Creatinine no greater than the institutional upper limits of normal Creatinine within . x the ULN institutional limits Creatinine within normal institutional limits Creatinine =< upper normal institutional limits PIKCA WILD TYPE COHORT (closed //): Creatinine =< upper normal institutional limits ENDOCRINE RESISTANT COHORT: Creatinine =< upper normal institutional limits Free T within institutional normal limits. Creatinine within normal institutional limits Serum creatinine within normal institutional limits OR Creatinine within normal institutional limits Creatinine within institutional normal limits Creatinine within normal institutional limits Creatinine within normal institutional limits OR Creatinine within . x normal institutional limits. Creatinine within . x upper limit of normal institutional limits Creatinine within . x normal institutional limits Serum creatinine within the institutional normal limits, OR if the creatinine is elevated Creatinine within normal institutional limits OR Serum creatinine =< . x normal institutional limits Creatinine within normal institutional limits, assessed within days prior to registration OR Creatinine within normal institutional limits OR according to institutional magnetic resonance imaging (MRI) policy PHASE II: Serum creatinine within normal institutional limits Creatinine within normal institutional limits Glucose within normal institutional limits Creatinine < . x institutional upper limits of normal (ULN) Creatinine within normal institutional limits OR according to Johns Hopkins MRI policy Creatinine within normal institutional limits OR Creatinine within normal institutional limits OR Creatinine within or below normal institutional limits Creatinine within normal institutional limits OR Creatinine within normal institutional limits Urinalysis within normal institutional limits Cardiac function within institutional normal limits on echocardiogram Creatinine within normal institutional limits OR Creatinine within normal institutional limits OR Creatinine within normal institutional limits OR Creatinine =< x institutional upper limits of normal Creatinine =< normal institutional limits OR Renal insufficiency: anything over institutional normal limits for creatinine that is also clinically documented Within days of registration: Creatinine within normal institutional limits OR Creatinine < x institutional limits Creatinine within . x the upper limit of normal (ULN) institutional limits Patients must have normal organ and marrow function as defined below: leukocytes ?,/mcL, absolute neutrophil count ?,/mcL, platelets ?,/mcL, total bilirubin within normal institutional limits, aspartate aminotransferase AST(SGOT)/ alanine aminotransferase ALT(SGPT) ?. X institutional upper limit of normal, creatinine within normal institutional limits OR creatinine clearance ? mL/min/. m^ for patients with creatinine levels above institutional normal. Creatinine within normal institutional limits OR creatinine within normal institutional limits OR Creatinine < . x institutional upper limits of normal Creatinine =< x normal institutional limits creatinine within normal institutional limits OR Cardiac function within institutional normal limits on echocardiogram Serum creatinine within normal institutional limits Creatinine up to . X normal institutional limits Creatinine within normal institutional limits OR Hemoglobin within institutional normal limits Platelet count within institutional normal limits Creatinine within normal institutional limits for age Creatinine =< institutional upper limits of normal (ULN) Platelets >= the lower institutional limits Creatinine =< the upper institutional limits Creatinine within normal institutional limits Creatinine within institutional limits of normal or judged to be not clinically significant by the investigator Creatinine within normal institutional limits Normal renal function (defined as creatinine within normal institutional limits) Known chronic kidney disease with creatinine greater than normal institutional limits Within days of eligibility confirmation: Creatinine not above the upper limit of normal institutional limits Platelets within normal institutional limits Creatinine =< the upper institutional limits Creatinine within institutional normal limits Creatinine within normal institutional limits Creatinine within normal institutional limits