Bilirubin =< . x upper limit of normal (ULN) Direct bilirubin =< x upper limit of normal (ULN) for age, and Bilirubin =< . upper limit of normal (ULN) Direct bilirubin =< x upper limit of normal (ULN), unless suspected leukemic involvement of the liver Bilirubin less than or equal to . x upper limit of normal (ULN) (CTCAE grade ) Bilirubin =< . upper limit of normal (ULN) Direct bilirubin < . x upper limit of normal (ULN) Obtained =< days prior to registration: Total Bilirubin =< . x upper limit of normal (ULN)\r\n* NOTE: For bilirubin elevation to . x ULN, alanine aminotransferase (ALT) above . x ULN (upper limit of normal) is not permitted\r\n* NOTE: For bilirubin elevation to . x ULN, aspartate aminotransferase (AST) above . x ULN (upper limit of normal) is not permitted Patients with bilirubin =< x upper limit of normal INCLUSION CRITERIA FOR THIRD-LINE THERAPY: Bilirubin =< . X the upper limit of normal Bilirubin =< . x upper limit of normal (ULN) Serum bilirubin =< . x upper limit of normal (ULN) Serum bilirubin < . x the upper limit of normal (ULN) or < x the ULN if secondary to liver metastasis TREATMENT: Bilirubin =< x upper limit of normal Bilirubin < . mg/dL, ALT < x upper limit of normal Serum bilirubin < x upper limit of normal (ULN) Patients with bilirubin ? x upper limit of normal INCLUSION - INFUSION: Patients with bilirubin ? x upper limit of normal Serum bilirubin =< x upper limit of normal (ULN) Bilirubin > . x the upper limit of normal Bilirubin ? X upper limit of normal Bilirubin ? x upper limit of normal ELIGIBILITY CRITERIA AT TIME OF TREATMENT: Patients with bilirubin ? x upper limit of normal Patients with bilirubin ? x upper limit of normal Serum bilirubin =< . x upper limit of normal (ULN) Bilirubin < . x upper limit of normal (ULN) Serum bilirubin > . x upper limit of normal (ULN) Bilirubin ? . x upper limit of normal Serum bilirubin =< . the upper limit of normal (ULN). Direct bilirubin =< x upper limit of normal (ULN) unless deemed to be related to underlying leukemia. Bilirubin < . X upper limit of normal (ULN) Bilirubin < . x upper limit of normal (ULN) Bilirubin < . x upper limit of normal Serum bilirubin =< . x upper limit of normal (ULN). Bilirubin < x upper limit of normal (ULN) Bilirubin =< . x upper limit of normal (ULN) Bilirubin =< . x upper limit of normal (ULN) Serum bilirubin =< . x upper limit of normal (ULN) Bilirubin > upper limit of normal (ULN) Serum bilirubin =< . x upper limit of normal (ULN) Bilirubin =< x upper limit of normal (ULN) Bilirubin < x upper limit of normal (ULN) and Bilirubin < . x the upper limit of normal (ULN) Serum bilirubin > upper limit of normal (ULN) Serum bilirubin =< . x upper limit of normal (ULN) (institutional upper limit of normal) Bilirubin < . x upper limit of normal (ULN) Bilirubin =< x upper limit of normal (ULN) Bilirubin =< . x upper limit of normal (ULN) Bilirubin > upper limit of normal (ULN) Serum bilirubin =< . x upper limit of normal (ULN) Serum bilirubin =< x upper limit of normal (ULN) Bilirubin =<. x upper limit of normal (ULN) TREATMENT: Bilirubin < upper limit of normal (ULN) TREATMENT: Patients with bilirubin ? x upper limit of normal Serum bilirubin =< x upper limit of normal (ULN) Serum bilirubin =< . x upper limit of normal (ULN) Bilirubin =< . x upper limit of normal (ULN) Serum bilirubin =< . x upper limit of normal (ULN) Serum direct bilirubin =< . x ULN (upper limit of normal) Serum bilirubin < x upper limit of normal (ULN) Conjugated (direct) bilirubin less than x upper limit of normal Bilirubin =< . x the upper limit of normal Bilirubin =< x upper limit of normal Bilirubin =< x upper limit of normal (ULN) Bilirubin < . x upper limit of normal (ULN) Bilirubin less than or equal to x upper limit of normal Bilirubin =< x upper limit of normal Hepatic (bilirubin < x upper limit of normal [ULN]) or Bilirubin =< . fold the upper limit of normal Serum bilirubin =< . x upper limit of normal (ULN) Direct bilirubin > x upper limit of normal Bilirubin =< x upper limit of normal Bilirubin < x upper limit of normal Bilirubin < . x upper limit of normal Hepatic-bilirubin > X upper limit of normal (ULN) Direct bilirubin ? x upper limit of normal (ULN) Bilirubin ? . x upper limit of normal (ULN) Bilirubin =< . x upper limit of normal Direct bilirubin =< . x upper limit of normal (ULN) for age, and Bilirubin < x upper limit of normal (ULN) Direct bilirubin < . x upper limit of normal (ULN) for age and institution Bilirubin < . x upper limit of normal (ULN) Bilirubin =< x upper limit of normal (ULN) Bilirubin =< . x upper limit of normal (ULN) Serum bilirubin =< . x upper limit of normal (ULN) Bilirubin < . x upper limit of normal (ULN) Bilirubin less than . x upper limit of normal (ULN) Bilirubin =< x upper limit of normal value Serum bilirubin >= . x upper limit of normal (ULN) Bilirubin =< x upper limit of normal Bilirubin < . x upper limit of normal (ULN) Serum bilirubin =< . x upper limit of normal (ULN) Direct bilirubin equal to or less than . x upper limit of normal (ULN) Bilirubin < or equal to . x upper limit of normal (ULN) Serum bilirubin =< . x upper limit of normal (ULN) Bilirubin < x upper limit of normal (ULN) Bilirubin < x the upper limit of normal Bilirubin =< . x upper limit of normal Bilirubin < . x the upper limit of normal (ULN) Bilirubin =< . x upper limit of normal (ULN), except for patients with documented history of Gilberts disease who may have direct bilirubin =< . x upper limit of normal (ULN) Direct bilirubin ? . x upper limit of normal (ULN) Bilirubin =< . x upper limit of normal (ULN) AT THE TIME OF INFUSION: Bilirubin ? x upper limit of normal Adequate hepatic function, with bilirubin < . x the upper limit of normal (ULN) Bilirubin < . x the upper limit of normal (ULN) Direct bilirubin within upper limit of normal (ULN) Serum bilirubin =< . x upper limit of normal (ULN) Bilirubin > . upper limit of normal (ULN) when it is clearly not related to GVHD Bilirubin =< . the upper limit of normal (ULN) for the institution Serum bilirubin =< . x upper limit of normal (ULN) Bilirubin < X upper limit of normal (ULN) Bilirubin =< . x the upper limit of normal (ULN) Serum bilirubin =< . x upper limit of normal (ULN) Bilirubin < . x the upper limit of normal (ULN) Bilirubin =< x upper limit of normal (ULN) Serum bilirubin < . x the upper limit of normal (ULN) Bilirubin =< x upper limit of normal (ULN) DONOR: Bilirubin =< . x upper limit of normal (ULN) Patients with bilirubin =< x upper limit of normal Serum bilirubin =< . x upper limit of normal (ULN) Bilirubin < . x upper limit of normal (ULN) Bilirubin less than or equal to . x upper limit of normal, CTCAE v . grade Bilirubin =< . x upper limit of normal (ULN) Direct bilirubin =< . x upper limit of normal (ULN) (unless considered due to leukemia involvement) Bilirubin =< . x upper limit of normal Bilirubin >= x upper limit of normal SELUMETINIB ARM: Serum bilirubin > . x upper limit of normal (ULN) Bilirubin < . x upper limit of normal (ULN) Bilirubin =< . x upper limit of normal (ULN) Bilirubin < x upper limit of normal Bilirubin > upper limit of normal (ULN) Conjugated bilirubin less than twice the upper limit of normal Bilirubin =< . x upper limit of normal (ULN) Bilirubin =< . x upper limit of normal (ULN) Serum bilirubin <=. x upper limit of normal (ULN) Bilirubin =< . x upper limit of normal (ULN) Bilirubin =< . x upper limit normal Bilirubin =< . x the upper limit of normal (ULN) Bilirubin =< . X upper limit of normal (ULN) serum bilirubin ?. X ULN (Upper Limit of Normal) Bilirubin ? . X upper limit of normal Bilirubin =< . upper limit of normal (ULN) Bilirubin =< . x upper limit of normal (ULN) Serum bilirubin must be within the upper limit of normal (ULN) Serum bilirubin =< . x upper limit of normal (ULN) Bilirubin =< . upper limit of normal (ULN) Serum bilirubin count < . x upper limit normal (ULN) Serum bilirubin =< . x upper limit of normal (ULN) Bilirubin =< . x upper limit of normal (ULN) Bilirubin =< . x upper limit of normal (ULN) Bilirubin =< x upper limit normal Bilirubin < x upper limit of normal Bilirubin < . x upper limit of normal (ULN) Bilirubin =< x upper limit of normal Direct bilirubin > x upper limit of normal (ULN) Bilirubin > . upper limit of normal (CTCAE grade ) Individuals with bilirubin > . x normal upper limit any time during the previous months Bilirubin > . x (upper limit of normal [ULN]) obtained < weeks prior to study enrollment Bilirubin > . x upper limit of normal (ULN) Bilirubin > . x upper limit of normal (ULN) Direct bilirubin ? . x upper limit of normal (ULN) bilirubin