The subject has a baseline corrected QT interval =< ms Patients with a prolonged corrected QT interval (QTc) interval (>= ms) Baseline corrected QT (QTc) < ms Baseline corrected QT (QTc) =< ms A baseline corrected QT interval of > ms; patients with left bundle branch block that is deemed not clinically significant may be enrolled with corrected QT > Congenital long QT syndrome or a corrected QTc interval ? ms at screening Clinically significant electrocardiogram (ECG) abnormality, including a marked baseline prolonged QT/QTc ([QT interval/corrected QT interval], e.g., a repeated demonstration of a QTc interval > ms) Clinically significant electrocardiogram (ECG) abnormality, including a marked baseline prolonged QT/ corrected QT (QTc) ([QT interval/corrected QT interval], eg, a repeated demonstration of a QTc interval > ms) Long QT or prolonged QTc (> ms) History of long QT syndrome or whose corrected QT(QTc) interval measured (Fridericia method) at screening is prolonged (> ms) Subject has QT interval corrected (QTc) > ms (both males and females) at Screening (repeat values may be obtained during the period between Screening and admission to the study site). Within two weeks prior to enrollment: Corrected QT (QTc) interval =< ms Subjects with a corrected QT (QTc) > ms (QTc > msec for subjects with a bundle branch block at baseline Patients with a corrected QT (QTc) > ms in the baseline electrocardiography (EKG) Subjects with a corrected QT (QTc) > ms (QTc > msec for subjects with a bundle branch block at baseline) Corrected QT (QTc) > ms at baseline (average of determinations at minute intervals) Baseline prolongation of the rate-corrected QT interval (QTc; example, repeated demonstration of QTc interval > millisecond [ms], or history of congenital long QT syndrome, or torsades de pointes). Corrected QT interval ([QTc] Fridericia) > ms Clinically active cardiac disease, including prolonged corrected QT (QTc) interval >= ms (i.e. >= grade ) Patients with baseline corrected QT (QTc) > ms or patients with symptomatic bradycardia Congenital QT syndrome, corrected QT (QTc) > ms Corrected QT (QTc) =< ms Corrected QT interval (QTc) > ms at baseline Corrected QT (QTc) interval =< ms by electrocardiogram (EKG) Prolongation of QT interval (QT)/corrected QT interval (QTc) (QTc interval > ms) using the Fridericia method of QTc analysis Patients with baseline corrected QT (QTc) > ms or patients who are taking medications that prolong the QTc interval at the time of screening The subject has a corrected QT interval (QTc) > ms at screening or has a history of long QT syndrome Baseline corrected QT interval (QTc) =< ms Averaged corrected QT interval (QTc) baseline in electrocardiography (ECG)s at least minutes apart of >= ms Corrected QT interval (QTc) greater than ms at baseline Subjects with heart-rate corrected QT (QTc) interval ? ms or other factors that increase the risk of QT prolongation or arrhythmic events. Congenital long QT syndrome or a corrected QT interval (QTc) ? ms at Screening (unless secondary to pacemaker or bundle branch block). Baseline corrected QT interval (QTc) < ms History of long QT syndrome or whose corrected QT interval (QTc) measured (Fridericia method) at screening is prolonged (> ms). Congenital long QT syndrome or a corrected QTc interval ? ms at the Screening visit. Corrected QT interval (QTc) > ms at baseline (average of determinations at minutes interval) Patients with a baseline electrocardiography (ECG) demonstrating a corrected QT (QTc) > ms History of long QT syndrome or whose corrected QT interval (QTc) measured (Fridericia method) at screening is prolonged (> ms). Individuals who screen fail due to this criterion are not eligible to be re-screened Baseline prolongation of the rate-corrected QT interval (QTc; example, repeated demonstration of QTc interval > millisecond [ms], or history of congenital, long-QT syndrome, or torsades de pointes). Clinically significant electrocardiogram (ECG) abnormality, including a marked baseline prolonged QT/corrected QT (QTc) ([QT interval/corrected QT interval], e.g., a repeated demonstration of a QTc interval > ms), a family or personal history of long or short QT syndrome, Brugada syndrome or known history of QTc prolongation, or torsade de pointes (TdP) Baseline screening corrected QT (QTc) < ms is eligible Corrected QT interval (QTc) =< ms within days before enrollment Patients will be required to have a baseline electrocardiogram (EKG) prior to the start of treatment; patients with a corrected QT (QTc) > millisecond (ms) are excluded from the study Baseline corrected QT interval (QTc) =< ms Subject has Long corrected QT interval (QTc) Syndrome at Screening. A baseline corrected QT interval of > ms Patients must have a corrected QT (QTc) interval < ms on baseline electrocardiogram (EKG) Patient must not have corrected QT (QTc) > ms within days before enrollment Patients with a baseline corrected QT interval (QTc) > ms The subject has a baseline corrected QT interval < within days before randomization For patients on mefloquine arm, a baseline electrocardiogram (EKG) without evidence of prolonged corrected QT (QTc) interval > ms or clinically significant arrhythmia must be obtained within days prior to registration Mean corrected QT (QTc) > ms at time of screening Baseline corrected QT interval (QTc) =< ms Corrected QT interval (QTc) < ms Corrected QT interval (QTc) greater than ms History of long QT syndrome or whose corrected QT interval (QTc) measured (Fridericia method) at screening is prolonged (> ms for males and females). Corrected QT (QTc) interval =< ms Corrected QT (QTc) interval =< ms Pre-treatment corrected QT (QTc) interval of greater than ms Corrected QT interval (QTc) < ms Clinically significant electrocardiogram (ECG) abnormality, including a marked Baseline prolonged QT interval/corrected QT interval ([QT/QTc], example, a repeated demonstration of a QTc interval > millisecond [ms]). The subject has a corrected QT interval (QTc) > ms at screening or has a history of long QT syndrome History of long QT syndrome or whose corrected QT interval (QTc) measured (Fridericia method) at screening is prolonged (> ms for males and > ms for females). Individuals who screen-fail due to this criterion are not eligible to be re-screened Corrected QT (QTc) interval =< ms Baseline corrected QT interval (QTc) > ms Correct QT (QTc) longer than ms Corrected QT (QTc) =< ms Corrected QT (QTc) interval =< ms Clinically significant electrocardiogram (ECG) abnormality, including a marked baseline prolonged QT/QTc ([QT interval/corrected QT interval], e.g., a repeated demonstration of a QTc interval > ms) EXCLUSION CRITERIA FOR CROSSOVER THERAPY: Clinically significant electrocardiogram (ECG) abnormality, including a marked baseline prolonged QT/QTc ([QT interval/corrected QT interval], e.g., a repeated demonstration of a QTc interval > ms) PATIENTS: History of prolonged corrected QT (QTc) interval (> ms) Patients with corrected QT (QTc) interval greater than ms Patients must not have baseline corrected QT (QTc) interval >= ms Patients with familial short QT syndrome or with corrected QT (QTc) interval =< ms Corrected QT interval (QTc) > ms per Fridericias correction Patients with corrected QT (QTc) interval > . seconds Corrected QT (QTc) (Fredericias formula) < ms Prolongation of corrected QT interval (QTc) to > ms as demonstrated by a repeated electrocardiogram (ECG) or a clinically significant ECG abnormality, including a marked prolonged QT/QTc interval (eg, a repeated demonstration of a QTc interval > ms). Congenital long QT syndrome or a corrected QTc interval of ? ms at the Screening visit.