Bilirubin =< 1.5 x upper limit of normal (ULN) Direct bilirubin =< 3 x upper limit of normal (ULN) for age, and Bilirubin =< 1.5 upper limit of normal (ULN) Bilirubin less than or equal to 1.5 x upper limit of normal (ULN) (CTCAE grade 1) Bilirubin =< 1.5 upper limit of normal (ULN) Direct bilirubin < 2.0 x upper limit of normal (ULN) Bilirubin =< 1.5 x upper limit of normal (ULN) Serum bilirubin =< 1.5 x upper limit of normal (ULN) Serum bilirubin < 1.5 x the upper limit of normal (ULN) or < 5 x the ULN if secondary to liver metastasis Serum bilirubin < 2 x upper limit of normal (ULN) Bilirubin =< 1.5 x upper limit of normal (ULN), within 14 days prior to registration Serum bilirubin =< 2 x upper limit of normal (ULN) Serum bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin < 1.5 x upper limit of normal (ULN) Serum bilirubin > 1.5 x upper limit of normal (ULN) Serum bilirubin =< 2.0 × the upper limit of normal (ULN). Serum bilirubin < 2 x upper limit of normal. Within 28 days prior to registration: Bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin < 1.5 X upper limit of normal (ULN) Bilirubin < 1.5 x upper limit of normal (ULN) Serum bilirubin =< 1.5 x upper limit of normal (ULN). Bilirubin < 2 x upper limit of normal (ULN) Bilirubin =< 2.0 x upper limit of normal (ULN) Serum bilirubin =< 1.5 x institutional upper limit of normal (ULN) Bilirubin =< 1.5 x upper limit of normal (ULN) Serum bilirubin =< 1.5 x upper limit of normal (ULN) Serum bilirubin =< 1.5 x institutional upper limit of normal (ULN) Within 14 days prior to registration: Bilirubin =< 1.5 x the upper limit of normal (ULN) Bilirubin > upper limit of normal (ULN) Serum bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin =< 2 x upper limit of normal (ULN) Serum bilirubin =< 1.5 x institutional upper limit of normal (ULN) Bilirubin < 2 x upper limit of normal (ULN) and Bilirubin < 1.5 x the upper limit of normal (ULN) Serum bilirubin < 2 x upper limit of normal Serum bilirubin > upper limit of normal (ULN) Serum bilirubin =< 1.5 x institutional upper limit of normal (ULN) Serum bilirubin =< 1.5 x upper limit of normal (ULN) (institutional upper limit of normal) Bilirubin < 2.5 x upper limit of normal (ULN) Bilirubin =< 3 x upper limit of normal (ULN) Bilirubin =< 1.5 x upper limit of normal (ULN) Serum bilirubin =< 1.5 x institutional upper limit of normal (ULN) Bilirubin > upper limit of normal (ULN) Serum bilirubin =< 1.5 x upper limit of normal (ULN) Serum bilirubin ? 1.5 x institutional upper limit of normal (ULN) Serum bilirubin =< 1.5 x upper limit of normal Adequate liver function: Alanine transaminase (ALT) < 2 x ULN and bilirubin < 1.5 x Upper Limit of Normal (ULN), (or if bilirubin is between 1.5 - 2 x ULN, they must have a normal conjugated bilirubin). Serum bilirubin =< 2 x upper limit of normal (ULN) Bilirubin =<1.5 x upper limit of normal (ULN) TREATMENT: Bilirubin < 3 × upper limit of normal (ULN) Serum bilirubin =< 2 x upper limit of normal (ULN) Serum bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin =< 1.5 x upper limit of normal (ULN) Serum bilirubin =< 1.5 x upper limit of normal (ULN) Serum bilirubin of =< 1.5 × upper limit of normal Serum direct bilirubin =< 2.0 x ULN (upper limit of normal) Serum bilirubin < 2x upper limit of normal (ULN) Bilirubin =< 3 x upper limit of normal (ULN) Bilirubin < 1.5 x upper limit of normal (ULN) Serum bilirubin =< 2 x upper limit of normal Hepatic (bilirubin < 2 x upper limit of normal [ULN]) or Serum bilirubin =< 1.5 x upper limit of normal (ULN) Serum bilirubin =< 2 x the institutional upper limit of normal (ULN) Hepatic-bilirubin > 2 X upper limit of normal (ULN) Direct bilirubin ? 2x upper limit of normal (ULN) Bilirubin and creatinine less than 2 × upper limit of normal (ULN) for the institution Bilirubin ? 