For patients to be treated with a regimen containing bevacizumab:
All previous treatments are acceptable as long as they did not contain bevacizumab, ramucirumab or PARP inhibitors
Patients with prior treatment with bevacizumab (or any other anti vascular therapy, e.g., cediranib) for platinum resistant recurrence; (Note: prior bevacizumab in initial therapy and/or platinum sensitive recurrent setting is allowed)
Prior bevacizumab therapy is excluded.
Subject has received bevacizumab (Avastin).
Patients who have received prior therapy with bevacizumab, or related drugs (previous therapy with carboplatin is allowed)
Has received trebananib or another angiopoietin- directed therapy (prior treatment with bevacizumab is not an exclusion criteria)
Patients must not have received prior anti-VEGF therapy including bevacizumab (i.e. patients must be bevacizumab naive)
Prior bevacizumab
Patients who have had previous treatment with bevacizumab
There is no limit on the number of prior relapses but the most recent relapse must be the first relapse on a bevacizumab-containing regimen
Patients who have received investigational or licensed drugs that target vascular endothelial growth factor [VEGF] or VEGF receptors/pathways (such as bevacizumab, sorafenib, pazopanib, sunitinib, axitinib, cabozantinib, etc.) for the treatment of recurrent cancer are not eligible; exceptions: prior treatment with bevacizumab in the up-front or maintenance setting is allowed, provided the patient had a favorable response to bevacizumab; favorable response is defined as having had a disease free interval of >  months following completion of a bevacizumab-containing regimen; if questions, contact the principal investigator (PI)
Patients must have been previously treated with radiation therapy and temozolomide (bevacizumab-naive  groups  and ) or radiation therapy, temozolomide and bevacizumab (bevacizumab-exposed  groups  and ); therapy with these agents may be given together or sequentially in the past
If participant was treated with bevacizumab, at least  weeks must elapse before treatment with either agent (cyclophosphamide or rQNestin.v.)
For biopsy cohort, participants must be bevacizumab naive or received the last bevacizumab treatment at least  months prior to Cycle  Day  and according to the investigator's judgment the planned biopsies would not expose participants to substantially increased risk of complications
Patients may have had previous systemic treatment regimens (no limit to number of prior therapies); patients with prior treatment with bevacizumab are eligible for enrollment into the study; NOTE: except for bevacizumab, a  day wash-out period prior to registration is mandatory for all systemic treatments
Prior use of bevacizumab
Patients may not have had prior bevacizumab, based on case reports of tracheoesophageal fistula in patients treated with bevacizumab and radiotherapy
Patients who have had any prior bevacizumab, due to case reports suggesting a possible risk of severe toxicity in combination with radiotherapy
Prior treatment with any anti-angiogenic agent (including bevacizumab)
Patients may have received previous NY-ESO- vaccine therapy; patients who received maintenance paclitaxel or bevacizumab are eligible for enrollment provided they have discontinued therapy (at least  weeks for prior taxane or prior bevacizumab) prior to randomization and recovered from toxicities to less than grade 
Patients who have had previous treatment with bevacizumab and/ or NovoTTF A system
Patients with advanced adenocarcinoma of the colon or rectum not curable with surgery or radiotherapy and have been previously treated for their disease with FOLFIRI plus bevacizumab in the first line metastatic setting; patients will only be eligible if their last line of therapy prior to enrolling onto the study was FOLFIRI and bevacizumab received no more than  months prior to enrolling in this study; they should have been treated with FOLFIRI plus bevacizumab until disease progression is radiographically documented
Bevacizumab within the last  weeks before enrollment on trial
No more than two prior regimens targeting the VEGF pathway; no prior bevacizumab therapy
Bevacizumab naive
Patients must not have received prior treatment with bevacizumab.
