Cluster 547: chimeric humanized fusion anaphylactic proteins antibodies reactions allergic hypersensitivity severe Cluster 1231: antibodies monoclonal hypersensitivity reactions severe history mabs allergy humanized reaction Cluster 1434: anaphylactic allergic reactions severe monoclonal antibody history reaction humanized murine Cluster 1539: hypersensitivity severe asthma monoclonal reactions antibodies nci anaphylaxis ctcae known Cluster 2452: allergens allergic unknown severe reactions components history drugs vaccines anaphylaxis Cluster 2482: dtpa gadolinium known gd acid reaction allergic dimeglumine anaphylactic acetic