Primary brain tumors or clinical evidence of active brain metastasis Untreated or uncontrolled brain metastasis. Cytologic or unequivocal radiographic confirmation of leptomeningeal metastasis by dural puncture and/or neuroimaging with or without known brain metastasis Have brain metastasis without prior radiotherapy. Primary brain tumor or active brain metastasis Active or previous brain metastasis Known osteoblastic bony metastasis Subjects with brain metastasis Presence of untreated brain metastasis Patients who have a single, operable brain metastasis No history of intracranial brain metastasis Bulky intracranial metastatic disease with shift of midline structures or progressive brain metastasis such that ongoing therapy for these brain metastasis is required at the time of enrollment. A subject with prior brain metastasis may be considered if they have completed their treatment for brain metastasis at least weeks prior to study registration, have been off of corticosteroids for >= weeks, and are asymptomatic Known brain metastasis History of uncontrolled brain metastasis unless: Patients with known or suspected brain metastasis Patient with brain metastasis must have had treatment of their brain metastasis completed at least day prior to enrollment and be on stable dose of steroids or off steroids at the time of enrollment Untreated brain metastasis(es) that may be considered active Subjects with known or suspected brain metastasis, or brain as the only site of disease are excluded with the following exceptions Active/untreated brain metastasis; whole brain radiation or gamma knife radiosurgery performed less than weeks prior to first administration of study drug; previously treated brain metastasis allowed as long as not requiring steroids and stable on imaging at least weeks after completing radiation therapy Active/untreated brain metastasis: whole brain radiation or gamma knife radiosurgery performed less than weeks prior to first administration of study drug; previously treated brain metastasis allowed as long as not requiring steroids and stable on imaging at least weeks after completing radiation therapy Patients with untreated brain metastasis are excluded; patients with a prior history of brain metastasis are eligible if they have received prior brain radiation, have improved or stable intracranial disease for at least months after completion of last course of radiation, and are not taking corticosteroids for treatment of brain metastasis; patients with a prior history of brain metastases who meet other eligibility criteria Known parenchymal brain metastasis Known parenchymal brain metastasis MRI scan consistent with brain metastasis as per radiology report Untreated brain metastasis that may be considered active Newly dignosed or active brain metastasis Have extrahepatic metastasis. Patients have known active brain metastasis Patients with documented central nervous system or leptomeningeal metastasis (brain metastasis) at the time of study entry; patients with prior brain metastasis may be considered if they have completed their treatment for brain metastasis, no longer require corticosteroids, and are asymptomatic Known brain metastasis Known bone metastasis Have a history of brain metastasis Known untreated brain metastasis or brain metastasis treated within months prior to enrollment in this trial Patients with brain metastasis A subject with prior brain metastasis may be considered if they have completed their treatment for brain metastasis at least weeks prior to study registration, have been off of corticosteroids for >= weeks, and are asymptomatic. One brain metastasis or brain metastasis resection cavity with maximal diameter >= cm (or >= cc) and =< cm (or =< cc) Hepatic metastasis permissible; appropriate candidates with metastasis to liver may be considered for ablative hypofractionation using SBRT Subjects with brain metastasis Untreated brain metastasis Patients with known brain metastasis Patients with documented central nervous system or leptomeningeal metastasis (brain metastasis) at the time of study entry; patients with prior brain metastasis may be considered if they have completed their treatment for brain metastasis and no longer require corticosteroids No brain metastasis, history of seizures, encephalitis, or multiple sclerosis Patients with brain metastasis have no signs of progressive disease months after the completion of brain metastasis treatment (radiation therapy, surgery, etc.) do not require anticonvulsants or corticosteroids, and have been off such drugs for at least days Known brain metastasis MRI detected active brain metastasis witch require other therapies such as surgery and/or radiation therapy. Patients already treated for their brain metastasis, surgery or radiation therapy, and have had stable disease for more than two month and NOT requiring steroids may however be included in this study. Known active brain metastasis unless they have been treated and shown documented radiographic stability for days Known or suspected brain metastasis Presence of central nervous system metastasis (including active brain metastasis); active brain metastasis would be defined as untreated brain metastases; if the brain metastases have received prior treatment (usually either with surgery or radiation), they are no longer active Patients with brain metastasis Patients have known active brain metastasis Known osteoblastic bony metastasis. Known brain metastasis Documented extracranial metastasis History of or known brain metastasis. Known brain metastasis The patient has a primary brain tumor(s) or brain metastasis (unless metastasis is treated and stable for > days). In patients who are symptomatic, a brain scan is required to exclude metastasis. Known brain metastasis Known brain metastasis Known brain metastasis Known CNS disease, except for treated brain metastasis Participants may have brain metastasis Patients with measurable brain metastasis outside a -mm margin around either hippocampus Known brain metastasis Brain metastasis unless treated and neurologically stable Symptomatic brain metastasis or asymptomatic brain metastasis that are cm or greater in size; patients with asymptomatic sub-centimeter brain metastasis are eligible Patients with more than a single brain metastasis ( > cm) Known brain metastasis. Patients may have a history of brain metastasis provided certain protocol criteria are met Known brain metastasis Participant with a brain metastasis with symptoms or requiring treatment. Brain metastasis Known parenchymal brain metastasis Patients with known brain metastasis Brain metastasis are excluded unless Known brain metastasis Known or suspected brain metastasis; Known brain metastasis Subjects with known or suspected brain metastasis unless previously treated and without evidence of progression Pulmonary or brain metastasis, liver metastasis is allowed if LFTs are not elevated Presence of clinically apparent or suspected brain metastasis. Known brain metastasis or visceral organ metastasis Documented cerebral metastasis Patients will be excluded if they have brain metastasis Brain metastasis Subjects with a history of brain metastasis. Known brain metastasis Subjects with radiographically suspected, histologically or cytologically confirmed primary brain tumors or brain metastasis are eligible Known brain metastasis Patients with brain metastasis that have been treated, asymptomatic and off any steroid use are permitted for study Have a history of brain metastasis provided that all of the following criteria are met: