease measurable tumor imaging evidence days bone Cluster 509: tomography ct computed pet emission positron measurable scan disease cm Cluster 510: ct chest abdomen pelvis scan tomography imaging computed mri contrast Cluster 511: imaging resonance magnetic tomography computed ct mri scan measurable disease Cluster 512: tomography emission positron pet ct computed scan imaging disease mri Cluster 513: seropositive hiv immunodeficiency virus human known patients active infection eligible Cluster 514: virus htlv human lymphotropic hiv immunodeficiency cell infection seropositive leukemia Cluster 515: lower ejection fraction left ventricular normal limit lvef lln institutional Cluster 516: ef ejection fraction ventricular left cardiac echocardiogram heart dimensional uncontrolled Cluster 517: ejection left ventricular fraction cardiac rest function greater arrhythmias disease Cluster 518: fraction liver shortening ejection portal capacity tlc approve pi supplementary Cluster 519: fraction shortening ejection left ventricular fractional cardiac function cardiologist greater Cluster 520: lvef left ejection fraction ventricular cardiac known improve symptomatic rest Cluster 521: dose therapy study male starting method contraception agree adequate use Cluster 522: method contraception barrier use effective childbearing potential willing discontinuation females Cluster 523: effective contraception use agree sterile patients surgically fertile study dose Cluster 524: highly effective contraception study use male female methods period potential Cluster 525: reproductive contraception potential effective use agree female study method male Cluster 526: contraception use adequate method agree study male duration willing agrees Cluster 527: fcbp lenalidomide pregnancy effective method days agree commit begin starts Cluster 528: female childbearing potential male contraception partners use effective patients agree Cluster 529: contraceptive use study agree potential effective methods method dose childbearing Cluster 530: avoidance producing measures child agree male contraception potential female use Cluster 531: waldenstrm macroglobulinemia wm lymphoplasmacytoid lpl lymphoma lymphocytic secretory stated criteria Cluster 532: hcv hepatitis hbv infection active viral virus chronic load known Cluster 533: hepatitis virus hbv hcv infection active known chronic positive patients Cluster 534: virus hepatitis hcv hbv hiv immunodeficiency human infection known active Cluster 535: antiviral infection chronic hepatitis requiring active therapy current hiv immunodeficiency Cluster 536: virus hepatitis seropositive hcv hbv hiv immunodeficiency human viral known Cluster 537: hbv hcv infection hiv active known htlv history deficiency disease Cluster 538: hbv hcv virus hepatitis infection cleared known hiv chronic immunodeficiency Cluster 539: opinion psychiatric investigator medical prevent interfere illness major completion illnesses Cluster 540: potentially completion interfere illness psychiatric according opinion medical investigators protocol Cluster 541: adherence interfere opinion ability condition investigators clinically medical protocol significant Cluster 542: threatening illness unrelated life cancer opinion psychiatric potentially medical interfere Cluster 543: fish ihc hybridization situ fluorescence immunohistochemistry negative positive fluorescent breast Cluster 544: receptor er estrogen progesterone pr positive negative breast epidermal growth Cluster 545: tamoxifen aromatase raloxifene inhibitors therapy estrogen selective breast receptor cancer Cluster 546: er pr positive breast cancer negative ihc staining receptor pgr Cluster 547: receptor estrogen positive progesterone hormone breast cancer negative status tumor Cluster 548: copy probe signals number average cep ihc ratio ish dual Cluster 549: receptor negative ihc er pr progesterone estrogen immunohistochemistry hybridization fish Cluster 550: wbc white blood cell count mm mcl days hydroxyurea registration Cluster 551: white cells wbc blood mcl days ml ul wbcs administration Cluster 552: white blood count cell mm ul hydroxyurea cells mcl meet Cluster 553: mcl platelet count cells thrombocytosis pi days transfused marrow mm Cluster 554: blast count hydroxyurea peripheral circulating blood marrow counts ul mm Cluster 555: immunosuppressive therapy chronic systemic corticosteroids agents receiving treatment ongoing patients Cluster 556: corticosteroids systemic patients receiving weeks dose treatment prior replacement days Cluster 557: major surgery recovered effects starting weeks prior study patient fully Cluster 558: intra thoracic surgery abdominal injury pelvic major starting procedure effects Cluster 559: starting weeks received effects therapy drug study recovered prior nitrosourea Cluster 560: surgery radiation therapy weeks treatment major chemotherapy prior study recovered Cluster 561: major traumatic injury surgery significant study effects recovered days weeks Cluster 562: effects surgery recovered major undergone starting weeks drug prior study Cluster 563: complications recovered adequately toxicity intervention major surgery starting prior therapy Cluster 564: major surgery weeks planned study prior elective course starting treatment Cluster 565: effects recovered surgery radiotherapy prior recent antineoplastic patients therapy chemotherapy Cluster 566: interstitial lung disease history signs symptoms ongoing time informed consent Cluster 567: pulmonary obstructive copd chronic disease severe lung asthma requiring oxygen Cluster 568: pneumonitis history induced active ongoing drug years radiation confirmed patients Cluster 569: ild interstitial lung pneumonitis history disease induced evidence active drug Cluster 570: severely lung impaired function interstitial concurrent condition severity history judged Cluster 571: interstitial pneumonitis lung history disease active requiring patients radiation clinically Cluster 572: interstitial lung evidence disease clinically history asymptomatic active patients dyspnea Cluster 573: cardiac disease arrhythmia history shunts patients known condition active requiring Cluster 574: noninfectious pneumonitis interstitial evidence lung history active steroids required disease Cluster 575: cytokine support count neutrophil absolute growth factor transfusion platelet mcl Cluster 576: growth factor support neutrophil absolute count anc mcl ul days Cluster 577: growth anc mm neutrophil absolute factor count support days factors Cluster 578: anderson md center cancer mdacc patients care pa seen protocol Cluster 579: aware nature indicating informed sign consent investigational study patients risks Cluster 580: awareness indicating nature program signed investigational informed consent scheduling cct Cluster 581: nature benefits willingly alternatives risks aware informed discomforts experimental neoplastic Cluster 582: keeping anderson aware policies nature center consent md indicating investigational Cluster 583: play lansky score performance karnofsky scale pediatric status years older Cluster 584: ps ecog performance status score subjects patient scale screening patients Cluster 585: zubrod performance status patients ps karnofsky score criteria scale equal Cluster 586: scale karnofsky performance kps status score lansky ps higher greater Cluster 587: lansky karnofsky performance status score dependent adult pediatric age kps Cluster 588: score karnofsky performance status greater patients higher adult adequate time Cluster 589: age score years lansky performance karnofsky lps status scale kps Cluster 590: kps score ci hct aged greater modified definitions rpa patients Cluster 591: ms qtc qt corrected interval baseline ecg prolongation males electrocardiogram Cluster 592: msec qtc interval ecg prolongation screening baseline qt males females Cluster 593: qtc interval qt corrected milliseconds prolongation baseline demonstration marked repeated Cluster 594: msec qtcf ecg interval screening males females mean baseline electrocardiogram Cluster 595: msec qtc corrected qt interval prolongation rate mean fridericia screening Cluster 596: leukemia liver chronic fatty leukemias secretory burkitt accelerated inherited alcoholic Cluster 597: leukemia chronic leukemias secretory burkitt accelerated myelogenous blast lymphocytic plasma Cluster 598: bleeding hemorrhage event terminology ctcae common events adverse grade criteria Cluster 599: grade ctcae common adverse toxicity terminology events criteria neuropathy alopecia Cluster 600: neuropathy terminology common ctcae events adverse peripheral criteria grade existing Cluster 601: platelet mm count cells greater days randomization starting weeks prior Cluster 602: platelet count obtained registration days mm prior randomization mcl untransfused Cluster 603: ul platelet count days prior cells untransfused obtained treatment thrombocytopenia Cluster 604: mcl neutrophil absolute count registration days weeks prior cohort cells Cluster 605: peripheral anc neutrophil absolute ul count marrow bone solid tumors Cluster 606: neutrophil absolute count ml days enrollment prior microliters randomization patient Cluster 607: ul neutrophil absolute count cells days registration arm prior cohort Cluster 608: ul anc neutrophil absolute count cells days registration prior neutropenia Cluster 609: anc neutrophil absolute count days ul prior treatment study cells Cluster 610: mcl anc neutrophil absolute count registration days prior performed equal Cluster 611: microliter hiv cd cells registration haart count positive note antiretroviral Cluster 612: unsupported platelets days transfusions hemoglobin mm count dl ul neutrophil Cluster 613: initiation mcl neutrophil anc absolute count days performed treatment nabsolute Cluster 614: oximetry pulse dyspnea rest exercise room air intolerance evidence indication Cluster 615: minute creatinine clearance ml calculated gault serum cockcroft formula measured Cluster 616: creatinine clearance gault cockcroft hour collection min ml urine formula Cluster 617: equation creatinine gault cockcroft clearance min ml calculated estimated using Cluster 618: creatinine gault clearance cockcroft formula min calculated ml using uln Cluster 619: creatinine clearance gault cockcroft min ml calculated mg dl formula Cluster 620: gault cockcroft clearance creatinine min ml formula calculated renal function Cluster 621: estimation creatinine gault cockcroft basis clearance min glomerular filtration ml Cluster 622: estimated cockcroft gault creatinine clearance min ml cc serum equal Cluster 623: formula estimated creatinine gault clearance ml cockcroft min cockroft using Cluster 624: crcl creatinine gault cockcroft clearance formula ml min using calculated Cluster 625: permitting release personal authorization information health approved signed informed consent Cluster 626: privacy protected regulations dated authorization purpose accordance information risks national Cluster 627: authorization release information health research written obtained use signed protected Cluster 628: protected understand authorization information purpose risks ability provide health study Cluster 629: toxicity grade alopecia therapy prior severity anti progressing ongoing cancer Cluster 630: resolved toxicities grade prior alopecia therapy related treatment neuropathy previous Cluster 631: toxicity recovered prior therapy grade patients previous acute treatment days Cluster 632: resolved grade toxicity prior related therapy acute alopecia previous treatment Cluster 633: toxicities grade related alopecia prior recovery resolution therapy treatment significant Cluster 634: toxicity related grade returned prior therapy baseline irreversible deemed persisting Cluster 635: extramedullary isolated disease cns relapse leukemia testicular solitary marrow bone Cluster 636: remission complete cr leukemia relapse risk high induction patients disease Cluster 637: cr response complete pr achieved partial cri disease leukemia patients Cluster 638: ckit favorable karyotype mutated cr remission npm mutation inv risk Cluster 639: line therapy prior chemotherapy received disease patients treatment systemic second Cluster 640: therapy prior systemic received chemotherapy patients treatment disease allowed radiation Cluster 641: therapy prior patients allowed radiation dose weeks days treatment chemotherapy Cluster 642: radiation therapy prior chemotherapy patients treatment days field gy allowed Cluster 643: therapies prior number received cancer anti patients allowed systemic limit Cluster 644: sorafenib hcc prior treatment systemic therapy received intolerance progression patients Cluster 645: conventional therapy chemotherapy radiation curable weeks patients tumor disease treatment Cluster 646: newly diagnosed cancer patients breast histologically stage disease untreated confirmed Cluster 647: stage iv cancer breast disease metastatic iii patients diagnosed diagnosis Cluster 648: breast diagnosis cancer stage years confirmed current hr primary patients Cluster 649: stage melanoma iv unresectable iii histologically confirmed metastatic diagnosis iiic Cluster 650: pheochromocytoma patients concurrent diagnosis metastatic regorafenib biochemically phases untreated hyper Cluster 651: stage breast cancer iii ii diagnosed diagnosis early newly histologically Cluster 652: stage iii iv ii arbor ann disease cancer iva figo Cluster 653: stage disease clinical patients ib iiia bclc ii ia cancer Cluster 654: colorectal cancer metastatic chemotherapy patients crc diagnosed prior stage breast Cluster 655: reaction antibody monoclonal hypersensitivity severe history mab components infusion allergy Cluster 656: pembrolizumab nivolumab hypersensitivity prior dose treatment received therapy known mk Cluster 657: mannitol hypersensitivity boron bortezomib azacitidine known suspected allergy velcade history Cluster 658: talazoparib components hypersensitivity known capsule suspected bmn treatment previous prior Cluster 659: reaction allergic history prior hypersensitivity involved known severe protocol drug Cluster 660: component hypersensitivity known formulation allergy bevacizumab study reaction history drug Cluster 661: components allergy history drug study known hypersensitivity nivolumab treatment reaction Cluster 662: fentanyl allergy history propofol opioids patches transdermal tolerant lidocaine midazolam Cluster 663: formulation components allergy hypersensitivity identified previously study subject treatment known Cluster 664: formulations allergy components hypersensitivity identified previously component study known cobimetinib Cluster 665: gilbert bilirubin uln upper normal limit total syndrome unless disease Cluster 666: bilirubin total gilbert mg dl syndrome uln subjects patients serum Cluster 667: gilbert syndrome history known disease diagnosis patients eligible bilirubin glucuronidation Cluster 668: gilbert bilirubin uln total syndrome unless documented disease serum patients Cluster 669: liver gallstones biliary disease asymptomatic gilbert exception chronic syndrome assessment Cluster 670: bilirubin total gilbert normal syndrome upper mg dl limit institutional Cluster 671: gilbert mg dl bilirubin syndrome total unless hemolysis disease known Cluster 672: bilirubin uln gilbert total direct syndrome normal patients range serum Cluster 673: liver function disease patients metastases tests tumor lfts burden volume Cluster 674: organ function marrow bone adequate defined days laboratory registration patients Cluster 675: organ function marrow normal defined patients bone tests days subjects Cluster 676: reserve marrow bone adequate inadequate demonstrated function organ evidenced laboratory Cluster 677: liver function adequate defined acceptable demonstrated subjects normal bilirubin participant Cluster 678: marrow bone function adequate defined evidenced subject lymphodepleting patient participants Cluster 679: sponge ring jellies vaginal study double diaphragm cream spermicidal contraceptive Cluster 680: contraception suppository film methods cream gel spermicidal foam vault cap Cluster 681: pugh child score class liver function hepatic disease points ascites Cluster 682: pugh cirrhosis child liver class score classification present patients worse Cluster 683: pugh hepatic impairment child class severe moderate patients baseline liver Cluster 684: pugh child impairment hepatic classification according currently clinically significant class Cluster 685: childs cirrhosis pugh class score liver severe hepatic known disease Cluster 686: kg weigh cd cells minimum stem patients cell weighing apheresis Cluster 687: eso ny expression ihc immunohistochemistry tumor positive rt immunotherapeutics pcr Cluster 688: marrow bone aspirate biopsy peripheral blood patients days performed prior Cluster 689: flow cytometry cd expression marrow immunohistochemistry cells bone peripheral blood Cluster 690: cd cells expression cell positive prior cll tumor diagnosis car Cluster 691: gfr renal glomerular filtration rate insufficiency min ml patients contrast Cluster 692: gfr glomerular filtration rate min ml estimated creatinine calculated uln Cluster 693: glomerular filtration rate creatinine min ml gfr mg dl serum Cluster 694: min ml renal creatinine function gfr glomerular filtration rate adequate Cluster 695: estimated glomerular filtration rate egfr min ml creatinine renal cockcroft Cluster 696: radioisotope gfr creatinine glomerular filtration min clearance rate ml serum Cluster 697: renal hepatic disease significant pulmonary cardiovascular endocrine investigator gastrointestinal metabolic Cluster 698: cardiac significant clinically disease history uncontrolled dysfunction pulmonary active months Cluster 699: cardiovascular significant including disease clinically uncontrolled pulmonary poorly active condition Cluster 700: cardiovascular significant disease clinically uncontrolled history pulmonary active diseases months Cluster 701: tolerance impair opinion investigator significant diseases treatment example trial inflammatory Cluster 702: cardiac impaired function clinically significant diseases disease following including patients Cluster 703: significant clinically disease history uncontrolled metabolic heart immunosuppression medical study Cluster 704: morbidities active clinically disease significant compromise pulmonary uncontrolled participation condition Cluster 705: uncontrolled concurrent significant compromise clinically medical severe participation neurological pulmonary Cluster 706: cardiovascular history conditions disease evidence risk following uncontrolled unstable current Cluster 707: significant disease interpretation affect diseases pulmonary uncontrolled concomitant results compliance Cluster 708: hemoglobin dl days obtained prior treatment randomization study day cycle Cluster 709: severe infections weeks prior day cycle infection enrollment randomization systemic Cluster 710: rems program revlimid registered mandatory comply requirements mitigation willing able Cluster 711: revassist program mandatory registered comply willing requirements able participants study Cluster 712: rems adhere program revlimid scheduled reproductive testing females pregnancy required Cluster 713: brain metastases treated weeks progression evidence mri imaging administration resonance Cluster 714: resonance magnetic imaging mri contrast brain mr undergo patients contraindication Cluster 715: brain mri metastases imaging ct resonance magnetic contrast weeks tomography Cluster 716: assess measurable scans mris disease used ct completed resonance magnetic Cluster 717: mri undergo unable contrast patients inability brain able scan imaging Cluster 718: transponders anchored mr artifact imaging image monitored safe lung tumors Cluster 719: vaccines influenza flu live allowed seasonal inactivated mist generally intranasal Cluster 720: influenza attenuated vaccine live season october march vaccination cycle approximately Cluster 721: vaccines live attenuated typhoid rubella mumps yellow measles influenza bcg Cluster 722: bcg intravesical induction months disease calmette cis guerin doses prior Cluster 723: longer whichever lives half preceding investigational drug days dose study Cluster 724: investigational whichever half longer lives product agent prior days study Cluster 725: half lives agents investigational prior days treatment therapy study drug Cluster 726: taken half investigational lives days shorter whichever agents minimum drug Cluster 727: immunostimulatory whichever lives half agents systemic shorter treatment drug weeks Cluster 728: shorter whichever half lives therapy weeks prior investigational chemotherapy treatment Cluster 729: shorter half lives whichever days investigational dose drug study minimum Cluster 730: whichever longer half lives drug investigational study days dose weeks Cluster 731: antibody monoclonal lives half elapsed dose prior antibodies treatment days Cluster 732: disorder bleeding unrelated significant congenital acquired cancer history cml presence Cluster 733: disorder bleeding history bipolar psychiatric autoimmune known patients active anxiety Cluster 734: thrombocytopenia heparin induced history platelets known platelet coagulopathy drug complications Cluster 735: bleeding active risk high pathologic disorder carry major coagulopathy conditions Cluster 736: coagulopathy bleeding disorder uncontrolled uncorrectable known existing history disorders patients Cluster 737: disorders bleeding psychiatric history known patients neurological thrombotic major significant Cluster 738: parp inhibitor treatment olaparib prior previous including inhibitors received patients Cluster 739: ribose poly adp parp polymerase inhibitor adenosine diphosphate prior treatment Cluster 740: carcinoma cell basal local cervix resection exception squamous treated skin Cluster 741: carcinoma malignancies cell situ basal cervix squamous skin years treated Cluster 742: carcinoma prostate cancer cell basal situ squamous treated skin years Cluster 743: superficial cancer bladder basal cell carcinoma squamous skin malignancy situ Cluster 744: cured carcinoma malignancy basal cervix years skin situ excised cell Cluster 745: curatively carcinoma treated malignancy situ skin basal cell years squamous Cluster 746: carcinoma cell basal malignancy situ skin squamous cervix years treated Cluster 747: resected completely cell basal squamous skin carcinoma exceptions situ recurred Cluster 748: intent treated curative carcinoma malignancy years situ cell basal skin Cluster 749: situ carcinoma cervix breast cis uteri bladder adequately history treated Cluster 750: situ carcinoma definitively cervix squamous basal melanoma skin malignancy cell Cluster 751: infectious interstitial pneumonitis lung non active evidence disease history known Cluster 752: pneumonitis infectious steroids required non known history cohort current participants Cluster 753: pregnancy current known female patient active exclusion patients required test Cluster 754: infectious pneumonitis non evidence active known history patient process steroids Cluster 755: pneumonitis infectious steroids current required non history active known evidence Cluster 756: pneumonitis infectious interstitial non lung steroids required history disease evidence Cluster 757: pt time intended prothrombin anticoagulant anticoagulants inr normalized range ptt Cluster 758: aptt intended anticoagulant ptt activated anticoagulants thromboplastin range pt partial Cluster 759: inr range normalized ratio international coumadin therapeutic anticoagulant normal enroll Cluster 760: inr desired anticoagulation anticoagulant recommended range level stable receiving normalized Cluster 761: pt time anticoagulant intended anticoagulants prothrombin ptt inr range normalized Cluster 762: myelodysplastic syndrome known leukemia presence history patients myeloproliferative neoplasm diagnosis Cluster 763: blasts raeb anemia refractory excess mds myelodysplastic high leukemia risk Cluster 764: myelomonocytic cmml leukemia chronic mds juvenile myeloproliferative mpn myelodysplastic diagnosis Cluster 765: transplant organ solid allogeneic stem cell tissue prior marrow bone Cluster 766: transplantation stem organ allogeneic cell solid prior including history transplant Cluster 767: transplant organ solid prior marrow bone history hematologic requiring immunosuppressive Cluster 768: allogenic transplant stem autologous