Patients with uncontrolled coagulopathy or bleeding disorder are not eligible Participants with active bleeding disorder/coagulopathy Participant must not have a history of a coagulopathy or a platelet disorder. History of coagulopathy Bleeding disorder/coagulopathy Uncontrolled coagulopathy Has a clinically significant coagulopathy per investigator’s assessment Uncontrolled coagulopathy or bleeding disorder Patients with uncontrolled coagulopathy or bleeding disorder Subject has first degree family member with a known hereditary coagulopathy. Has evidence or a coagulopathy or hemostasis problem. Uncontrolled coagulopathy Active coagulopathy Patients with uncontrolled coagulopathy or bleeding disorder uncorrectable coagulopathy Active coagulopathy Patients with coagulopathy with an elevated INR ?1.5, or platelets <50 Current Grade 3 or higher coagulopathy, thrombosis and/or hemostasis disorders, History of clinically significant coagulopathy Patients with uncontrolled coagulopathy or bleeding disorder Coagulopathy tests will be obtained within 2 weeks of enrollment History of abnormal bleeding and coagulopathy Use of full dose, therapeutic anti-coagulation or patients with uncontrolled coagulopathy or bleeding disorder Uncontrolled coagulopathy Has a clinically significant coagulopathy per investigator’s assessment Patient has a coagulopathy or bleeding disorder Known coagulopathy or bleeding disorders are controlled Known bleeding disorder or coagulopathy Coagulopathy characterized by an INR >1.40 without other known causes. Coagulopathy which contraindicates transperineal and intraprostatic needle insertion Known, existing uncontrolled coagulopathy Known, existing coagulopathy or receiving anticoagulants Patient has a coagulopathy or bleeding disorder which is uncontrolled. Patients with uncontrolled coagulopathy or bleeding disorder Known, existing uncontrolled coagulopathy History of coagulopathy or known thrombophilias Known, existing uncontrolled coagulopathy Known, existing uncontrolled coagulopathy No history of clinical coagulopathy No known coagulopathy Nonreversible or uncorrectable coagulopathy. INR should not be >1.5, Patients with uncontrolled coagulopathy or bleeding disorders Hereditary or chronic hemorrhagic or coagulopathy conditions (i.e., hemophilia) Known bleeding disorder or coagulopathy Clinically significant coagulopathy or bleeding disorder. Uncorrected coagulopathy Subjects with uncorrected coagulopathy Uncorrectable coagulopathy Coagulopathy Patient has an uncorrectable coagulopathy Uncontrollable coagulopathy Coagulopathy Uncontrolled coagulopathy or bleeding disorders History of coagulopathy or bleeding disorders Coagulopathy Known inherited bleeding disorder or coagulopathy Severe coagulopathy or bleeding disorder Uncorrectable coagulopathy Uncorrectable coagulopathy Known coagulopathy Uncorrectable coagulopathy prohibiting biopsy. (INR > 1.5 and/ or platelets < 50,000) Coagulopathy Evidence of a coagulopathy