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+Patients baseline blood pressure must be adequately controlled with or without antihypertensive medications prior to enrollment (systolic <  mmHg, diastolic <  mmHg)
+Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg) despite antihypertensive medication
+Inadequately controlled hypertension (defined as systolic blood pressure ?  mmHg and/or diastolic blood pressure ?  mmHg) on more than one occasion in the month before planned day of infusion
+Poorly-controlled hypertension as defined blood pressure (BP) > / mmHg, or systolic blood pressure (SBP) >  mmHg when diastolic blood pressure (DBP) <  mmHg, on at least  repeated determinations on separate days within  months prior to study enrollment
+Systolic blood pressure >  mmHg or <  mmHg
+Uncontrolled hypertension (diastolic blood pressure >  mmHg; systolic blood pressure >  mmHg)
+Patients baseline blood pressure must be adequately controlled with or without antihypertensive medications prior to enrollment (systolic =<  mmHg, diastolic =<  mmHg)
+Uncontrolled hypertension defined as persistent systolic blood pressure ?  mmHg or diastolic blood pressure ?  mmHg despite current therapy.
+Uncontrolled hypertension (systolic blood pressure ?  mmHg or diastolic blood pressure ?  mmHg)
+Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and /or diastolic blood pressure >  mmHg)
+Subject has blood pressure controlled to <  mmHg systolic and <  mmHg diastolic at screening
+Inadequately controlled hypertension (defined as systolic blood pressure >=  mmHg and /or diastolic blood pressure >=  mmHg) within  days of first study treatment
+Uncontrolled high blood pressure (i.e. systolic blood pressure >  mmHg, diastolic blood pressure >  mmHg)
+(Bevacizumab-related exclusion) Inadequately controlled hypertension (defined as systolic blood pressure > mmHg and/or diastolic blood pressure >  mmHg)
+Inadequately controlled hypertension (defined as persistent systolic blood pressure (SBP) >  and/or diastolic blood pressure (DBP) >  mmHg)
+Poorly controlled hypertension (defined as systolic blood pressure [SBP] of >  mmHg or diastolic blood pressure [DBP] of >  mmHg)
+Systolic blood pressure (SBP) > mmHg or < mmHg at screening.
+Uncontrolled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg)
+Supine systolic blood pressure <  millimeter of mercury (mmHg), or symptomatic orthostatic hypotension, defined as a decrease in systolic blood pressure upon standing of >  mmHg despite medical management (eg, midodrine, fludrocortisones) in the absence of volume depletion
+Systolic blood pressure (SBP) >  mmHg or <  mmHg at screening; if initial screening SBP is outside of the eligible range, blood pressure may be re-checked after intervention; SBP must be documented as stable and within the eligible range prior to starting study drug
+As determined by the treating investigator, the patient must have well-controlled blood pressure, defined as systolic blood pressure <  mmHg and/or diastolic blood pressure <  mmHg for the majority of measurements
+Subjects with acute PE categorized as high-risk or massive, or who are hemodynamically unstable, evidenced by a heart rate >  /min and a systolic blood pressure (SBP) of <  mmHg for more than  consecutive minutes or a drop in SBP of >  mmHg since presentation;
+Patients with chronic hypertension that is well controlled with systolic blood pressure of <  mmHg or diastolic blood pressure of <  mmHg, and in whom there has been no change in blood pressure medication in the last two weeks, are eligible
+Patients with uncontrolled hypertension (defined as sustained systolic blood pressure >  mmHg or diastolic blood pressure >  mmHg)
+As determined by the treating investigator, the patient must have well-controlled blood pressure, defined as systolic blood pressure <  mmHg and/or diastolic blood pressure <  mmHg for the majority of measurements
+Uncontrolled hypertension (defined as a sustained systolic pressure >=  mmHg and/or a diastolic pressure >=  mmHg
+Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg); anti-hypertensive therapy to achieve these parameters is allowable
+Patients with a cumulative lifetime history of anthracycline greater than  mg/m^ are eligible, after consultation with a cardiologist, if there are none of the following cardiac risk factors:\r\n*Diabetes mellitus\r\n*History of acute coronary syndrome\r\n*Hypertension; defined as a sustained systolic blood pressure greater than  mmHg and/or diastolic blood pressure greater than  mmHg OR use of an antihypertensive medication for the indication of hypertension
