Women of childbearing potential and men must use adequate contraception prior to study entry and for the duration of study participation; contraception should continue to be used for a minimum of mean half-lives after the last dose of study drugs (mean trastuzumab half-life at mg/kg days; mean half-life ruxolitinib: hours) Monoclonal antibody treatment and agents with known prolonged half-lives: At least three half-lives must have elapsed prior to enrollment.\r\n* Note: a list of the half-lives of commonly used monoclonal antibodies is available on the Pediatric Brain Tumor Consortium (PBTC) webpage under Generic Forms and Templates Less than days since last dose of anti CD therapy or less than half-lives since last dose of previous systemic therapy. Subjects must have been off any prior TKIs for at least half-lives of that drug, or any prior chemotherapy for at least weeks prior to study enrollment Clinical conditions requiring treatment with oral or parenteral anticoagulants or antiplatelet agents unless treatment can be discontinued days (or half-lives) prior to initiation of study treatment (except used as flushes for indwelling catheters) Oral targeted therapy within half-lives (if known) or weeks (if half-life is unknown) of study entry Any non-chemotherapy anti-cancer drug less than half-lives ( days for biologics) or less than days for small molecule therapeutics, or if half-life is not known. Received any anti-cancer drug known to have anti-VEGF/VEGFR activity within a period of half-lives of this drug (e.g. days for bevacizumab, days for ramucirumab) prior to the first scheduled dose of MM- Administration of any antineoplastic therapy within half-lives of the antineoplastic therapy before the first dose of ORH-, with the exception of hydroxyurea that should be discontinued day prior to the first dose of ORH- Must have appropriate wash out (> half-lives) of androgen receptor antagonists, alpha reductase inhibitors or ketoconazole prior to the start of cycle ; if the agent is not in the table below, the washout should be weeks\r\n* Bicalutamide; approximate half-life: days; washout period required: days\r\n* Flutamide; approximate half-life: hours; washout period required: hours\r\n* Nilutamide approximate half-life: days; washout period required: days\r\n* Finasteride; approximate half-life: hours; washout period required: hours\r\n* Aminoglutethimide; approximate half-life: hours; washout period required: days\r\n* Ketoconazole; approximate half-life: hours; washout period required: hours Patient has received other investigational drugs with days before enrollment (or must be > than four half-lives of the experimental agent); no prior SAR anti-CD antibody therapy allowed Non-cytotoxic therapy less than or equal to half-lives prior to registration Patient has received other investigational drugs within days prior to cycle , day ; exceptions allowed if greater than four half-lives of the experimental agent) Use of other investigational agents within days or half-lives prior to the first dose of study drug. As long as patient has recovered from any related toxicities ? Grade . Other cancer therapy including chemotherapy, small molecules, and antibodies within half-lives of the cancer therapy before first ZW dosing experimental agents within half-lives prior to enrollment, unless progression is documented on therapy Has received other investigational agents within weeks or half-lives of planned first dose of study agents At the time of treatment, patients should be off other anti-tumor agents for at least half-lives of the agent or weeks from the last day of treatment, whichever is shorter to enroll in group ; patients must not have been treated with anti-tumor agents to enroll in group or group ; patients must be off prior antibody therapy for at least half-lives before starting treatment; patients may enroll on study even while receiving treatment Receiving other investigational drugs or biologics within month or five half-lives. Cytotoxic or biologic are not permitted throughout the study. obinutuzumab (terminal half-life in NHL = . days); required washout = days ( weeks) Must have discontinued cancer treatments, including experimental agents for days or a minimum of half-lives (for any biologics) prior to the start of treatment. Enrollment after exposure levels of a biologic have fallen below an active level as established in the summary basis of approval is acceptable. No antibodies within half-lives prior to study enrollment (applicable to phase only) Treatment with any investigational drug within days or half-lives of day of treatment on this study. Concomitant receipt of the breast cancer resistance protein (BCRP) transporter-sensitive substrate rosuvastatin (unless