organ cell solid history prior bone Cluster 769: allogeneic transplant marrow bone prior received previous organ history stem Cluster 770: progenitor transplantation organ solid marrow bone allogeneic cell history prior Cluster 771: attacks accident cerebrovascular transient ischemic embolic past events months including Cluster 772: thromboembolic event history months arterial events venous past hemorrhagic anticoagulation Cluster 773: embolic thrombotic attacks arterial thrombosis events cerebrovascular venous transient deep Cluster 774: intravenous bacterial fungal antibiotics acute requiring infection time registration active Cluster 775: fungal mycobacterial nail beds antibiotics infection infections excluding bacterial episode Cluster 776: excluded pregnant women study patients men breastfeeding participating studied trial Cluster 777: breastfeeding discontinued excluded pregnant women participants mother lactating study treated Cluster 778: mother discontinued breastfeeding agent study excluded pregnant women treated discontinuation Cluster 779: milk stored future mother breastfeeding note pregnant breast treated use Cluster 780: mother breastfeeding discontinued pregnant treated women excluded study agents apply Cluster 781: breastfeeding women excluded pregnant discontinued study prior nursing avoided treatment Cluster 782: nursing pregnancy infant mother donor patients females active women excluded Cluster 783: hyperbilirubinemia benign bilirubin total congenital uln unless serum hereditary syndrome Cluster 784: bilirubin gilberts mg dl total syndrome patients unless uln equal Cluster 785: syndrome history gilberts patients stevens johnson known kostmann shwachman serotonergic Cluster 786: gilberts bilirubin uln total syndrome disease patients unless documented subjects Cluster 787: bilirubin origin rise hepatic gilberts syndrome unless non uln gilbert Cluster 788: hemolysis gilberts bilirubin syndrome unless mg total dl hyperbilirubinemia normal Cluster 789: gilberts bilirubin upper uln normal total limit syndrome unless disease Cluster 790: products investigational treatment dose drug study days therapy weeks allergic Cluster 791: agent investigational days received enrollment prior use randomization treatment therapeutic Cluster 792: myelosuppressive nitrosourea chemotherapy weeks received prior days study enrollment dose Cluster 793: infusion lymphocyte donor dli days cell received prior infusions enrollment Cluster 794: experimental drug therapy study days use weeks treatment prior baseline Cluster 795: month prior treatment study enrollment therapy radiation use received past Cluster 796: drugs investigational days received enrollment patient study use prior dose Cluster 797: anticancer therapy investigational receipt treatment study systemic prior days drug Cluster 798: agent investigational type dose received days treatment study subject drug Cluster 799: infection requiring drug completed systemic recent dose days treatment study Cluster 800: bleomycin prior treatment radiosurgery chemotherapy use enrollment contraindicates morbid agent Cluster 801: sex having condom woman use drug study pregnant agrees dose Cluster 802: investigational drug days treatment study prior dose received enrollment use Cluster 803: understand able provide consent written informed willing review patients starting Cluster 804: assent provide willing able written trial informed consent study participation Cluster 805: valid consent informed able written willing provide benefits understanding nature Cluster 806: provide able consent informed willing patients patient capable signed study Cluster 807: willing written able provide informed consent trial patient subject participate Cluster 808: comply informed consent procedures written able provide study willing requirements Cluster 809: provide written able consent informed patients guardian patient study registration Cluster 810: mab weeks earlier monoclonal administered antibody prior recovered adverse events Cluster 811: earlier weeks administered adverse events recovered agents entering radiotherapy chemotherapy Cluster 812: weeks mitomycin nitrosoureas earlier entering administered adverse events recovered agents Cluster 813: weeks earlier administered monoclonal recovered adverse events antibody baseline prior Cluster 814: nci institute national neuropathy common ctcae grade terminology peripheral criteria Cluster 815: effects toxic terminology common grade ctcae institute resolution national adverse Cluster 816: institute national terminology events common adverse nci ctcae grade criteria Cluster 817: pathology national nci institute cancer laboratory confirmation confirmed diagnosis metastatic Cluster 818: resolved institute terminology national common grade version ctcae nci cancer Cluster 819: institute national nci common grade ctcae version adverse cancer events Cluster 820: antiretroviral combination hiv ineligible positive immunodeficiency virus human therapy patients Cluster 821: individuals antiretroviral combination hiv ineligible positive immunodeficiency virus human therapy Cluster 822: hiv load viral cd immunodeficiency antiretroviral virus human positive haart Cluster 823: antiretroviral combination undertaken hiv therapy studies indicated appropriate immunodeficiency virus Cluster 824: positivity antiretroviral combination hiv immunodeficiency virus human known therapy know Cluster 825: aminotransferase times aspartate ast upper alanine normal alt limit serum Cluster 826: aminotransferase alanine aspartate ast alt upper normal limit uln institutional Cluster 827: transaminase uln aspartate ast alanine alt upper normal limit liver Cluster 828: times upper normal limit alt liver ast uln transaminases igm Cluster 829: uln aminotransferase bilirubin alt ast aspartate alanine normal upper limit Cluster 830: institutional aminotransferase ast aspartate upper normal limit times uln days Cluster 831: unl bilirubin aminotransferase upper limit normal serum transaminase ast metastases Cluster 832: aminotransferase uln ast alt aspartate alanine liver upper normal limit Cluster 833: sgpt upper sgot alt limit normal ast institutional uln liver Cluster 834: alanine aminotransferase alt upper limit normal times uln institutional age Cluster 835: aspartate ast aminotransferase normal upper limit uln transaminase limits registration Cluster 836: anti pd antibody pathways targeting specifically ctla checkpoint stimulation cell Cluster 837: pd anti pathway targeting antibody therapeutic agents agonists ctla treatment Cluster 838: ctla therapies targeted pd excluded prior pdl stimulatory targeting checkpoint Cluster 839: gvhd host versus graft disease immunosuppressive active requiring therapy chronic Cluster 840: host versus graft transplantation allogeneic stem cell gvhd disease immunosuppressive Cluster 841: vs host graft transplant stem disease elapsed cell active rescue Cluster 842: graft versus host disease active chronic grade treatment cgvhd criteria Cluster 843: tacrolimus cyclosporine versus host post prevent transplant graft agents receiving Cluster 844: years gvhd ago allogeneic hematopoietic transplantation versus host symptoms undergone Cluster 845: gvhd host versus graft disease acute active grade ii chronic Cluster 846: transplant host versus graft allogeneic stem gvhd cell disease active Cluster 847: absorption gastrointestinal affect condition interfere oral drug malabsorption medication significantly Cluster 848: gastrointestinal alter impairment absorption function significantly incidence disease metabolism rapamycin Cluster 849: metabolism outcomes dysfunction threatening absorption undue compromise safety organ interfere Cluster 850: disorders absorption gastrointestinal interfere extensive drug study surgery medical history Cluster 851: excretion metabolism distribution absorption interfere gastrointestinal significantly disease condition presence Cluster 852: promyelocytic leukemia acute diagnosis aml patients classification pml favorable cytogenetics Cluster 853: world organization health diagnosis performance status classification aml criteria confirmed Cluster 854: apl promyelocytic leukemia acute aml diagnosis diagnosed world organization health Cluster 855: british french fab american promyelocytic leukemia classification aml acute mds Cluster 856: arthritis rheumatoid lupus autoimmune disease erythematosus systemic sclerosis multiple inflammatory Cluster 857: autoimmune disease syndrome sclerosis guillain systemic granulomatosis barre vasculitis erythematosus Cluster 858: autoimmune disease systemic erythematosus lupus vasculitis bowel inflammatory rheumatoid arthritis Cluster 859: scleroderma lupus active connective dermatomyositis collagen erythematosus tissue systemic disease Cluster 860: psa rising apart value ng week progression ml values prostate Cluster 861: psa prostate specific ng antigen ml days serum cancer value Cluster 862: ng psa ml level prostatectomy serum nadir prostate vitamin post Cluster 863: gleason psa prostate score risk ng stage ml tb intermediate Cluster 864: measure psa reference nd rising days value taken rises initial Cluster 865: age years patients patient subject participants subjects months women greater Cluster 866: older years old women men patients eighteen japan korea participants Cluster 867: age male female years patients time consent subjects informed obtaining Cluster 868: aged years patients child parents men women children consent time Cluster 869: older age years men women female patients time eighteen subjects Cluster 870: men women age years ages greater patients adult status country Cluster 871: aged older years male female females time males men adult Cluster 872: age years adult patients subjects legal majority amenorrhea appropriate male Cluster 873: inclusive years age aged female male donor adult participants men Cluster 874: adults years age older old unable infants individuals consent aged Cluster 875: older male female years age patients participants subjects consent time Cluster 876: steroid systemic therapy concurrent intolerance immunosuppressive use known weeks physiologic Cluster 877: physiologic therapy consultation doses steroid sponsor immunosuppressive form corticosteroids approved Cluster 878: steroid prednisone therapy equivalent immunosuppressive mg systemic immunodeficiency receiving form Cluster 879: therapy steroid immunosuppressive form trial immunodeficiency diagnosis systemic receiving dose Cluster 880: therapy steroid immunosuppressive form receiving systemic immunodeficiency diagnosis days prior Cluster 881: currently investigational receiving drug eligible patients drugs excluded therapy participation Cluster 882: treatments agents concurrent anti use cancer experimental investigational study days Cluster 883: agents anti receiving cancer currently patients eligible investigational study entry Cluster 884: years chemotherapy cancer ages prior treatment completion entry post patients Cluster 885: month entry investigational therapy study prior patients treatment antitumor neoplastic Cluster 886: compression carcinomatous meningitis spinal cord seizure brain metastases disorder active Cluster 887: compression cord leptomeningeal spinal metastases brain disease cns carcinomatosis uncontrolled Cluster 888: muscular myopathies dystrophy neuromuscular amyotrophic atrophy lateral ck sclerosis spinal Cluster 889: spinal cord compression untreated brain metastases leptomeningeal symptomatic metastasis stable Cluster 890: brain carcinomatous compression meningitis spinal cord leptomeningeal new evidence metastases Cluster 891: spinal cord compression tumor evidence cauda imminent brainstem impending radiation Cluster 892: compression cord spinal brain metastases stable unless asymptomatic steroids treatment Cluster 893: pectoris symptomatic unstable congestive angina uncontrolled failure heart illness arrhythmia Cluster 894: pectoris angina unstable uncontrolled requiring known arrhythmia medication subjects months Cluster 895: platinum resistant disease based refractory progression months therapy sensitive ovarian Cluster 896: taxane chemotherapy prior anthracycline based received therapy regimen platinum metastatic Cluster 897: platinum based chemotherapy regimen line disease received prior therapy progression Cluster 898: regimen chemotherapy prior received treatment patients therapy disease based regimens Cluster 899: anthracycline therapy prior received chemotherapy based containing exposure regimen patients Cluster 900: neck head radiation prior therapy chemotherapy cancer previous region patients Cluster 901: neck head cancer patients primary dissection diagnosis tumor lung recurrent Cluster 902: lymphedema group treatment edema neck head cancer iii therapists primary Cluster 903: rvo retinal csr hypercoagulability glaucoma hyperviscosity hypertension ocular history occlusion Cluster 904: portal vein main thrombosis invasion mesenteric smv superior encasement occlusion Cluster 905: rvo retinal occlusion vein history current evidence risk factors patients Cluster 906: retinopathy retinal serous occlusion vein rvo csr central history current Cluster 907: retinal detachment macular degeneration degenerative history vein ophthalmologic occlusion neurosensory Cluster 908: response evaluation solid recist criteria tumors measurable disease evaluable defined Cluster 909: criteria measurable response disease revised lymphoma iwg rano according malignant Cluster 910: criteria response recist solid evaluation tumors measurable disease lesion evaluable Cluster 911: version solid recist response evaluation tumors measurable criteria disease defined Cluster 912: lymphoma nervous central cns known leptomeningeal primary active history patients Cluster 913: involvement nervous central known lymphoma active leukemia myeloma patients history Cluster 914: lymphoma cell mantle leukemia nk large patients primary cutaneous ptcl Cluster 915: leukemia cns nervous central active known patients clinically evidence clinical Cluster 916: cns disease patients lymphoma nervous central active leukemia primary eligible Cluster 917: nervous central cns disease active malignancy patients history known primary Cluster 918: intravascular disseminated coagulation dic leukostasis evidence cns bleeding leukemia uncontrolled Cluster 919: involvement cns nervous central active known malignancy leukemia leptomeningeal lymphoma Cluster 920: neurologic confound dysfunction evaluation brain develop prognosis adverse metastases events Cluster 921: metastases brain evidence enlarging returned trial neurologic imaging symptoms meningitis Cluster 922: metastases meningitis carcinomatous brain evidence stability trial enlarging returned regardless Cluster 923: brain remained metastases patients stable carcinomatous meningitis trial excluded metastatic Cluster 924: uncontrolled heart york association nyha iii class iv new failure Cluster 925: heart class nyha york association new failure congestive ii chf Cluster 926: heart association iii york class iv new disease cardiac nyha Cluster 927: heart york association failure new congestive class ii iv symptomatic Cluster 928: heart york association new failure nyha congestive grade cardiac iii Cluster 929: heart york association new ii congestive greater failure nyha grade Cluster 930: heart functional classification congestive cardiovascular york association arrhythmia class failure Cluster 931: heart classification york association new iii iv functional failure nyha Cluster 932: heart class iv iii failure york association new nyha congestive Cluster 933: gm albumin dl serum plasma neratinib uln trametinib mg subjects Cluster 934: leukocytes mcl days registration phase obtained initiation ii treatment prior Cluster 935: albumin dl days registration prior obtained serum study treatment mg Cluster 936: albumin dl serum arm decreased cohort prothrombin range unless equal Cluster 937: hemoglobin registration dl obtained days prior mg creatinine step study Cluster 938: calcium mg registration dl days corrected serum step documented prior Cluster 939: prestudy physical obtained registration history days prior exam pre study Cluster 940: performed albumin initiation dl mg days treatment hemoglobin registration dehydration Cluster 941: hgb hemoglobin dl registration obtained days prior treatment study protocol Cluster 942: albumin mg dl supplementation serum intravenous day cycle days hypercalcemia Cluster 943: cabozantinib prior treatment dose days dl albumin platelets obtained hemoglobin Cluster 944: albumin initiation dl mg days treatment cohort sbrt noted determined Cluster 945: consecutive mature potential months naturally childbearing sexually hysterectomy undergone postmenopausal Cluster 946: wocbp consecutive women months naturally postmenopausal menses hysterectomy undergone preceding Cluster 947: bleeding ulcer peptic active diathesis uncontrolled epistaxis disease patients spontaneous Cluster 948: ulcer peptic disease active gastritis history gastrointestinal months esophagitis bleeding Cluster 949: active illness uncontrolled gastritis peptic diatheses including ulcer hepatitis pectoris Cluster 950: platelet count ml days administration treatment study prior measured transfusions Cluster 951: hematologic visit factors growth screening values laboratory days obtained transfusions Cluster 952: factors growth hematopoietic days transfusions prior treatment erythropoietin therapy platelet Cluster 953: platelet help transfusions meet eligibility allowed criteria days count enrollment Cluster 954: ischemic attack stroke transient infarction myocardial angina unstable months heart Cluster 955: arterial cerebrovascular accident transient thromboembolic ischemic infarction myocardial angina attack Cluster 956: measurable disease non patients subjects presence site allowed defined metastatic Cluster 957: recist measurable criteria disease according defined patients tumor lesion lesions Cluster 958: version recist measurable disease according lesion defined criteria site patients Cluster 959: recist measurable defined disease lesion patients ct imaging non presence Cluster 960: measureable recist disease lesion version defined radiographically criteria presence according Cluster 961: recist measurable disease according lesion presence patients phase non site Cluster 962: evaluable recist measurable disease criteria non according version lesion patients Cluster 963: injections articular intranasal inhaled topical intra local injection steroid medication Cluster 964: applications sprays drops eye injections airways rash topical inhaled articular Cluster 965: corticosteroids sprays drops applications airways eye articular uses rash obstructive Cluster 966: mtor inhibitors inhibitor rapamycin prior treatment mammalian target received patients Cluster 967: temsirolimus mtor everolimus sirolimus rapamycin inhibitor mammalian prior treatment target Cluster 968: pik inhibitor mtor akt inhibitors treatment prior kinase rapamycin pathway Cluster 969: diagnosis institutions kettering sloan mskcc memorial cancer epithelial sarcoma center Cluster 970: pathology review confirmed diagnosis central report reviewed histologically center slides Cluster 971: kettering sloan memorial mskcc center cancer confirmed msk diagnosis pathology Cluster 972: assent parents representatives appropriate guidelines informed consent according authorized sign Cluster 973: ich gcp conference local good written harmonization international consent informed Cluster 974: guidelines according institutional informed consent signed obtained written assent local Cluster 975: weight kg body donor kilograms ideal kilogram lbs significantly patients Cluster 976: weight loss months past program unintentional body prior watchers experienced Cluster 977: childbearing potential female contraception non subjects use women females willing Cluster 978: effective contraception childbearing potential use highly study dose agree months Cluster 979: fcbp females childbearing pregnancy potential agree testing ongoing practice contraception Cluster 980: dose study contraception adequate days use participants potential childbearing method Cluster 981: partner female potential childbearing contraception use effective vasectomy agree men Cluster 982: study men duration agree contraception participation adequate pregnant use completion Cluster 983: contraception childbearing women potential men adequate use agree practice study Cluster 984: bearing child potential contraception use women effective agree study men Cluster 985: protein polyneuropathy organomegaly endocrinopathy poems plasma changes dyscrasia monoclonal skin Cluster 986: polyneuropathy organomegaly endocrinopathy poems changes monoclonal syndrome skin protein gammopathy Cluster 987: echocardiogram ejection fraction left ventricular lvef echo muga assessed radionuclide Cluster 988: gated muga acquisition multi echocardiogram fraction scan ejection cardiac echo Cluster 989: gated muga acquisition echocardiogram lvef left fraction ejection ventricular scan Cluster 990: fraction echocardiogram shortening ejection radionuclide angiogram gated muga study cardiac Cluster 991: ejection fraction cardiac echocardiogram radionuclide echo normal angiogram muga function Cluster 992: multigated acquisition muga echocardiogram fraction ejection left scan ventricular echo Cluster 993: echocardiography ejection left fraction muga ventricular acquisition lvef gated scan Cluster 994: immunodeficiency acquired known testing virus syndrome human positive history hiv Cluster 995: immunodeficiency aids known acquired syndrome hiv virus human testing positive Cluster 996: interpretation affect results malignancy compliance protocol second judgment history primary Cluster 997: malignancy concurrent active treatment presence patients patient actively skin years Cluster 998: malignancy concurrent requiring active intervention therapy treatment participants immediate requires Cluster 999: remission malignancy primary years history invasive second complete patients year Cluster 1000: malignancies active concurrent expectant observation killer patients natural requiring history Cluster 1001: second malignancy active currently requiring years primary cancer concurrent treatment Cluster 1002: cancers primary active skin requiring patients systemic treatment second cured Cluster 1003: constant antagonist pump proton antacids enzymes antagonists uses requirement pancreatic Cluster 1004: ppi pump proton inhibitor daily taken receiving dose study use Cluster 1005: proton pump inhibitors histamine antacids antagonists ppis use receptor study Cluster 1006: diverticulosis crohns colitis diarrhea ulcerative enroll gi disease inflammatory bowel Cluster 1007: colitis ulcerative crohns disease gastrointestinal inflammatory bowel history active chronic Cluster 1008: crohn colitis ulcerative disease inflammatory bowel active gastrointestinal documented resection Cluster 1009: crohns colitis ulcerative disease bowel inflammatory documented active prior history Cluster 1010: coloproctitis hemorrhagic crohn diseases gastrointestinal colitis ulcerative irritable alter including Cluster 1011: entire pregnancy unwilling avoid unable period acceptable wocbp method use Cluster 1012: plus duration instructions drug wocbp method treatment contraception follow study Cluster 1013: wocbp method nivolumab contraception half plus use pregnancy avoid lives Cluster 1014: contraindications mri medical patients metallic nrt known claustrophobia use pancreatectomy Cluster 1015: clips metal aneurysm mri implants pacemakers metallic devices objects ferromagnetic Cluster 1016: injectables combined implants contraceptives devices partner iuds intrauterine condoms oral Cluster 1017: implanted devices electronic device pacemakers pacemaker defibrillators defibrillator stimulator brain Cluster 1018: implants breast metal metallic bilateral patients mri contraindicated reconstruction women Cluster 1019: tissue paraffin embedded formalin fixed tumor available biopsy ffpe archival Cluster 1020: slides unstained tissue tumor block available paraffin archival availability biopsy Cluster 1021: paraffin formalin fixed embedded ffpe tumor tissue slides block availability Cluster 1022: bronchial palliation occlusion bleeding major amenable receives preparative elapsed cohort Cluster 1023: toxicities recovered related grade prior treatment radiotherapy patients radiation