Patient is concurrently receiving chemotherapy, biologics, immunotherapy for cancer treatment; systemic anti-cancer treatment or investigational treatment Patient is concurrently using other anti-cancer therapy. Patients who are receiving other anti-neoplastic therapy (e.g. chemotherapy, targeted therapy or radiotherapy) concurrently or within 2 weeks of starting study treatment with sonidegib Patient is concurrently using other approved or investigational antineoplastic agent Patient is concurrently using other approved or investigational antineoplastic agent Concurrently using fibrin sealants or other anastomosis care devices Patient is concurrently using other approved or investigational antineoplastic agent Patient is concurrently using other approved or investigational antineoplastic agents Patient is concurrently using other anti-cancer therapy. Patients who are receiving other anti-neoplastic therapy (e.g. chemotherapy, targeted therapy or radiotherapy) concurrently Patients who are receiving other anti-neoplastic therapy (e.g. chemotherapy, targeted therapy or radiotherapy) concurrently or within 2 weeks of starting LDE225 Patients who are receiving other anti-neoplastic therapy (e.g. chemotherapy, targeted therapy, or radiotherapy) concurrently or within 2 weeks of starting treatment Patient who is concurrently using any other approved or investigational anti-neoplastic agent Patient is concurrently using other approved or investigational antineoplastic agent Patient is concurrently using other approved or investigational antineoplastic agents Patients who are receiving other anti-neoplastic therapy (e.g. chemotherapy, targeted therapy or radiotherapy) concurrently or within 2 weeks of starting treatment with LDE225