Patients baseline blood pressure must be adequately controlled with or without antihypertensive medications prior to enrollment (systolic <  mmHg, diastolic <  mmHg)

Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg) despite antihypertensive medication

Inadequately controlled hypertension (defined as systolic blood pressure ?  mmHg and/or diastolic blood pressure ?  mmHg) on more than one occasion in the month before planned day of infusion

Poorly-controlled hypertension as defined blood pressure (BP) > / mmHg, or systolic blood pressure (SBP) >  mmHg when diastolic blood pressure (DBP) <  mmHg, on at least  repeated determinations on separate days within  months prior to study enrollment

Systolic blood pressure >  mmHg or <  mmHg

Uncontrolled hypertension (diastolic blood pressure >  mmHg; systolic blood pressure >  mmHg)

Patients baseline blood pressure must be adequately controlled with or without antihypertensive medications prior to enrollment (systolic =<  mmHg, diastolic =<  mmHg)

Uncontrolled hypertension defined as persistent systolic blood pressure ?  mmHg or diastolic blood pressure ?  mmHg despite current therapy.

Uncontrolled hypertension (systolic blood pressure ?  mmHg or diastolic blood pressure ?  mmHg)

Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and /or diastolic blood pressure >  mmHg)

Subject has blood pressure controlled to <  mmHg systolic and <  mmHg diastolic at screening

Inadequately controlled hypertension (defined as systolic blood pressure >=  mmHg and /or diastolic blood pressure >=  mmHg) within  days of first study treatment

Uncontrolled high blood pressure (i.e. systolic blood pressure >  mmHg, diastolic blood pressure >  mmHg)

(Bevacizumab-related exclusion) Inadequately controlled hypertension (defined as systolic blood pressure > mmHg and/or diastolic blood pressure >  mmHg)

Inadequately controlled hypertension (defined as persistent systolic blood pressure (SBP) >  and/or diastolic blood pressure (DBP) >  mmHg)

Poorly controlled hypertension (defined as systolic blood pressure [SBP] of >  mmHg or diastolic blood pressure [DBP] of >  mmHg)

Systolic blood pressure (SBP) > mmHg or < mmHg at screening.

Uncontrolled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg)

Supine systolic blood pressure <  millimeter of mercury (mmHg), or symptomatic orthostatic hypotension, defined as a decrease in systolic blood pressure upon standing of >  mmHg despite medical management (eg, midodrine, fludrocortisones) in the absence of volume depletion

Systolic blood pressure (SBP) >  mmHg or <  mmHg at screening; if initial screening SBP is outside of the eligible range, blood pressure may be re-checked after intervention; SBP must be documented as stable and within the eligible range prior to starting study drug

As determined by the treating investigator, the patient must have well-controlled blood pressure, defined as systolic blood pressure <  mmHg and/or diastolic blood pressure <  mmHg for the majority of measurements

Subjects with acute PE categorized as high-risk or massive, or who are hemodynamically unstable, evidenced by a heart rate >  /min and a systolic blood pressure (SBP) of <  mmHg for more than  consecutive minutes or a drop in SBP of >  mmHg since presentation;

Patients with chronic hypertension that is well controlled with systolic blood pressure of <  mmHg or diastolic blood pressure of <  mmHg, and in whom there has been no change in blood pressure medication in the last two weeks, are eligible

Patients with uncontrolled hypertension (defined as sustained systolic blood pressure >  mmHg or diastolic blood pressure >  mmHg)

As determined by the treating investigator, the patient must have well-controlled blood pressure, defined as systolic blood pressure <  mmHg and/or diastolic blood pressure <  mmHg for the majority of measurements

Uncontrolled hypertension (defined as a sustained systolic pressure >=  mmHg and/or a diastolic pressure >=  mmHg

Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg); anti-hypertensive therapy to achieve these parameters is allowable

Patients with a cumulative lifetime history of anthracycline greater than  mg/m^ are eligible, after consultation with a cardiologist, if there are none of the following cardiac risk factors:\r\n*Diabetes mellitus\r\n*History of acute coronary syndrome\r\n*Hypertension; defined as a sustained systolic blood pressure greater than  mmHg and/or diastolic blood pressure greater than  mmHg OR use of an antihypertensive medication for the indication of hypertension

