Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal (using Cockcroft Gault formula) Acceptable renal function: o Serum creatinine within normal limits, OR calculated creatinine clearance 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal. Creatinine =< 1.5 x above institutional normal or >= 60 ml/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 50 mL/min for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance > 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (using Cockcroft-Gault formula) Creatinine within institutional normal limits (WNL) OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance ? 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Obtained within 21 days prior to study registration: creatinine within normal institutional limits OR creatinine clearance ? 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Serum creatinine within normal institutional limits or creatinine clearance >= 40 ml/min Creatinine =< upper limit of normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits, OR creatinine clearance >= 60 mL/min, based either on Cockcroft-Gault estimate or based on urine collection (12 or 24 hour), for participants with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normal Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance ? 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 times normal institutional limits OR creatinine clearance >= 40 ml/min for patients Creatinine =<1.5 x normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above 1.5 x institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine up to 1.5 upper institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal 14 days or fewer from registration Creatinine within normal institutional limits or creatinine clearance (estimated glomerular filtration rate [eGFR]) >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine levels within normal institutional limits; or, creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal; unless decreased due to renal involvement by lymphoma Serum creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine within normal institutional limits or creatinine clearance > 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine =< 2 x normal institutional limits OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal as defined by the Cockcroft-Gault equation Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits; OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Serum creatinine within normal institutional limits OR measured creatinine clearance >= 50 mL/min/for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine 1.5 x the normal institutional limits OR creatinine clearance >= 40 mL/min/1.73 m^2 Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/ per Cockroft-Gault equation\r\nfor patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine not greater than upper institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance >= 45 mL/min/1.73 m^2 as estimated by either Cockcroft-Gault or 24-hour urine collection for patients with creatinine levels above institutional normal Creatinine =< 1.5 x institutional upper limits of normal OR creatinine clearance of >= 50 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal by 24-hour urine Creatinine within normal institutional limits OR creatinine clearance > 50 mL/min for patients with creatinine levels above institutional normal PHASE I STUDY ELIGIBILITY CRITERIA:\r\nCreatinine =< 1.5 X within normal institutional limits OR measured creatinine clearance >= 50 mL/min/1.73 m^2 Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal, determined within 14 days of registration Creatinine within normal institutional limits OR creatinine clearance > 45 mL/min for patients with creatinine levels above institutional normal Creatinine within normal institutional limits (< 1.5) OR creatinine clearance >= 50 mL/min/1.73m^2 (for creatinine level above normal) Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine < 1.5x institutional upper limits of normal (ULN) or creatinine clearance ? 60 mL/(min 1.73 m^2) for patients with elevated creatinine levels (? 21d of study day 1) Creatinine clearance > 50 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal limits EXCLUSION CRITERIA FOR TREATMENT: Creatinine clearance > 50 ml/min/1.73m^2 for patients with creatinine levels above institutional normal limits Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR calculated creatinine clearance >= 60 mL/min/1.73 m^2 (Cockroft-Gault formula) for patients with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR calculated creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine within normal institutional limits or creatinine clearance must be at least 60 ml/min Creatinine < 1.5 x normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine level above institutional normal based either on Cockroft-Gault estimate or based on urine collection (12 or 24 hour) Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine within normal institutional limits or a creatinine clearance >= 60 mL/min for patients with creatinine levels above institutional normal Serum creatinine within normal institutional limits or a creatinine clearance >= 60 ml/min within 2 weeks prior to registration Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits for age OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above ULN Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional limits Creatinine within normal limits (creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal) Obtained within 30 days of registration: Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits, OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine within normal institutional limits, or creatinine clearance (calculated by Cockcroft-Gault) >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine within normal institutional limits for age OR creatinine clearance >= 70 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within institutional limits of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal obtained =<14 days prior to randomization Serum creatinine within normal institutional limits or creatinine clearance at least 60 ml/min within 30 days prior to registration Serum creatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 40 mL/min for patients with creatinine levels above institutional normal Creatinine within 1.5 X normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal by Cockcroft-Gault equation Patients must have normal organ and marrow function as defined below: leukocytes ?3,000/mcL, absolute neutrophil count ?1,500/mcL, platelets ?100,000/mcL, total bilirubin within normal institutional limits, aspartate aminotransferase AST(SGOT)/ alanine aminotransferase ALT(SGPT) ?2.5 X institutional upper limit of normal, creatinine within normal institutional limits OR creatinine clearance ?60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal. REGISTRATION INCLUSION CRITERIA: Creatinine =< 1.5 institutional upper limits of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 x institutional upper limits of normal OR creatinine clearance of >= 50 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal by 24 hour urine Creatinine within normal institutional limits OR creatinine clearance >= 50mL/min for patients with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 x normal institutional limits or creatinine clearance > 50mL/min Creatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with serum creatinine < 2 mg/mL Creatinine below or within the upper institutional limits of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 X normal institutional limits or creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above normal institutional limit (a calculated one may be used) Creatinine OR creatinine clearance within normal institutional limits OR > 60 Ml/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (as calculated by Cockcroft-Gault) Creatinine within normal institutional limits or creatinine clearance >= 60mL/min/1.73 m^2 for subject with creatinine levels above institutional normal Creatinine within normal institutional limits OR calculated creatinine clearance >= 60 mL/min/1.73 m^2 for patients with levels above institutional normal using modified Cockcroft-Gault Creatinine:\r\n* Creatinine levels within normal institutional limits (< 1.5 x ULN); or,\r\n* Creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 x institutional upper limits of normal OR creatinine clearance > 50 mL/min/1.73 m^2 for patients with creatinine levels above 1.5 x institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min for patients with creatinine levels above institutional normal, as determined by a measured 24-hour creatinine clearance Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (unless due to lymphoma) Creatinine within normal institutional limits OR creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min for patients with creatinine levels above institutional normal Creatinine =< 1.5 x upper normal limits OR creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal, as calculated by the Cockcroft Gault formula Creatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within institutional limits of normal or creatinine clearance >= 60 ml/min/m^2 if elevated creatinine Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance or calculated >= 60 mL/min/1.73 m^2 for patients with creatinine clearance or estimated creatinine levels above institutional glomerular filtration rate (eGFR) normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine less than upper limit of normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine within normal institutional limits or less than the lower limit of normal institutional limits; or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 if serum creatinine > institutional normal Creatinine within normal institutional limits OR creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 55 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 30 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal; (calculated via Cockcroft-Gault equation) SURGICAL ARM: creatinine within normal institutional limits or creatinine clearance > 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normal limit Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine within normal institutional limits or\r\n* Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Subject must have adequate renal function with creatinine within normal institutional limits or creatinine clearance > 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance ? 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (calculated via Cockcroft-Gault equation) Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= 30 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (calculated via Cockcroft-Gault equation) Creatinine within normal institutional limits or creatinine clearance > 60 mL/min/1.73 m2 for subjects with creatinine levels above institutional normal. Creatinine within normal institutional limits or creatinine clearance > 60 mL/min/1.73 m2 for subjects with creatinine levels above institutional normal.