Willingness to provide biopsy samples for research purposes (patients >= years of age at the National Cancer Institute [NCI] Clinical Center only) Willingness to release archival tissue sample for research purposes, if available . Willingness to provide consent for biopsy samples; Willingness to provide mandatory blood samples for research purposes Willingness to provide blood and new tumor biopsy samples for research purposes if on the expansion phase of the study Willingness to provide blood and new tumor biopsy samples for research purposes if on the expansion phase of the study Willingness to provide blood and urine samples for research purposes Patient must be willing to provide mandatory tissue samples (unstained slides) for research purposes Be willing to provide blood and tissue samples for research purposes\r\n* Blood and tissue leftover from protocol specified analyses and those collected not specifically for protocol defined research require optional consent for retaining for unspecified research purposes Willingness to provide blood and biopsy samples for research purposes if on the expansion phase of the study The presence of disease that can be biopsied for research purposes is not an inclusion criterion Subjects must agree to allow use of any pre-treatment tissue remaining after definitive diagnosis is made (ie, archival and or fresh tissue) for research purposes; in addition, subjects must consent to allow use of their residual post-operative tissue for research purposes Consent for tumor biopsies (for patients enrolled in stage only) and blood draws for research purposes (for all patients) Consent for use of available archived tissue and tumor obtained during a standard procedure, for research purposes Has existing archived tissue and is willing to consent to providing sample for correlative research purposes Willing to provide consent for an additional tissue biopsy for research purposes, to allow a part of their surgical tumor tissue to be utilized for research (in case tumor tissue has not already been saved in the tumor tissue bank), and to donate samples of blood and saliva collected weekly through the treatment UROTHELIAL CARCINOMA EXPANSION COHORT: Willingness to release archival tissue sample for research purposes, if available Willing to provide mandatory tissue samples for research purposes Willing to provide mandatory tissue and blood samples for research purposes\r\n* NOTE: Patients must be willing to provide at the time surgical resection; for patients who do not undergo surgery, any on-study tumor biopsy obtained for clinical purposes subsequent to the baseline biopsy must also be available for analysis Consent for use of archived tissue for research purposes Willingness to provide consent for use of archived tissue for research purposes Ability to understand and the willingness to sign a written informed consent document, and willing to provide blood samples before and during preoperative therapy; patients are also asked but not required to have research biopsies performed before and after therapy Willingness to provide pre- and post-treatment tissue for translational studies. Pre-treatment fresh frozen tissue must be available for research purposes. This tissue can be collected from preoperative laparoscopy, other diagnostic biopsy, or a research-specific biopsy. Willingness to provide blood and tissue samples for correlative research purposes; (Note: these tissue samples are from archived tissue, if available; new biopsies are not required) Willing to provide blood and tissue (can be archival) samples for mandatory research purposes The participant is willing to provide blood, urine, and tissue samples for research purposes. Willing to provide tissue for research purposes Willing to provide tissue for translational research Are willing to provide blood/serum/plasma and tumor tissue samples for research purposes. Submission of blood/serum/plasma and tumor tissue samples is mandatory for participation in this study, unless restricted per local regulations. Consent for blood draws for research purposes Consent for use of available archived tissue for research purposes If patient has a clinically indicated surgery or biopsy at any time during treatment with Reolysin, a tissue sample will be collected for correlative research purposes Consent for tumor biopsies and blood draws for research purposes Consent for use of available archived tissue for research purposes Willingness to release and confirmed availability of archival tissue sample for research purposes Willing to provide tissue and blood samples for mandatory banking purposes Willing to provide tissue samples for research purposes Mayo Rochester patients only: willingness to provide mandatory blood samples for research purposes Willingness to provide blood samples for immune assessment and other tests Willingness to provide blood and tissue samples as required per protocol Willing to provide tissue for research purposes Patients must be willing to consent to tumor biopsy for research purposes Willingness to provide blood and tissue samples for research studies as required by the protocol Willingness to provide consent for biopsy samples Patients with multicentric or bilateral disease are eligible if the target lesions meet the other eligibility criteria; samples from all available tumors are requested for research purposes Available tissue for AR testing for research purposes Willing to provide blood samples for research purposes (Mayo Clinic sites only). Willing to undergo post-NAC, pre-treatment biopsy for research purposes only, and to allow surgical tissue sample from definitive surgery to be used for research purposes Be willing to provide blood and tissue samples for research purposes (blood and tissue leftover from protocol specified analyses and those collected not specifically for protocol defined research require optional consent for retaining for unspecified research purposes) Willingness to provide mandatory hour urine collection samples for research purposes Pre-treatment fresh frozen tissue available for research purposes; this tissue can be collected from preoperative laparoscopy, other diagnostic biopsy, or a research-specific biopsy Willingness to provide tissue and blood samples for mandatory translational research Willing to provide blood for research. Willingness to provide blood samples for research tests specified in the protocol Willingness to provide mandatory tissue for research purposes Willingness to provide tissue samples for research purposes Willingness to provide blood samples for toxicity monitoring and research purposes Willingness to provide blood and tissue specimens for research purposes Willing to allow use or collection of pathology tissue for the purposes of research from either clinical biopsy or surgical procedure (if adequate tissue is available) or research only biopsy Patients with multicentric disease are eligible. Samples from all available tumors are requested for research purposes Patients must be willing to provide mL of blood for research use Patient must be willing to provide consent for use of archived tissue for research DYNAMIC COHORT: Willing to consent to collection of pathology tissue for the purposes of research at the time of clinical biopsy or surgical procedure