therapies Cluster 1024: antibody decline colonic allow colonoscopy receives preparative time elapsed anti Cluster 1025: toxicities receives recovered preparative grade elapsed weeks minor vitiligo patients Cluster 1026: intrauterine device placement established pregnancy confirmed women iud containing contraceptive Cluster 1027: injected contraception implanted hormonal oral methods use established hormone transdermal Cluster 1028: intrauterine iud ius device placement releasing hormone established progestin systems Cluster 1029: birth control intrauterine device iud methods pills use potential contraceptive Cluster 1030: serous ovarian peritoneal fallopian grade high tube cancer endometrioid primary Cluster 1031: fallopian tube peritoneal ovarian primary epithelial cancer carcinoma diagnosis histologic Cluster 1032: melanoma uveal ocular mucosal metastatic primary patients diagnosis histologic origin Cluster 1033: malignant tumors epithelial low borderline ovarian potential mullerian tumor mixed Cluster 1034: adenocarcinoma carcinoma epithelial cell endometrioid serous histologic undifferentiated clear mixed Cluster 1035: uln alkaline phosphatase involvement liver subjects limit cancer lymphoma direct Cluster 1036: alkaline phosphatase uln ast alt equal institutional days registration alk Cluster 1037: ggt gamma glutamyl transpeptidase uln alkaline phosphatase transferase lactate ldh Cluster 1038: phosphatase alkaline times upper normal limit liver unless limits phos Cluster 1039: alp alkaline phosphatase uln liver metastases bone ulrr aminotransferase ast Cluster 1040: alkaline phosphatase normal upper limit uln institutional alk limits liver Cluster 1041: alkaline phosphatase uln metastases liver bone documented present involvement patients Cluster 1042: metastasis alkaline phosphatase liver present bone absence upper limit normal Cluster 1043: lymphoma follicular grade transformed fl indolent prior diagnosis treatment transformation Cluster 1044: lymphoma large cell diffuse dlbcl follicular mediastinal primary transformation nhl Cluster 1045: dlbcl lymphoma transformed fl confirmed histologically indolent refractory cell novo Cluster 1046: hepatitis surface antigen positive known infection suspected active rna virus Cluster 1047: hepatitis virus indicating sag hcv hbv ribonucleic surface positive antigen Cluster 1048: hepatitis surface antibody antigen positive virus negative hiv core immunodeficiency Cluster 1049: hbv hepatitis dna positive negative viral hbsag surface virus antibody Cluster 1050: poems syndrome plasma leukemia amyloidosis cell waldenstrom macroglobulinemia primary myeloma Cluster 1051: macroglobulinemia waldenstrom waldenstroms courses failed workshop clinicopathological immunoglobulin igm myeloma Cluster 1052: gammopathy significance undetermined monoclonal smoldering mgus myeloma multiple amyloidosis macroglobulinemia Cluster 1053: uncontrolled diabetes hypertension days prior randomization assessment toxicity conditions interfere Cluster 1054: severe intercurrent infection sepsis patients medical infusion procurement acute conditions Cluster 1055: conditions cardiac medical following affect impose study compliance opinion comorbid Cluster 1056: conditions medical interfere uncontrolled psychiatric treatment severe participation affect study Cluster 1057: preclude disorder participation medical outlined uncontrolled psychiatric active geographic adherence Cluster 1058: nodal lesions mm axis recorded short accurately longest dimension calipers Cluster 1059: mm accurately dimension longest diameter recorded measured spiral measurable techniques Cluster 1060: mm calipers exam ray recorded accurately longest dimension chest diameter Cluster 1061: mm repeated accurately suitable accurate measurements axis longest irradiated lesion Cluster 1062: measured measurable lesion accurately dimension mm ct disease defined mri Cluster 1063: limits bilirubin total institutional normal gilberts upper registration cohort serum Cluster 1064: bilirubin uln direct total gilberts normal syndrome upper limit serum Cluster 1065: bilirubin unless normal upper limit gilberts total involvement leukemic direct Cluster 1066: amylase uln serum normal upper limit pancreatic institutional pancreatitis grade Cluster 1067: times bilirubin total upper limit normal uln institutional gilberts serum Cluster 1068: urea nitrogen bun blood mg dl normal times upper limit Cluster 1069: iuln bilirubin institutional upper normal limit total gilberts registration syndrome Cluster 1070: ldh lactate dehydrogenase uln serum normal upper times limit level Cluster 1071: lower limit normal range potassium lln upper institutional times hemoglobin Cluster 1072: bilirubin serum uln institutional gilberts pretreatment institutions equal levels level Cluster 1073: times bilirubin upper limit normal uln serum institutional age range Cluster 1074: limits corrected normal calcium albumin potassium magnesium serum supplements sodium Cluster 1075: calcium ionized serum albumin normal corrected lln total limits supplementation Cluster 1076: correctable supplements potassium range normal lln magnesium calcium limits corrected Cluster 1077: magnesium potassium normal calcium serum limits supplementation levels range sodium Cluster 1078: albumin serum hypersensitivity calcium abnormal range corrected normal concentration lln Cluster 1079: uncontrolled unacceptable risks cause compromise safety severe concurrent compliance medical Cluster 1080: obtaining existing disorder safety conditions interfere pre unstable compliance psychiatric Cluster 1081: compromise psychiatric interpretation participation study follow safety disorder interfere compliance Cluster 1082: allow compromise disorder compliance psychiatric appropriate does protocol consent informed Cluster 1083: likely interfere illness psychiatric participation medical clinical study patients opinion Cluster 1084: subject study treatment protocol france investigator following french subjects condition Cluster 1085: preclude participation investigator condition opinion medical study trial safe clinical Cluster 1086: condition medical investigator opinion participation study interfere psychiatric protocol compliance Cluster 1087: interfere cooperate likely deemed ability participate condition mental investigator sign Cluster 1088: coexisting likely condition medical procedures interfere results study psychiatric hazard Cluster 1089: results interfere interpretation medical likely participation laboratory investigator history including Cluster 1090: patient study investigator participate treatment disease medical therapy protocol unlikely Cluster 1091: extenuating circumstance significantly additional interfere opinion illness compliance condition medical Cluster 1092: psychological medical condition compliance investigator compromise participation social opinion study Cluster 1093: polysorbate formulated hypersensitivity drugs docetaxel reaction history severe reactions containing Cluster 1094: glycol polyethylene peg hypersensitivity polysorbate reactions growth allergic history excipients Cluster 1095: board review irb approved institutional consent informed signed form written Cluster 1096: authorized legally irb representative board applicable review document approved understand Cluster 1097: signed consent informed given study document patients approved registration prior Cluster 1098: board irb review approved sign document institutional informed consent understand Cluster 1099: irb board review approved sign understand able institutional document informed Cluster 1100: institutional regulatory dated accordance board review guidelines signed irb approved Cluster 1101: signed written informed consent provide provided irb subjects study approved Cluster 1102: conforms federal consent guidelines approved institutional form provide signed able Cluster 1103: fungal bacterial viral infection clinically significant exhibits active uncontrolled systemic Cluster 1104: bacterial fungal viral taking progression currently uncontrolled clinical medication symptoms Cluster 1105: infection improvement despite exhibiting signs bacterial fungal antibiotics viral appropriate Cluster 1106: bacterial fungal viral infection active uncontrolled systemic time enrollment controlled Cluster 1107: infections fungal bacterial viral active uncontrolled unresponsive infection patients therapy Cluster 1108: bacterial fungal viral requiring systemic active infection uncontrolled therapy infections Cluster 1109: cypa grapefruit metabolized window predominantly narrow medications therapeutic hybrids star Cluster 1110: ketoconazole itraconazole ritonavir clarithromycin telithromycin grapefruit voriconazole cypa inhibitors nelfinavir Cluster 1111: ritonavir verapamil erythromycin inhibitors amprenavir ketoconazole cypa indinavir clarithromycin itraconazole Cluster 1112: inhibitors cypa boosted boceprevir telaprevir ritonavir cobicistat ciprofloxacin diltiazem olaparib Cluster 1113: phase ii patients randomized disease portion prior trial measurable ecog Cluster 1114: phase ib expansion portion treatment patients prior study eligibility trial Cluster 1115: illness qt heart situations intercurrent congenital social arrhythmia compliance ongoing Cluster 1116: illness situations pectoris social intercurrent compliance arrhythmia requirements psychiatric unstable Cluster 1117: obtaining morbid inappropriate make judgment physicians informed consent patient clinician Cluster 1118: proper prescribed inappropriate morbid illnesses make significantly judgment regimens safety Cluster 1119: asct patients stem relapsed post prior therapy eligible autologous refractory Cluster 1120: relapsed refractory disease therapy patients prior line treatment aml cell Cluster 1121: myeloma multiple criteria symptomatic standard according diagnosis diagnosed crab damage Cluster 1122: myeloma multiple diagnosis relapsed confirmed refractory therapy treatment prior patients Cluster 1123: myeloma imwg working international multiple group criteria diagnosis according diagnostic Cluster 1124: aml secondary therapy relapsed patients prior chemotherapy diagnosis related refractory Cluster 1125: altered mental prohibit dementia informed status consent understanding giving precluding Cluster 1126: cognitive impairment consent psychiatric preclude informed significant mental study participation Cluster 1127: rendering understanding altered prohibit mental dementia consent informed status psychiatric Cluster 1128: feeding breast pregnant patients patient currently subject subjects donor participant Cluster 1129: feeding women breast pregnant currently study lactating excluded entered childbearing Cluster 1130: breastfeeding pregnant patients intending currently participants wocbp participant donor study Cluster 1131: pregnant patient currently participants plan study subjects trying women non Cluster 1132: hepatitis reactive qualitative detected hbsag rna hcv ribonucleic surface acid Cluster 1133: virus hepatitis positive hcv immunodeficiency rna known hiv antigen ribonucleic Cluster 1134: hepatitis seronegative antibody antigen tested rna rt pcr hcv reverse Cluster 1135: hcv rna hepatitis positive antibody negative ribonucleic acid pcr virus Cluster 1136: hcv hepatitis hbv virus positive rna surface antigen antibody acid Cluster 1137: bearing child female pregnancy test potential negative serum urine patients Cluster 1138: bearing child pregnancy test negative potential women serum urine days Cluster 1139: measures contraceptive potential pregnancy bearing feeding dosing child start negative Cluster 1140: paracentesis requiring ascites thoracentesis effusions pleural days subjects prior randomization Cluster 1141: causes dyspnea effusion ascites pleural respiratory compromise grade ctcae version Cluster 1142: light chain protein free serum mg measurable dl urine ratio Cluster 1143: immunoglobulin light chain protein serum free kappa monoclonal mg lambda Cluster 1144: flc serum light mg chain abnormal protein involved ratio free Cluster 1145: postmenopausal women status defined menstrual patient premenopausal female months year Cluster 1146: menses year postmenopausal defined screening spontaneous prior post menopausal estradiol Cluster 1147: visit screening postmenopausal year months investigational prior weeks subjects days Cluster 1148: hrt cessation menopausal estradiol female hormone fsh year value experienced Cluster 1149: arrhythmic anti arrhythmias ventricular cardiac requiring therapy drugs fibrillation atrial Cluster 1150: blockers beta arrhythmic digoxin anti cardiac arrhythmias requiring channel therapy Cluster 1151: atrial fibrillation arrhythmia cardiac controlled uncontrolled arrhythmias history requiring flutter Cluster 1152: anemia fanconi hemolytic aplastic marrow patients active syndromes sickle failure Cluster 1153: thrombotic uremic thrombocytopenic purpura hemolytic microangiopathy syndrome history hus ttp Cluster 1154: hemolytic autoimmune anemia thrombocytopenia uncontrolled itp purpura idiopathic aiha immune Cluster 1155: procedure surgical major anticipation need course study cycle day prior Cluster 1156: traumatic injury surgical procedure significant major days brain study prior Cluster 1157: open traumatic injury biopsy major significant procedure surgical days start Cluster 1158: procedure surgical major cranial anticipation traumatic open injury need course Cluster 1159: major procedure surgical anticipation traumatic injury need course open significant Cluster 1160: diabetes mellitus diagnosis type glucose fasting insulin patients hypoglycemic current Cluster 1161: type diabetes mellitus ii insulin controlled patients hypothyroidism autoimmune uncontrolled Cluster 1162: diabetes uncontrolled mellitus hypertension unreasonably hazardous medical disease sugar hypothyroidism Cluster 1163: diabetes controlled poorly insulin patients history uncontrolled diabetic diagnosed oral Cluster 1164: excipients hypersensitivity known drugs intolerance study allergies allergy ribociclib history Cluster 1165: pembrolizumab excipients hypersensitivity severe known grade epacadostat substance active history Cluster 1166: palbociclib ribociclib cdk possible hypersensitivity fulvestrant endocrine excipients abemaciclib previous Cluster 1167: various analogues formulations excipients allergy medications agent known study allergic Cluster 1168: sirolimus temsirolimus everolimus hypersensitivity rapamycins known excipients analogs rapamycin intolerance Cluster 1169: classes excipients formulations hypersensitivity study drugs allergy suspected given drug Cluster 1170: allergies known drug intolerance subjects classes separate history vaccine adhesives Cluster 1171: azd structure similar inactive excipients chemical osimertinib drugs hypersensitivity class Cluster 1172: schedule comply follow able visit unable treatment study willing plan Cluster 1173: examinations visits including undergoing scheduled comply willing duration follow able Cluster 1174: assessments complete follow able study baseline lack laboratory availability screening Cluster 1175: follow return visits required assess obtain inability studies toxicity therapy Cluster 1176: visits follow willing able attend study comply travel protocol nih Cluster 1177: infections disorders illnesses respiratory cardiovascular coagulation restrictive immune active major Cluster 1178: illnesses antibiotics infections requiring disorders bleeding active fallopian falls false Cluster 1179: infective illnesses coagulation infections active disorders major medical systemic requiring Cluster 1180: uncontrolled ischemia heart conduction electrocardiographic abnormalities arrhythmias ventricular class angina Cluster 1181: angina sick severe uncontrolled heart sinus electrocardiographic conduction ischemia pacemaker Cluster 1182: heart uncontrolled electrocardiographic conduction ischemia relevant ecg medically abnormalities abnormality Cluster 1183: grade examination neuropathy peripheral pain clinical period screening patient initiation Cluster 1184: higher neuropathy grade peripheral patients ctcae neurotoxicity current ii arm Cluster 1185: ctcae grade nci version neuropathy ongoing infection uln peripheral toxicity Cluster 1186: neuropathy peripheral grade enrollment patient days applicable ahct ctcae initiation Cluster 1187: grade neuropathy fl pain hypertriglyceridemia edema peripheral ae hyperglycemia low Cluster 1188: grades pain neuropathy significant grade days prior enrollment randomization day Cluster 1189: neuropathy grade baseline patients ctcae significant neurosensory time diabetic enrollment Cluster 1190: phase inclusion criteria ii additional ecog expansion search specific bilirubin Cluster 1191: exclusion criteria tnbc cohort specific treatment patients patient phase screening Cluster 1192: expansion escalation dose ii enrollment participants biopsies syndrome history segment Cluster 1193: inclusion criteria registration specific screening treatment patients arm cohort patient Cluster 1194: cohorts expansion participants enrolled patients combination dose disease treatment prior Cluster 1195: cohort expansion patients dose criteria participants inclusion treatment specific phase Cluster 1196: ribociclib pdr fulvestrant cohort dose prior expansion treatment run long Cluster 1197: escalation dose cohort expansion phase patients enrolled stage combination portion Cluster 1198: eligibility criteria infusion lymphodepletion tvs ctl meet proceed phase specific Cluster 1199: abdominal perforation fistula gastrointestinal abscess intra history months prior ulcer Cluster 1200: abdominal diverticulitis abscess carcinomatosis obstruction intra gi coming gastrointestinal acute Cluster 1201: perforation gastrointestinal history fistula fistulae months ulceration bleeding gi prior Cluster 1202: abdominal including dose treatment disorders fistula study filter abscess ischemic Cluster 1203: abdominal bowel obstruction perforation abscess intra diverticulitis gastrointestinal carcinomatosis factors Cluster 1204: composition compounds chemical similar attributed allergic reactions biologic history hypersensitivity Cluster 1205: reactions allergic history attributed hypersensitivity patients compounds similar components paclitaxel Cluster 1206: composition chemical compounds attributed similar reactions allergic biologic used agents Cluster 1207: olaparib hypersensitivity excipients product known patients tremelimumab cabazitaxel composition chemical Cluster 1208: studies correlative tissue tumor consent future specimens blood patients provide Cluster 1209: research samples purposes provide correlative blood willing tissue mandatory willingness Cluster 1210: herbal ephedra kava gingko yohimbe ginseng medications dehydroepiandrosterone biloba ma Cluster 1211: prohibited use bisphosphonates huang yohimbe ephedra kava ginseng concurrent ma Cluster 1212: cypa strong inhibitors rifampin phenytoin ketoconazole carbamazepine inducers itraconazole cytochrome Cluster 1213: wort st johns john herbal hypericum perforatum remedy rifampin use Cluster 1214: phenobarbital carbamazepine phenytoin wort rifabutin inducers st cypa rifampin johns Cluster 1215: hemoglobin dl hgb achieve transfusion intervention acceptable note use registration Cluster 1216: vaccine live received dose days study prior drug treatment medication Cluster 1217: live vaccine received days prior registration enrollment weeks treatment initiation Cluster 1218: live vaccine trial received dose days treatment prior run prohibited Cluster 1219: live vaccine planned start received days study therapy virus medication Cluster 1220: live virus vaccination contain flu seasonal planned vaccines start received Cluster 1221: interstitial fibrosis lung pulmonary pneumonitis disease history pneumonia extensive idiopathic Cluster 1222: pneumonitis idiopathic fibrosis organizing pneumonia induced pulmonary chest history scan Cluster 1223: pneumonitis organizing pneumonia fibrosis obliterans bronchiolitis cryptogenic idiopathic induced chest Cluster 1224: hypomagnesemia hypokalemia electrolyte hypocalcemia imbalance hyponatremia mmol lower corrected supplementation Cluster 1225: torsade pointes factors history hypokalemia risk family qt long additional Cluster 1226: pd checkpoint inhibitor immune ctla anti received inhibitors treatment prior Cluster 1227: pd anti agent received prior therapy treatment merck participated pembrolizumab Cluster 1228: pd prior therapy treatment inhibitor anti ctla received patients pathway Cluster 1229: anti ctla adverse pd effects immune weeks dose ctcae met Cluster 1230: pd durvalumab including inhibitor previous tremelimumab ctla treatment anti pdl Cluster 1231: anti pd ctla prior checkpoint pdl cd antibody immune antibodies Cluster 1232: checkpoint immune inhibitor inhibitors prior therapy treatment blockade immunotherapy therapies Cluster 1233: grant inability compliance medical non consent history regimen patient regimens Cluster 1234: compliance regimens unreliable non medical entire history potentially complete considered Cluster 1235: instructions staff compliance comply given unwilling regimens medical unable non Cluster 1236: expected patients survival weeks compliance non receive available study medical Cluster 1237: creatinine institutional normal levels clearance min ml upper limit patients Cluster 1238: iuln creatinine serum registration days prior clearance min levels cockcroft Cluster 1239: creatinine institutional normal limits clearance min levels ml patients gault Cluster 1240: creatinine clearance min ml uln calculated normal upper limit serum Cluster 1241: creatinine hour clearance min ml serum uln hr cr institutional Cluster 1242: scr creatinine ccr renal serum clearance min ml upper limit Cluster 1243: eligible patients disease study prior therapy treatment tumor provided criteria Cluster 1244: following criteria treatment satisfy cardiac patients diagnoses use combination patient Cluster 1245: ceritinib inclusion criteria prior dose capsules alk swallow gi therapy Cluster 1246: prior study criteria therapy disease treatment patients weeks history inclusion Cluster 1247: interventional agrees participate subject study treatment participant inclusion present randomization Cluster 1248: turnstile ii infusion equal til inclusion chemotherapy criteria cell patients Cluster 1249: meet criteria following inclusion patients laboratory subjects eligible study exclusion Cluster 1250: regorafenib prior use treatment criteria sunitinib inclusion tas patients exclusion Cluster 1251: cll sll iwcll treatment diagnosis therapy prior criteria patients received Cluster 1252: pre registration inclusion criteria optional tissue secondary days post cystectomy Cluster 1253: brachytherapy radiation prostate therapy external beam prostatectomy prior cryotherapy radical Cluster 1254: beam external brachytherapy pelvic radiation radiotherapy prior received therapy prostate Cluster 1255: radical prostatectomy prostate cystectomy cryosurgery cancer undergo scheduled adenocarcinoma patients Cluster 1256: prostatectomy prostate prior cancer therapy cryosurgery cryotherapy radiation hyperthermia patients Cluster 1257: untreated nervous central metastases cns active symptomatic brain known progressing Cluster 1258: cns metastases nervous central symptomatic untreated neurologically patients known primary Cluster 1259: cns metastases symptomatic untreated patients active known uncontrolled excluded brain Cluster 1260: excluded subjects metastases brain clinical trial cancers treated cns primary Cluster 1261: brain symptomatic metastases inclusive uncontrolled requiring corticosteroids limited concurrent radiation Cluster 1262: metastases brain known participants excluded patients corticosteroids treated imaging clinical Cluster 1263: brain metastases excluded trial clinical known patients participants untreated symptomatic Cluster 1264: smoking cessation pack cigarettes history current year tobacco years smokers Cluster 1265: smoker current cigarettes daily self smoking day ex smoked pack Cluster 1266: prohibitions restrictions adhere specified willing protocol able schedule visit study Cluster 1267: schedule adhere visit requirements protocol able study willing ability consent Cluster 1268: specified protocol therapy concomitant pre use meet patients laboratory requirements Cluster 1269: maximum creatinine age serum mg dl years male female gender Cluster 