Be at least  days from the last administration of bevacizumab
Has previously received treatment with bevacizumab
Has received anti-angiogenic or anti-VEGF targeted agents (e.g. bevacizumab, cediranib, aflibercept, vandetanib, XL-, sunitinib, etc)
Patients with prior bevacizumab use for tumor treatment; patients who received bevacizumab for symptom management, including but not limited to cerebral edema, pseudoprogression can be included in the study
Have adequately recovered from second look surgery to be able to start bevacizumab within  weeks of this procedure
Participant may have received bevacizumab (or other antiangiogenic agent) and/or cyclophosphamide in the past
Prior hypersensitivity to bevacizumab or toxicity requiring discontinuation of bevacizumab
Treatment with trastuzumab, bevacizumab or other targeted therapies within the past  weeks
Patients may have received prior targeted therapy such as bevacizumab
Bevacizumab or other anti-angiogenic therapy.
Prior therapy with bevacizumab
Subjects must not have received capecitabine or bevacizumab for this disease
Unequivocal evidence of tumor progression during prior bevacizumab treatment per RANO criteria.
Has been treated previously with bevacizumab
Patients previously treated with bevacizumab.
COHORT I: Non-bevacizumab failure, i.e. either no prior bevacizumab or bevacizumab stable/responder, which is defined as stable for at least  months from prior treatment with bevacizumab without experiencing a bevacizumab adverse event of special interest (AESI) while on a bevacizumab-containing regimen, such as:\r\n* >= grade  hypertension not controlled by medication, hypertensive crisis, or hypertensive encephalopathy\r\n* >= grade  proteinuria that does not resolve or nephrotic syndrome\r\n* Any grade gastrointestinal (GI) perforation\r\n* >= grade  infusion-related reaction\r\n* >= grade  wound healing complications\r\n* >= grade  hemorrhage or any grade central nervous system (CNS) hemorrhage or >= grade  hemoptysis\r\n* Any grade arterial thromboembolic event (e.g. myocardial infarction or cerebral infarction) or >= grade  venous thromboembolic event\r\n* Any grade posterior reversible encephalopathy syndrome (PRES)\r\n* >= grade  congestive heart failure\r\n* >= grade  non-GI abscesses and fistulae
COHORT II: Prior progression on a bevacizumab-containing regimen (defined as having progressed/grown through bevacizumab by RANO criteria within  months of prior bevacizumab treatment)
Bevacizumab-naive  no prior exposure to bevacizumab
Patients with an impending fracture who have had bevacizumab are eligible provided there will be a -week window between their last infusion and surgery
Prior therapy with bevacizumab, liposomal doxorubicin, or everolimus
Stage  non-squamous cell lung cancer that has not been treated previously with systemic chemotherapy or bevacizumab, but may have received prior targeted treatment (e.g., alk inhibitor)
Prior treatment with bevacizumab within  weeks of study entry
Treated with antiangiogenic agents (like bevacizumab) within  weeks before biopsy
Patients receiving bevacizumab within  weeks prior to protocol treatment
Prior treatment with bevacizumab
Receipt of bevacizumab (Avastin) therapy within  weeks of scheduled M administration; (receipt of bevacizumab [Avastin] greater than  weeks of scheduled M administration does not exclude patient)
Current or recent (within  days prior to first dose of bevacizumab) use of aspirin (>  mg/day)
No more than  prior chemotherapies and  relapse; prior bevacizumab therapy is allowed
Prior treatment with agents targeting the VEGF pathway, including bevacizumab
Prior treatment with irinotecan and/or bevacizumab
Patients may not have previously been treated with bevacizumab or lapatinib
Patients treated with any systemic anti-cancer therapy for NSCLC within  days prior to randomization ( weeks for Bevacizumab).
Bevacizumab will be allowed if given for symptomatic control of vasogenic edema and to avoid high dose of corticosteroids.