1.0 x upper limit of normal (ULN) Serum bilirubin =< 2.5 x institutional upper limit of normal (ULN) Direct bilirubin =< 1.5 x upper limit of normal (ULN) for age, and Bilirubin < 3 x upper limit of normal (ULN) Direct bilirubin < 1.5 x upper limit of normal (ULN) for age and institution Bilirubin < 1.5 x upper limit of normal (ULN) Bilirubin =< 2 x upper limit of normal (ULN) Bilirubin =< 1.5 x upper limit of normal (ULN) Serum bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin < 1.5 x upper limit of normal (ULN) Bilirubin less than 1.5 x upper limit of normal (ULN) Serum bilirubin >= 1.5 x upper limit of normal (ULN) Serum bilirubin =< 1.5x upper limit of normal Serum bilirubin up to 1.2 x upper limit of normal Serum bilirubin < 1.5x upper limit of normal Serum bilirubin < 1.5 x institutional upper limit of normal (ULN) Bilirubin < 1.5 x upper limit of normal (ULN) Serum bilirubin =< 1.5 x upper limit of normal (ULN) Direct bilirubin equal to or less than 1.5 x upper limit of normal (ULN) Bilirubin < or equal to 1.5 x upper limit of normal (ULN) Serum bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin < 3 x upper limit of normal (ULN) Bilirubin < 1.5 x the upper limit of normal (ULN) Serum bilirubin =< 1.5x institutional upper limit of normal (ULN) Bilirubin =< 1.5 x upper limit of normal (ULN), except for patients with documented history of Gilbert’s disease who may have direct bilirubin =< 1.5 x upper limit of normal (ULN) Direct bilirubin ? 1.5 x upper limit of normal (ULN) Bilirubin =< 1.5 x upper limit of normal (ULN) At least 4 weeks (28 days) prior to registration: Serum bilirubin =< 1.5 x upper limit of normal (ULN) Serum bilirubin =< 1.8 X upper limit of normal Adequate hepatic function, with bilirubin < 1.5 x the upper limit of normal (ULN) Bilirubin < 1.5 x the upper limit of normal (ULN) Direct bilirubin within upper limit of normal (ULN) Serum bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin > 1.5 upper limit of normal (ULN) when it is clearly not related to GVHD Bilirubin =< 1.5 the upper limit of normal (ULN) for the institution Serum bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin < 2 X upper limit of normal (ULN) Bilirubin =< 1.5 x the upper limit of normal (ULN) Serum bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin < 1.5 x the upper limit of normal (ULN) Bilirubin =< 2 x upper limit of normal (ULN) Serum bilirubin < 1.5 x the upper limit of normal (ULN) Bilirubin =< 2 x upper limit of normal (ULN) DONOR: Bilirubin =< 2.5 x upper limit of normal (ULN) Serum Bilirubin must be ? 3 x Upper Limit of Normal (ULN) if this elevation is solely due to ASM/MCL, otherwise serum bilirubin must be Serum bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin < 1.5 x upper limit of normal (ULN) Serum bilirubin =< 2 x the institutional upper limit of normal (ULN) Bilirubin =< 1.5 x upper limit of normal (ULN) SELUMETINIB ARM: Serum bilirubin > 1.5 x upper limit of normal (ULN) Bilirubin < 1.5 x upper limit of normal (ULN) Bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin > upper limit of normal (ULN) Serum bilirubin less than 3 X upper limit of normal Bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin =< 1.5 x upper limit of normal (ULN) Serum bilirubin =< 2 x upper limit of normal Serum bilirubin <=1.5 x upper limit of normal (ULN) Bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin =< 1.5 x the upper limit of normal (ULN) Bilirubin =< 1.5 X upper limit of normal (ULN) serum bilirubin ?1.5 X ULN (Upper Limit of Normal) Bilirubin =< 1.5 upper limit of normal (ULN) Bilirubin =< 3.0 x upper limit of normal (ULN) Serum bilirubin must be within the upper limit of normal (ULN) Serum bilirubin =< 1.5 x upper limit of normal (ULN) Serum bilirubin < 2 x upper limit of normal Bilirubin =< 1.5 upper limit of normal (ULN) Serum bilirubin count < 1.5 x upper limit normal (ULN) Serum bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin less than or equal to 1.5 x upper limit of the normal range (ULN) Bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin =< 1.5 x upper limit of normal (ULN) Bilirubin < 1.5 x upper limit of normal (ULN) Direct bilirubin > 2 x upper limit of normal (ULN) Bilirubin > 1.5 x (upper limit of normal [ULN]) obtained < 2 weeks prior to study enrollment Bilirubin > 1.5 x upper limit of normal (ULN) Bilirubin > 1.5 x upper limit of normal (ULN) Direct bilirubin ? 1.5 x upper limit of normal (ULN) Serum bilirubin ? 1.5 x ULN (upper limit of normal).