No angina or myocardial infarction within 182 days of registration; in view of potential cardiac risk with lenalidomide, patients with stable angina will be excluded History of myocardial infarction or unstable angina within 12 months prior to day 1 Patients with myocardial infarction or unstable angina < 6 months prior to starting study drug Unstable angina or myocardial infarction. Must not have a history of myocardial infarction, severe or unstable angina, peripheral vascular disease or familial QT prolongation Myocardial infarction of unstable angina within 6 months prior to the planned start date of study drug. Any comorbidity or condition which, in the opinion of the investigator, may interfere with the assessments and procedures of this protocol e.g. unstable angina, myocardial infarction within 6 months, severe infection, etc. Myocardial infarction or unstable angina within 6 months of the first date of treatment on this study. History of cerebral vascular accident, unstable angina, myocardial infarction, or ventricular arrhythmia within the last 6 months Having known myocardial infarction or unstable angina within 6 months before first ZW25 dosing History of myocardial infarction or unstable angina within 6 months of registration History of myocardial infarction or unstable angina within 6 months prior to day 1 Has a history of myocardial infarction or unstable angina within 6 months before enrollment Patients with unstable angina and/or myocardial infarction within 6 months prior to screening History of myocardial infarction or unstable angina within 6 months prior to first study treatment Unstable angina or a history of myocardial ischemia within prior 6 months History of myocardial infarction or unstable angina within 3 months prior to cycle 1, day 1 Myocardial infarction or unstable angina within 6 months of enrollment Myocardial infarction within the past 12 months, or stable or unstable angina History of myocardial infarction or severe unstable angina Patients with a history of myocardial infarction, unstable angina, or uncontrolled arrhythmia within 3 months from enrollment. History of myocardial infarction or unstable angina within 6 months prior to study enrollment History of myocardial infarction or unstable angina within the past 12 months History of myocardial infarction or unstable angina within 6 months prior to day 1 Patients with a myocardial infarction or unstable angina within 6 months of study entry Unstable angina or a history of myocardial ischemia within prior 6 months Myocardial infarction or uncontrolled angina within 6 months History of a stroke, myocardial infarction, or unstable angina in the previous 6 months Has a medical history of myocardial infarction or unstable angina History of myocardial infarction within 6 months or unstable angina within the past 6 months. History of stroke, unstable angina, myocardial infarction, or ventricular arrhythmia requiring medication or mechanical control within the last 6 months Myocardial infarction or unstable angina less than 6 months before registration History of myocardial infarction or unstable angina within 6 months prior to Day 1 Must not have a history of myocardial infarction, severe or unstable angina, or peripheral vascular disease Myocardial infarction or unstable angina < 6 months prior to registration History of myocardial infarction or unstable angina within 6 months prior to study enrollment Unstable angina and/or myocardial infarction within 6 months prior to screening History of myocardial infarction (within 12 months) or unstable angina (within 6 months) prior to study enrolment. Patients are excluded if they have a history of myocardial infarction or unstable angina within 6 months prior to randomization History of stroke, unstable angina, myocardial infarction, or ventricular arrhythmia requiring medication or mechanical control within the last 6 months; Unstable angina or new-onset angina (begun within the last 3 months), or myocardial infarction within the 6 months prior to enrollment Myocardial infarction or unstable angina within 6 months prior to registration. Diagnosis of unstable angina or myocardial infarction within 6 months of study entry Patients with a history of stroke, myocardial infarction, or unstable angina within 6 months prior to registration are not eligible Myocardial infarction or unstable angina within 6 months prior to Day 1 of the study. Unstable angina (angina symptoms at rest), new-onset angina (begun within the last 3 months) or myocardial infarction less than 6 months prior to randomization History of stroke, unstable angina, myocardial infarction, or ventricular arrhythmia requiring medication or mechanical control within the last 6 months Myocardial infarction or unstable angina within 6 months prior to the first dose of study drug. History of stroke, unstable angina, myocardial infarction, or ventricular arrhythmia requiring medication