the participant can be transferred to another medication at least half-lives prior to the start of study treatment) Patients must not have received any investigational agents within days of study entry unless they have exceeded terminal half-lives of the previous study drug used for treatment Any drug interactions that are deemed to be medically significant would require a washout of -half-lives of the interaction agent before enrollment can occur Treatment with an investigational drug within half-lives of the compound In the absence of rapidly progressive disease, the interval from prior treatment to the time of initiation of protocol therapy will be at least days for prior anti-leukemic therapy, with the exception of hydrea, or at least half-lives for cytotoxic/noncytotoxic agents, whichever is shorter. The half-life for the therapy in question will be based on published pharmacokinetic literature (abstracts, manuscripts, investigator brochures, or drug-administration manuals) and will be documented in the protocol eligibility document. The toxicity from prior therapy should have resolved to grade =<, however alopecia and sensory neuropathy grade =< not constituting a safety risk based on investigators judgement is acceptable. Since the effect of most IO-agents, hypomethylating agents (HMA)-therapies, SMO-inhibitors may be delayed, use of hydroxyurea for patients with rapidly proliferative disease is allowed before the start of study therapy and will not require a washout. Patient must have received their last dose of the biologic agent >= days prior to study registration\r\n* For biologic agents that have a prolonged half-life, at least three half-lives must have elapsed prior to registration Experimental agents within half-lives prior to enrollment, unless progression is documented on therapy No antibodies within half-lives prior to study enrollment experimental agents within half-lives prior to enrollment, unless progression is documented on therapy Previous treatment with any radiopharmaceutical within a period corresponding to half-lives of the radionuclide used for labeling the respective radiopharmaceutical prior to the administration of study drug. Receiving any investigational agent currently or within days or half-lives of day of treatment on this study Receipt of any investigational agent within days or half-lives of starting BP Received previous chemotherapy, immunotherapy, radiotherapy or any other investigational therapy within days or half-lives for targeted therapies prior to this study entry. In the absence of rapidly progressing disease, the interval from prior treatment to time of initiation of IACS- administration will be at least weeks or half-lives (whichever is shorter) for cytotoxic/noncytotoxic agents and biological/immune therapies, including investigational agents; the half-life for the therapy in question will be based on published pharmacokinetic literature (abstracts, manuscripts, investigator brochures, or drug-administration manuals) and will be documented in the protocol eligibility document; the use of chemotherapeutic or anti-leukemic agents is not permitted during the study with the following exceptions: () intrathecal therapy for subjects with controlled CNS leukemia at the discretion of the principal investigator (PI) and with the agreement of the sponsor; () use of hydroxyurea for subjects with rapidly proliferative disease is allowed before the start of study therapy and for the first cycles on therapy; these medications will be recorded in the case-report form Treatment with an investigational drug within five half-lives of the compound Receipt of investigational agents within half-lives of last dose of investigational agent A minimum of half-lives of last dose of investigational agent must have elapsed prior to CD. Treatment with an investigational drug within five half-lives of the compound or any of its related material. In the absence of rapidly progressing disease, the interval from prior treatment to time of study drug administration should be ? weeks for cytotoxic agents or at least half-lives for noncytotoxic agents. Persistent clinically significant toxicities from prior chemotherapy or radiotherapy must not be greater than Grade . Chemotherapy or immunotherapy < half-lives prior to screening. Has received any prior systemic therapy, excluding corticosteroids, within days (or half-lives) of treatment Receipt of investigational agents within half-lives of last dose of investigational agent In the absence of rapidly progressing disease, the interval from prior treatment to time of initiation of -azacytidine and nivolumab will be at least weeks OR at least half-lives for cytotoxic/noncytotoxic agents; the half-life for the therapy in question will be based on published pharmacokinetic literature (abstracts, manuscripts, investigator brochures, or drug-administration manuals) and will be documented in the protocol eligibility document; since the effect of both nivolumab and -azacytidine may be delayed; use of one dose of cytarabine (up to g/m) or hydroxyurea for patients with rapidly proliferative disease is allowed before the start of study therapy and during the study treatment; concurrent therapy for central nervous system (CNS) prophylaxis or continuation of therapy for controlled CNS disease is permitted The interval from prior treatment to time of study drug administration should be at least weeks for cytotoxic agents or at least half-lives for noncytotoxic agents; if the patient is on hydroxyurea to control peripheral blood leukemic cell counts, the patient must be off hydroxyurea for at least hours before initiation of treatment on this protocol; persistent clinically significant toxicities from prior therapy must not be greater than grade Patients receiving any other standard or investigational treatment for their hematologic malignancy within past weeks for cytotoxic agents or at least half-lives for noncytotoxic agents In the absence of rapid progressive disease, the interval from prior systemic anticancer treatment to time of TAK- administration should be at least weeks for cytotoxic agents (other than hydroxyurea), or at least half-lives for noncytotoxic agents, and participants have to have recovered from acute toxicities of these therapies. Participants who are on hydroxyurea may be included in the study and may continue on hydroxyurea for the first days while participating in this study. Systemic anti-cancer treatment (including investigational agents) <= days or <= *their half-lives before the first dose of study treatment. (For example, if the *the half-life is shorter than days, *half-life should be used as the washout period. However, a minimum of days should elapse from prior therapy to initiating protocol therapy.) Patients are eligible for enrollment if they have not had prior investigational or approved cytotoxic chemotherapy within days prior to the first dose (week , day ); days in the case of alkylating agents; days or half-lives (whichever is less; but not less than days) in case of investigational or approved molecularly targeted agent; days in the case of radiotherapy; any number of prior therapies is allowable The patient is less than half-lives from prior ALK inhibitor or targeted therapy (for adequate wash-out) without recovery from treatment toxicities to < grade or to their pre-treatment levels Patients on prior investigational agents must wait at least half-lives before enrollment into the trial, or weeks if the half-life of the investigational agent is not known. Patients may NOT concurrently be on biologic therapy such as etanercept, adalimumab, alefacept, infliximab, rituximab or rilonacept; if there is a history of use of biologic agents, there must be a washout period of at least half-lives prior to study initiation Receipt of systemic anti-lymphoma therapy within the following intervals prior to the therapeutic Y-ibritumomab tiuxetan dose:\r\n* < days for intravenously-administered cytotoxic chemotherapy and/or monoclonal antibodies\r\n* < half-lives for all other anti-cancer agents (e.g., targeted therapies, corticosteroids, immunomodulatory agents, etc.) Monoclonal antibody treatment and agents with known prolonged half-lives: at least three half-lives must have elapsed prior to enrollment Phototoxic or Photosensitizing Agents: Concomitant agents posing a clinically significant risk of photosensitivity reaction within half-lives of PV- administration. Investigational therapy administered < half-lives before the first dose of HTI- Any anticancer therapy administered < half-lives before first dose of HTI-; any prior immune-oncology products administered within weeks or half-lives before the first dose of HTI- as described above; or surgery or radiotherapy administered within weeks before the first dose of HTI-. Treatment with investigational therapy(ies) within half-lives of the investigational therapy prior to the first scheduled day of dosing with VT, or weeks if the half-life of the investigational agent is not known. Treatment with an investigational drug within five half-lives of the compound Chemo-, hormone- or immunotherapy, within weeks or within less than four half lives of the date of first administration of study drug and/or persistence of toxicities of prior anti-cancer therapies which are deemed to be clinically relevant Have received treatment with systemic immunomodulatory agents within days prior to administration of the first dose of CMB, or half-lives of the drug, whichever occurs sooner. Prior Treatment:\r\n* PARP inhibitor: Most oral PARP inhibitors (the immediate prior therapy) have a half-life for which half-lives is = days, treatment of olaparib and/or AZD should not begin for half-lives or at least days, whichever is shorter.\r\n* Any hormonal therapy directed at the malignant tumor must be discontinued at least one week prior to registration (study enrollment). Continuation of hormone replacement therapy is permitted.\r\n* Any other prior therapy directed at the malignant tumor, including immunologic agents, must be discontinued at least three weeks prior to first dose of study drug ( weeks for nitrosoureas or mitomycin C). Patients who have received any other investigational product within days of treatment are not eligible for this study; a wash out period ? days or half- lives (whichever is greater) is required from investigational treatment, prior to start of study treatment; please Note:\r\n* If patient is registered prior to completion of washout, start date of treatment will need to be confirmed prior to registration; please see assigned QAM with questions\r\n* The half-lives time period will be determined by investigational pharmacy\r\n* If half life is not known and cannot be predicted, then wash out of ? days is required In the absence of rapidly progressing disease, the interval from prior treatment to time of study drug administration should be at least weeks for cytotoxic agents, or at least half-lives for noncytotoxic agents; exceptions are ) hydroxyurea that requires no washout prior to the start of HuF, and ) up to doses of single-agent cytarabine (up to grams/m^) given for palliative purposes for which a washout of >= hours (hrs) is required Patients must have sufficiently recovered (=< grade ) from any toxicity of prior therapy; the required waiting period between the last dose of the most recent chemotherapy agent and the first dose of eribulin will be determined based on the half-life of the chemotherapy agent; the minimum time between stopping prior therapy and administering the first dose of eribulin should be . half-lives with the following exceptions: an interval of at least weeks must elapse since treatment with a nitrosourea and at least weeks since the last dose of bevacizumab Patients who have received radiation therapy to more than half of the pelvis or more than half of the spine within =< weeks prior to starting study treatment; or who have not yet recovered from side effects of such therapies Previous treatment with other HER targeted agents allowed; (previous treatment with HER inhibitors and investigational drugs to be discontinued prior to starting study treatment [at least days for trastuzumab and other antibodies; at least days for lapatinib; at least half-lives for other agents]) Discontinuation of prior AML treatment before the start of study treatment (except hydroxyurea or other treatment to control leukocytosis) for at least weeks for cytotoxic agents, or for at least half-lives for non cytotoxic agents. Treatment with any other investigational agent, device, or procedure, within days (or half-lives, whichever is greater) of enrollment. Subjects participating in a GVHD prophylaxis study or conditioning regimen should be discussed with the sponsor's medical monitor before enrollment. Systemic anti cancer therapy completed within a minimum of half lives of study entry. Use of any other experimental medication(s) within days or half-lives but in no case < days prior to the start of the study treatment on Cycle , Day . Treatment with investigational drug = half-lives before study enrollment; such cases will need to be discussed with the principal investigator Patient has had any treatment specific for tumor control within weeks of dosing with investigational drugs and cytotoxic agents, or within weeks of cytotoxic agent given weekly, or within weeks of nitrosoureas or mitomycin C, or within half-lives of biological targeted agents with half-lives and pharmacodynamic effects lasting less than days (that includes, but is not limited to, erlotinib, sorafenib, sunitinib, bortezomib, and other similar agents) Patients may not be receiving any other investigational agents within the past days; NOTE: if agents half-life x is < days, patient may have taken it within the last days, provided at least half-lives have passed since having last taken it Use of any investigational anti-cancer drug within days or -half-lives (minimum days), prior to start of study medication (Note: Dabrafenib monotherapy within days prior to starting combination therapy is allowed for crossover subjects in Cohort A); Patients must have been off previous chemotherapy or radiotherapy for the three weeks prior to entering