Uncontrolled hypertension, defined as: systolic blood pressure ?  mmHg and/or diastolic blood pressure ?  mmHg;

Patients must not have uncontrolled hypertension as defined by systolic blood pressure (SBP) >=  mmHg or diastolic blood pressure (DBP) >=  mmHg; patients whose blood pressure can be controlled medically are allowed to be rescreened once blood pressure (BP) is under control

Hypertension not controlled by medical therapy (systolic blood pressure greater than  millimeter of mercury [mmHg] or diastolic blood pressure greater than  mmHg)

PHASE I STUDY ELIGIBILITY CRITERIA:\r\nAdequately controlled blood pressure (systolic blood pressure [SBP] <  mmHg and diastolic blood pressure [DBP] <  mmHg) on a maximum of three antihypertensive medications

Subject currently exhibits symptomatic or persistent, uncontrolled hypertension defined as diastolic blood pressure >  mmHg or systolic blood pressure >  mmHg; subjects may be re-screened if blood pressure is shown to be controlled with or without intervention

History of uncontrolled hypertension, defined as blood pressure > / mmHg, or systolic blood pressure >  mmHg when diastolic blood pressure <  mmHg, on at least  repeated determinations on separate days within  months prior to study enrollment

Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg)

Systolic blood pressure greater than  mmHg or diastolic blood pressure greater than  mmHg

Inadequately controlled hypertension (blood pressure: systolic >  mmHg and/or diastolic >  mmHg)

Uncontrolled systemic vascular hypertension (systolic blood pressure >  mmHg, diastolic blood pressure >  mmHg on medication)

Uncontrolled hypertension as indicated by at least  consecutive measurements of a resting systolic blood pressure >  mmHg or diastolic blood pressure >  mmHg at the Screening Visit

Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg); to control hypertension, the addition or increase of standard of care antihypertensive regimen is allowed

Inadequately controlled hypertension (defined as systolic blood pressure >  and/or diastolic blood pressure >  mmHg); initiation of antihypertensive is permitted provided adequate control is documented over at least  week prior to day  of study drug

Supine systolic blood pressure <  mmHg or supine diastolic blood pressure <  mmHg at screening and baseline

Uncontrolled hypertension (untreated systolic blood pressure >  mmHg, or diastolic blood pressure >  mmHg)

A common skin contaminant cultured from  or more blood cultures drawn on the same or consecutive calendar days from a subject with fever (greater than . degrees C), chills, or hypotension (systolic blood pressure less than  mmHg);

Uncontrolled hypertension on anti-hypertensive medication (systolic blood pressure > mmHg or diastolic blood pressure > mmHg)

Blood pressure < / mmHg

Inadequately controlled hypertension (systolic blood pressure [SBP] > mmHg, diastolic blood pressure [DBP] > mg Hg)

Inadequately controlled hypertension (systolic blood pressure of >  mmHg or diastolic pressure >  mmHg on anti-hypertensive medications)

Patients with systolic blood pressure (SBP) >=  mmHg or diastolic blood pressure (DBP) >=  mmHg at the screening visit are ineligible; patients with an initial clinic blood pressure (BP) >= / mmHg may be included if SBP <  mmHg and DBP <  mmHg is confirmed in two subsequent BP measurements on the same day

Uncontrolled arterial hypertension defined as persistent elevation of systolic blood pressure >=  mmHg or diastolic blood pressure >=  mmHg despite medical treatment

Patients with hypertension on medical management must have systolic blood pressure <  mmHG or diastolic pressure <  mmHG at study entry

Uncontrolled hypertension (defined as a systolic pressure ?  mmHg and/or a diastolic pressure ?  mmHg).

Hypertension not controlled by medical therapy (systolic blood pressure [BP] greater than  millimeters of mercury [mmHg] or diastolic blood pressure great than  mmHg)

Inadequately controlled hypertension (defined as systolic blood pressure > mmHg and/or diastolic blood pressure >  mmHg)

Systolic blood pressure <  mmHg and/or diastolic blood pressure <  mmHg

Uncontrolled high blood pressure (i.e., systolic blood pressure >=  mmHg, diastolic blood pressure >=  mmHg)

Hemodynamic parameters:\r\n* Systolic blood pressure <  mmHg\r\n* Diastolic blood pressure <  mmHg

For patients receiving antihypertensive medication:systolic blood pressure <  mmHg\n             and/or diastolic blood pressure <  mmHg at screening.

