investigational device drug study days treatment participation currently agent trial month participation study clinical product investigational involved preceding involving medication trial trials included participation agents investigational duration clinical start days trial investigational participation clinical agent days drug prior treatment study participation study investigational clinical involving drug days weeks studies prior therapeutic weeks study participation drug treatment clinical molecule participated procedures investigation participated clinical dosing investigational month currently drug prior patients product participation clinical investigational study weeks days receipt months prior allergy suspected agent given trial known course sorafenib association investigational