Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial; previously treated brain metastases, neurologically stable, and no ongoing or anticipated need for steroid therapy are eligible Patients with known brain metastases should be excluded from early clinical trials Patients with known leptomeningeal or brain metastases or spinal cord compression should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Participants with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases are excluded Patients with known brain metastases should be excluded from this clinical trial; a scan to confirm the absence of brain metastasis is not required Patients with known brain metastases should be excluded from this clinical trial Participants with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial except as those described below Patients with known active or history of brain metastases should be excluded from this clinical trial Patients with known brain metastases should be excluded from this clinical trial