Inadequately controlled hypertension (defined as systolic blood pressure >  and/or diastolic blood pressure >  mmHg on antihypertensive medications)

Uncontrolled hypertension with systolic blood pressure > mmHg

For Cohort C: Has hypotension (systolic blood pressure < millimeters of mercury [mmHg]) or uncontrolled hypertension (systolic blood pressure > mmHg or diastolic blood pressure > mmHg) at the screening visit

Poorly controlled hypertension (defined as systolic blood pressure [systolic blood pressure (SBP) of >=  mmHg or diastolic blood pressure (DBP)] of >=  mmHg)

Patient must have a systolic blood pressure =<  mmHg and diastolic blood pressure must be =<  mmHg, measured within  weeks prior to randomization; initiation or adjustment of anti-hypertensives prior to starting study treatment is allowed

Patients are ineligible if they have inadequately controlled hypertension (defined as systolic blood pressure >  and/or diastolic blood pressure >  mmHg on antihypertensive medications)

Uncontrolled blood pressure (systolic pressure greater than  mmHg or diastolic pressure greater than  mmHg on repeated measurements).

Subjects with a blood pressure of >/ mmHg.

Uncontrolled hypertension (defined as a systolic pressure ?  mmHg and/or a diastolic pressure ?  mmHg).

Systolic Blood Pressure (SBP) > or < mmHg

Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg); anti-hypertensive therapy to maintain a systolic blood pressure <  mmHg and/or diastolic blood pressure <  mmHg is permitted

Treatment refractory hypertension defined as a blood pressure of systolic > millimeter of mercury (mmHg) and/or diastolic > mmHg which cannot be controlled by antihypertensive therapy.

Uncontrolled arterial hypertension defined as persistent elevation of systolic blood pressure >=  mmHg or diastolic blood pressure >=  mmHg despite current therapy

Inadequately controlled hypertension (defined as average systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg)

Hypotension as indicated by systolic blood pressure <  mmHg on  consecutive measurements at the Screening visit.

Uncontrolled hypertension as indicated by systolic blood pressure >  mmHg or diastolic blood pressure >  mmHg on  consecutive measurements at the Screening visit.

Systolic blood pressure greater than  mmHg or less than  mmHg at screening

Uncontrolled hypertension (blood pressure > mmHg systolic and > mmHg diastolic).

Patients with uncontrolled hypotension (systolic blood pressure <  mmHg and/or diastolic blood pressure <  mmHg)

Patients with poorly controlled hypertension (systolic blood pressure of  mmHg or higher or diastolic blood pressure of  mmHg or higher) are ineligible; patients with a history of hypertension (HTN) and stable blood pressure (BP) < / on anti-HTN regimen are eligible

Inadequately controlled hypertension (i.e., systolic blood pressure > mmHg or diastolic blood pressure > mmHg) (patients with values above these levels must have their blood pressure controlled with medication prior to starting treatment).

Uncontrolled systemic vascular hypertension (systolic blood pressure >  mmHg, diastolic blood pressure >  mmHg on medication)

Significant active cardiovascular disease including:\r\n* Uncontrolled high blood pressure (i.e., systolic blood pressure >  mmHg, diastolic blood pressure >  mmHg)\r\n* Grade  or higher valvular disease\r\n* Grade  or higher atrial fibrillation\r\n* Grade  or higher bradycardia\r\n* Endocarditis\r\n* Pulmonary embolism\r\n* Recent cerebrovascular accident within  months prior to enrollment

Diastolic blood pressure above the % for age in children and >  mmHg systolic or >  mmHg diastolic in adults on at least  of  measurements with an appropriate-size cuff who are unable to achieve blood pressure control with optimal anti-hypertensive therapy; patients who are treated with antihypertensive medications with good response are eligible

Known impaired cardiac function or clinically significant cardiac disease such as ventricular arrhythmia requiring therapy, congestive heart failure and uncontrolled hypertension (defined as systolic blood pressure > mmHg and/or diastolic blood pressure >  mmHg on antihypertensive medications).

Subject has uncontrolled hypertension as indicated by a resting systolic blood pressure >  millimeter of mercury (mmHg) or diastolic blood pressure >  millimeter of mercury (mmHg) at Screening.

