Cluster 377: toxicity grade alopecia therapy prior severity anti progressing ongoing cancer Cluster 520: resolved toxicities grade prior alopecia therapy related treatment neuropathy previous Cluster 791: toxicity recovered prior therapy grade patients previous acute treatment days Cluster 1216: resolved grade toxicity prior related therapy acute alopecia previous treatment Cluster 1244: toxicities grade related alopecia prior recovery resolution therapy treatment significant Cluster 2343: toxicity related grade returned prior therapy baseline irreversible deemed persisting