+Uncontrolled hypertension, defined as: systolic blood pressure ?  mmHg and/or diastolic blood pressure ?  mmHg;
+Patients must not have uncontrolled hypertension as defined by systolic blood pressure (SBP) >=  mmHg or diastolic blood pressure (DBP) >=  mmHg; patients whose blood pressure can be controlled medically are allowed to be rescreened once blood pressure (BP) is under control
+Hypertension not controlled by medical therapy (systolic blood pressure greater than  millimeter of mercury [mmHg] or diastolic blood pressure greater than  mmHg)
+PHASE I STUDY ELIGIBILITY CRITERIA:\r\nAdequately controlled blood pressure (systolic blood pressure [SBP] <  mmHg and diastolic blood pressure [DBP] <  mmHg) on a maximum of three antihypertensive medications
+Subject currently exhibits symptomatic or persistent, uncontrolled hypertension defined as diastolic blood pressure >  mmHg or systolic blood pressure >  mmHg; subjects may be re-screened if blood pressure is shown to be controlled with or without intervention
+History of uncontrolled hypertension, defined as blood pressure > / mmHg, or systolic blood pressure >  mmHg when diastolic blood pressure <  mmHg, on at least  repeated determinations on separate days within  months prior to study enrollment
+Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg)
+Systolic blood pressure greater than  mmHg or diastolic blood pressure greater than  mmHg
+Inadequately controlled hypertension (blood pressure: systolic >  mmHg and/or diastolic >  mmHg)
+Uncontrolled systemic vascular hypertension (systolic blood pressure >  mmHg, diastolic blood pressure >  mmHg on medication)
+Uncontrolled hypertension as indicated by at least  consecutive measurements of a resting systolic blood pressure >  mmHg or diastolic blood pressure >  mmHg at the Screening Visit
+Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg); to control hypertension, the addition or increase of standard of care antihypertensive regimen is allowed
+Inadequately controlled hypertension (defined as systolic blood pressure >  and/or diastolic blood pressure >  mmHg); initiation of antihypertensive is permitted provided adequate control is documented over at least  week prior to day  of study drug
+Supine systolic blood pressure <  mmHg or supine diastolic blood pressure <  mmHg at screening and baseline
+Uncontrolled hypertension (untreated systolic blood pressure >  mmHg, or diastolic blood pressure >  mmHg)
+A common skin contaminant cultured from  or more blood cultures drawn on the same or consecutive calendar days from a subject with fever (greater than . degrees C), chills, or hypotension (systolic blood pressure less than  mmHg);
+Uncontrolled hypertension on anti-hypertensive medication (systolic blood pressure > mmHg or diastolic blood pressure > mmHg)
+Blood pressure < / mmHg
+Inadequately controlled hypertension (systolic blood pressure [SBP] > mmHg, diastolic blood pressure [DBP] > mg Hg)
+Inadequately controlled hypertension (systolic blood pressure of >  mmHg or diastolic pressure >  mmHg on anti-hypertensive medications)
+Patients with systolic blood pressure (SBP) >=  mmHg or diastolic blood pressure (DBP) >=  mmHg at the screening visit are ineligible; patients with an initial clinic blood pressure (BP) >= / mmHg may be included if SBP <  mmHg and DBP <  mmHg is confirmed in two subsequent BP measurements on the same day
+Uncontrolled arterial hypertension defined as persistent elevation of systolic blood pressure >=  mmHg or diastolic blood pressure >=  mmHg despite medical treatment
+Patients with hypertension on medical management must have systolic blood pressure <  mmHG or diastolic pressure <  mmHG at study entry
+Uncontrolled hypertension (defined as a systolic pressure ?  mmHg and/or a diastolic pressure ?  mmHg).
+Hypertension not controlled by medical therapy (systolic blood pressure [BP] greater than  millimeters of mercury [mmHg] or diastolic blood pressure great than  mmHg)
+Inadequately controlled hypertension (defined as systolic blood pressure > mmHg and/or diastolic blood pressure >  mmHg)
+Systolic blood pressure <  mmHg and/or diastolic blood pressure <  mmHg
+Uncontrolled high blood pressure (i.e., systolic blood pressure >=  mmHg, diastolic blood pressure >=  mmHg)
+Hemodynamic parameters:\r\n* Systolic blood pressure <  mmHg\r\n* Diastolic blood pressure <  mmHg
+For patients receiving antihypertensive medication:systolic blood pressure <  mmHg\n             and/or diastolic blood pressure <  mmHg at screening.
