Cluster 1587: unresolved toxicity grade previous alopecia therapy ctcae anticancer anti prior Cluster 1908: toxicities anticancer therapy previous unresolved recovered ctcae grade alopecia exception Cluster 2084: grade enter anticancer toxicities alopecia ctcae therapies recovered related version Cluster 2113: toxicity exacerbated reasonably irreversible expected unresolved hearing included ctcae grade Cluster 2216: aes events adverse alopecia grade recovered baseline prior anticancer resolved