Patients who have undergone prior resection, radiation therapy, and/or chemotherapy (except bevacizumab)
Patients who have received bevacizumab, Gliadel, or are on active therapy with Optune are not eligible
Participants who have received anti-VEGF targeted agents (e.g. bevacizumab, cediranib, aflibercept, vandetanib, XL, sunitinib etc)
An interval of >=  weeks after the last administration of any investigational agent, bevacizumab, or prior cytotoxic therapy
Prior treatment affecting the VEGF/VEGFR pathway or the angiopoietin pathway in the recurrent setting, including but not limited to thalidomide, bevacizumab, sunitinib, sorafenib, pazopanib, cediranib, nintedanib, and trebananib; bevacizumab used in the upfront setting in conjunction with chemotherapy and/or as maintenance to treat newly diagnosed disease will be allowed
Prior exposure to another anti-angiogenic therapy (eg, bevacizumab, sunitinib)
Arm  patients must have not received bevacizumab previously
Arm  patients must have progressed/recurred on bevacizumab as the most recent regimen; patients on arm  should continue on bevacizumab as clinically necessary to control brain edema
Patients who have been off bevacizumab for <  days prior to baseline MRI
Patients undergoing pre-treatment secondary cytoreduction will undergo therapy with bevacizumab on cycle #
Patient is to receive bevacizumab as maintenance treatment
No prior therapy with drugs other than oxaliplatin and a fluoropyrimidine plus bevacizumab for this disease; chemotherapy drugs and bevacizumab may be stopped and started as long as no prior disease progression requiring change in chemotherapy agents occurred
Patients for whom, in the opinion of the Investigator, there is clinical benefit to administer bevacizumab as a first-line treatment and for whom bevacizumab is approved and available in this setting.
Patients with gliomas who have had prior treatment with bevacizumab (Avastin) are excluded
Patients who will be enrolled under protocol amendment #  must have previously received bevacizumab, either discontinued due to intolerability, or progressed after at least  cycles of bevacizumab
Continued treatment with bevacizumab with documented evidence of disease progression on a bevacizumab-containing regimen
At least  days since the last dose of bevacizumab, other antibody, or interferon.
Bevacizumab will be allowed if given for symptomatic control of vasogenic edema and to avoid high dose of corticosteroids
An interval of >=  weeks after the last administration of any investigational agent or prior cytotoxic therapy (except bevacizumab); there should be  days interval between the last dose of bevacizumab and first day of treatment on study
Prior treatment with bevacizumab within twelve weeks before the first infusion.
Radiographic progression on bevacizumab by Revised Assessment in Neuro-Oncology (RANO) criteria
Prior receipt of antiangiogenic treatment, including but not limited to bevacizumab, is optional. If used, it can be used in the first line or recurrent setting.
Patient has previously received standard of care chemo-radiation with temozolomide,  adjuvant temozolomide and bevacizumab and now has radiographic evidence of recurrent/progressive GBM or GS during or after bevacizumab.
Participants who have received prior bevacizumab are eligible unless there is evidence of unacceptable toxicity due to prior bevacizumab exposure
Capecitabine and bevacizumab considered appropriate treatment for the patient
Intolerance to bevacizumab defined as any NCI CTCAE grade  or grade  toxicity attributed to this agent that required discontinuation of bevacizumab (e.g., arterial thromboembolism [ATE], perforation, wound healing difficulty, proteinuria, reversible posterior leukoencephalopathy syndrome [RPLS]); Note: patients with prior grade  bevacizumab-related hypertension may be permitted if hypertension was manageable with standard oral antihypertensives as so judged by the treating physician
Previous therapy with bevacizumab is allowed, but patient who experienced serious dose-limiting toxicities while on prior bevacizumab therapy are excluded
Treatment with any additional Food and Drug Administration (FDA)-approved biologic agent (i.e. bevacizumab, cetuximab, or panitumumab) is allowed according to standard practice
Progression following both standard combined modality treatment with radiation and temozolomide chemotherapy, as well as bevacizumab
Has been treated previously with bevacizumab
Treatment with bevacizumab in at least one prior line of therapy for metastatic disease
Prior intolerance to irinotecan and/or bevacizumab despite dose reduction
Advanced unresectable, metastatic or recurrent colorectal carcinoma (CRC) for which treatment with FOLFOX with or without bevacizumab, FOLFIRI with or without bevacizumab, CAPOX, or regorafenib would be acceptable as determined by the Investigator. FOLFIRI-refractory patients with CRC enrolling on the FOLFIRI study arm must have failed treatment with one FOLFIRI with or without bevacizumab regimen for unresectable or metastatic disease. Treatment failure is defined as progression of disease (clinical or radiologic) during treatment with FOLFIRI with or without bevacizumab or <  months after the last dose of treatment with FOLFIRI with or without bevacizumab. Patients with CRC enrolling on the regorafenib arm of this study will have previously received at least two previous lines of therapy for advanced colorectal cancer, and will have previously received treatment with a fluoropyrimidine, oxaliplatin, and irinotecan. Patients with K-ras wild type tumors enrolling on the regorafenib arm will also have previously received either cetuximab or panitumumab.