+Inadequately controlled hypertension (defined as systolic blood pressure >  and/or diastolic blood pressure >  mmHg on antihypertensive medications)
+Uncontrolled hypertension with systolic blood pressure > mmHg
+For Cohort C: Has hypotension (systolic blood pressure < millimeters of mercury [mmHg]) or uncontrolled hypertension (systolic blood pressure > mmHg or diastolic blood pressure > mmHg) at the screening visit
+Poorly controlled hypertension (defined as systolic blood pressure [systolic blood pressure (SBP) of >=  mmHg or diastolic blood pressure (DBP)] of >=  mmHg)
+Patient must have a systolic blood pressure =<  mmHg and diastolic blood pressure must be =<  mmHg, measured within  weeks prior to randomization; initiation or adjustment of anti-hypertensives prior to starting study treatment is allowed
+Patients are ineligible if they have inadequately controlled hypertension (defined as systolic blood pressure >  and/or diastolic blood pressure >  mmHg on antihypertensive medications)
+Uncontrolled blood pressure (systolic pressure greater than  mmHg or diastolic pressure greater than  mmHg on repeated measurements).
+Subjects with a blood pressure of >/ mmHg.
+Uncontrolled hypertension (defined as a systolic pressure ?  mmHg and/or a diastolic pressure ?  mmHg).
+Systolic Blood Pressure (SBP) > or < mmHg
+Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg); anti-hypertensive therapy to maintain a systolic blood pressure <  mmHg and/or diastolic blood pressure <  mmHg is permitted
+Treatment refractory hypertension defined as a blood pressure of systolic > millimeter of mercury (mmHg) and/or diastolic > mmHg which cannot be controlled by antihypertensive therapy.
+Uncontrolled arterial hypertension defined as persistent elevation of systolic blood pressure >=  mmHg or diastolic blood pressure >=  mmHg despite current therapy
+Inadequately controlled hypertension (defined as average systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg)
+Hypotension as indicated by systolic blood pressure <  mmHg on  consecutive measurements at the Screening visit.
+Uncontrolled hypertension as indicated by systolic blood pressure >  mmHg or diastolic blood pressure >  mmHg on  consecutive measurements at the Screening visit.
+Systolic blood pressure greater than  mmHg or less than  mmHg at screening
+Uncontrolled hypertension (blood pressure > mmHg systolic and > mmHg diastolic).
+Patients with uncontrolled hypotension (systolic blood pressure <  mmHg and/or diastolic blood pressure <  mmHg)
+Patients with poorly controlled hypertension (systolic blood pressure of  mmHg or higher or diastolic blood pressure of  mmHg or higher) are ineligible; patients with a history of hypertension (HTN) and stable blood pressure (BP) < / on anti-HTN regimen are eligible
+Inadequately controlled hypertension (i.e., systolic blood pressure > mmHg or diastolic blood pressure > mmHg) (patients with values above these levels must have their blood pressure controlled with medication prior to starting treatment).
+Uncontrolled systemic vascular hypertension (systolic blood pressure >  mmHg, diastolic blood pressure >  mmHg on medication)
+Significant active cardiovascular disease including:\r\n* Uncontrolled high blood pressure (i.e., systolic blood pressure >  mmHg, diastolic blood pressure >  mmHg)\r\n* Grade  or higher valvular disease\r\n* Grade  or higher atrial fibrillation\r\n* Grade  or higher bradycardia\r\n* Endocarditis\r\n* Pulmonary embolism\r\n* Recent cerebrovascular accident within  months prior to enrollment
+Diastolic blood pressure above the % for age in children and >  mmHg systolic or >  mmHg diastolic in adults on at least  of  measurements with an appropriate-size cuff who are unable to achieve blood pressure control with optimal anti-hypertensive therapy; patients who are treated with antihypertensive medications with good response are eligible
+Known impaired cardiac function or clinically significant cardiac disease such as ventricular arrhythmia requiring therapy, congestive heart failure and uncontrolled hypertension (defined as systolic blood pressure > mmHg and/or diastolic blood pressure >  mmHg on antihypertensive medications).
+Subject has uncontrolled hypertension as indicated by a resting systolic blood pressure >  millimeter of mercury (mmHg) or diastolic blood pressure >  millimeter of mercury (mmHg) at Screening.
