Subjects with solitary plasmacytoma; active or history of plasma cell leukemia (PCL); Waldenstrom's macroglobulinemia; Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, Skin changes (POEMS) syndrome; or symptomatic amyloidosisXx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXDiagnosis of any of the following cancers:\r\n* POEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein [M-protein] and skin changes)\r\n* Non-secretory myeloma (no measurable protein on serum free lite assay)\r\n* Plasma cell leukemia\r\n* Human T-cell lymphotrophic virus (HTLV)1/HTLV2 positiveXx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXHas polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes (POEMS) syndrome, monoclonal gammopathy of unknown significance, smoldering myeloma, solitary plasmacytoma, amyloidosis, Waldenstrom macroglobinemia or immunoglobulin M (IgM) myeloma, or lymphoplasmacytic lymphoma (LPL).Xx_NEWLINE_xXSubjects with known POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes) or light-chain (AL) amyloidosis.Xx_NEWLINE_xXPOEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein [protein] and skin changes)Xx_NEWLINE_xXDiagnosis of Waldenstrom's macroglobulinemia, POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome, plasma cell leukemia, primary amyloidosis, myelodysplastic syndrome, or myeloproliferative syndrome.Xx_NEWLINE_xXPlasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein (M-protein), and skin changes (POEMS) syndromeXx_NEWLINE_xXDiagnosis of Waldenstrom’s macroglobulinemia, POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome, plasma cell leukemia, myeloproliferative syndrome, or primary amyloidosis (with the exception of patients whose amyloidosis has been documented as a complication of MM, who will be evaluated on a case-by-case basis for trial participation)Xx_NEWLINE_xXPOEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes)Xx_NEWLINE_xX>= grade 3 neuropathy and/or polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes (POEMS syndrome)Xx_NEWLINE_xXPatients with a diagnosis of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes) or plasma cell leukemia (> 2.0 x 10^9/L circulating plasma cells by standard differential)Xx_NEWLINE_xXPOEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein [M-protein] and skin changes)Xx_NEWLINE_xXDiagnosis of amyloidosis, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS), Waldenstrom’s macroglobulinemiaXx_NEWLINE_xXPatients with non-secretory multiple myeloma, active plasma cell leukemia, defined as either having 20% of peripheral white blood cells comprised of CD138+ plasma cells, or an absolute plasma cell count of 2 x 10^9/L, known amyloidosis, or known POEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXDiagnosis of smoldering MM, Waldenström's macroglobulinemia, POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome, plasma cell leukemia, primary amyloidosis, myelodysplastic syndrome, or myeloproliferative syndrome.Xx_NEWLINE_xXPolyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes (POEMS) syndromeXx_NEWLINE_xX>= grade 3 neuropathy and/or POEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXPOEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXSubjects with known polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions (POEMS) syndrome, and subjects with myeloma and amyloidosis will be eligible if they have measurable diseaseXx_NEWLINE_xXHistory of primary amyloidosis, hyperviscosity or POEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXCriteria 3 POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXSubject has plasma cell leukemia or Waldenstrom’s macroglobulinemia or POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes) or amyloidosisXx_NEWLINE_xXSymptomatic amyloidosis, active 'polyneuropathy, organomegaly, endocrinopathy, myeloma protein, and skin changes' (POEMS) syndrome, active plasma cell leukemia at the time of screening.Xx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXSubject has plasma cell leukemia, Waldenstrom's macroglobulinemia, POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes), or primary amyloidosisXx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes)Xx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXPatients with plasma cell leukemia, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome, or amyloidosis are excluded from this trialXx_NEWLINE_xXHas any type of amyloidosis, hyperviscosity, plasma cell leukemia, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome, Waldenstrom's macroglobulinemia, non-secretory multiple myeloma or IgM myelomaXx_NEWLINE_xXPatients must not have > grade 2 neuropathy and/or POEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXDiagnosis of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndromeXx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXPlasma cell leukemia or POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes) syndromeXx_NEWLINE_xXPatients must not have POEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXSubjects with monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM), primary amyloidosis, Waldenstrom's macroglobulinemia, or POEMS syndrome (plasma cell dyscrasia with poly neuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXPOEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein [M-protein] and skin changes)Xx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXDiagnosed with smoldering MM, monoclonal gammopathy of undetermined significance, Waldenstrom macroglobulinemia, plasma cell leukemia, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome or amyloidosisXx_NEWLINE_xXDiagnosis of Waldenstrom's macroglobulinemia, POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome, plasma cell leukemia, primary amyloidosis, myelodysplastic syndrome, or myeloproliferative syndrome.Xx_NEWLINE_xXPOEMS syndrome (plasma cell dyscrasias with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein [M-protein] and skin changes) or amyloid light-chain (AL) amyloidosesXx_NEWLINE_xXPolyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin (POEMS) syndromeXx_NEWLINE_xXPolyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndromeXx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXDiagnosis of Waldenstrom's macroglobulinemia, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome, plasma cell leukemia, primary amyloidosis, myelodysplastic syndrome, or myeloproliferative syndrome.Xx_NEWLINE_xXPolyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndromeXx_NEWLINE_xXSubjects with leukemia are excluded, with the exception of chronic lymphocytic leukemia (CLL), who are allowed in the dose escalation phase. Subjects with Burkitt lymphoma, plasma cell leukemia, POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes), or amyloidosis are also excluded.Xx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes).Xx_NEWLINE_xXPOEMS (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein [M-protein] and skin changes) syndromeXx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes).Xx_NEWLINE_xXPlasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein (M-protein), and skin changes (POEMS) syndromeXx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXDiagnosis of Waldenstrom's macroglobulinemia, POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome, plasma cell leukemia, myeloproliferative syndrome, or primary amyloidosis (with the exception of patients in whom amyloidosis has been documented as a complication of MM, who will be evaluated on a case-by-case basis for trial participation)Xx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes).Xx_NEWLINE_xXPOEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXActive polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome.Xx_NEWLINE_xXPolyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndromeXx_NEWLINE_xXPOEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein [M-protein] and skin changes)Xx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xXSubject has plasma cell leukemia, Waldenstrom's macroglobulinemia, POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes), or primary amyloidosisXx_NEWLINE_xXPolyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome.Xx_NEWLINE_xXPOEMS syndrome [plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein (M-protein) and skin changes]Xx_NEWLINE_xXPOEMs syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes).Xx_NEWLINE_xXPOEMS (Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) syndrome, monoclonal gammopathy of unknown significance, smoldering myeloma, solitary plasmacytoma, amyloidosis, Waldenström macroglobulinemia, or IgM myeloma.Xx_NEWLINE_xXPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes)Xx_NEWLINE_xX