For patients to be treated with a regimen containing bevacizumab:
Prior or concurrent treatment with Avastin (bevacizumab)
Patients who have received previous treatment with bevacizumab for CNS disease are not eligible for participation
Maintenance treatment is allowed at the end of the penultimate platinum regimen, including bevacizumab
Prior treatment with doxorubicin and/or bevacizumab
Prior treatment with bevacizumab
FOR COHORT : (BEVACIZUMAB ELIGIBLE)
FOR COHORT  (BEVACIZUMAB INELIGIBLE):
Treatment with trastuzumab, bevacizumab or other targeted therapies within the past  weeks
Patients must have been previously treated with radiation therapy and temozolomide (bevacizumab-naive - groups  and ) or radiation therapy, temozolomide and bevacizumab (bevacizumab-exposed -groups  and ); therapy with these agents may be given together or sequentially in the past
Prior disease progression/recurrence during or immediately following treatment with bevacizumab; any questions should be directed to the PI
Patients who have had prior chemotherapy within the past  weeks ( weeks for nitrosoureas or mitomycin C); patients must be off treatment with temozolomide for at least  days; patients who received non-cytotoxic drug therapy must be off treatment for at least  weeks; for patients enrolling in Part  or Part  AND who have progressed on a prior bevacizumab-containing regimen, patients may continue treatment with bevacizumab  mg/kg monotherapy, with last dose of bevacizumab administered no fewer than  days from start of plerixafor and bevacizumab; for participants enrolling in Part  or Part  AND who have progressed on a prior anti-VEGF(R) (other than bevacizumab) containing regimen, patients must be off anti-VEGF(R) treatment for at least  days before receiving plerixafor and bevacizumab; for patients enrolled in Part  (surgical substudy) AND who have progressed on a prior bevacizumab or other anti-VEGF(R) containing regimen, patients must be off anti-VEGF(R) treatment for at least  days prior to surgery; NOTE: participants must have recovered to a grade  or  from the toxic effects of prior therapy (with the exception of lymphopenia, which is common after therapy with temozolomide); for any patient who received prior bevacizumab or an anti-VEGF(R) therapy, patient must NOT have discontinued that treatment regimen due to a treatment-related toxicity
Patients must be willing to forego other drug therapy against the tumor while being treated with bevacizumab and temozolomide
Subjects who have progressed on Bevacizumab treatment
Patients who are pregnant (positive pregnancy test) or nursing. Use of effective means of contraception (men and women) in subjects of child-bearing potential. To date, no fetal studies in animals or humans have been performed. The possibility of harm to a fetus is likely. Bevacizumab specifically inhibits VEGF, which is responsible for formation of new blood vessels during development, and antibodies can cross the placenta. Therefore, bevacizumab should not be administered to pregnant women.
(continued from no. ) Subjects will be apprised of the large potential risk to a developing fetus. It is not known whether bevacizumab is excreted in human milk. Because many drugs are excreted in human milk, bevacizumab should not be administered to nursing women. Patients of childbearing potential must agree to use contraceptive measures during study therapy and for at least six months after completion of bevacizumab therapy.
Patients who have received prior therapy with any anti-VEGF drug, including bevacizumab.
Previous bevacizumab within  weeks prior to enrollment
Prior treatment with bevacizumab is not allowed.
If patients have been treated with anti-VEGF agents, such as bevacizumab, last dose must be >=  weeks
st progression of GBM on bevacizumab-containing regimen or within  weeks of discontinuing bevacizumab. In either case, must have received a minimum of  weeks ( infusions) of bevacizumab.
 days from last dose of bevacizumab
Prior antiangiogenic therapy (e.g., Bevacizumab/Avastin)
Bevacizumab will be allowed for patients with non-squamous carcinoma. Prescribing information must be followed and precautions have to be taken into consideration (e.g., patients having presented a serious hemorrhage or recent hemoptysis should not receive bevacizumab).