1270: mg dl years age creatinine male female serum gender gfr Cluster 1271: males mg dl females creatinine years age serum maximum gender Cluster 1272: male female years creatinine subjects gender serum age patients maximum Cluster 1273: fasting lipid lowering cholesterol triglycerides exceeded thresholds mmol included case Cluster 1274: mmol potassium serum sodium normalize registration levels despite intervention days Cluster 1275: cholesterol mg triglyceride dl fasting level serum total mmol levels Cluster 1276: triglycerides fasting mg dl hypertriglyceridemia cholesterol uncontrolled equal mmol serum Cluster 1277: tyrosine kinase inhibitor inhibitors tki therapy prior treatment bruton egfr Cluster 1278: egfr tki treatment tm mutation erlotinib prior generation progression gefitinib Cluster 1279: philadelphia chromosome ph positive abl kinase bcr tyrosine patients tki Cluster 1280: egfrmut antineoplastic tm met phase egfr ii group tki nave Cluster 1281: medication oral able swallow unable dissolving consume crushing chewing patient Cluster 1282: unwilling comply unable eligible protocol patients swallow oral medication requirements Cluster 1283: pills swallow able ability patients unable impairs patient condition mouth Cluster 1284: inability oral swallow medications medication gastrointestinal absorption unwillingness absorb administration Cluster 1285: swallow tablet capsule able drugs ability study liquids drug unable Cluster 1286: swallow able study drug tablet comply requirements enzalutamide intolerance oral Cluster 1287: preclude oral illnesses absorption gastrointestinal olaparib medications able swallow cediranib Cluster 1288: fast maintain mln hours hour oral administration medication required able Cluster 1289: matched partially hla donor member family antigen related restricted cells Cluster 1290: member haplotype family matched single donor suitable investigator subject falls Cluster 1291: leukocyte hla antigen human positive donor identical patients related subtyping Cluster 1292: pregnancy test positive urine period lactating screening day female serum Cluster 1293: lactating period female pregnancy test positive screening serum patients breastfeeding Cluster 1294: reversible effects recovered toxicity grade fully failure prior chemotherapy therapy Cluster 1295: alopecia grade excluding recovery prior recovered neuropathy effects adverse toxicity Cluster 1296: toxic effects recovered fully entering acute prior chemotherapy immunotherapy radiotherapy Cluster 1297: toxic grade effects resolution alopecia acute prior therapy resolved neuropathy Cluster 1298: toxicities recovered grade therapy prior reversible chemotherapy effects previous alopecia Cluster 1299: recover reversible effects fully regardless failure acute interval prior chemotherapy Cluster 1300: toxic effects recovered therapy prior grade acute alopecia chemotherapy fully Cluster 1301: prisoners excluded vulnerable study eligible considered individuals pregnant populations children Cluster 1302: prisoner patient subject incarcerated incompetent vulnerable mentally institutionalized person impending Cluster 1303: incarcerated prisoners involuntarily subjects individuals patients persons likely person participants Cluster 1304: reach hemoglobin dl transfusion cut transfused acceptable subjects hgb level Cluster 1305: deciliter grams hemoglobin dl gram liter albumin millimoles equal level Cluster 1306: transfused hemoglobin dl hgb patients meet level value criterion days Cluster 1307: organ transplant allogeneic history major patients primary immunodeficiency having hematopoietic Cluster 1308: source stem donor blood cell cells peripheral marrow hematopoietic unrelated Cluster 1309: hematopoietic transplant stem cell autologous prior allogeneic months received relapse Cluster 1310: comorbidity index ci hct score hematopoietic age transplant cell years Cluster 1311: myeloablative transplant conditioning stem months hematopoietic cell non allogeneic prior Cluster 1312: allo hsct sct hct post cell gvhd stem transplant allogeneic Cluster 1313: impair receive ability disorder medical uncontrolled protocol infection active subject Cluster 1314: uncontrolled medical jeopardized disorder illnesses malignant infection active non infections Cluster 1315: uncontrolled disorder prohibits medical obtaining examples cava vena superior poor Cluster 1316: impair ability underlying condition medical receive patient protocol infection treatment Cluster 1317: document willingness understand sign ability written informed consent subject subjects Cluster 1318: understand ability informed consent provide willingness written nature signed study Cluster 1319: participate study consent willing patients informed patient refuse willingness ability Cluster 1320: ability consent informed willingness donor patients lack demonstrate precludes likely Cluster 1321: voluntarily understand ability informed consent sign form document willingness fanca Cluster 1322: sign willingness understand ability written informed consent subjects registration patients Cluster 1323: consent informed patients capacity willingness documented refuses assent subjects understand Cluster 1324: competent mentally consent informed sign understand form willingness ability irb Cluster 1325: sign willingness form understand ability consent informed written study initiation Cluster 1326: cancer melanoma skin non years invasive malignancies situ past history Cluster 1327: invasive malignancy years prior history past cancer treated active treatment Cluster 1328: cancers invasive years malignancy skin non cancer melanoma situ history Cluster 1329: cancer malignancies excluded present invasive contraindicates melanoma exception skin years Cluster 1330: curable apparently cured cancers locally malignancy cancer years previous superficial Cluster 1331: melanoma skin non malignancy cancer years treated cancers exception active Cluster 1332: cancers melanoma non malignancies skin years situ active hematologic patients Cluster 1333: bpm beats rate minute heart bradycardia hr resting ecg screening Cluster 1334: bradycardia resting significant symptomatic beats clinically minute medically baseline pacemaker Cluster 1335: return monitoring institution enrolling follow phase willing active study observation Cluster 1336: mayo clinic return follow rochester willing willingness institution enrolling arizona Cluster 1337: return enrolling institution follow willing willingness site alliance study operative Cluster 1338: karnofsky performance status patients ecog higher days greater registration prior Cluster 1339: kps karnofsky performance status score greater patients equal patient ecog Cluster 1340: age years lansky karnofsky performance status patients scale children ecog Cluster 1341: status performance ecog karnofsky appendix occasional help care patients able Cluster 1342: old lansky years karnofsky performance score patients status younger individuals Cluster 1343: equal greater age years karnofsky performance status lansky ecog participants Cluster 1344: lansky score karnofsky performance years patients inclusion scores greater adults Cluster 1345: karnofsky ecog poor health rating index screening time false fancc Cluster 1346: registration prior days weeks therapy chemotherapy patients radiation study biologic Cluster 1347: discontinued prior therapy weeks days treatment biologic study registration radiation Cluster 1348: directed discontinued therapy tumor malignant prior immunologic registration hormonal agents Cluster 1349: threshold seizure lower substituted medications discontinued known prior entry weeks Cluster 1350: exclusionary weeks diagnostic node resolved lymph discontinued effects adverse radiation Cluster 1351: study pregnant potential women contraception bearing inform immediately woman child Cluster 1352: pregnant participating inform immediately suspect woman physician treating study partner Cluster 1353: pregnant study inform suspect immediately participating woman barrier birth physician Cluster 1354: sgpt pyruvate glutamate transaminase serum normal upper limit uln iu Cluster 1355: pyruvate sgpt glutamate transaminase alt alanine uln aminotransferase upper limit Cluster 1356: pyruvate glutamate sgpt transaminase alanine alt aminotransferase upper normal serum Cluster 1357: sgpt purpose transaminase pyruvate uln glutamate alt alanine aminotransferase serum Cluster 1358: pyruvate sgpt glutamate transaminase alt alanine aminotransferase serum uln institutional Cluster 1359: hemo dialysis peritoneal renal failure requiring hematological fap fanconi fancd Cluster 1360: hemodialysis dialysis peritoneal renal patients failure requiring requirement replacement therapy Cluster 1361: dialysis renal patients requiring currently failure creatinine mg contrast dl Cluster 1362: confounds interpret data condition places ability study unacceptable abnormalities participate Cluster 1363: places unacceptable participate condition risk laboratory subject abnormalities study presence Cluster 1364: uncontrolled active places unacceptable signing prevent hemorrhage artery mellitus coronary Cluster 1365: reason complicates participate interferes opinion investigator undue patient data interpretation Cluster 1366: neuropathy greater grade peripheral equal patients baseline cause ii severity Cluster 1367: existing pre neuropathy grade peripheral greater conditions higher sensory patients Cluster 1368: sensory neuropathy grade peripheral preexisting baseline greater patients evidence equal Cluster 1369: neuropathy peripheral grade patients baseline ctcae presence preexisting cause current Cluster 1370: grade sensory alopecia neuropathy persisting related toxicity constituting nci ctcae Cluster 1371: motor sensory neuropathy grade ctcae equal peripheral preexisting existing pre Cluster 1372: myopathy history chronic donor rhabdomyolysis steroid existing simvastatin patients pre Cluster 1373: uncontrolled infection active systemic patients time subject transplantation patient enrollment Cluster 1374: infection active evidence systemic patients month responding pericardial past pulmonary Cluster 1375: untreated infection active hepatitis presence patients uncontrolled previously systemic hypothyroidism Cluster 1376: uncontrolled infection patients concurrent systemic hepatitis grade excluded evidence disease Cluster 1377: hepatitis infection active known patients hiv evidence uncontrolled transmitting fluids Cluster 1378: infections active clinically patients antibiotics evidence hepatitis known grade controlled Cluster 1379: plateau exhaustion volitional output exchange perceived exertion rpe hrmax power Cluster 1380: dyspnea rest intrinsic resulting lung evidence lungs extensive exertion involvement Cluster 1381: expectancy life weeks years predicted subject subjects minimum year patient Cluster 1382: expectancy life months predicted patients patient weeks subjects expected physician Cluster 1383: estimated expectancy life weeks investigator judgment years participant permit greater Cluster 1384: expectancy life greater weeks equal year years patients month inclusion Cluster 1385: expectancy life weeks patients severely limited diseases year malignancy days Cluster 1386: lymphocytic leukemia chronic cll lymphoma sll small diagnosis iwcll workshop Cluster 1387: transformation aggressive richters cll lymphoma richter evidence fl hodgkin large Cluster 1388: richter transformation prolymphocytic leukemia cll syndrome lymphocytic dlbcl confirmed lymphoma Cluster 1389: mean ms ecgs electrocardiograms correction corrected qt qtc interval rate Cluster 1390: msec qtcf fridericia qt interval formula corrected using correction ecg Cluster 1391: msecs qtc interval corrected qt formula using bazetts bazett prolongation Cluster 1392: ms qtcf fridericia qt corrected interval formula ecg screening subject Cluster 1393: qtcf ecg triplicate mean screening msec correction ecgs interval fridericia Cluster 1394: qt qtc msec syndrome long corrected interval congenital history fridericia Cluster 1395: creatinine serum uln times institutional concentration days prior equal levels Cluster 1396: creatinine upper limit normal times institutional serum uln institution age Cluster 1397: amylase lipase uln serum normal institutional days registration prior limits Cluster 1398: potassium limits normal meq serum range institutional institution wnl supplementation Cluster 1399: limits creatinine normal institutional upper serum uln times troponin days Cluster 1400: limits bilirubin normal upper total uln serum institutional times ast Cluster 1401: renal creatinine function uln serum adequate times defined normal mg Cluster 1402: area body surface enrollment patients bsa time study design dose Cluster 1403: bsa area body surface level dose patients mg enrolled cover Cluster 1404: steroids systemic inhaled requirement topical doses immunosuppressive corticosteroids drugs prior Cluster 1405: corticosteroids inhaled topical immunosuppressive systemic allowed steroids chronic treatment therapy Cluster 1406: steroids topical systemic inhaled use steroid immunosuppressive treatment doses replacement Cluster 1407: premedication steroids injection reactions articular intranasal corticosteroids inhaled hypersensitivity topical Cluster 1408: steroid immunosuppressive form excess chronic medication systemic doses replacement therapy Cluster 1409: lactation pregnancy breastfeeding test positive current year women standards time Cluster 1410: breastfeeding pregnancy current active women reported self planning possibility intention Cluster 1411: breastfeeding pregnancy test negative pregnant entry days study childbearing women Cluster 1412: pregnancy pregnant test women positive breastfeeding serum lactating study urine Cluster 1413: pregnant planning feeding breast breastfeeding study months pregnancy female lactating Cluster 1414: feeding pregnancy breast test positive unwillingness women known urine effective Cluster 1415: breastfeeding women lactating study participants eligible registration time zydelig fancd Cluster 1416: pregnancy test positive women serum administration enrollment product wocbp urine Cluster 1417: hypertensive encephalopathy crisis history prior hypertension controlled inadequately years mmhg Cluster 1418: hypertensive anti controlled hypertension pressure blood medications patients history mmhg Cluster 1419: gsk chemically idiosyncrasy delayed immediate reaction drugs hypersensitivity related known Cluster 1420: idiosyncrasy chemically delayed immediate reaction drugs hypersensitivity dmso related sulfoxide Cluster 1421: tablets swallow unable subject inability unwilling intact capsules patients absorb Cluster 1422: capsules swallow able inability patients unable bbi intact unwilling daily Cluster 1423: tablets swallow able capsules intact patients inability nasogastric ribociclib tube Cluster 1424: thalidomide lenalidomide hypersensitivity known pomalidomide rash prior imids immunomodulatory applicable Cluster 1425: proteasome inhibitor immunomodulatory imid prior therapy bortezomib lenalidomide refractory lines Cluster 1426: carfilzomib treatment prior bortezomib received therapy lenalidomide refractory dose days Cluster 1427: intravenous antibiotics infection requiring active iv oral systemic uncontrolled registration Cluster 1428: antibiotics iv oral prophylactic urinary tract obstructive prevention weeks day Cluster 1429: antibiotics infection requiring active iv systemic chronic study suppressive weeks Cluster 1430: caregiver patient primary identified family friend caregivers person willing parent Cluster 1431: providing capable consent informed procedures written complying patient parent guardian Cluster 1432: guardian legal consent informed patient parent able provide written sign Cluster 1433: guardian informed explained consent copy understood patient signed given procurement Cluster 1434: legal incapacity capacity limited subject providing patients granted authorization guardian Cluster 1435: parent guardian assent consent informed written patient legal signed minor Cluster 1436: guardian unwillingness legal representative research inability participant written consent informed Cluster 1437: previous treatment therapy exposure study chemotherapy assignment radiation months permanently Cluster 1438: pomalidomide prior previous treatment therapy exposure received combination pregnancy dexamethasone Cluster 1439: present previous enrollment study randomization enrolment assignment treatment family fap Cluster 1440: cypa inhibitors inducers medications strong cypc cytochrome concomitant study use Cluster 1441: inducers strong inhibitors cytochrome cyp gp treatment cypc glycoprotein drugs Cluster 1442: subfamily cytochrome cypa family polypeptide strong inhibitors inducers medications substances Cluster 1443: subfamily cytochrome polypeptide family cypa cypc inhibitors strong medications inducers Cluster 1444: inducer cypa strong inhibitor potent cytochrome medication use enzyme days Cluster 1445: cyp cytochrome strong inhibitor requires treatment inducer subfamily inhibitors use Cluster 1446: substrates cypa narrow cypc therapeutic index sensitive cypd inhibitors strong Cluster 1447: substances inducers medications cypa inhibitors ineligible receiving strong patients cytochrome Cluster 1448: strong inhibitor cypa cytochrome treatment require ibrutinib continuous dose gp Cluster 1449: strong cypa inducers inhibitors treatment concomitant requires study medications cytochrome Cluster 1450: concomitant medications therapy use protocol systemic malignancies study disorder uncontrolled Cluster 1451: potent cypa inducers inhibitors use medications stop known supplements receiving Cluster 1452: transplantation marrow bone history organ solid tuberculosis primary previous immunodeficiency Cluster 1453: primary immunodeficiency history active secondary tuberculosis form subject known patients Cluster 1454: tuberculosis previous diagnosis clinical known history ppd purified eligibility phase Cluster 1455: hepatitis active known patients hepatic participants patient tuberculosis subject disorder Cluster 1456: venous thrombosis thromboembolism arterial deep history embolism months pulmonary patients Cluster 1457: thrombosis deep vein embolism pulmonary dvt history pe months venous Cluster 1458: embolus deep thrombosis pulmonary vein history months venous patients enrollment Cluster 1459: dvt deep thrombosis embolism venous accident cerebrovascular attack transient pulmonary Cluster 1460: programmed death pd ligand cell prior protein lymphocyte cytotoxic anti Cluster 1461: agonist ctla ipilimumab prior inhibitor lymphocyte cd cytotoxic treatment history Cluster 1462: anti pd programmed death ligand cell antibody ctla lymphocyte cytotoxic Cluster 1463: values laboratory following adequate organ clinical function screening specified days Cluster 1464: organ function adequate defined follows protocol criteria following days baseline Cluster 1465: hematologic end organ function adequate days study treatment initiation obtained Cluster 1466: organ function adequate including demonstrates baseline days following evidenced registration Cluster 1467: female subject eligible defined enter amenorrhea follows childbearing participate potential Cluster 1468: impaired cardiac function following including problems history protocol defined known Cluster 1469: meeting criteria following disease measurable defined iwcll function adequate hematologic Cluster 1470: renal function adequate liver acceptable defined follows following cardiac days Cluster 1471: organ marrow function adequate defined requirements follows subjects patient protocol Cluster 1472: parameters laboratory range protocol defined adequate acceptable meet medical following Cluster 1473: hepatic function adequate encephalopathy defined follows evidenced history dysfunction met Cluster 1474: immune mediated auto disease history therapy related prior suppressive suppression Cluster 1475: autoimmune disease history active deficiency diseases immune patients inactive documented Cluster 1476: autoimmune syndrome systemic disease patients immune history demyelinating recur phospholipid Cluster 1477: abdominal cavity radiotherapy prior radiation pelvis portion patients received outside Cluster 1478: pelvis radiation prior abdomen radiotherapy therapy outside metastatic previous treatment Cluster 1479: remains cavity prior portion abdominal localized pelvis head neck years Cluster 1480: care medical consent voluntary prejudice withdrawn future understanding procedure written Cluster 1481: care medical consent prejudice voluntary withdrawn future understanding given procedure Cluster 1482: trastuzumab emtansine prior treatment lapatinib patients therapy ado chemotherapy regimen Cluster 1483: pertuzumab trastuzumab emtansine dm prior ado therapy lapatinib setting metastatic Cluster 1484: abstinent agreement remain methods contraceptive rate year period dose women Cluster 1485: refrain agreement abstinent remain donating sperm contraceptive measures men intercourse Cluster 1486: revascularization ischemic coronary symptoms history cardiac events including acs mi Cluster 1487: chimeric humanized fusion anaphylactic proteins antibodies reactions allergic hypersensitivity severe Cluster 1488: antibodies monoclonal hypersensitivity reactions severe history mabs allergy humanized reaction Cluster 1489: anaphylactic allergic reactions severe monoclonal antibody history reaction humanized murine Cluster 1490: hypersensitivity severe asthma monoclonal reactions antibodies nci anaphylaxis ctcae known Cluster 1491: allergens allergic unknown severe reactions components history drugs vaccines anaphylaxis Cluster 1492: dtpa gadolinium known gd acid reaction allergic dimeglumine anaphylactic acetic Cluster 1493: epo dependency erythropoietin mmol transfusion assessment hemoglobin days dl initiation Cluster 1494: mmol hemoglobin dl days initiation performed treatment transfusion registration assessment Cluster 1495: calcium mg dl serum mmol corrected albumin adjusted hypercalcemia levels Cluster 1496: calcium corrected serum normal uln albumin phosphate institutional hypercalcemia levels Cluster 1497: node lymph involvement dissection disease cm biopsy tumor patients regional Cluster 1498: nodes lymph regional cm disease metastatic patients pelvic ct imaging Cluster 1499: node sentinel axillary lymph dissection biopsy mastectomy lumpectomy surgery nodes Cluster 1500: cytotoxic chemotherapy setting metastatic adjuvant prior lines neoadjuvant treatment therapy Cluster 1501: setting metastatic prior therapy received adjuvant chemotherapy regimens line lines Cluster 1502: neoadjuvant adjuvant chemotherapy prior therapy months setting received metastatic treatment Cluster 1503: neuroendocrine cell small carcinoma histology cancer tumors prostate features acinar Cluster 1504: differentiated neuroendocrine poorly grade carcinoid tumor pancreatic tumors moderately carcinoma Cluster 1505: small prostate carcinoma cell neuroendocrine consistent pathological finding histologic diagnosis Cluster 1506: neuroendocrine prostate adenocarcinoma differentiation features cell histologically small confirmed cytologically Cluster 1507: msi microsatellite instability mmr high mss dmmr mismatch msh repair Cluster 1508: vascular peripheral disease collagen symptomatic significant clinically arterial patients active Cluster 1509: repair aortic aneurysm arterial vascular thrombosis recent peripheral surgical significant Cluster 1510: aortic vascular aneurysm dissection significant disease peripheral clinically history cardiac Cluster 1511: lesion measurable irradiated recist disease previously radiation cm mm index Cluster 1512: lesions target measurable patients bone cm irradiated disease radiation tumor Cluster 1513: target designated irradiated field persistence lesions confirm tumors assess progression Cluster 1514: target lesion measurable recist disease criteria lesions radiation response tumor Cluster 1515: measurable neuroblastoma lesions mibg disease fluid detected gallium bone collections Cluster 1516: oropharynx hpv squamous carcinoma cell associated positive proven biopsy nc Cluster 1517: carcinoma cell squamous adenocarcinoma histologically cancer confirmed adenosquamous nasopharyngeal patients Cluster 1518: cavity oropharynx larynx hypopharynx oral squamous carcinoma cell neck histologically Cluster 1519: histology cell small