--- a +++ b/clusters/9knumclustersv2/clust_1507.txt @@ -0,0 +1,56 @@ +Histologically confirmed locally advanced gastric (primary endpoint includes proximal and mid-body stomach) or esophagogastric adenocarcinoma; distal gastric (antral) adenocarcinomas are eligible for enrollment but will not be included in the primary analysis +History of gastric or small bowel surgery involving any extent of gastric or small bowel resection. +Squamous cell or undifferentiated gastric cancer +Gastric carcinoma. +Gastric bypass +Symptomatic evidence of gastric outlet obstruction +Uncontrolled or active gastric or duodenal ulcer disease within days of enrollment +Active inflammatory gastrointestinal disease or previous gastric resection or lap band +Advanced Gastric Cancer +History of gastrointestinal mal-absorption or gastric bypass surgery +Have a history of gastric bypass surgery or severe malabsorption that may interfere with the absorption of the study agents +Metastatic or relapsed Gastric cancer (adenocarcinoma) (module ) +Presence of duodenal or gastric invasion by the tumor as noted by esophagogastroduodenoscopy (EGD) at time of fiducial placement +Evidence of gross duodenal invasion, gastric outlet obstruction +History of gastric or duodenal ulcers or untreated hyperacidity syndromes +Symptomatic evidence of gastric outlet obstruction +Subject has gastric outlet syndrome or persistent/recurrent vomiting. +Subject with recent gastric bleeding or symptomatic subjects with proven gastric ulcers that would exclude the subject from participation. +Must have operable gastric adenocarcinoma, T-Ta, N-N, M +History of gastric or small bowel surgery. +History of gastric or small bowel surgery involving any extent of gastric or small bowel resection. +Her- positive gastric tumor +No uncontrolled gastric ulcer disease (grade gastric ulcer disease) within days of registration +Subjects (NSCLC and gastric adenocarcinoma) must be determined to have HA-high levels from their tumor biopsies. +Gastric adenocarcinoma subjects with brain metastases +Squamous cell or undifferentiated gastric cancer +Phase expansion: Gastric Cancer +Gastric Cancer +Diagnosis of squamous or undifferentiated gastric cancer +Malabsorption, total gastric resection +Participant has active, high risk bleeding (such as, via gastric ulcers or gastric varices) within days prior to randomization +The participant has squamous cell or undifferentiated gastric cancer. +Squamous cell or undifferentiated gastric cancer +Active uncontrolled gastric or duodenal ulcer +Gastric or duodenal ulcer (at least mm in size) within mm of expected endoscopy puncture site(s) for photodynamic therapy (PDT) +Gastric cancer (including gastric and EGJ cancers): at least prior systemic regimens in adjuvant, advanced, or metastatic setting and, as appropriate, a human epidermal growth factor receptor (HER) targeted agent. +More than one prior line of therapy for advanced gastric cancer +For subjects with gastric cancer: +Prior gastric surgery, small bowel resection, or other conditions that may impede adequate absorption of oral study drug +Patients with clinical bleeding, active gastric, or duodenal ulcer +Impaired gastrointestinal (GI) function such as from significant small bowel resection or gastric bypass surgery or inability to swallow up to five ceritinib capsules daily +Patients who have a history of previous gastric or duodenal surgery +A history of gastric or duodenal ulcers or hyperacidity syndromes +Delayed gastric emptying syndrome +Patients must not have documented history of gastric/duodenal ulcer within the last months; participant must not currently be on treatment for gastric/duodenal ulcer or be experiencing symptoms at study entry; patients with gastroesophageal reflux disease (GERD) are eligible, however, and these patients may receive over-the-counter histamine- (H) antagonists; proton-pump inhibitors, or other prescription-based treatment for GERD +History of gastric ulcer within the past years (with or without bleeding) +Individuals with prior gastric bypass surgery or procedure that would impair absorption of nutrients +History of gastric surgery +Patients with a history of gastric bypass surgery +Individual with history of gastric bypass due to any reason +Gastric paresis +History of gastric ulcer within the past years (with or without bleeding) +Active inflammatory gastrointestinal disease or previous gastric resection or lap band +History of gastric bypass surgery, gastric banding, bowel resection, malabsorption syndromes such as celiac sprue or pancreatic insufficiency, or other conditions that may affect gastric absorption +Gastric bypass +History of gastric bypass surgery, gastric banding, bowel resection, malabsorption syndromes such as celiac sprue or pancreatic insufficiency, or other conditions that may affect the absorption of kava