Further exclusion criteria apply Other Exclusion Criteria May Apply. Further exclusion criteria apply COHORT A: All other inclusion and exclusion criteria apply Other exclusion criteria may apply Other exclusion criteria may apply Other exclusion criteria may apply Further Exclusion criteria apply Further exclusion criteria apply. Further exclusion criteria apply Further exclusion criteria apply Other exclusion criteria may apply Active or chronic hepatitis C and/or B infection Additional exclusion criteria apply Other Exclusion Criteria May Apply Criteria 7, Other Exclusion Criteria May Apply Other Exclusion Criteria May Apply