carcinoma mixed squamous adenocarcinoma clear cytology variant Cluster 1520: junction gastroesophageal adenocarcinoma gastric gej esophagus histologically confirmed stomach metastatic Cluster 1521: neck head squamous carcinoma cell histologically confirmed cancer hnscc scchn Cluster 1522: astrocytoma anaplastic grade oligodendroglioma glioma glioblastoma oligoastrocytoma diagnosis iii gliomas Cluster 1523: conducted assessed renal liver laboratory adequate marrow bone function following Cluster 1524: kidney function liver adequate bone marrow hematological disease stones solitary Cluster 1525: renal function marrow bone adequate hepatic liver cardiac coagulation metabolic Cluster 1526: hematological renal adequate hepatic function coagulation liver assessments laboratory metabolic Cluster 1527: hematology values chemistry laboratory renal function biochemical liver adequate limits Cluster 1528: functions adequate renal organ marrow bone liver hepatic defined hematological Cluster 1529: oxygen saturation pulse oximetry rest resting hypoxemia baseline pao arterial Cluster 1530: air saturation room oxygen baseline desaturation ambulatory rest function pulmonary Cluster 1531: room air perform forced predicted capacity pulmonary oximetry fvc pulse Cluster 1532: pulse room air oximetry oxygen saturation pulmonary dyspnea reserve level Cluster 1533: oximetry pulse room air infusion inclusion patients treatment previously radiation Cluster 1534: procedures comply inability protocol required study knowledge visits likely subject Cluster 1535: unwillingness inability procedures follow comply protocol required study outlined cooperate Cluster 1536: unwillingness inability comply protocol participate duration study reason requirements written Cluster 1537: cfr code donor regulations federal eligibility agency outlined donation guidance Cluster 1538: heart enrollment cerebral months accident stroke vascular cardiovascular arrhythmia infarction Cluster 1539: intracranial hemorrhage stroke history months enrollment prior randomization significant registration Cluster 1540: stroke history months accident hemorrhagic cerebrovascular cerebral hemorrhage prior known Cluster 1541: subarachnoid brain tia cva cerebrovascular stroke history accident hemorrhage attack Cluster 1542: coagulopathy diathesis anticoagulation bleeding therapeutic absence evidence significant thromboembolic permitted Cluster 1543: coagulopathy diathesis bleeding evidence history significant clinically inherited known risk Cluster 1544: bleeding diathesis active evidence history patients known uncontrolled anticoagulation correctable Cluster 1545: block lafb rbbb fascicular excluded av anterior degree conduction right Cluster 1546: block rhythm resting morphology degree important conduction abnormalities bundle branch Cluster 1547: block bundle branch left complete bifascicular right hemiblock anterior lbbb Cluster 1548: intermediate dipss risk prognostic dynamic scoring international myelofibrosis high mf Cluster 1549: ipss mds intermediate prognostic scoring risk high international revised int Cluster 1550: risk high intermediate patients disease neuroblastoma following defined factors criteria Cluster 1551: utilize condom partner sexually birth concluded methods effective control willing Cluster 1552: restrictions men apply birth control study practicing regulations regarding sexually Cluster 1553: wocbp partners birth control fertile effective using men sexually sexual Cluster 1554: invading vessels encasing major blood tumor subject contact vessel abutting Cluster 1555: cavitating lesion radiographic pulmonary evidence subject centrally vessel nsclc abutting Cluster 1556: lesions endobronchial infiltrating vessels pulmonary major known bronchi hemorrhage increase Cluster 1557: nursing female pregnant patients eligible participants subjects lactating intend study Cluster 1558: gestation termination conception state hcg nursing lactating laboratory female pregnancy Cluster 1559: desquamating nodosum characterized erythema rash thalidomide development taking similar drugs Cluster 1560: healing fracture wound ulcer non bone presence untreated active nonhealing Cluster 1561: wound healing surgery major trauma fracture dose ulcer days non Cluster 1562: incomplete healing surgery wound injuries major treatment recovery planned study Cluster 1563: free disease years cancer malignancy unless history subject patient considered Cluster 1564: negligible death metastasis malignancies risk outcome exception years expected curative Cluster 1565: malignancies years free disease prior history unless study subject exception Cluster 1566: tc clinical ajcc cancer th breast edition stage invasive joint Cluster 1567: th edition ajcc stage joint committee american cancer staging iv Cluster 1568: joint ajcc committee american stage cancer staging iv melanoma metastatic Cluster 1569: blasts marrow bone blood peripheral leukemic aml circulating patients leukemia Cluster 1570: aml mds patients prior cmml therapy blasts leukemia secondary relapsed Cluster 1571: leukemia acute biphenotypic blasts myeloid diagnosis lymphoblastic marrow remission lineage Cluster 1572: leukemia lymphoma acute hodgkin chronic myeloid lymphocytic lymphoblastic myeloma remission Cluster 1573: myeloid leukemia acute aml relapsed refractory blasts marrow patients remission Cluster 1574: lymphoblastic leukemia lymphoma acute cell patients precursor burkitt diagnosis relapsed Cluster 1575: obstruction bowel biliary signs stent intestinal history symptoms evidence partial Cluster 1576: seizures seizure disorder patients controlled history epilepsy febrile uncontrolled antiepileptic Cluster 1577: anticonvulsants inducing enzyme seizure disorder controlled enrolled patients non receiving Cluster 1578: seizure disorder medication requiring history uncontrolled patients controlled active neurologic Cluster 1579: anticoagulants therapeutic use dose current inr parenteral thrombolytic recent days Cluster 1580: warfarin use therapeutic anticoagulants concurrent thrombolytic requires current requiring condition Cluster 1581: geographical psychological permit familial sociological compliance protocol conditions follow unwillingness Cluster 1582: hampering sociological potentially familial psychological schedule compliance condition follow study Cluster 1583: familial sociological psychological geographical schedule potentially compliance follow protocol hamper Cluster 1584: hampering sociological geographical familial psychological schedule potentially follow compliance protocol Cluster 1585: federal accordance guidelines institutional written informed consent local signed provide Cluster 1586: federal informed accordance nature guidelines given written consent institutional investigational Cluster 1587: informed federal accordance nature guidelines institutional consent investigational written sign Cluster 1588: concurrent agents investigational receiving therapy biological use chemotherapy radiation patients Cluster 1589: anticancer concurrent therapy investigational approved agents treatment therapeutic therapeutics steroids Cluster 1590: concurrent therapy treatment protocol allowed cancer use radiation permitted investigational Cluster 1591: immunotherapy radiotherapy chemotherapy investigational therapy agents treatment prior days concurrent Cluster 1592: fertile unwilling contraceptive practice methods men period study appropriate follow Cluster 1593: infertility exists documentation practice effective fertile unless men contraceptive methods Cluster 1594: fertile unwilling use contraceptive men months techniques women post transplant Cluster 1595: srs brain wbrt radiosurgery stereotactic lesions metastases patients radiation treated Cluster 1596: eligible brain metastases fewer radiosurgery stereotactic diameter asymptomatic month cm Cluster 1597: brain radiation therapy prior radiosurgery stereotactic metastases treatment wbrt radiotherapy Cluster 1598: agents investigational receiving patients subjects ineligible patient treatment days registration Cluster 1599: current use malignancy treatment history diagnosis study disease planned prior Cluster 1600: agents investigational weeks use study treatment days prior current receiving Cluster 1601: statin use current therapy donor pbsc months treatment drugs pravastatin Cluster 1602: concurrently investigational receiving agents study patients drug days treatment participation Cluster 1603: medication immunosuppressive prior use current days dose systemic treatment exceptions Cluster 1604: hipaa authorization health release information informed personal consent accountability portability Cluster 1605: accountability portability insurance act hipaa health consent informed authorization written Cluster 1606: diet mdrd glomerular filtration formula modification rate renal min ml Cluster 1607: modification diet mdrd renal creatinine min ml calculated equation disease Cluster 1608: ckd epi epidemiology collaboration kidney min creatinine ml chronic equation Cluster 1609: current hepatitis virus liver alcohol abuse cirrhosis history clinically significant Cluster 1610: liver alcoholic fatty inherited cirrhosis disease viral hepatitis significant clinically Cluster 1611: cirrhosis alcohol viral abuse liver clinically hepatitis significant including current Cluster 1612: investigational study participated therapy device participating currently agent used receiving Cluster 1613: investigational participated device agent participating currently using study weeks dose Cluster 1614: agents receiving participants study patients concurrently currently treatment weeks prior Cluster 1615: neoplasm agent considered primary investigational receiving treatment registration currently prior Cluster 1616: agent investigational receiving patients currently received weeks days agents study Cluster 1617: currently agents investigational receiving vaccines received weeks patients previous tumor Cluster 1618: cmv vaccine investigational anti time prior agent received activity recipient Cluster 1619: participants agents investigational receiving stratum study days cancer treatment received Cluster 1620: mutation flt ras testing tumor activating itd kras egfr patients Cluster 1621: exon egfr mutation lr insertion deletion mutations activating gx lq Cluster 1622: alk egfr ros mutation nsclc rearrangement mutations patients translocation approved Cluster 1623: cells platelets mm registration days prior obtained si study ml Cluster 1624: plt platelets mm transfusions mcl days ml obtained start registration Cluster 1625: platelets mcl registration days prior obtained study performed mm step Cluster 1626: leukocytes mm ml registration obtained days prior cells equal phase Cluster 1627: illness uncontrolled heart social compliance psychiatric congestive pectoris failure situations Cluster 1628: giving dementia understanding prohibit situations psychiatric social compliance illness requirements Cluster 1629: social illness compliance psychiatric requirements limit situations study situation ability Cluster 1630: illness uncontrolled compliance requirements study limit social inter psychiatric situations Cluster 1631: illness compliance intercurrent situations uncontrolled social requirements psychiatric limited limit Cluster 1632: prostate adenocarcinoma histologically confirmed documented cancer diagnosis biopsy metastatic primary Cluster 1633: proven biopsy diagnosis histologically cancer pathologically disease patients carcinoma breast Cluster 1634: prostate proven adenocarcinoma biopsy histologically cancer histopathological histopathologically pathologically histopathology Cluster 1635: gleason score biopsy prostate cores higher cancer pattern grade core Cluster 1636: dihydropyrimidine deficiency dehydrogenase dpd known fluorouracil fluoropyrimidine hypersensitivity capecitabine severe Cluster 1637: gpd phosphate deficiency dehydrogenase glucose known history patients hereditary normal Cluster 1638: deficiency phosphate glucose dehydrogenase known history pd patients porphyria phosphatase Cluster 1639: oxaliplatin irinotecan fluoropyrimidine fluorouracil fu leucovorin bevacizumab capecitabine chemotherapy therapy Cluster 1640: requires immunosuppressive organ transplant use undergone treatment medications history fallopian Cluster 1641: allografts organ patients transplant renal excluded history transplants subjects subject Cluster 1642: immunosuppressives requires organ use transplant history disorders autoimmune steroids severe Cluster 1643: prohibited medications use medication current concomitant treatment study requires require Cluster 1644: pain scale score worst cancer patients opioid rating related nrs Cluster 1645: pain uncontrolled related tumor tumour cancer does hypercalcemia chronic favor Cluster 1646: delirium memorial scale assessment rating cognitive score hours mixed cognition Cluster 1647: potency manifestations psoriasis hydrocortisone arthritis autoimmune patients lichen oral chronicus Cluster 1648: autoimmune requiring trigger recur hypothyroidism vitiligo mellitus psoriasis replacement diabetes Cluster 1649: past years psoriasis vitiligo disease autoimmune graves requiring systemic documented Cluster 1650: dermatitis atopic cohort skin exfoliative epidermis patients disrupts psoriasis subjects Cluster 1651: deteriorate hypo hyperthyroid autoimmune psoriasis vitiligo disease diabetes type requiring Cluster 1652: thromboplastin partial ptt time normal upper limit uln times institutional Cluster 1653: thromboplastin aptt activated partial time uln ptt institutional normal upper Cluster 1654: time prothrombin pt ptt thromboplastin partial normal uln upper limit Cluster 1655: inr ptt pt uln aptt normal coagulation limits upper patients Cluster 1656: fda food met nci institute national studies administration institutional human Cluster 1657: locally recurrent metastatic disease breast cancer advanced prior therapy inoperable Cluster 1658: ovarian cancer epithelial platinum breast patients treatment prior borderline recurrent Cluster 1659: breast cancer prior diagnosed therapy history treatment radiation patients recurrent Cluster 1660: malignancy years history past prior previous active evidence exceptions diagnosed Cluster 1661: taking currently medications patients drugs medication study treatment immunosuppressive lithium Cluster 1662: prohibited medication currently taking listed treatments treatment receiving concomitant protocol Cluster 1663: metformin taking hypersensitivity reason insulin diabetic currently known subjects patients Cluster 1664: cns radiographic completion metastases directed hemorrhage interim provided anticonvulsants optic Cluster 1665: anticancer therapies offered lapatinib nf imatinib erlotinib basis bevacizumab antibody Cluster 1666: optic nerve chiasm glioma pathway apparatus nf tumor patients medulla Cluster 1667: supratentorial tumor location remote brain compartment elective craniotomy glioma evidence Cluster 1668: braf mek inhibitor kinase inhibitors prior mitogen therapy activated treatment Cluster 1669: mek inhibitor prior treatment kinase raf mitogen braf therapy activated Cluster 1670: transfusions provided red known platelet evaluable counts hematologic receive toxicity Cluster 1671: hematologic toxicity evaluable transfusions patients limiting provided enrolled observed red Cluster 1672: ct pet imaging mri diagnostic contrast patients fdg undergo scanning Cluster 1673: pet scan ct fdg bone imaging disease weeks mri patients Cluster 1674: scans mri undergo able pet contrast tolerate patients unable willing Cluster 1675: eligibility step criteria registration randomization pre verify induction patients change Cluster 1676: pre registration criteria exclusion eligibility chemotherapy procedure initiated final met Cluster 1677: women unwilling childbearing contraception nursing men potential reproductive effective pregnant Cluster 1678: women employ unwilling nursing men contraception adequate childbearing potential pregnant Cluster 1679: persons unwilling nursing employ contraception adequate potential pregnant following childbearing Cluster 1680: unwilling women stopping use reproductive intercourse men vasectomy effective having Cluster 1681: testosterone ng dl serum nmol level castration levels screening androgen Cluster 1682: castrate testosterone ng dl level levels nmol prostate serum resistant Cluster 1683: options treatment standard curative available informed patients exhausted therapy therapeutic Cluster 1684: amenable curative advanced metastatic locally intent disease recurrent surgery therapy Cluster 1685: potentially curative amenable therapy patients disease standard resection available extending Cluster 1686: hep hepatitis infection active hiv virus known immunodeficiency human positive Cluster 1687: hepatitis hiv immunodeficiency virus human known positive active history serology Cluster 1688: seropositivity hiv immunodeficiency virus human known history infection hepatitis patients Cluster 1689: hepatitis ml copies viremic iu dna deoxyribonucleic carrier virus active Cluster 1690: viral hepatitis bacterial fungal infection hiv immunodeficiency virus human active Cluster 1691: positivity hiv immunodeficiency virus human known hepatitis procurement history active Cluster 1692: virus infection hepatitis active immunodeficiency human hiv known positive chronic Cluster 1693: immunodeficiency hiv virus human infection negative history donor antibody patients Cluster 1694: hepatitis virus infection active known hiv evidence reactivation positive history Cluster 1695: hepatitis virus immunodeficiency human hiv infection known active chronic history Cluster 1696: bilateral oophorectomy hysterectomy tubal ligation surgical salpingo sterilization salpingectomy prior Cluster 1697: history bilateral reproductive menopausal ligation menses tubal oophorectomy hysterectomy potential Cluster 1698: study agree barrier method course use accepted contraception dose drug Cluster 1699: male contraception agree study use barrier subjects dose method drug Cluster 1700: practice agree entire contraception barrier effective period study dose sterilized Cluster 1701: donate sperm study agree dose drug months intend eggs receiving Cluster 1702: biopsy bronchoscopic accessed percutaneous thoracoscopic safely perspective undergo willingness waived Cluster 1703: biopsy tumor accessible undergo patients amenable core biopsies treatment tissue Cluster 1704: needle biopsy core fine aspiration fna breast diagnosis tumor invasive Cluster 1705: tumor primary brain patients biopsies positive biopsy metastatic diagnosis resection Cluster 1706: undergo willing biopsy biopsies tumor willingness treatment able pre research Cluster 1707: undergone consecutive celibate orientation choice remaining months meets sexual regardless Cluster 1708: undergone consecutive bearing child woman potential pregnant celibate study remaining Cluster 1709: consecutive undergone childbearing potential orientation months naturally meets sexual regardless Cluster 1710: ekg electrocardiogram qtc qt interval corrected significant msec clinically patients Cluster 1711: ecg electrocardiogram clinically significant lead abnormal investigator abnormalities findings screening Cluster 1712: qt points resting ecg msec family qtc long electrocardiogram hour Cluster 1713: electrocardiogram qtc msec qt corrected interval ecg screening ekg baseline Cluster 1714: prolonged qtc interval qt corrected msec history electrocardiogram calculated rate Cluster 1715: sites disease metastatic patients measurable radiation primary treatment prior site Cluster 1716: malignancy history prior kind primary metastatic patients hematopoietic exception underlying Cluster 1717: site primary disease tumor patients radiation biopsy prior measurable unknown Cluster 1718: bleeding acquired disorder diagnosed viii von disorders congenital willebrands unrelated Cluster 1719: predisposition inherited thrombosis bleeding known hypercoagulable history state patient jeopardize Cluster 1720: hemophilia von bleeding willebrands disorders known willebrand disease diathesis predisposition Cluster 1721: proteins murine allergy mouse hypersensitivity history known egg chimeric ige Cluster 1722: contained formulation excipient hypersensitivity drug known proteins recombinant tesirine rovalpituzumab Cluster 1723: antibody anti hama mouse human ctla prior murine titer elisa Cluster 1724: pleural effusion clinically malignant significant ascites fluid chest ray pericardial Cluster 1725: ascites paracentesis clinically encephalopathy significant hepatic trace moderate presence clinical Cluster 1726: effusions pleural ascites malignant pericardial significant patients exudative symptomatic peritoneal Cluster 1727: infiltrates chest pulmonary improving ray presumed fungal progressive attributed infections Cluster 1728: effusion pleural ascites pericardial drainage requiring symptomatic uncontrolled recurrent fluid Cluster 1729: urethra ureter bladder pelvis transitional renal urothelial carcinoma cell histologically Cluster 1730: muscle invasive bladder urothelial carcinoma non cancer ta transitional high Cluster 1731: urothelial carcinoma bladder tract cell histologically upper pure metastatic histologic Cluster 1732: treated previously patients ixazomib therapy eligible prior subjects study chemotherapy Cluster 1733: bevacizumab prior treatment patients therapy received weeks treated previously regimen Cluster 1734: ibrutinib prior treatment therapy btk exposure investigational inhibitors previously patients Cluster 1735: avastin bevacizumab received prior weeks treatment therapy use scheduled planned Cluster 1736: gi tolerance swallowing difficulty absorption procedure interfere gastrointestinal oral ixazomib Cluster 1737: gi gastrointestinal disease absorption interfere surgery history oral bleeding bleed Cluster 1738: swallowing difficulty capsules malabsorption capable hamper participate procedures absorption willing Cluster 1739: ethnic groups races racial background eligible trial men women restrictions Cluster 1740: members ethnic races groups eligible trial men included women minorities Cluster 1741: beta chorionic gonadotropin hcg negative human test potential childbearing pregnancy Cluster 1742: menopausal sterilization bearing post child beta hcg potential surgical previous Cluster 1743: chorionic hcg gonadotropin beta human pregnant women positive serum test Cluster 1744: hcg iu units sensitivity chorionic gonadotropin minimum test equivalent pregnancy Cluster 1745: beta pregnancy pregnant subject established hcg chorionic result confirmation gonadotropin Cluster 1746: axillary nodes lymph mammary breast positive internal supraclavicular primary infraclavicular Cluster 1747: axis cm short diameter lymphadenopathy nodes lymph exceeding long node Cluster 1748: diameter lymph axis node mm short lesion measurable longest recist Cluster 1749: alt ast uln liver serum times metastasis patients metastases bilirubin Cluster 1750: sgpt sgot uln alt ast liver metastases institutional present serum Cluster 1751: uln liver ast alt metastases bilirubin function hepatic transaminases total Cluster 1752: times uln bilirubin total liver creatinine metastases serum ast alt Cluster 1753: dlco predicted pulmonary fev fvc corrected function oxygen pfts saturation Cluster 1754: fvc vital forced capacity predicted corrected pulmonary hemoglobin expected value Cluster 1755: infarction myocardial months history prior mi past study registration acute Cluster 1756: cerebrovascular accident cva months infarction myocardial history unstable angina mi Cluster 1757: sexual latex contact condom vasectomy successful agree use potential men Cluster 1758: abstinence true contact heterosexual study interruption interruptions agree monthly commit Cluster 1759: female interruptions contact successful vasectomy abstinence condom sexual true undergone Cluster 1760: radiographic evidence disease progression clinical metastatic documented cavitary necrotic measurable Cluster 1761: radiological progression evidence disease amphotericin triazole clinical metastatic documentation receipt Cluster 1762: disease inflammatory hashimoto bowel syndrome hypothyroidism autoimmune replacement following graves Cluster 1763: disease syndrome inflammatory celiac hashimoto systemic following consultation diet patients Cluster 1764: bilirubin upper limit normal uln serum direct institutional