+Patients must have controlled blood pressure with a systolic blood pressure <  mmHg and diastolic <  mmHg; anti-hypertensive medications are permitted
+Blood pressure well controlled and must have systolic <  mmHg and diastolic <  mmHg
+Systolic blood pressure > or < mmHg
+Has existing uncontrolled arterial hypertension (systolic blood pressure [SBP] ? mmHg or diastolic blood pressure [DBP] ? mmHg) despite appropriate medical therapy
+Patients with inadequately controlled hypertension (defined as systolic blood pressure >  and/or diastolic blood pressure >  mmHg) are not eligible for participation
+Poorly controlled hypertension, defined as systolic blood pressure >=  mmHg or diastolic blood pressure of >=  mmHg
+Generally well-controlled blood pressure with systolic blood pressure =<  mmHg AND diastolic blood pressure =<  mmHg prior to enrollment; the use of anti-hypertensive medications to control hypertension is permitted
+Vital signs within the ranges: systolic blood pressure - mmHg , diastolic blood pressure - mmHg, pulse rate - bpm, oral body temperature .-.C.
+Patients with poorly controlled hypertension (systolic blood pressure of  mmHg or higher or diastolic blood pressure of  mmHg or higher) are ineligible
+History or evidence of cardiovascular risk (LVEF < LLN; QTcB >=  msec; blood pressure or systolic >= mmHg or diastolic >=  mmHg which cannot be controlled by anti-hypertensive therapy)
+Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg)
+Systolic blood pressure (SBP) >  mmHg; diastolic blood pressure (DBP) >=  mmHg
+Patients baseline blood pressure must be adequately controlled with or without antihypertensive medications prior to enrollment (systolic <  mmHg, diastolic <  mmHg)
+Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg)
+Inadequately controlled hypertension (i.e. systolic blood pressure [SBP] >  mmHg or diastolic blood pressure [DBP] >  mmHg)
+Uncontrolled systemic vascular hypertension (systolic blood pressure >  mmHg, diastolic blood pressure >  mmHg on medication)
+Uncontrolled systemic vascular hypertension (systolic blood pressure >  mmHg, diastolic blood pressure >  mmHg on medication)
+Controlled blood pressure (defined as systolic BP </=  mmHg and diastolic </=  mmHg)
+Systolic blood pressure - mmHg
+Seated systolic blood pressure  to  mmHg
+Uncontrolled hypertension defined as systolic blood pressure ? mmHg and/or diastolic blood pressure ? mmHg confirmed upon repeated measures
+Uncontrolled hypertension defined as systolic blood pressure ?  mmHg and/or diastolic blood pressure ?  mmHg confirmed upon repeated measures
+Uncontrolled hypertension as indicated by at least  consecutive measurements of a resting systolic blood pressure >  mmHg or diastolic blood pressure >  mmHg at the screening visit.
+Supine systolic blood pressure <  mmHg or diastolic blood pressure <  mmHg.
+Patients must have blood pressure no greater than  mmHg (systolic blood pressure) and  mmHg (diastolic blood pressure) for eligibility; initiation or adjustment of antihypertensive medications is permitted prior to study entry provided that the average of three blood pressure measurements at enrollment visit is less than / mmHg
+Blood pressure ? / mmHg.
+Poorly controlled hypertension (defined as systolic blood pressure [SBP] of ?  mmHg or diastolic blood pressure [DBP] of ?  mmHg) on more than one occasion
+Inadequately controlled hypertension (defined as systolic blood pressure > mmHg and/or diastolic blood pressure >  mmHg)
+Hypotension at the time of screening (i.e., systolic blood pressure less than  mmHg. Diastolic blood pressure less than  mmHg)
+Poorly controlled hypertension [defined as systolic blood pressure (SBP) of ?  mmHg or diastolic blood pressure (DBP) of ? mmHg].
+Confirmed systolic blood pressure <  mmHg or diastolic blood pressure <  mmHg
+Intraocular pressure >  mmHg as measured by tonometry
+Subjects with uncontrolled hypertension (systolic blood pressure > mmHg or diastolic blood pressure > mmHg) are excluded. Subjects requiring  or more medications to control hypertension are eligible with Medical Monitor approval.
+Uncontrolled high blood pressure (that is, systolic blood pressure > millimeter of mercury [mmHg], diastolic blood pressure > mmHg).