Patients must have controlled blood pressure with a systolic blood pressure <  mmHg and diastolic <  mmHg; anti-hypertensive medications are permitted

Blood pressure well controlled and must have systolic <  mmHg and diastolic <  mmHg

Systolic blood pressure > or < mmHg

Has existing uncontrolled arterial hypertension (systolic blood pressure [SBP] ? mmHg or diastolic blood pressure [DBP] ? mmHg) despite appropriate medical therapy

Patients with inadequately controlled hypertension (defined as systolic blood pressure >  and/or diastolic blood pressure >  mmHg) are not eligible for participation

Poorly controlled hypertension, defined as systolic blood pressure >=  mmHg or diastolic blood pressure of >=  mmHg

Generally well-controlled blood pressure with systolic blood pressure =<  mmHg AND diastolic blood pressure =<  mmHg prior to enrollment; the use of anti-hypertensive medications to control hypertension is permitted

Vital signs within the ranges: systolic blood pressure - mmHg , diastolic blood pressure - mmHg, pulse rate - bpm, oral body temperature .-.C.

Patients with poorly controlled hypertension (systolic blood pressure of  mmHg or higher or diastolic blood pressure of  mmHg or higher) are ineligible

History or evidence of cardiovascular risk (LVEF < LLN; QTcB >=  msec; blood pressure or systolic >= mmHg or diastolic >=  mmHg which cannot be controlled by anti-hypertensive therapy)

Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg)

Systolic blood pressure (SBP) >  mmHg; diastolic blood pressure (DBP) >=  mmHg

Patients baseline blood pressure must be adequately controlled with or without antihypertensive medications prior to enrollment (systolic <  mmHg, diastolic <  mmHg)

Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg)

Inadequately controlled hypertension (i.e. systolic blood pressure [SBP] >  mmHg or diastolic blood pressure [DBP] >  mmHg)

Uncontrolled systemic vascular hypertension (systolic blood pressure >  mmHg, diastolic blood pressure >  mmHg on medication)

Uncontrolled systemic vascular hypertension (systolic blood pressure >  mmHg, diastolic blood pressure >  mmHg on medication)

Controlled blood pressure (defined as systolic BP </=  mmHg and diastolic </=  mmHg)

Systolic blood pressure - mmHg

Seated systolic blood pressure  to  mmHg

Uncontrolled hypertension defined as systolic blood pressure ? mmHg and/or diastolic blood pressure ? mmHg confirmed upon repeated measures

Uncontrolled hypertension defined as systolic blood pressure ?  mmHg and/or diastolic blood pressure ?  mmHg confirmed upon repeated measures

Uncontrolled hypertension as indicated by at least  consecutive measurements of a resting systolic blood pressure >  mmHg or diastolic blood pressure >  mmHg at the screening visit.

Supine systolic blood pressure <  mmHg or diastolic blood pressure <  mmHg.

Patients must have blood pressure no greater than  mmHg (systolic blood pressure) and  mmHg (diastolic blood pressure) for eligibility; initiation or adjustment of antihypertensive medications is permitted prior to study entry provided that the average of three blood pressure measurements at enrollment visit is less than / mmHg

Blood pressure ? / mmHg.

Poorly controlled hypertension (defined as systolic blood pressure [SBP] of ?  mmHg or diastolic blood pressure [DBP] of ?  mmHg) on more than one occasion

Inadequately controlled hypertension (defined as systolic blood pressure > mmHg and/or diastolic blood pressure >  mmHg)

Hypotension at the time of screening (i.e., systolic blood pressure less than  mmHg. Diastolic blood pressure less than  mmHg)

Poorly controlled hypertension [defined as systolic blood pressure (SBP) of ?  mmHg or diastolic blood pressure (DBP) of ? mmHg].

Confirmed systolic blood pressure <  mmHg or diastolic blood pressure <  mmHg

Intraocular pressure >  mmHg as measured by tonometry

Subjects with uncontrolled hypertension (systolic blood pressure > mmHg or diastolic blood pressure > mmHg) are excluded. Subjects requiring  or more medications to control hypertension are eligible with Medical Monitor approval.

Uncontrolled high blood pressure (that is, systolic blood pressure > millimeter of mercury [mmHg], diastolic blood pressure > mmHg).