equal institution Cluster 1765: total bilirubin uln institutional age concentration institution days equal liver Cluster 1766: creatinine upper limit normal uln serum institutional age equal registration Cluster 1767: lipase normal upper limit serum institutional limits iuln pancreas institution Cluster 1768: total bilirubin upper limit normal stenting biliary institution laboratory age Cluster 1769: bilirubin serum normal equal indirect count direct family fap fanconi Cluster 1770: normal bilirubin upper limit range transaminases reference institution patients direct Cluster 1771: normal upper alt limit ast uln institution range donor institutional Cluster 1772: prostate cancer prior chemotherapy diagnosis therapy treatment resistant metastatic castration Cluster 1773: adjuvant neo chemotherapy therapy prior treatment months cancer received completion Cluster 1774: chemotherapy received prior patients radiation therapy cancer radiotherapy previous adjuvant Cluster 1775: fulvestrant treatment prior combination endocrine cohort therapy received study dose Cluster 1776: endocrine therapy breast cancer prior adjuvant chemotherapy metastatic treatment received Cluster 1777: remains received chemotherapy prior localized pelvic adjuvant years abdominal cancer Cluster 1778: cancer cell basal situ squamous adequately skin treated years cervical Cluster 1779: cancer adequately treated remission cell complete stage currently patient basal Cluster 1780: malignancy melanomatous cancer skin curatively resected non adequately concurrent basal Cluster 1781: cancer carcinoma cell prostate cured thyroid gleason impact adequately unlikely Cluster 1782: adequately cell basal treated squamous skin malignancy carcinoma cancer years Cluster 1783: carcinomas malignancies basal squamous skin cell treated adequately years past Cluster 1784: cell basal skin carcinoma squamous malignancy cancer years malignancies active Cluster 1785: cancer diagnosis active history years patients prior evidence previous skin Cluster 1786: curatively treated cancer years situ skin melanoma adequately solid evidence Cluster 1787: treated adequately evidence malignancy situ disease lentigo maligna melanoma cancer Cluster 1788: curatively primary cancer treated resected outcome cervical skin present solid Cluster 1789: cancer treated situ curatively distinct superficial carcinoma bladder cervical years Cluster 1790: pap intraepithelial smear cancer situ cervical localized remission curatively squamous Cluster 1791: stem transplant cell autologous received prior patients asct therapy chemotherapy Cluster 1792: hsct allogeneic prior autologous undergoing patients transplant patient previous days Cluster 1793: transplant autologous stem cell allogeneic prior months eligible patients study Cluster 1794: stem transplant allogeneic cell prior patients received eligible history previous Cluster 1795: transplants stem cell prior organ allogeneic kind patients autologous transplant Cluster 1796: rescue stem cell high chemotherapy dose autologous requiring previous transplant Cluster 1797: transplant marrow bone stem cell autologous allogeneic prior rescue previous Cluster 1798: venous access central catheter adequate apheresis leukapheresis peripheral donor line Cluster 1799: sampling blood suitable access venous required study pk serial marrow Cluster 1800: vaccination attenuated receipt live days durvalumab entry receiving tremelimumab prior Cluster 1801: vaccine live attenuated administration weeks study anticipation day cycle prior Cluster 1802: inactivated vaccines vaccination avelumab prohibited administration weeks dose trial influenza Cluster 1803: immunotherapy vaccines type tumor completion days weeks completed initiation oncolytic Cluster 1804: live receipt vaccine attenuated days dose prior study ip treatment Cluster 1805: vaccinated attenuated vaccines live weeks drug dose study starting tremelimumab Cluster 1806: vaccination live vaccine days prior start treatment minimum attenuated received Cluster 1807: live vaccines attenuated study days weeks vaccinations treatment prior vaccination Cluster 1808: candidates patients surgical deemed considered surgery resection chemotherapy appropriate therapy Cluster 1809: candidate surgical patient surgery appropriate surgeon resection medical deemed curative Cluster 1810: cm measurable ct dimension disease longest lesion tomography computed scan Cluster 1811: diameter cm maximum lesion tumor longest lesions measurable largest maximal Cluster 1812: bi dimensionally measurable cm lesion dimensional disease ct dimension scan Cluster 1813: measurable assessed disease ct registration days prior documented non tomography Cluster 1814: care standard patients therapy patient supportive treatment hospice clinic cancer Cluster 1815: phobia needed reasons examinations claustrophobia inability complete care standard imaging Cluster 1816: ancillary considered bisphosphonates supportive therapy concurrent allowed care investigational note Cluster 1817: responsive accepted care relapse progressive therapy curative standard non surgery Cluster 1818: lymphoma lymphocytic zone marginal follicular cell small mantle leukemia sll Cluster 1819: marginal zone splenic lymphoma nodal extranodal mzl malt mucosa follicular Cluster 1820: contraception methods oophorectomy hormone ovulation sterilization women case abstinence intrauterine Cluster 1821: contraception contraceptives intrauterine barrier methods device effective potential oral contraceptive Cluster 1822: contraceptive device double methods women barrier bearing acceptable use child Cluster 1823: wocbp contraceptive contraception effective highly pregnancy heterosexually continuously exempt active Cluster 1824: contraception methods oophorectomy child highly women bearing effective intrauterine appropriate Cluster 1825: oophorectomy appropriate bearing child considered potential vasomotor spontaneous amenorrhea profile Cluster 1826: molecule therapy targeted small prior chemotherapy radiation weeks administered recovered Cluster 1827: grade tinnitus recovered note typical surgery hearing prior return qualify Cluster 1828: radiation recovered note nilotinib registration aside imatinib dasatinib qualify weeks Cluster 1829: recovered grade note therapy prior qualify molecule criterion targeted administered Cluster 1830: delayed toxicity chemotherapy weekly therapy immunotherapy biologic extensive weeks days Cluster 1831: cytotoxic weeks agents chemotherapy cytokines biologic antibodies nitrosoureas mitomycin investigational Cluster 1832: concurrent chemotherapy radiation allowed therapy receiving patients immunotherapy cytotoxic biologic Cluster 1833: counts blood platelet cell mm neutrophil wbc white prior absolute Cluster 1834: wbc white cells mm blood cell bil count weeks enrollment Cluster 1835: wbc white ul blood cells cell count days counts obtained Cluster 1836: gemcitabine paclitaxel nab cisplatin prior hypersensitivity treatment received chemotherapy patients Cluster 1837: paclitaxel nab carboplatin hypersensitivity known history cremophor arm weekly prior Cluster 1838: bleeding gastrointestinal months history significant gi hemorrhage clinically prior grade Cluster 1839: hemorrhage bleeding event grade ctcae weeks nci study start prior Cluster 1840: bleeding clinically significant history unexplained entering days disorder study gastrointestinal Cluster 1841: plasma leukemia current cell past diagnosis faint family fap fanconi Cluster 1842: plasma leukemia cell circulating cells differential active amyloidosis standard diagnosis Cluster 1843: presence infection uncontrolled active hours disease cancer chronic invasion major Cluster 1844: responded refractory primary mr therapy prior participants eligible egfr disease Cluster 1845: primary disease patients refractory myelofibrosis cancer invasion history endometrial tumor Cluster 1846: diagnosis immunodeficiency confirmed time disease following patients histologic nf malignancy Cluster 1847: verification histologic diagnosis original neuroblastoma relapse patients tumors tumor malignancy Cluster 1848: solid tumor advanced malignancy diagnosis histologic cytologic metastatic confirmation pathologically Cluster 1849: uncontrolled arrhythmia significant clinically cardiac condition symptomatic arrhythmias medical confounding Cluster 1850: arrhythmias cardiac uncontrolled ventricular history symptomatic pressor significant disease known Cluster 1851: ventricular pacemaker cardiac arrhythmias contractions medication requiring premature supraventricular pericarditis Cluster 1852: uncontrolled hepatitis heart severe chronic congestive symptomatic disease quantifiable cardiac Cluster 1853: comprehend informed consent able sign document written willing subjects form Cluster 1854: written informed consent given provides obtained able participate patient study Cluster 1855: irb approved sign document informed understand consent willing written able Cluster 1856: specific study entry consent informed provide prior patient sign patients Cluster 1857: understand able sign consent informed document willing patients read patient Cluster 1858: sign consent informed patients able willing written refusal document patient Cluster 1859: legally authorized representative consent informed written provide patient sign understand Cluster 1860: document sign understand written consent willing informed able patient patients Cluster 1861: unwillingness inability consent informed supplementation written transfused vitamin individual folic Cluster 1862: guardians parents legal sign consent written informed patients benefits indicating Cluster 1863: able consent informed willing patients patient subjects study participants eligible Cluster 1864: pertinent aspects informed dated indicating signed document consent legally trial Cluster 1865: comply able protocol informed consent sign requirements signed willing icf Cluster 1866: inability consent informed provide understand written obtain assent document sign Cluster 1867: legal representative consent informed able written provide patient understand sign Cluster 1868: unwilling unable consent informed sign form document written patients icd Cluster 1869: count platelet hemoglobin neutrophil absolute dl anc function marrow bone Cluster 1870: marrow bone involvement count neutrophil absolute anc unless platelet cytopenias Cluster 1871: anc neutrophil absolute count ml platelet liter csf greater platelets Cluster 1872: microliter count neutrophil absolute platelet anc mcl leukocyte equal randomization Cluster 1873: filgrastim support neutrophil absolute mm count greater anc equal gcsf Cluster 1874: equal greater neutrophil absolute count anc mm mcl ul creatinine Cluster 1875: microl count absolute equal neutrophil greater platelets platelet registration anc Cluster 1876: activity physical moderate engage minutes week intensity vigorous questionnaire sedentary Cluster 1877: exercise strenuous week intensity moderate minutes program vigorous able musculoskeletal Cluster 1878: icf signing form time informed years age consent subject signed Cluster 1879: signing consent informed age years time form day female subject Cluster 1880: fgfr inhibitor selective fgf prior receipt treatment amplification alterations tumor Cluster 1881: gene therapy prior product idh modified mutation amplification treatment tumor Cluster 1882: laboratory clia improvement certified clinical amendments mutation act results tumor Cluster 1883: creatinine clearance calculated uln crcl place institutional gfr glomerular filtration Cluster 1884: creatinine clearance calculated crcl uln place gfr glomerular filtration institutional Cluster 1885: inability comply protocol requirements assessments investigator follow available study willing Cluster 1886: unable comply protocol requirements opinion investigator follow study patient consent Cluster 1887: monitoring safety comply opinion requirements able investigator study eligible patients Cluster 1888: noncompliance regimens medical history haart unreliable protocol comply unable therapy Cluster 1889: unwilling follow unable requirements protocol consent instruction informed render instructions Cluster 1890: abide cooperate fully unwilling designee unable protocol investigator study subject Cluster 1891: addictive preclude psychiatric disorders meeting conditions requirements opinion patient investigator Cluster 1892: unwilling comply unable protocol patients requirements study procedures assessed investigator Cluster 1893: exclude opinion investigator subject presence following study enrollment patient patients Cluster 1894: compliant initiative investigator means protocol patient opinion proximity team study Cluster 1895: alcohol drinks consumption excessive day use alcoholic oz wine ounces Cluster 1896: sleep apnea sleepiness daytime excessive obstructive syndrome result supplemental conditions Cluster 1897: trial confound best abnormality results interfere participate laboratory duration current Cluster 1898: confound results study situation subject condition significantly participation risk opinion Cluster 1899: personal history family syndrome qt long cancer crc melanoma participants Cluster 1900: qt syndrome long history family interval risk subject prolonged tdp Cluster 1901: congenital qt long syndrome history diagnosed family suspected sudden patients Cluster 1902: qt prolongation interval risk long qtc syndrome arrhythmic heart factors Cluster 1903: qtc family history long syndrome personal ventricular prolongation bigeminy msec Cluster 1904: final study administration period donate screening drug starting subject female Cluster 1905: final study starting barrier administration birth method control screening period Cluster 1906: try final study administration agree pregnant drug days heterosexually months Cluster 1907: tcl obtained cutaneous registration hepatosplenic angioimmunoblastic ul cm days panniculitis Cluster 1908: ul platelets cells days prior registration obtained treatment weeks enrollment Cluster 1909: platelets mm cu weeks days day prior wbc study enrollment Cluster 1910: leukocytes ul secondary days treatment obtained radiotherapy prior cells performed Cluster 1911: plt ul platelets registration days obtained transfusion thrombocytopenia prior sgn Cluster 1912: finding metabolic reasonable suspicion contraindicates examination dysfunction physical render giving Cluster 1913: physical exam mental imaging examination disease cm limitations study findings Cluster 1914: unequivocal metastatic radiologic cytologic pathologic disease physical examination invasive metastasis Cluster 1915: function cardiac adequate assessed physical normal examination pulmonary history clinically Cluster 1916: examination physical registration history days prior complete patients medical digital Cluster 1917: orally medication swallow unable likely absorption administered interfere disorders gastrointestinal Cluster 1918: impaired function decisionally cognitively renal patients absorption egfr severely gastrointestinal Cluster 1919: gut dysphagia ingestion short gastroparesis orally syndrome absorption administered gastrointestinal Cluster 1920: quit smoking date trying attempt users interested willing set current Cluster 1921: hpv oropharyngeal papillomavirus positive status human vaccination pcr polymerase tumor Cluster 1922: il interferon concomitant therapies regimens immunotherapy immunosuppressive non interleukin following Cluster 1923: ifn interferon immunostimulatory interleukin alpha il limited agents systemic cycle Cluster 1924: women postmenopausal fsh defined hormone bilateral potential follicle menarche amenorrhea Cluster 1925: menopausal hormone postmenopausal post age fsh follicle oophorectomy bilateral stimulating Cluster 1926: nsaids hypersensitivity sulfonamides nonsteroidal asa drugs celecoxib days antiinflammatory inflammatory Cluster 1927: interpretation results safety interfere evaluation condition opinion study investigator patient Cluster 1928: risk condition pose investigator unacceptable place study opinion interfere patient Cluster 1929: absorption gastrointestinal disorder affecting gastrectomy interfere rucaparib peptic opinion investigator Cluster 1930: pose safety risk opinion consulted condition disorder amgen interfere investigator Cluster 1931: ventilation mechanical oxygen supplemental requiring saturation room air higher respiratory Cluster 1932: oxygen dyspnea rest continuous complications supplementary advanced malignancy requiring therapy Cluster 1933: oxygen supplemental requiring requirement daily continuous patients saturation use therapy Cluster 1934: hematocrit hct hemoglobin anemia donor dl reached days males transfusion Cluster 1935: greater hemoglobin dl equal gm screening values visit transfusion level Cluster 1936: hb hemoglobin dl gm level transfusion correct transfusions equal anemia Cluster 1937: transfused gm hemoglobin dl rbcs achieve blood requirement prior level Cluster 1938: hemoglobin level dl reached transfusion eligibility gm days achieve registration Cluster 1939: aphasia paresis brain cerebellar psychosis injuries epilepsy dementia organic cns Cluster 1940: cns cerebellar disorder dementia ischemia hemorrhage cerebrovascular disease autoimmune involvement Cluster 1941: corticosteroids permitted equivalents prednisone systemic mg autoimmune topical daily dye Cluster 1942: equivalents prednisone daily mg corticosteroids immunosuppressive medications inhaled systemic adrenal Cluster 1943: daily prednisone equivalent mg corticosteroids immunosuppressive inhaled medications systemic condition Cluster 1944: immunosuppressive medications systemic corticosteroids treatment weeks use prior requiring condition Cluster 1945: rectal chemoradiation exclude protocol radiotherapy standard marrow bone subject concluded Cluster 1946: surgically childbearing potential abstain heterosexual activity sterile sterilized study subjects Cluster 1947: bilateral potential females childbearing postmenopausal surgically hysterectomy oophorectomy sterile tubal Cluster 1948: sterile surgically documented postmenopausal effective month contraception hysterectomy screening post Cluster 1949: women childbearing potential amenorrhea possibly amenorrheic bilateral months suppression antiestrogens Cluster 1950: lactating pregnant subject subjects intending patient non participant woman exclusion Cluster 1951: breastfeeding pregnant patient lactating stop does agree fancd fascia farber Cluster 1952: lactating female pregnant patients subject subjects breastfeeding patient non male Cluster 1953: enrolled protocol subjects female intensification subject point treatment radiation completed Cluster 1954: breastfeeding subject pregnant female healthy intends enrolling days study fancc Cluster 1955: lactating pregnant patients eligible participation practicing breastfeeding registration known ineligible Cluster 1956: female participants subjects patients years breastfeeding patient prefer whichever method Cluster 1957: female pregnant breastfeeding patients ineligible subjects eligible intends study actively Cluster 1958: fever infection active unexplained celsius hours scheduled degrees day enrollment Cluster 1959: degrees febrile fahrenheit unexplained temperature celsius illness infection requiring active Cluster 1960: creatinine mg dl equal renal cr umol level plasma norms Cluster 1961: creatinine uln institutional equal cohort baseline greater age biopsy plasma Cluster 1962: creatinine mg dl serum umol equal registration days prior renal Cluster 1963: albumin dl equal hypoalbuminemia screening greater plasma level levels low Cluster 1964: plasma bone marrow cells dl clonal myeloma mg lesions serum Cluster 1965: severe bacteremia pneumonia hospitalization complications infection limited infections including weeks Cluster 1966: illness intercurrent uncontrolled limited including concurrent significant infection subject patient Cluster 1967: illness infection active medical intercurrent psychiatric including uncontrolled patients concurrent Cluster 1968: hemoglobin dl mg minimum patients enrollment phase weeks anemia arm Cluster 1969: zubrod performance registration status days prior step documented patients study Cluster 1970: step registration prior crossover days patients treatment mcl optional dl Cluster 1971: exclusion registration criteria randomization neratinib secondary intraperitoneal experiencing mucinous borderline Cluster 1972: step randomization prior registration ii days criteria dl enrollment hemoglobin Cluster 1973: childbearing effective potential contraception women agreement forms use partners men Cluster 1974: childbearing correctly potential consistently use highly agreement partners rate continue Cluster 1975: unknown nursing mother infants potential effects women pregnant teratogenic abortifacient Cluster 1976: nursing pregnant patient females entry physiologically previous female time capable Cluster 1977: nursing pregnant females patients subjects non potential harm infants study Cluster 1978: breastfeed infants lactating females agreed plan unless eligible study female Cluster 1979: labs screening adequate performed organ days function demonstrate initiation treatment Cluster 1980: bilirubin uln total direct levels subjects serum initiation days performed Cluster 1981: lab values performed creatinine uln surgeon results serum prior prevent Cluster 1982: total bilirubin serum uln institutional days initiation grade performed treatment Cluster 1983: coronary history heart evidence cardiac angioplasty stenting controlled syndromes including Cluster 1984: coronary angioplasty stenting bypass acute myocardial infarction artery angina syndromes Cluster 1985: sufficient involved field days interval small radiotherapy considered administration ixazomib Cluster 1986: field wide radiation palliation radiotherapy weeks limited therapy effects study Cluster 1987: irradiated radiotherapy weeks better effects palliation recovered marrow bone received Cluster 1988: vegf bevacizumab prior anti sunitinib sorafenib received inhibitor therapy pathway Cluster 1989: endothelial vegf growth vascular factor vegfr bevacizumab receptor prior anti Cluster 1990: phq questionnaire score suicidal mood ideation health patient question thoughts Cluster 1991: epic questionnaire complete composite expanded willingness ability index prostate domains Cluster 1992: assistance questionnaire complete ability diary medication english qol independently diaries Cluster 1993: assistance questionnaires interpreter complete ability english questions minimal member able Cluster 1994: complete questionnaires able english quality study baseline willing forms assessment Cluster 1995: medi small cohort lung cell cancer eligibility phase ii non Cluster 1996: medi phase cohort ii eligibility cancer criteria study ovarian colorectal Cluster 1997: pectoris angina infarction myocardial months unstable starting prior acute drug Cluster 1998: heart uncontrolled failure congestive hypertension disease angina significant unstable symptomatic Cluster 1999: uncontrolled myocardial infarction angina congestive heart failure months cardiac unstable Cluster 2000: angioplasty stenting cardiac heart infarction myocardial angina unstable vascular cardiovascular Cluster 2001: angina myocardial infarction unstable months history prior day study enrollment Cluster 2002: angina unstable months prior entry intervention disease medical surgical study Cluster 2003: heart arterial thrombotic evidenced disease infarction myocardial measurement york unstable Cluster 2004: infarction myocardial cardiac months history prior entry stress study unstable Cluster 2005: angina new heart onset months cardiac rest anginal nyha infarction Cluster 2006: heart congestive myocardial failure infarction months unstable angina history cardiac Cluster 2007: vitamin warfarin antagonists anticoagulation equivalent requires phenprocoumon antagonist days require Cluster 2008: vitamin warfarin antagonists concomitant use supplementation antagonist iu patients day Cluster 2009: seizure history disorders predispose patients anticonvulsant activity months condition disorder Cluster 2010: seizure cortical predispose trauma stroke brain history condition consciousness significant Cluster 2011: seizure consciousness loss brain arteriovenous malformation attack transient ischemic history Cluster 2012: hiv immunodeficiency virus human known infection positive