No history of arterial thrombotic events such as myocardial infarction (MI), unstable angina pectoris or any ischemic or hemorrhagic cerebrovascular accident (CVA) within past months . Subjects with any other concurrent, uncontrolled illness, including known psychiatric or substance abuse disorders which may interfere with the ability of the subject to cooperate and participate in the trial. Other examples of such conditions would include unstable angina, myocardial infarction (MI) or cerebrovascular accident (CVA) within months of study entry. Severe uncontrolled cardiac disease within months of study entry, including but not limited to uncontrolled hypertension; unstable angina; myocardial infarction (MI) or cerebrovascular accident (CVA). History of arterial thromboembolic event in past months (including cerebrovascular accident [CVA], myocardial infarction [MI]) Myocardial infarction or cerebrovascular accident (CVA) within months. History of cerebrovascular accident (CVA), myocardial infarction or unstable angina within the previous months before starting therapy. Patients with a history of New York Heart Association class or heart failure, or history of myocardial infarction, unstable angina, or cerebrovascular accident (CVA) within months of protocol registration No cerebrovascular accident (CVA) within months, no myocardial infarction (MI) within months Patients with a history of serious cardiac events defined as: New York Heart Association class or heart failure, or history of myocardial infarction, unstable angina or cerebrovascular accident (CVA) within months of protocol registration No cerebrovascular accident (CVA) within months, no recent myocardial infarction (MI) within months Patients with clinically significant cardiovascular disease: History of CVA (cerebrovascular accident) within months, myocardial infarction or unstable angina within months, unstable angina pectoris Patients with clinically significant cardiovascular disease: history of cerebrovascular accident (CVA) within months, myocardial infarction or unstable angina within months, or unstable angina pectoris History of cerebrovascular accident (CVA), myocardial infarction or unstable angina within the previous months before starting therapy Patients with clinically significant cardiovascular disease: history of cerebrovascular accident (CVA) within months, myocardial infarction or unstable angina within months, or unstable angina pectoris Patients with clinically significant cardiovascular disease: history of cerebrovascular accident (CVA) within months; myocardial infarction or unstable angina within months; unstable angina pectoris; New York Heart Association class > II Patients with clinically significant cardiovascular disease: history of cerebrovascular accident (CVA) within months, myocardial infarction or unstable angina within months, unstable angina pectoris, New York Heart Association class CHF score II Patients with history of acute myocardial infarction (MI) or cerebrovascular accident (CVA) within the last months Patients with evidence/history of cardiac disease including congestive heart failure, symptomatic arrhythmia not controlled by medication, unstable angina or cardiac disease, history of acute myocardial infarction (MI) or cerebrovascular accident (CVA) within the past six months Patients with history of serious cardiac events defined as: \r\n* Patients with a history of New York Heart Association class or heart failure, or history of myocardial infarction, unstable angina or cerebrovascular accident (CVA) within months of protocol registration \r\n* Patients who have history of PR prolongation (grade or higher) or atrioventricular (AV) block Myocardial infarction (MI); cerebrovascular accident (CVA); uncontrolled congestive heart failure (CHF); significant liver disease; or unstable angina within months prior to enrollment Myocardial infarction (MI); cerebrovascular accident (CVA); uncontrolled congestive heart failure (CHF); or unstable angina within months prior to enrollment Myocardial infarction (MI); cerebrovascular accident (CVA); uncontrolled congestive heart failure (CHF); significant liver disease; or unstable angina within months prior to enrollment Myocardial infarction (MI); cerebrovascular accident (CVA); uncontrolled congestive heart failure (CHF); or unstable angina within months prior to enrollment Had within months prior to enrollment: myocardial infarction (MI), cerebrovascular accident (CVA), uncontrolled congestive heart failure (CHF), significant liver disease, unstable angina Severe uncontrolled cardiac disease within months of study entry, including but not limited to uncontrolled hypertension; unstable angina; myocardial infarction (MI) or cerebrovascular accident (CVA). Severe or uncontrolled/unstable cardiac, pulmonary, hepatic or renal disease, including MI or CVA within months prior to treatment. Myocardial infarction (MI); cerebrovascular accident (CVA); uncontrolled congestive heart failure (CHF); significant liver disease; or unstable angina within months prior to enrollment