Procurement: Patients with life expectancy >= months
>= weeks from protocol tissue procurement since treatment (surgery, chemo-, radiation-, hormone- therapy, check point blockade [e.g., anti-CTLA-, PD-, PDL-]); (windows are in relation to the date of the protocol tissue procurement)
PROCUREMENT: Patients with life expectancy >= weeks
PROCUREMENT: Patient able to give informed consent
PROCUREMENT: Patients with active human immunodeficiency virus (HIV) positive at time of procurement (can be pending at the time of blood draw)
INCLUSION CRITERIA FOR BLOOD PROCUREMENT:
EXCLUSION CRITERIA FOR BLOOD PROCUREMENT:
PROCUREMENT INCLUSION CRITERIA: Patients with life expectancy ? weeks
PROCUREMENT INCLUSION CRITERIA: Hemoglobin (Hgb) > . (transfusions allowed)
PROCUREMENT EXCLUSION CRITERIA: Patients with active human immunodeficiency virus (HIV) infection at time of procurement
INCLUSION - PROCUREMENT: Life expectancy greater than weeks
INCLUSION - PROCUREMENT: If pheresis required to collect blood:\r\n* Creatinine <. upper limit normal
INCLUSION - PROCUREMENT: EBV positive tumor (can be pending)
INCLUSION - PROCUREMENT: Weighs at least kg
INCLUSION - PROCUREMENT: Life expectancy of greater than weeks
PROCUREMENT INCLUSION: Diagnosis of relapsed/refractory HL or NHL
PROCUREMENT INCLUSION CRITERIA: Patients with life expectancy ? weeks
PROCUREMENT INCLUSION CRITERIA: Hemoglobin (Hgb) > . (transfusions allowed)
PROCUREMENT EXCLUSION CRITERIA: Patients diagnosed with primary central nervous system (CNS) tumors
PROCUREMENT EXCLUSION CRITERIA: Patients with active human immunodeficiency virus (HIV) infection at time of procurement (can be pending at the time of blood draw)
PROCUREMENT EXCLUSION CRITERIA: Patients in remission who are enrolled on another study where time to progression or disease free survival is a primary endpoint
PROCUREMENT CRITERIA
CELL PROCUREMENT: Life expectancy >= weeks
CELL PROCUREMENT: Bilirubin =< . x upper limit of normal (ULN), unless attributed to Gilberts syndrome, obtained within hrs prior to procurement
CELL PROCUREMENT: Aspartate aminotransferase (AST) =< . x ULN, obtained within hrs prior to procurement
CELL PROCUREMENT: Alanine aminotransferase (ALT) =< . x ULN, obtained within hrs prior to procurement
CELL PROCUREMENT: Subjects currently receiving maintenance doses of chemotherapy are eligible and the need for intrathecal prophylaxis prior to procurement is left to the discretion of the investigator; maintenance doses of chemotherapy are defined as methotrexate =< mg/m^/week, mercaptopurine =< mg/m^/day and vincristine =< mg/ days; corticosteroid-containing maintenance therapy is permitted only if corticosteroids are administered > days prior to procurement; (Note: corticosteroid use with doses at the discretion of the treating physician are allowed after procurement up to the beginning of lymphodepletion; corticosteroid use is contraindicated following iC-CAR infusion unless medically necessary e.g., to treat CRS)
CELL PROCUREMENT: Received anti-CD antibody-based therapy OR cytotoxic chemotherapy not described as maintenance therapy within weeks of procurement
PRIOR TO CELL PROCUREMENT: Negative serum pregnancy test in females within hours prior to procurement or documentation that the subject is post-menopausal or premenarchal
PRIOR TO CELL PROCUREMENT: Pregnant or lactating
AT THE TIME OF PROCUREMENT: Recurrent or refractory GBM
AT THE TIME OF PROCUREMENT: Subjects having a tumor resection
AT THE TIME OF PROCUREMENT: Karnofsky score of ?
PROCUREMENT: Karnofsky score ? %
PROCUREMENT: Diagnosis of myeloma after receiving at least one treatment regimen
PROCUREMENT: Patients with life expectancy ? weeks
PROCUREMENT: Patient able to give informed consent
PROCUREMENT: Patients with severe active infection
PROCUREMENT: Patients with active human immunodeficiency virus (HIV) infection at time of procurement (can be pending at the time of blood draw)
INCLUSION CRITERIA AT TIME OF PROCUREMENT:
EXCLUSION CRITERIA AT TIME OF PROCUREMENT:
PROCUREMENT INCLUSION CRITERIA:
PROCUREMENT EXCLUSION CRITERIA:
PROCUREMENT ELIGIBILITY:
PROCUREMENT ELIGIBILITY:
AT TIME OF PROCUREMENT:
AT TIME OF PROCUREMENT:
PROCUREMENT INCLUSION CRITERIA:
PROCUREMENT EXCLUSION CRITERIA:
AT THE TIME OF PROCUREMENT: EBV positive tumor
ELIGIBILITY FOR BLAST COLLECTION (PROCUREMENT)
Procurement consent signed and faxed to Research Coordinator