this study; six weeks will be required if the patient has received therapy which is known to have delayed toxicity (mitomycin or a nitrosourea); five half-lives will be required for biologic/targeted therapies with short (< hour) half-lives and pharmacodynamic effects; patients may have received palliative radiation immediately before (or during) treatment provided radiation does not target the only measurable or evaluable disease Subject has received investigational therapy within days or half-lives prior to the first dose of study drug. Biological therapy within half-lives prior to CD The interval from prior treatment to time of initiation of FLX administration will be ? weeks for cytotoxic agents and ? half-lives for investigational/non-cytotoxic agents. For patients with rapidly proliferative disease, use of hydroxyurea is allowed if started prior to initiation of study therapy; Have an interval of ? weeks (or ? weeks for NMC participants) since chemotherapy (? weeks for nitrosoureas or mitomycin C), immunotherapy, hormone therapy or any other anticancer therapy or surgical intervention resection, or ? half-lives for monoclonal antibodies, or ? half-lives for other non-cytotoxic agents (whichever is longer) RECURRENT/ PROGRESSIVE DIPG (STRATUM ): Monoclonal antibody treatment and agents with known prolonged half-lives: at least three half-lives must have elapsed prior to enrollment\r\n* Note: A list of the half-lives of commonly used monoclonal antibodies is available on the Pediatric Brain Tumor Consortium (PBTC) webpage under Generic Forms and Templates No treatment with investigational agents within weeks prior to study drug administration, except patients receiving targeted therapies such as kinase inhibitors with half-lives < hours may be treated if > days have elapsed after the last dose and related toxicities have recovered to =< grade Received an investigational agent within weeks prior to enrollment, except patients receiving targeted therapies such as kinase inhibitors with half-lives < hours may be treated if > days have elapsed after the last dose and related toxicities have recovered to =< grade < half-lives for all other anticancer medications, or sponsor approval chemotherapy including molecular-targeting therapy within days (for molecular-targeted agents that are not associated with myelosuppression or immunosuppression, the minimum interval is half-lives if that is less than days) chemotherapy including molecular-targeting therapy within days prior to planned first dose of study drug (for molecular-targeted agents that are notis half-lives if that is less than days), Chemotherapy or other investigational therapy within five half-lives of a biologic agent with a minimum of days prior to the start of Cycle within weeks or half lives prior to the first dose of KTN in the case of anticancer therapy involving MAbs, or Subject's interval from prior treatment to time of study drug administration is at least weeks for cytotoxic agents (except hydroxyurea given for controlling blast cells), or at least half-lives for prior experimental agents or noncytotoxic agents. Have received investigational agents or systemic anticancer agents (other than neurotoxic compounds) within days of day of treatment, or days for those agents with unknown elimination half-lives, or known elimination half-lives greater than hours; or weeks for mitomycin C or for nitrosourea agents The interval from prior treatment to time of study drug administration should be at least half-lives for cytotoxic and noncytotoxic agents. Prior use of any MAb, radioimmunoconjugate, or antibody-drug conjugate (ADC) within weeks or half-lives before Cycle Day Use of targeted therapy within two half-lives of registration Participants previously treated with murine double minute (MDM) antagonist therapies or participants receiving interferon-alpha, anagrelide, or ruxolitinib within days or half-lives, or hydroxyurea within day, or participants receiving any other cytoreductive or investigational agents within days or half-lives of initial dose. Aspirin is permitted per treatment guidelines for PV unless medically contraindicated In the absence of rapidly progressing disease, the interval from prior treatment to time of study drug administration should be at least weeks for cytotoxic agents or at least half-lives for noncytotoxic agents. If a patient is on hydroxyurea to control peripheral blood leukemic cell counts, the patient must have discontinued hydroxyurea for at least hours before initiation of treatment with study drug. Persistent clinically significant toxicities from prior chemotherapy must not be greater than grade ? half-lives for non-cytotoxic therapy prior to CD. Patients must have a wash-out period