or mechanical control within the last 6 months prior to first dose of study drug History of myocardial infarction or unstable angina within 6 months prior to study Day History of myocardial infarction or unstable angina within 6 months prior to day 1 History of myocardial infarction or unstable angina within 6 months prior to day -3 Patients with myocardial infarction or unstable angina =< 6 months prior to starting study drug Patients with myocardial infarction or unstable angina =< 6 months prior to registration History of myocardial infarction or unstable angina within 12 months prior to day 1 History of myocardial infarction or unstable angina within 6 months prior to enrollment. Unstable angina (angina symptoms at rest), new-onset angina (begun within the last 3 months). Myocardial infarction less than 6 months before start of study treatment Myocardial infarction or uncontrolled angina within 3 months; History of stroke, unstable angina, myocardial infarction, or ventricular arrhythmia requiring medication or mechanical control within the last 6 months History of myocardial infarction or unstable angina within 6 months prior to Day 1 Active coronary artery disease, unstable or newly diagnosed angina or myocardial infarction less than 6 months prior to first study drug administration Has a medical history of myocardial infarction or unstable angina. History of myocardial infarction or unstable angina within 6 months prior to first study treatment unstable angina or myocardial infarction within 6 months of enrollment. Patients with myocardial infarction or unstable angina =< 6 months prior to starting study drug Patients with myocardial infarction or unstable angina ? 6 months prior to starting study drug. Myocardial infarction or unstable angina < 6 months prior to enrollment History of unstable angina or myocardial infarction within 12 months prior to Day 1 or ischemic heart disease. Myocardial infarction, severe angina, or unstable angina within 6 months prior to administration of first dose of study drug History of myocardial infarction within 6 months prior to Cycle 1, Day 1, or history of unstable angina History of myocardial infarction or unstable angina within 6 months of enrollment Unstable angina or myocardial infarction within 6 months prior to first dose History of myocardial infarction, acute inflammatory heart disease, unstable angina, or uncontrolled arrhythmia within the past 6 months. History of myocardial infarction, severe or unstable angina, peripheral vascular disease or familial QTc prolongation. Transmural myocardial infarction or unstable angina within 3 months prior to study registration History of myocardial infarction or uncontrolled angina within 12 months prior to administration of study drug Myocardial infarction or unstable angina within 6 months prior to the first administration of study drug; Unstable angina or myocardial infarction within 6 months of enrolment, History of myocardial infarction within 6 months before Cycle 1, Day 1, or history of unstable angina Myocardial infarction or unstable angina within 6 months of day 1 prior to registration Significant cardiovascular diseases (i.e., hypertension not controlled by medical therapy, unstable angina, history of myocardial infarction within the past 6 months, History of a stroke, myocardial infarction, or unstable angina in the previous 6 months Significant cardiovascular disease, such as cardiac disease, myocardial infarction within the previous 3 months, unstable arrhythmias, or unstable angina History of myocardial infarction or unstable angina within 6 months prior to day 1 Myocardial infarction or unstable angina within 6 or 1 month of starting nintedanib treatment, respectively History of unstable angina or myocardial infarction in the last week History of unstable angina or myocardial infarction 1 month prior to study enrollment History of myocardial infarction or unstable angina within 12 months prior to day 1 No unstable angina, regular use of nitroglycerin for exertional angina, or myocardial infarction (MI) within the last 12 months History of unstable angina or myocardial infarction 1 month prior to study enrollment History of unstable angina or myocardial infarction 1 month prior to study enrollment Patients with myocardial infarction or unstable angina < 6 months prior to starting study Medically eligible to use nicotine replacement therapy (patient currently hospitalized with acute myocardial infarction/ST elevation myocardial infarction [STEMI], unstable angina, uncontrolled arrhythmia, stroke, peripheral arterial disease vascular surgery will not be eligible for inclusion) Subjects with a history of stroke, unstable angina, myocardial infarction, or ventricular arrhythmia requiring medication or mechanical control Subjects with a history of stroke, unstable angina, myocardial infarction, or ventricular arrhythmia requiring medication or mechanical control