History of uncontrolled hypertension, defined as systolic blood pressure >  mmHg while simultaneous diastolic blood pressure >  mmHg, or systolic blood pressure >  mmHg when diastolic blood pressure <  mmHg, on at least  repeated determinations on separate days within  months prior to study enrollment

Uncontrolled hypertension: systolic blood pressure of >  mmHg or diastolic blood pressure of >  mmHg documented on  consecutive measurements taken at least  hours apart

Treatment refractory hypertension defined as systolic blood pressure > millimetres of mercury (mmHg) and/or diastolic blood pressure > mmHg which cannot be controlled by antihypertensive therapy

Uncontrolled hypertension as indicated by a resting systolic blood pressure > mmHg or diastolic blood pressure > mmHg

Have uncontrolled hypertension (systolic blood pressure greater than mmHg or diastolic blood pressure greater than mmHg); or history of congestive heart failure (equal to or greater than Grade ).

Poorly controlled hypertension (defined as systolic blood pressure of>= millimeter of mercury (mmHg) or diastolic blood pressure of > mmHg based on a mean of three measurements at approximately -minute intervals)

Grade  hypertension (systolic blood pressure [SBP] >=  mmHg and/or diastolic blood pressure [DBP] >=  mmHg despite maximal medical therapy)

Inadequately controlled hypertension (systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg despite antihypertensive medication)

Generally well-controlled blood pressure with systolic blood pressure =<  mmHg AND diastolic blood pressure =<  mmHg prior to enrollment; the use of antihypertensive medications to control hypertension is permitted

Inadequately controlled hypertension (systolic blood pressure of >  mmHg or diastolic pressure >  mmHg on anti-hypertensive medications)

Uncontrolled hypertension: systolic blood pressure >  mmHg or diastolic blood pressure > mmHg on  or more antihypertensive medications, documented on  consecutive measurements taken at least  hours apart.

Poorly controlled hypertension [defined as systolic blood pressure of > or =  mmHg or diastolic blood pressure of > or =  mmHg].

Systolic blood pressure < mmHg.

Uncontrolled hypertension, defined as systolic blood pressure >=  mmHg or a diastolic pressure >=  mmHg (the use of antihypertensive medications to achieve these goals is allowed)

Poorly controlled systemic vascular hypertension (systolic blood pressure >  mmHg, diastolic blood pressure >  mmHg)

Uncontrolled hypertension with systolic blood pressure > mmHg

Uncontrolled hypertension (defined as systolic blood pressure [SBP] of >=  mmHg or diastolic blood pressure [DBP] of >=  mmHg)

Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg); anti-hypertensive therapy to achieve these parameters is allowed

Systolic pressure >  mmHg or diastolic pressure >  mmHg at the time of study enrollment

Sitting systolic blood pressure >  mmHg

Systolic blood pressure ? mmHg or diastolic blood pressure ? mmHg;

Systolic pressure >  mmHg or diastolic pressure >  mmHg at the time of study enrollment

Systolic pressure >  mmHg or diastolic pressure >  mmHg at the time of study enrollment

Uncontrolled hypertension (systolic blood pressure >=  mmHg or diastolic blood pressure >=  mmHg)

Low resting systolic blood pressure: <  mmHg

Uncontrolled or poorly controlled hypertension, defined as systolic blood pressure >=  mmHg or diastolic blood pressure >=  mmHg, whether or not the subject is receiving anti-hypertensive treatment; subjects may be rescreened if the blood pressure is successfully and promptly controlled within  days using conventional anti-hypertensive therapy to achieve optimal blood pressure control (< / mmHg)

Patients who are hypotensive with a systolic blood pressure reading of <  mmHg at any time over the  days prior to study entry

Poorly controlled hypertension (systolic blood pressure >  mmHg or diastolic blood pressure >  mmHg), with or without antihypertensives

Have uncontrolled hypertension and resting blood pressure exceeding / mmHg

Blood pressure between  and  mmHg systolic, inclusive, and not higher than  mmHg diastolic.

Uncontrolled hypertension defined by a Systolic Blood Pressure (SBP) ?  mmHg and/or Diastolic Blood Pressure (DBP) ?  mmHg, with or without anti-hypertensive medication.

Intraocular pressure >  mmHg as measured by tonometry

Uncontrolled hypertension defined as systolic blood pressure ?  mmHg or diastolic blood pressure ?  mmHg, despite medical management