Patients with a history of allergic reactions attributed to compounds of similar composition, including macrolide and ketolide antibiotics, temsirolimus/other mTOR inhibitors, temozolomide or irinotecan are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to irinotecan, decitabine or SGI- Patients with history of allergic reactions attributed to compounds of similar composition to pazopanib, irinotecan, or temozolomide are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to VX- or irinotecan History of allergic reactions attributed to compounds of similar chemical or biologic composition to irinotecan, topotecan, gadolinium, or lipids History of allergic reactions attributed to fluorouracil (-FU), leucovorin, irinotecan or oxaliplatin or to compounds of similar chemical or biologic composition A history of allergic reactions attributed to compounds of similar chemical or biologic composition to sorafenib or irinotecan A history of allergic reaction attributed to compounds of similar chemical or biologic composition to fluorouracil (FU), oxaliplatin, or leucovorin History of hypersensitivity reaction specifically attributed to compounds of similar chemical or biologic composition to -FU, leucovorin, capecitabine or bevacizumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to irinotecan History of allergic reactions attributed to compounds of similar chemical or biologic composition to -fluorouracil, oxaliplatin, irinotecan or gemcitabine History of hypersensitivity or allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine, Taxotere, Xeloda, cisplatin, or irinotecan History of allergic reactions attributed to compounds of similar chemical or biological composition to metformin or oxaliplatin or fluorouracil (-FU) History of allergic reaction(s) attributed to compounds of similar chemical or biologic composition to -fluorouracil, irinotecan, or oxaliplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN, including but not limited to established allergic reaction to benzodiazepines, -FU (fluorouracil), leucovorin (leucovorin calcium) or oxaliplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to irinotecan, cetuximab, and/or bevacizumab that led to discontinuation of those agents History of allergic reactions attributed to compounds of similar chemical or biologic composition to -fluorouricil, irinotecan, oxaliplatin, or losartan History of allergic reactions attributed to FU, leucovorin, irinotecan or oxaliplatin or to compounds of similar chemical or biologic composition. History of allergic reactions attributed to compounds of similar chemical or biologic composition to topotecan or irinotecan History of allergic reactions attributed to compounds of similar chemical or biologic composition to -fluorouracil, irinotecan, or oxaliplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to fluorouracil (-FU), capecitabine, oxaliplatin, leucovorin, bevacizumab, and/or vitamin D History of allergic reactions attributed to compounds of similar chemical or biologic composition to irinotecan, -FU, leucovorin or any of the products to be administered during dosing History of allergic reactions attributed to compounds of similar chemical or biologic composition to irinotecan or selinexor History of allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine, oxaliplatin, fluorouracil (-FU), docetaxel, or irinotecan A history of allergic reactions attributed to compounds of similar chemical or biologic composition to pemetrexed (pemetrexed disodium), -FU (fluorouracil), leucovorin (leucovorin calcium) or oxaliplatin, or other agents used for premedication in the study