Patients who are taking bevacizumab or have taken bevacizumab within the past  weeks for treatment of their brain metastases
Bevacizumab within  weeks.
Patients who have previously discontinued bevacizumab-containing regimes due to drug-related toxicity.
Prior treatment with bevacizumab within twelve weeks before the first infusion.
For those receiving bevacizumab, standard medical exclusionary conditions apply
Participants with newly detected enhancement are eligible, with bevacizumab treatment hoped to prevent symptoms
- bevacizumab or aflibercept
Prior treatment with bevacizumab or an experimental anti-angiogenic agent.
Has the subject received Avastin (bevacizumab) for this recurrence/progression, or within the  weeks prior to planned Visit ?
Prior therapy with bevacizumab or other VEGF pathway targeted therapy in the recurrent setting; bevacizumab in the upfront setting is allowed
Bevacizumab-refractory patients: these patients may not have more than  prior relapses not counting the current relapse being treated by this protocol and must have received multiple chemotherapy regimens, including a temozolomide regimen and a bevacizumab regimen
Planned to receive bevacizumab
The last dose administered of bevacizumab must be at least -days but not more than -days from enrollment
Last dose of bevacizumab >=  weeks prior to registration (Phase I); note: for the phase II study only, prior exposure to bevacizumab is not allowed
Prior hypersensitivity to bevacizumab or toxicity requiring discontinuation of bevacizumab (Phase I)
Patients enrolling onto Cohort b who have been taken off bevacizumab must have had at least a  day washout from any previous administration of bevacizumab. It is preferred that patients who fail bevacizumab prior to trial entry remain on bevacizumab in the trial.
Have received any prior treatment with bevacizumab (Avastin).
Received prior bevacizumab therapy or had clinically documented reason why not administered
Medical conditions that would contraindicate bevacizumab therapy in non-squamous NSCLC (Arms C, D, E, and F)
Subjects receiving bevacizumab for maintenance therapy are excluded (subjects who received bevacizumab as part of their adjuvant therapy will be permitted)
Has received bevacizumab within  weeks prior to randomization
No bevacizumab =<  months of study registration
Failure on bevacizumab (either as a monotherapy or a combination) as most recent regimen confirmed by tumor recurrence on MRI.
The patient must have failed no more than one regimen of bevacizumab.
Prior allergic reaction to bevacizumab or severe adverse event with bevacizumab.
Prior therapy with bevacizumab
Known allergies to oxaliplatin (or other platinum agents), leucovorin, -FU, nab-paclitaxel (or other taxanes) or gemcitabine Exclusion Criteria Specific to Bevacizumab-Containign Arms (Arms A, B, and F) (Patients who meet any of the following criteria will be excluded from enrollment into bevacizumab-containing Arms A, B, and F:)
Anti-angiogenic agents including bevacizumab:  weeks
Progression of disease assessed by local site using Revised Assessment in Neuro-Oncology (RANO) criteria, with plan to administer bevacizumab, either as single therapy or in conjunction with other chemotherapeutic regimens, in order to treat tumor progression/recurrence per the treating physician; patients receiving bevacizumab primarily for reduction of edema (i.e. alleviation of symptoms) rather than for tumor treatment are excluded
Patients who have not previously received a bevacizumab-containing regimen (i.e., this must be the first bevacizumab-containing therapy administered to the patient)
Patient must be scheduled to receive treatment with a bevacizumab containing chemotherapy regimen; patient can be treated with bevacizumab alone or in combination with other chemotherapies; patient may also be receiving treatment with Optune
Platelets >= ,/mcL for bevacizumab monotherapy cohort; > ,/mcL for bevacizumab + lomustine cohort
Participants who have received any treatment regimen including a VEGF-R inhibitor such as bevacizumab or cediranib, or plan to receive such agents as part of initial management for glioblastoma