patients testing infected Cluster 2013: hiv immunodeficiency positive virus human patients excluded retroviral receiving anti Cluster 2014: hiv antibodies immunodeficiency virus human known history testing required cohort Cluster 2015: hiv immunodeficiency virus human known infection history patients testing diagnosis Cluster 2016: hiv infection known history patients status testing subjects test htlv Cluster 2017: immunodeficiency test human virus hiv positive result screening history known Cluster 2018: immunodeficiency virus human infection known history subject immunosuppressive testing disease Cluster 2019: serology hiv positive immunodeficiency virus human known negative infection evidence Cluster 2020: cluster differentiation cd hiv count positive immunodeficiency virus cells human Cluster 2021: immunocompromised hiv patients positive immunodeficiency virus human known antiretroviral currently Cluster 2022: hiv authority mandated health testing local unless immunodeficiency virus required Cluster 2023: immunodeficiency hiv virus human positive known patients status serologically individuals Cluster 2024: contraceptive reproductive method potential effective agreed use women participate pregnant Cluster 2025: contraceptive measures reproductive bilateral effective pregnancy celibacy potential chooses heterosexually Cluster 2026: agreed reproductive sexually contraceptive effective duration method potential participation use Cluster 2027: menarchal girls agreed females tests method entered pregnancy participate males Cluster 2028: bowels stomach alter retain malabsorption absorption abnormalities swallow resection gastrointestinal Cluster 2029: significant abnormalities clinically gastrointestinal urinalysis absorption disorders results affect relevant Cluster 2030: malabsorption stomach bowel absorption resection small syndrome gastrointestinal major affect Cluster 2031: gi manifestations reason alter unknown malabsorption gastrointestinal absorption mln stomata Cluster 2032: medications able oral orally patients patient tube feeding willing retain Cluster 2033: retain swallow oral medication able ability subject medications patient orally Cluster 2034: study increase interpretation associated results participation interfere abnormality risk inappropriate Cluster 2035: increase risk medical toxicity opinion condition investigator patients potentially illness Cluster 2036: substantially increase judgment risk associated participation investigator condition illness major Cluster 2037: impair study opinion participation investigator medical uncontrolled disorder increase associated Cluster 2038: acidosis lactic metabolic history metformin associated risk meq alcoholic beverages Cluster 2039: females feeding breast pregnant feed lactating taking lenalidomide agree study Cluster 2040: lactating females pregnant donor feed exclusion intend excluded criteria agree Cluster 2041: feeding female breast pregnant patients lactating participants stop patient agree Cluster 2042: hgb dl transfusion hemoglobin days blood allowed prior rbc criteria Cluster 2043: gm hemoglobin dl hgb transfusion creatinine days si equal prior Cluster 2044: transfusions hemoglobin dl hgb allowed receive blood days permitted permissible Cluster 2045: transfusion meet inclusion blood allowed criteria mm count hb neutrophil Cluster 2046: hgb hemoglobin dl days anemia starting gr mg therapy treatment Cluster 2047: transfusion hemoglobin dl permitted days blood prior administration past preceding Cluster 2048: hodgkin lymphoma non nhl refractory relapsed cell classical confirmed histologically Cluster 2049: predominant lymphocyte nodular hodgkin lymphoma hl classical hodgkins rich diagnosis Cluster 2050: hospitalization requiring registration exacerbation precluding coagulation respiratory obstructive transmural months Cluster 2051: thallium restrictive comparable stress obstructive respiratory illnesses coagulation active pulmonary Cluster 2052: amyloidosis al primary known systemic non patients diagnosis myeloma complicated Cluster 2053: amyloid light amyloidosis chain al involvement systemic stain known primary Cluster 2054: spine mri lumbar vertebral patients brain osteoporosis prior hip surgery Cluster 2055: cns involvement nervous central puncture lumbar active known patients disease Cluster 2056: cerebrospinal fluid csf cns nervous central involvement cytology leptomeningeal lymphoma Cluster 2057: involvement nervous cns central known lymphoma patients intrathecal refractory aml Cluster 2058: evidence leukemic cns active involvement definitively meningeal cerebral disease nervous Cluster 2059: markedly acuity decreased visual macular degeneration glaucoma uncontrolled patients causes Cluster 2060: history disease known prior patients glaucoma heart oxalate urethral stricture Cluster 2061: clear rcc cell component histologically histology metastatic confirmed sarcomatoid advanced Cluster 2062: cell renal carcinoma clear rcc confirmed histologically component metastatic histological Cluster 2063: kinase inhibitor molecule small investigational treatment metabolites compound including receipt Cluster 2064: jak inhibitor janus kinase prior ruxolitinib therapy inhibitors treatment received Cluster 2065: inhibitor prior treatment hsp therapy received hdac kinase previous met Cluster 2066: cdk inhibitor prior treatment received therapy patient inhibitors patients previous Cluster 2067: valproic acid deacetylase hdac histone panobinostat prior patients treatment need Cluster 2068: cdk cyclin dependent kinase inhibitor prior treatment received therapy previously Cluster 2069: splenic irradiation splenectomy months prior current history mmb immunodeficiency drug Cluster 2070: splenectomy prior undergone history patients immunocompromised having allowed patient previous Cluster 2071: hysterectomy prior undergone removal cervix simple having report women radical Cluster 2072: individuals contact immunocompromised household avoid eczemoid eczema vaccination close nursing Cluster 2073: growth factor support transfusion days independent hemoglobin hematopoietic platelets dl Cluster 2074: involvement marrow lymphoma platelets bone unless documented mcl platelet mm Cluster 2075: platelet independent transfusion count transfusions mm ul receiving defined enrollment Cluster 2076: transfusion hemoglobin dl support allowed independent days factors growth prior Cluster 2077: platelets mcl initiation days performed treatment labs ul prior working Cluster 2078: microliter platelets wbc transfusion randomization independent factors growth granulocytes prior Cluster 2079: platelet transfusion count days mm support ul prior weeks internal Cluster 2080: equal platelets greater mcl ul mm ctcae plts grade independent Cluster 2081: transfusion platelets independent mm platelet days support mcl prior ul Cluster 2082: equal platelet greater count mm mcl transfusion ul support turnstile Cluster 2083: uncompensated severe respiratory diseases uncontrolled evidence systemic unstable cardiac hepatic Cluster 2084: diatheses uncontrolled bleeding active including severe diseases hepatitis systemic evidence Cluster 2085: distress respiratory syndrome thermometer patients severe nccn comprehensive network hypertension Cluster 2086: uncontrolled lung active severe conditions uncompensated parenchymal diatheses disease renal Cluster 2087: randomization major surgery weeks prior days kyphoplasty date radiotherapy elapsed Cluster 2088: randomization days prior radiotherapy surgery chemotherapy therapy participant radiation date Cluster 2089: severe disease uncontrolled systemic infection active concurrent morbidity current septicemia Cluster 2090: visceral disease crisis threatening metastases metastasis life rapid liver severe Cluster 2091: infection uncontrolled eligible patients subjects active stratum untreated study participation Cluster 2092: infection controlled antibiotics active eligible uncontrolled patients judged antimicrobial treatment Cluster 2093: threatening life infection uncontrolled active disease untreated patients antimicrobial severe Cluster 2094: spread threatening visceral term life short symptomatic complications risk advanced Cluster 2095: threatening life potentially autoimmune active disease second activated patients history Cluster 2096: transplantation solid organ received eligible prior patients history hsct tuberculosis Cluster 2097: allograft organ transplantation history prior allogeneic immunosuppression transplant transplanted marrow Cluster 2098: corneal allograft transplant organ history including transplantation keratitis disease ulceration Cluster 2099: transplantation allogeneic organ marrow bone prior solid patients allograft autologous Cluster 2100: cord umbilical blood transplant marrow double bone units transplantation donor Cluster 2101: entering radiotherapy prior study weeks chemotherapy patients therapy wait large Cluster 2102: nitrosoureas weeks mitomycin chemotherapy prior study radiotherapy therapy entering patients Cluster 2103: healed wound surgery fully major incision weeks surgical enrollment incompletely Cluster 2104: dental oral jaw extraction surgery healed tooth planned procedures invasive Cluster 2105: cellulose microcrystalline stearate colloidal silicon magnesium dioxide crospovidone mannitol excipients Cluster 2106: hamster chinese ovary recombinant products antibodies hypersensitivity human cell known Cluster 2107: hamster chinese ovary produced biopharmaceuticals formulation atezolizumab hypersensitivity component cells Cluster 2108: parenteral nutrition obstruction routine requirement tube signs symptoms gi hydration Cluster 2109: nutrition parenteral hydration tpn total dependency obstruction require gastrostomy tube Cluster 2110: hematologic malignancy malignancies non acceptable patients oncologic relapse transplant status Cluster 2111: malignancy active secondary relapse uncontrolled patients treatment treated transplant requires Cluster 2112: lymphoma pr cr initial nhl eligible mantle cell lymphoplasmacytic prolymphocytic Cluster 2113: cr subsequent leukemias biphenotypic undifferentiated lymphoma leukemia burkitts nd prolymphocytic Cluster 2114: undergoing patients treatment cancer therapy chemotherapy surgery radiation laparotomy currently Cluster 2115: lung cancer radiation prior therapy patients chemotherapy diagnosis screening surgery Cluster 2116: currently receiving treatment therapy patients chemotherapy patient radiation medications neoplastic Cluster 2117: emergency surgery room requiring leukapheresis radiation needs hyperleukocytosis undergoing procedure Cluster 2118: antineoplastic expected require form therapy localized systemic study patient protocol Cluster 2119: adverse events grade related prior immune recovered therapy treatment event Cluster 2120: irae grade event immune unresolved adverse related immunotherapy receiving previous Cluster 2121: components hypersensitivity known study analogs drugs drug patients niraparib patient Cluster 2122: hypersensitivity known drugs thalidomide study agents analogs allergy anaphylactic patients Cluster 2123: bmi index mass body patients scanner weight greater overweight bore Cluster 2124: bmi kg mass index body obese overweight greater equal weight Cluster 2125: outpatient transluminal attack cerebrovascular transient ischemic vascular accident disease stent Cluster 2126: attack accident cerebrovascular bypass transient coronary ischemic artery graft angina Cluster 2127: ischemic revascularization artery event procedures including fibrillation attack cerebrovascular transient Cluster 2128: hemoptysis teaspoon weeks dose red drug blood excess ml bleeding Cluster 2129: indicative months dose teaspoon hemoptysis hemorrhage signs red treatment pulmonary Cluster 2130: bright hemoptysis teaspoon red blood episode month history prior day Cluster 2131: nervous central metastatic options disease available therapeutic radiotherapy including fanca Cluster 2132: chemotherapy metastatic prior disease adjuvant regimen received advanced therapy systemic Cluster 2133: rcc advanced metastatic nephrectomy systemic prior therapy received treated radical Cluster 2134: regimens cytotoxic chemotherapy prior metastatic received disease recurrent advanced systemic Cluster 2135: lines therapy prior received systemic advanced disease chemotherapy treatment number Cluster 2136: lymphocyte count absolute ul mm registration days cells obtained study Cluster 2137: granulocyte count mm absolute ul agc peripheral starting days platelets Cluster 2138: plt platelet count ul mm registration obtained days prior peripheral Cluster 2139: neutrophils ul absolute days obtained cells registration mm randomization count Cluster 2140: alc lymphocyte absolute count ul mm cells blood cell product Cluster 2141: cbc blood count differential complete obtained registration function days prior Cluster 2142: ul lymphocyte count cycle day obtained days treatment study prior Cluster 2143: lymphocyte count mcl mm absolute days total equal enrollment blood Cluster 2144: proteinuria grade urinalysis ctcae greater hrs hematuria hours persistent gm Cluster 2145: urine proteinuria random sample protein ratio hrs measured persistent grade Cluster 2146: remain procedure able duration imaging hour minutes patient pet approximately Cluster 2147: endotracheal endobronchial tumor evidence anus invading rectum esophagus cabozantinib tract Cluster 2148: diffusion capacity monoxide carbon dlco predicted lung corrected pulmonary hemoglobin Cluster 2149: diffusing monoxide carbon dlco capacity predicted corrected lung hemoglobin lungs Cluster 2150: pulmonary carbon monoxide dlco oxygen capacity function diffusing saturation room Cluster 2151: psychological substance abuse interfere social conditions study evaluation results participation Cluster 2152: illicit user abuse regular recreational alcohol drugs substance recent including Cluster 2153: addiction alcohol drug illicit ongoing caregiver drugs active assessed known Cluster 2154: alcohol abuse drug known history active suspected illicit months investigator Cluster 2155: leukapheresis prior undergo donor weeks chemotherapeutic cladribine lymphotoxic contraindications agents Cluster 2156: bisphosphonate therapy bisphosphonates continue initiated receiving prior treatment patients allowed Cluster 2157: denosumab bisphosphonates treatment rankl activator started bone patients atezolizumab ligand Cluster 2158: stable corticosteroids dose decreasing days mri baseline prior patients steroids Cluster 2159: decreasing stable dose corticosteroids corticosteroid prior days receiving enrollment patients Cluster 2160: deficits neurologic stable week neurological minimum enrollment prior patients registration Cluster 2161: medication switched different qt discontinued interval treatment prolong torsades pointes Cluster 2162: torsades pointes medications risk known qt prolongation associated qtc causing Cluster 2163: strong inhibitors discontinued cypa inducers different switched treatment isoenzyme medication Cluster 2164: prolonging torsade relative switched inducing pointes qt different interval medications Cluster 2165: hcc systemic diagnosis fibrolamellar prior mixed advanced therapy patients cholangiocarcinoma Cluster 2166: hepatocellular carcinoma hcc cholangiocarcinoma diagnosis fibrolamellar liver confirmed mixed histologically Cluster 2167: histological confirmation diagnosis breast cancer carcinoma metastatic required tumor patients Cluster 2168: cytological histological diagnosis metastatic confirmation adenocarcinoma evidence cancer advanced prostate Cluster 2169: inflammatory breast cancer patients diagnosis subjects patient carcinoma td metastatic Cluster 2170: breastfeeding pregnant women childbearing potential months intend plan currently study Cluster 2171: females breastfeeding pregnant currently ineligible excluded childbearing current potential plan Cluster 2172: lactating women pregnant excluded study eligible childbearing intending potential cohort Cluster 2173: home internet access computer address connection aim valid phase nursing Cluster 2174: access internet computer phone email smartphone regular mobile web tablet Cluster 2175: telephone access number address reached working research engage nurse functioning Cluster 2176: nsclc histologically cytologically confirmed stage iv squamous iiib diagnosis non Cluster 2177: nsclc stage iv iiib metastatic advanced diagnosis squamous treatment prior Cluster 2178: hormonal therapy prior cancer treatment months patients weeks chemotherapy study Cluster 2179: targeted therapy chemotherapy prior treatment agents received immunotherapy including therapies Cluster 2180: therapy chemotherapy hormonal radiation cancer prior weeks treatment including immunotherapy Cluster 2181: therapy biologic immunotherapy concurrent chemotherapy hormonal cancer treatment radiation embolization Cluster 2182: immunotherapy chemotherapy prior weeks therapy radiation treatment received patients study Cluster 2183: antiarrhythmic class ia iii procainamide sotalol dofetilide amiodarone quinidine receiving Cluster 2184: antiarrhythmic unstable tachycardia pacemaker block class temporary indwelling cardiac qt Cluster 2185: detained involuntarily compulsorily prisoners incarcerated infectious illness psychiatric physical subjects Cluster 2186: compulsorily detained physical infectious illness psychiatric subjects treatment disease prisoners Cluster 2187: pancreatitis history acute year chronic recent study entry past patients Cluster 2188: pancreatitis chronic acute renal known liver disease history symptomatic patients Cluster 2189: end stage renal disease liver dialysis kidney hemodialysis meld chronic Cluster 2190: organ undue kidney involving dysfunction place disease undergo risk concurrent Cluster 2191: effective labeling practice mandated method agree uspi smpc time summary Cluster 2192: time practice effective agree methods childbearing contraception signing potential informed Cluster 2193: agree abstain intercourse heterosexual practice time contraception completely signing effective Cluster 2194: contraception adequate beginning signing associate definition icf designated judgment principal Cluster 2195: flat lie pet tolerate unable ct scan scanner sub fit Cluster 2196: lie inability minutes flat scanning imaging pet entire ability supine Cluster 2197: weight lbs scanner pounds table weighing limit fit gantry pet Cluster 2198: nodal disease regional patients clinical evidence eligible involvement distant stage Cluster 2199: distant metastases evidence metastatic disease patients documented regional presence clinical Cluster 2200: distant metastasis evidence lymph induction organs liver bone clavicles patients Cluster 2201: glioblastoma gliosarcoma histologically grade glioma confirmed iv multiforme world organization Cluster 2202: glioma grade high diagnosis recurrent low patients confirmed histologically iv Cluster 2203: gbm recurrent histologically glioblastoma recurrence confirmed proven diagnosis gliosarcoma treatment Cluster 2204: females years age male japan cancer presenting breast routine cervical Cluster 2205: leukoencephalopathy multifocal pml progressive history meningeal cerebral participants confirmed cunningham Cluster 2206: cerebral meningeal underlying disease related malignancy metastases known hemorrhage active Cluster 2207: blocks slides tissue notified unavailable sent chair enrollment study available Cluster 2208: withstand compromise organ major ability disease therapy patients chair discussed Cluster 2209: hormone releasing lhrh luteinizing agonist orchiectomy antagonist androgen gnrh therapy Cluster 2210: androgen anti therapy receptor bicalutamide ar prior flutamide nilutamide generation Cluster 2211: deprivation androgen therapy prior adt prostate months orchiectomy cancer patients Cluster 2212: requiring infection systemic active therapy intravenous treatment patient patients admission Cluster 2213: infection antibiotic requiring systemic days therapy study enrollment iv intravenous Cluster 2214: antifungal antiviral infection antibiotic requiring active antibiotics systemic therapy agents Cluster 2215: antibiotic requiring infection active therapy systemic infections intravenous treatment iv Cluster 2216: tsh thyroid stimulating hormone normal limits free wnl thyroxine euthyroid Cluster 2217: thyroid cancer replacement patients hypothyroidism medullary papillary anaplastic hormone disease Cluster 2218: wheelchair ambulatory paralysis walk score assessing age years lansky purpose Cluster 2219: ambulatory walking non assistive aid walk able ecog devices self Cluster 2220: spoken english written understand language patient fluency proficient inability unable Cluster 2221: fluency english verbal data collection completion adequate lack caregiver patient Cluster 2222: incidental tnm ta finding tb prostate cancer carcinoma histologic stage Cluster 2223: tuberculosis tb known history bacillus active mycobacterium patients infection appropriately Cluster 2224: tuberculosis active history known latent hepatitis infection years preceding patients Cluster 2225: bacillus tb tuberculosis active known history patient step infection registration Cluster 2226: tb tuberculosis active excluded patients quantiferon ta latent test stages Cluster 2227: enzyme inducing epileptic drugs eiaed antiepileptic phenobarbital phenytoin carbamazepine anti Cluster 2228: cns epileptic inducing involvement enzyme completion stable tumor receiving metastases Cluster 2229: mds myelodysplastic syndrome diagnosis hypomethylating agent aml related treatment therapy Cluster 2230: myelodysplastic myeloid leukemia acute syndrome mds aml suggestive features smear Cluster 2231: decitabine azacitidine hypomethylating treatment cycles prior agent therapy hma response Cluster 2232: unsuitable makes opinion condition subject participation investigator trial investigators make Cluster 2233: integrity data investigators jeopardize opinion patient medical obtained compromise conditions Cluster 2234: jeopardize compliance opinion condition protocol concurrent undesirable investigators investigator makes Cluster 2235: blast cml crisis myeloid leukemia chronic phase myelogenous accelerated tyrosine Cluster 2236: cml phase chronic accelerated leukemia myeloid cp blast ph blasts Cluster 2237: crisis myelogenous leukemia blast chronic intolerant failed phase bcr abl Cluster 2238: myelogenous leukemia chronic cml acute aml phase accelerated patients crisis Cluster 2239: past days investigational therapy use tobacco received receiving smoke herbal Cluster 2240: cigarettes smoke tobacco products day use past smoked nicotine cigars Cluster 2241: signs infection progressing attributable symptoms interpreted persisting infections hemodynamic sepsis Cluster 2242: cd anti antibody therapy prior treatment monoclonal previous directed received Cluster 2243: globulin atg thymocyte anti antithymocyte campath alemtuzumab received days cell Cluster 2244: cetuximab panitumumab treatment prior egfr antibody infusion therapy hypersensitivity monoclonal Cluster 2245: daratumumab cd anti therapies received previously prior cluster sy differentiation Cluster 2246: woman childbearing pregnancy potential test negative wcbp serum hysterectomy prior Cluster 2247: pregnancy childbearing negative test registration potential women days prior serum Cluster 2248: pregnancy wocbp minimized women manner using potential avoid products childbearing Cluster 2249: women pregnancy test childbearing negative potential serum days prior study Cluster 2250: study pregnancy potential test negative childbearing contraception agree women use Cluster 2251: hours pregnancy test negative potential childbearing serum women urine study Cluster 2252: pregnancy potential women childbearing study importance wocbp advised avoiding test Cluster 2253: menopausal post pre pregnancy women test negative peri serum status Cluster 2254: urine pregnancy childbearing test negative potential women serum days prior Cluster 2255: urine test pregnancy negative serum hours medication female childbearing required Cluster 2256: pregnancy test miu negative sensitivity performed hours lenalidomide ip prior Cluster 2257: females pregnancy test negative childbearing potential serum urine days prior Cluster 2258: brain metastases known patients history active subjects presence patient treated Cluster 2259: leptomeningeal disease manifestation