PRIOR TO STUDY ENROLLMENT Major surgery within weeks of enrollment Major surgery within weeks of enrollment Major surgery within weeks prior to first dose, prior peripheral stem cell transplant within weeks of study enrollment Major surgery within weeks before enrollment Patients who have had major surgery within weeks prior to enrollment are not eligible; procedures such as placement of a central vascular catheter, or limited tumor biopsy, are not considered major surgery Incomplete recovery from major surgery within weeks of enrollment Subjects must not have received chemotherapy, or undergone major surgery within weeks and radiotherapy within hours prior to enrollment Patients who had undergone any major surgery within weeks of study enrollment Major surgery within weeks prior to enrollment (day ) Major surgery within weeks prior to enrollment Major surgery within weeks of enrollment No major surgery within weeks prior to enrollment Has had major surgery within weeks prior to enrollment Subjects must not have received chemotherapy, or undergone major surgery within weeks and radiotherapy within hours prior to enrollment Surgery within weeks prior to enrollment Patients who have had major surgery within weeks of enrollment in the study Major surgery within weeks prior to study enrollment. Patients who have undergone major surgery within weeks prior to study enrollment At least weeks since prior radiotherapy or stereotactic radiosurgery, and weeks since prior major surgery at time of study enrollment Has had major surgery within weeks prior to enrollment Major surgery or trauma within four weeks before enrollment. Have had any major surgery within four weeks of enrollment. Major surgery within weeks prior to enrollment Major surgery requiring the use of general anesthetic within weeks of study enrollment Patients that have undergone major surgery within the last weeks before enrollment; Major surgery within weeks of enrollment Major surgery within weeks of enrollment Major surgery within weeks prior to enrollment (day visit) Last surgery > weeks from enrollment Surgery less than two weeks before enrollment Patients must not have received chemotherapy, radiation therapy, or undergone major surgery within weeks prior to enrollment Patients who have undergone major surgery within weeks prior to study enrollment or who have not recovered from a major surgery COHORT A: Major surgery within weeks of enrollment (week visit) COHORT B: Major surgery within weeks of enrollment (week visit) Major surgery within weeks prior to study enrollment. No major surgery within weeks prior to enrollment Major surgery or radiation therapy within weeks of enrollment Major surgery within weeks prior to enrollment (day visit) Major surgery or radiation therapy within weeks of enrollment (day visit) Patients must not have received chemotherapy, radiation therapy, or undergone major surgery within weeks prior to enrollment No major surgery or radiation in the prior weeks prior to enrollment Major surgery within weeks of enrollment Major surgery within weeks prior to study enrollment Patients who have had major surgery within weeks prior to enrollment are not eligible; procedures such as placement of a central vascular catheter, or limited tumor biopsy, are not considered major surgery Prior major surgery or radiation therapy within weeks of enrollment; Patients who have had major surgery within weeks of enrollment Patients who have had major surgery within weeks prior to enrollment are not eligible; procedures such as placement of a central vascular catheter, or limited tumor biopsy, are not considered major surgery Major surgery within weeks of study enrollment No major surgery within weeks prior to signing of study enrollment No surgery in the last weeks prior to study enrollment A minimum of weeks from any major surgery prior to enrollment; coincident standard of care surgery with the research biopsy is permitted during the study