from their last chemotherapy of either ? weeks OR at least half-lives prior to CD. For patients whose most recent anti-tumor treatment regimen consisted of a multi-agent cocktail, the patient must have a wash-out period of at least half-lives of the agent with the longest half-life. Any treatment specific for tumor control within weeks of study drugs; or within weeks if cytotoxic agents were given weekly (within weeks for nitrosoureas or mitomycin C), or within half-lives for targeted agents with half-lives and pharmacodynamic effects lasting less than days (that includes but is not limited to erlotinib, sorafenib, sunitinib, bortezomib, and other similar agents); palliative radiation immediately before or during the study is acceptable provided there is evaluable disease that has not been radiated Patients treated with chemotherapy or biologic therapy or other investigational agent < weeks prior to starting study drug for compounds with a half-life ? days, and < weeks prior to starting study drug for compounds with a prolonged half-life were excluded. Interval from prior treatment to time of study drug at least half-lives for cytotoxic/ noncytotoxic agents. Interval from prior treatment to time of study drug at least half-lives or wks, which ever is shorter, for noncytotoxic agents Interval from prior treatment to time of study drug at least half-lives or wks, which ever is shorter, for noncytotoxic agents. Patients must have been off previous chemotherapy or radiotherapy for the three weeks prior to entering this study; six weeks will be required if the patient has received therapy which is known to have delayed toxicity (mitomycin or a nitrosourea); five half-lives will be required for biologic/targeted therapies with short (< hour) half-lives and pharmacodynamic effects; patients may have received palliative radiation immediately before (or during) treatment provided radiation is not to the only target lesion available Patient who lives alone Administered a radioisotope ? physical half-lives prior to the date of study PET/CT Lives in Guam or Saipan Participants receiving any systemic chemotherapy, radiotherapy, or targeted anti-cancer therapy within weeks or half-lives from the last dose prior to study treatment (or a longer period depending on the half-life of the agents used); the patient can receive bisphosphonates or steroids Receipt of radioisotope within physical half-lives prior to trial enrollment Prior or planned administration of a radiopharmaceutical within half-lives of the radionuclide Administered a radioisotope within physical half-lives prior to study drug injection Administered a radioisotope =< physical half-lives prior to the day of PET/CT Administered a radioisotope within physical half-lives prior to study enrollment Before the administration of Lymphoseek, has received any radiopharmaceutical within radioactive half-lives of that radiopharmaceutical Patient must not have had any anti-neoplastic biologic agent =< days prior to entry onto this study (or at least half-lives for biologic agents with a long half-life) No chemotherapy treatments within at least weeks prior to first dose of study treatment. For all prior anticancer treatment, including radiotherapy or targeted agents or hormonal therapy, a duration of more than half-lives of the targeted/hormonal agents used must have elapsed, and any encountered toxicity must have resolved to levels meeting all the other eligibility criteria. The following time periods must have elapsed prior to start of study treatment, the following time periods must have elapsed:\r\n* half-lives from any investigational agent\r\n* weeks from cytotoxic therapy (except days for temozolomide and weeks from nitrosoureas)\r\n* weeks from antibodies\r\n* Prior treatment with other immune modulating agents within fewer than weeks prior to the first dose of avelumab\r\n** Examples of immune modulating agents include blockers of CTLA-, -BB (CD), OX-, therapeutic vaccines, or cytokine treatments\r\n* weeks (or half-lives, whichever is shorter) from other anti-tumor therapies Systemic anti-cancer therapy completed within a minimum of half-lives of study entry Before the administration of Lymphoseek, has received any radiopharmaceutical within radioactive half-lives of that radiopharmaceutical Administered a radioisotope within physical half lives prior to study enrollment Receipt of radioisotope within physical half lives prior to trial enrollment Administration of a radionuclide within physical half-lives prior to projected administration of I-A PSCA minibody Use of any other experimental medication(s) within days or half-lives, but in no case < days prior to the start of treatment on Cycle , Day , except if approved by the Sponsor.