history presence evidence patients diffuse spread untreated Cluster 2260: meningitis carcinomatous subjects known history brain presence leptomeningeal patients metastases Cluster 2261: suspected metastasis leptomeningeal brain known active disease subject needing carcinomatosis Cluster 2262: leptomeningeal metastasis brain disease history known symptomatic presence active patients Cluster 2263: leptomeningeal metastases brain active cns evidence history known disease patients Cluster 2264: bisphosphonate denosumab therapy receiving treatment weeks hypercalcemia stable lack prior Cluster 2265: hypercalcemia uncontrolled symptomatic history bisphosphonate continued returns calcium patient requiring Cluster 2266: bisphosphonate hypercalcemia osteoporosis therapy symptomatic reasons metastasis allowed use bone Cluster 2267: survival anticipated months patient incompatible illness medical organ major failure Cluster 2268: survival estimated months probability gpa median month patients year weeks Cluster 2269: abiraterone enzalutamide acetate prior treatment ketoconazole tak ar therapy received Cluster 2270: ugta polymorphism homozygous udp diclofenac imipramine glucuronosyltransferase inhibitor ketoconazole mefenamic Cluster 2271: replacement systemic thyroxine pituitary insulin modifying physiologic adrenal insufficiency therapy Cluster 2272: adrenal insufficiency uncontrolled history chronic replacement disease therapy liver maintenance Cluster 2273: dysfunction adrenal pituitary history documented malignancy known viral liver symptomatic Cluster 2274: complying capable understanding protocol signed document informed consent requirements subject Cluster 2275: provide ability informed consent willingness english follow patient adhere assessments Cluster 2276: comply ability willingness protocol study requirements procedures follow consent informed Cluster 2277: length entire comply designee procedures understand study enrolling ability determined Cluster 2278: mental compromise comply impairment ability requirements informed consent study deficits Cluster 2279: voluntary written consent informed donor research related aspects procedures comply Cluster 2280: immunosuppressant cyclosporine tacrolimus systemic days concurrent prednisone drug dose chronic Cluster 2281: avoid pregnancy fathering precautions appropriate children screening child agree certainty Cluster 2282: fetal precautions counseled risks pregnancy exposure agree minimum contact days Cluster 2283: donor cross match cytotoxic pra hla positive cytometric allele matches Cluster 2284: hla positive allele patients expression phenotype express subject central restriction Cluster 2285: follow willing study available required procedures patients completion permit circumstances Cluster 2286: evaluations unable unwilling participate procedures required study judgment ibrutinib follow Cluster 2287: indicating purpose procedures understands study participate willing required consent informed Cluster 2288: bilateral breast orchiectomy synchronous cancer patients mastectomy unilateral cancers eligible Cluster 2289: ipsilateral breast radiation prior history cancer dcis previous therapy wall Cluster 2290: contralateral breast invasive cancer ipsilateral dcis synchronous previous history patients Cluster 2291: immunodeficiency combined form primary severe disease acquired aids deficiency syndrome Cluster 2292: deficiency immune acquired aids hiv syndrome immunodeficiency virus human known Cluster 2293: aids hiv known illness related positive including infection history positivity Cluster 2294: immunodeficiency acquired aids syndrome virus hiv human related illness known Cluster 2295: advanced locally metastatic cancer breast unresectable incurable recurrent patients therapy Cluster 2296: pancreas adenocarcinoma histologically cytologically confirmed metastatic proven resectable patients ductal Cluster 2297: intolerable ineffective standard proven advanced exist locally therapy metastatic solid Cluster 2298: locally advanced metastatic disease unresectable resectable therapy patients prior treatment Cluster 2299: cytologically advanced histologically locally metastatic confirmed unresectable adenocarcinoma documented nsclc Cluster 2300: advanced histologically locally metastatic confirmed unresectable solid proven adenocarcinoma patients Cluster 2301: unresectable metastatic disease melanoma patients inoperable confirmed histologically tumor advanced Cluster 2302: axitinib prior bosutinib studied treatment population thrombotic hypersensitivity parts ended Cluster 2303: inhibitors reductase prior alpha monoamine oxidase treatment use therapy finasteride Cluster 2304: xanthine rasburicase oxidase allergy inhibitors known contraindication allopurinol tls lysis Cluster 2305: adverse ae sodium potassium calcium values event terminology common version Cluster 2306: unresolved toxicities grade criteria ctcae alopecia terminology common exception adverse Cluster 2307: adverse events recovery supportive toxicities ctcae terminology common nonsignificant version Cluster 2308: common terminology ctcae adverse events grade criteria version diarrhea toxicity Cluster 2309: toxicities terminology common ctcae alopecia adverse grade events criteria version Cluster 2310: unresolved toxicity common terminology ctcae adverse events alopecia grade cancer Cluster 2311: adverse events ctcae terminology common grade criteria recovered prior alopecia Cluster 2312: dehydration grade nci ctcae exacerbated ctc version conditions common opinion Cluster 2313: impairment aged patient years known jeopardize mild hepatic renal moderate Cluster 2314: renal insufficiency failure disease impairment kidney patients creatinine severe history Cluster 2315: severe hepatic impairment moderate disease cirrhosis cardiovascular renal existing pre Cluster 2316: hearing loss grade impairment sensorineural existing significant cisplatin patients clinically Cluster 2317: existing pre interstitial lung disease known cardiovascular carotid ild liver Cluster 2318: arm patients study nivolumab prior exclusion randomized registration days treatment Cluster 2319: idelalisib prior treatment arm exposure pik mfolfox zydelig resistance exclusion Cluster 2320: hepatitis hbv virus positive hcv pcr antibody polymerase chain surface Cluster 2321: hepatitis pcr positive antibody polymerase chain antigen reaction surface core Cluster 2322: hepatitis polymerase chain reaction pcr positive active infection antiviral antigen Cluster 2323: methylation mgmt polymerase chain reaction pcr routinely status quantitative available Cluster 2324: unable consent informed cognitively patients written subjects subject study impaired Cluster 2325: provide unable consent informed unwilling patients written patient subjects adults Cluster 2326: unwilling unable study participate discontinue undergo use patients contraception prohibited Cluster 2327: inappropriate make medical condition psychiatric study patient investigator judgment participation Cluster 2328: inappropriate make judgment concurrent severe investigator patient morbidity disease infection Cluster 2329: behavior suicidal study ideation inappropriate interpretation recent make increase judgment Cluster 2330: bowel small condition modify study enzymes pancreas inappropriate interpretation make Cluster 2331: cirrhosis hepatitis chronic liver active disease persistent steatohepatitis alcoholic evidence Cluster 2332: hc hepatitis positive hcab serology immunoblot riba reflexively test assay Cluster 2333: serology hepatitis positive cirrhosis fibrosis liver chronic stage infection active Cluster 2334: histologically confirmed diagnosis cytologically cancer melanoma prostate breast disease hcc Cluster 2335: adenocarcinoma cytologically histologically confirmed prostate rectum colon diagnosis breast metastatic Cluster 2336: adenocarcinoma histologic prostate diagnosis confirmation cytologic rectum colon patients evidence Cluster 2337: rectal cancer colon digital prior adenocarcinoma surgery stage diagnosis stenosis Cluster 2338: new counter considering counseled medications interactions medicine prescribed patient herbal Cluster 2339: herbal palmetto saw supplements medications psa products decrease use alternative Cluster 2340: work carry light activities office able house activity walk physically Cluster 2341: blood products transfusion willing transfusions receive draw days donate patients Cluster 2342: accept willing leukapheresis able procedures transfusions product blood biopsies randomization Cluster 2343: triple negative breast cancer cohort tnbc metastatic confirmed histologically advanced Cluster 2344: carcinoma histologically breast confirmed invasive cytologically primary metastatic operable non Cluster 2345: histologically breast confirmed invasive cancer cytologically primary diagnosis metastatic subtypes Cluster 2346: pelvic radiotherapy prior previous patients surgery chemotherapy history received rt Cluster 2347: pelvic radiation prior therapy previous history considered marrow bone patients Cluster 2348: pelvic abdominal irradiation previous radiation brachytherapy prostate prior received vaginal Cluster 2349: recurrent disease metastatic patients progressive cancer refractory treatment received persistent Cluster 2350: stratum dipg patients criteria inclusion progressed progressive recurrent non eligible Cluster 2351: receive cytotoxic regimen persistent management allowed recurrent required additional disease Cluster 2352: regimens chemotherapy prior number received disease patients metastatic treatment progressive Cluster 2353: plan visits scheduled comply able laboratory tests willing treatment procedures Cluster 2354: visits ability scheduled understand document tests willingness plans comply informed Cluster 2355: visits comply scheduled willing able procedures tests laboratory study schedule Cluster 2356: visits scheduled tests comply willingness procedures plans ability laboratory study Cluster 2357: drugs supportive contraindication hydration treatments concomitant preexisting intolerance impairment required Cluster 2358: gastrointestinal vomiting diarrhea nausea malabsorption ulcerative impairment disease absorption alter Cluster 2359: gi diarrhea vomiting nausea alter significantly malabsorption ulcerative absorption bowel Cluster 2360: gi alter significantly impairment absorption function gastrointestinal disease panobinostat everolimus Cluster 2361: mgmt promoter unmethylated methylated tumor status gbm testing cohort methylation Cluster 2362: dependent transfusion thrombocytopenia oxygen anemia patient presence patients pacemaker maintained Cluster 2363: progressive massive thrombocytopenia lymphadenopathy evidence anemia splenomegaly lymphocytosis doubling symptomatic Cluster 2364: epidermal growth factor receptor egfr human positive prior therapy cancer Cluster 2365: alk kinase anaplastic egfr receptor epidermal lymphoma growth factor mutations Cluster 2366: flow angiographic maa duodenum technetium macroaggregated tc stop application detectable Cluster 2367: evaluable measurable disease patients subjects parts radiologically participants phase presence Cluster 2368: measurable disease defined following patients imaging non evaluable radiologically irrecist Cluster 2369: evaluable disease patients imaging metastatic response phase presence lesion evidence Cluster 2370: pancreatic previous cancer therapy chemotherapy radiation abdominal adenocarcinoma resection surgical Cluster 2371: pancreatic cancer prior chemotherapy treatment radiation metastatic therapy patients radiotherapy Cluster 2372: contraindication mri known medical ampicillin sulfamethoxazole prophylaxis hypersensitivity trimethoprim concomitant Cluster 2373: pacemaker defibrillator implantable cardiac mri cardioverter clip contraindication presence aneurysm Cluster 2374: steroids deficiencies stress necessary endocrine physiologic doses receive allowed patients Cluster 2375: contrast mri gadolinium allergy contraindication enhanced iodinated ct intravenous agents Cluster 2376: iodine contrast allergy radioactive intravenous history hypersensitivity materials iodide diet Cluster 2377: fluorescein allergy reaction known shellfish skin iodine test prior sodium Cluster 2378: submission specimen tumor available tissue review patients specimens offered samples Cluster 2379: tissue tumor needle specimens core biopsy samples paraffin acceptable slides Cluster 2380: intention trials treat observational acceptable imaging agents investigational disease therapy Cluster 2381: csf gm filgrastim cytology sargramostim prior weeks erythropoietin lumbar patients Cluster 2382: colony stimulating factor anc neutrophil count absolute granulocyte support csf Cluster 2383: colony stimulating granulocyte csf factor macrophage gm factors erythropoietin growth Cluster 2384: hepatitis hbsag positive surface antigen test antibody virus hcv hbcab Cluster 2385: hepatitis antibody antigen test hcv positive negative hbsag infection hbc Cluster 2386: brain metastases stable treated asymptomatic patients weeks treatment eligible steroids Cluster 2387: meningeal brain tumors metastatic symptomatic asymptomatic leptomeningeal allowed definitive treated Cluster 2388: metastasis brain known parenchymal patients bony subjects history active treated Cluster 2389: metastasis brain patients radiation treated steroids untreated active asymptomatic stable Cluster 2390: herpetic keratitis encephalitis complications lesions skin active infection hsv intermittent Cluster 2391: benefit clinical confer therapies intolerant provide known available treatment refractory Cluster 2392: medications systemic mineralocorticoids immunosuppressant fludrocortisone azathioprine dose tnf orthostatic anti Cluster 2393: azathioprine necrosis methotrexate thalidomide immunosuppressive medications tnf systemic anti cyclophosphamide Cluster 2394: therapeutic trial clinical participation concurrent current treatment simultaneous trials enrollment Cluster 2395: enrolled currently patients clinical trial study investigational trials protocol therapeutic Cluster 2396: trial clinical treatment participating trials participation participated patients investigational participate Cluster 2397: interventional study clinical observational enrollment concurrent follow studies participation unless Cluster 2398: expecting conceive trial projected screening children father visit breastfeeding duration Cluster 2399: vasectomized partner male sole azoospermia sterilization months confirmed female screening Cluster 2400: sexual end partner male wocbp contraception adequate willing use weeks Cluster 2401: autoimmune vitiligo childhood resolved disease asthma atopy history atopic dermatitis Cluster 2402: suspected autoimmune known active disease subjects participants patients exclusionary excluded Cluster 2403: autoimmune subjects excluded syndrome atopy childhood systemic bronchodilators intermittent injections Cluster 2404: malignancy currently second cancers melanoma active non skin considered completed Cluster 2405: malignancy considered currently active relapse completed second melanoma skin risk Cluster 2406: steroidal inflammatory anti non aspirin drugs nsaids use agents nsaid Cluster 2407: nonsteroidal nsaids aspirin inflammatory anti drugs agents use day nsaid Cluster 2408: airway enlargement obstruction location cause tumor lymphodepletion procurement exclusion fixed Cluster 2409: hepatitis hepatology patient consultation profile discussed benefit eligibility require determined Cluster 2410: cooperation substance abuse disorders interfere requirements psychiatric trial known study Cluster 2411: abuse substance alcohol history psychiatric active disorders mental disorder alcoholism Cluster 2412: schizophrenia disorder bipolar major depression psychiatric depressive ideation mental psychosis Cluster 2413: alcoholism addiction confuse hinder illness psychiatric follow evaluation drug active Cluster 2414: malabsorption condition absorption problem syndrome interfere intestinal syndromes history clinically Cluster 2415: enteral malabsorption route condition syndrome precludes administration absorption interfere history Cluster 2416: cyclodextrin captisol solubilize derivative carfilzomib allergy used known history bendamustine Cluster 2417: fludarabine cyclophosphamide hypersensitivity immediate reaction severe history phosphate aldesleukin clofarabine Cluster 2418: hypersensitivity used immediate agents reaction severe study history known previously Cluster 2419: detection interstitial management suspected pulmonary toxicity lung interfere related symptomatic Cluster 2420: progression disease evidence therapy documented prior treatment patients months study Cluster 2421: treated adequately disease evidence felt malignancy recurrence intent lentigo low Cluster 2422: recurrence local therapy disease progression evidence patients cancer radiation treatment Cluster 2423: suitable intent curative administered local therapy disease urothelial cancer carcinoma Cluster 2424: individuals malignancy years eligible following circumstances history recurrence different cell Cluster 2425: identity ensure entered process order approval open board date network Cluster 2426: regulatory received indication approval drug nonmyelosuppressive days myelosuppressive treatment respectively Cluster 2427: bearing child women potential pregnant breastfeeding reliable means using contraception Cluster 2428: mothers nursing pregnant women excluded breastfeeding bearing study child eligible Cluster 2429: nursing lactating pregnant women pdr plan discontinued breastfeeding bearing child Cluster 2430: staff conduct planning astrazeneca applies study involvement site present previous Cluster 2431: directly staff member spouse immediate involved sponsor family site prospective Cluster 2432: coumarin derivative anticoagulation therapeutic warfarin coumadin anticoagulants derivatives mg po Cluster 2433: coumadin warfarin anticoagulants derivative anticoagulant doses sodium therapeutic patients taking Cluster 2434: cancer cervix situ melanoma carcinoma skin non years malignancy remission Cluster 2435: resected completely malignancy successfully history free skin years carcinoma melanoma Cluster 2436: melanomatous invasive malignancy free skin non cancer years unless minimum Cluster 2437: free malignancy situ skin carcinoma cervix years melanoma cancer non Cluster 2438: malignancy melanotic cancer cervix situ exceptions skin carcinoma non specific Cluster 2439: permissible cavity melanomatous invasive free cervix minimum situ oral malignancy Cluster 2440: carcinoma appropriately melanoma treated malignancy skin uterine situ non cervix Cluster 2441: anesthesia general surgery requiring require scanning monitored major patients sedation Cluster 2442: incision larger involves percutaneous anesthesia general tube access placement venous Cluster 2443: aim phase sub ii prisoners protocol type outpatient cancer evaluation Cluster 2444: volunteers healthy cohorts normal enhancement sub patient contrast group adult Cluster 2445: oncology eastern group performance cooperative status ecog days registration prior Cluster 2446: eastern cooperative oncology group ecog performance status patients subject clinical Cluster 2447: score karnofsky performance eastern cooperative oncology group ecog status lansky Cluster 2448: ps eastern cooperative ecog oncology group performance status scale score Cluster 2449: karnofsky eastern cooperative performance oncology ecog group status kps lansky Cluster 2450: score eastern cooperative group oncology performance ecog status subjects patients Cluster 2451: expectancy life eastern cooperative ecog group oncology performance status months Cluster 2452: score eastern cooperative oncology group ecog performance equal ps subject Cluster 2453: eastern cooperative oncology group ecog scale participants enrollment current eligible Cluster 2454: performance scale eastern cooperative ecog oncology group status karnofsky ps Cluster 2455: swog southwest oncology group performance status southwestern karnofsky zubrod eastern Cluster 2456: zubrod eastern oncology cooperative ecog group status performance level karnofsky Cluster 2457: age years lansky corresponding scores ecog patients eastern cooperative oncology Cluster 2458: eastern cooperative oncology ecog group performance status patient randomization grade Cluster 2459: protein dipstick urine urinary urinalysis routine hour hours mg collection Cluster 2460: urine proteinuria hour protein collection dipstick urinalysis undergo quantitative hours Cluster 2461: proteinuria dipstick urine protein urinalysis hours hour discovered demonstrate collection Cluster 2462: hematological function adequate acceptable values biological malignancies defined confirmed status Cluster 2463: values range laboratory defined having patient function protocol outside hepatic Cluster 2464: coagulation anti adequate profile acceptable function disorder defects status parameters Cluster 2465: context ancillary investigation utilized fda indication research food approved immunotherapy Cluster 2466: spermicide contraception methods condom method male barrier plus diaphragm intrauterine Cluster 2467: spermicide diaphragm condom uterine device abstinence birth acceptable control hormonal Cluster 2468: esophageal varices gastric bleeding history cancer variceal months prior patients Cluster 2469: liver portal hypertension varices biliary hepatic esophageal fulminant encephalopathy hepatitis Cluster 2470: sarcoma soft tissue ewing rhabdomyosarcoma diagnosis tumor synovial kaposi gist Cluster 2471: seizures history past prior controlled epileptic encephalitis patients movement disorders Cluster 2472: disorders autoimmune inflammatory active documented immunosuppressive prior history requiring therapy Cluster 2473: autoimmune disease systemic requires steroids immunosuppressive syndrome agents documented history Cluster 2474: american asco society college pathologists cap guidelines receptor clinical er Cluster 2475: asa anesthesiologists society american score status class anesthesiology physical iv Cluster 2476: mcl platelets cells cohort weeks phase randomization discretion transfusions plts Cluster 2477: anc ul cells mcl ml cohort cumm liter granulocytes platelets Cluster 2478: mm anc granulocytes lymphocytes platelets count cells dl adequate hemoglobin Cluster 2479: prolong interval qt qtc known medications drugs concomitant use taking Cluster 2480: state curative current therapy quality prolong survival known proven disease Cluster 2481: graft hematopoietic stem study participation entry agents received cell patient Cluster 2482: deems unsuitable candidate investigators opinion condition receive drug participant study Cluster 2483: female reproductive employing birth control feeding effective pregnant breast potential Cluster 2484: excipient durvalumab hypersensitivity history tremelimumab medi known sgi substance component Cluster 2485: durvalumab tremelimumab dose female days monotherapy reproductive effective birth employ Cluster 2486: xrt radiation elapsed craniospinal irradiation substantial weeks local palliative pelvis Cluster 2487: irradiation prior pelvic brain body total tbi cranial craniospinal weeks Cluster 2488: bowel inflammatory disease history active gastrointestinal diarrhea patients chronic ongoing Cluster 2489: bowel disease celiac colitis diarrhea gastrointestinal inflammatory irritable chronic associated Cluster 2490: diarrhea grade chronic ctcae gastrointestinal persistent patients malabsorption etiology symptom Cluster 2491: fibrosis colitis pneumonitis inflammatory bowel pulmonary disease known history chronic Cluster 2492: protein urine mg hour reactive hr urinalysis monoclonal mgps albumin Cluster 2493: protein serum dl electrophoresis monoclonal urine spep mg measurable immunofixation Cluster 2494: protein hours urine mg level serum dl myeloma mm multiple Cluster 2495: acute exercise uncontrolled pulmonary cardiopulmonary failure dissecting myocarditis hemodynamic aggravated Cluster 2496: donor selection identical nmdp pregnant eligibility cell recipient haploidentical chimerism Cluster 2497: hla donor antibodies anti antibody specific mfi recipient positive presence Cluster 2498: hla donor drb allele loci identical haplotype related haploidentical recipient Cluster 2499: donor hla haploidentical locus typing class recipient match serologic related