+History of uncontrolled hypertension, defined as systolic blood pressure >  mmHg while simultaneous diastolic blood pressure >  mmHg, or systolic blood pressure >  mmHg when diastolic blood pressure <  mmHg, on at least  repeated determinations on separate days within  months prior to study enrollment
+Uncontrolled hypertension: systolic blood pressure of >  mmHg or diastolic blood pressure of >  mmHg documented on  consecutive measurements taken at least  hours apart
+Treatment refractory hypertension defined as systolic blood pressure > millimetres of mercury (mmHg) and/or diastolic blood pressure > mmHg which cannot be controlled by antihypertensive therapy
+Uncontrolled hypertension as indicated by a resting systolic blood pressure > mmHg or diastolic blood pressure > mmHg
+Have uncontrolled hypertension (systolic blood pressure greater than mmHg or diastolic blood pressure greater than mmHg); or history of congestive heart failure (equal to or greater than Grade ).
+Poorly controlled hypertension (defined as systolic blood pressure of>= millimeter of mercury (mmHg) or diastolic blood pressure of > mmHg based on a mean of three measurements at approximately -minute intervals)
+Grade  hypertension (systolic blood pressure [SBP] >=  mmHg and/or diastolic blood pressure [DBP] >=  mmHg despite maximal medical therapy)
+Inadequately controlled hypertension (systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg despite antihypertensive medication)
+Generally well-controlled blood pressure with systolic blood pressure =<  mmHg AND diastolic blood pressure =<  mmHg prior to enrollment; the use of antihypertensive medications to control hypertension is permitted
+Inadequately controlled hypertension (systolic blood pressure of >  mmHg or diastolic pressure >  mmHg on anti-hypertensive medications)
+Uncontrolled hypertension: systolic blood pressure >  mmHg or diastolic blood pressure > mmHg on  or more antihypertensive medications, documented on  consecutive measurements taken at least  hours apart.
+Poorly controlled hypertension [defined as systolic blood pressure of > or =  mmHg or diastolic blood pressure of > or =  mmHg].
+Systolic blood pressure < mmHg.
+Uncontrolled hypertension, defined as systolic blood pressure >=  mmHg or a diastolic pressure >=  mmHg (the use of antihypertensive medications to achieve these goals is allowed)
+Poorly controlled systemic vascular hypertension (systolic blood pressure >  mmHg, diastolic blood pressure >  mmHg)
+Uncontrolled hypertension with systolic blood pressure > mmHg
+Uncontrolled hypertension (defined as systolic blood pressure [SBP] of >=  mmHg or diastolic blood pressure [DBP] of >=  mmHg)
+Inadequately controlled hypertension (defined as systolic blood pressure >  mmHg and/or diastolic blood pressure >  mmHg); anti-hypertensive therapy to achieve these parameters is allowed
+Systolic pressure >  mmHg or diastolic pressure >  mmHg at the time of study enrollment
+Sitting systolic blood pressure >  mmHg
+Systolic blood pressure ? mmHg or diastolic blood pressure ? mmHg;
+Systolic pressure >  mmHg or diastolic pressure >  mmHg at the time of study enrollment
+Systolic pressure >  mmHg or diastolic pressure >  mmHg at the time of study enrollment
+Uncontrolled hypertension (systolic blood pressure >=  mmHg or diastolic blood pressure >=  mmHg)
+Low resting systolic blood pressure: <  mmHg
+Uncontrolled or poorly controlled hypertension, defined as systolic blood pressure >=  mmHg or diastolic blood pressure >=  mmHg, whether or not the subject is receiving anti-hypertensive treatment; subjects may be rescreened if the blood pressure is successfully and promptly controlled within  days using conventional anti-hypertensive therapy to achieve optimal blood pressure control (< / mmHg)
+Patients who are hypotensive with a systolic blood pressure reading of <  mmHg at any time over the  days prior to study entry
+Poorly controlled hypertension (systolic blood pressure >  mmHg or diastolic blood pressure >  mmHg), with or without antihypertensives
+Have uncontrolled hypertension and resting blood pressure exceeding / mmHg
+Blood pressure between  and  mmHg systolic, inclusive, and not higher than  mmHg diastolic.
+Uncontrolled hypertension defined by a Systolic Blood Pressure (SBP) ?  mmHg and/or Diastolic Blood Pressure (DBP) ?  mmHg, with or without anti-hypertensive medication.
+Intraocular pressure >  mmHg as measured by tonometry
+Uncontrolled hypertension defined as systolic blood pressure ?  mmHg or diastolic blood pressure ?  mmHg, despite medical management