--- a +++ b/clusters/9knumclustersv2/clust_1470.txt @@ -0,0 +1,57 @@ +Known interstitial lung disease, interstitial fibrosis, or history of tyrosine kinase inhibitor-induced pneumonitis +No known interstitial fibrosis or interstitial lung disease +History of interstitial lung disease (e.g., pneumonitis or pulmonary fibrosis) +Patients with previous history or active interstitial lung disease or pulmonary fibrosis, or a history of other clinically significant lung diseases +Known history or confirmation of active pneumonia, pneumonitis, symptomatic interstitial lung disease, or definitive evidence of interstitial lung disease described on CT scan, MRI, or chest x-ray in asymptomatic patients; dyspnea at rest requiring current continuous oxygen therapy. +Current or history of idiopathic pulmonary fibrosis, interstitial lung disease, or organizing pneumonia. +Subjects with interstitial lung disease (ILD) (including pneumonitis, bronchiolitis obliterans organizing pneumonia [BOOP], and pulmonary fibrosis). +Patients with blood oxygen saturation < % at rest; patients must not have symptomatic interstitial lung disease, pneumonitis, or known pulmonary fibrosis +History of extensive, disseminated, bilateral or presence of Grade or interstitial fibrosis or interstitial lung disease +Have evidence suggesting pulmonary fibrosis or interstitial pneumonia. +History of interstitial lung disease (eg, pneumonitis or pulmonary fibrosis) or evidence of interstitial lung disease on baseline chest computed tomography (CT) scan +Presence of cavitation of central pulmonary lesion, or radiographic evidence of pneumonitis or other extensive bilateral lung disease such as interstitial lung disease +History of interstitial pneumonitis or pulmonary fibrosis, or evidence of interstitial pneumonitis or pulmonary fibrosis on baseline chest CT scan +Has any history of interstitial lung disease (pulmonary fibrosis or severe radiation pneumonitis) or is suspected to have such disease by imaging during screening. +History of extensive, disseminated, bilateral or presence of grade or interstitial fibrosis or interstitial lung disease including pneumonitis, hypersensitivity pneumonitis, interstitial pneumonia, interstitial lung disease, obliterative bronchiolitis or pulmonary fibrosis; patients with history of prior radiation pneumonitis are not excluded +Participants with interstitial pneumonia or extensive and symptomatic fibrosis of the lungs +History of symptomatic idiopathic pulmonary fibrosis or interstitial lung disease +GROUP :\r\n* Limited cutaneous scleroderma and SSc-related pulmonary disease with FVC < % or hemoglobin-adjusted DLCO < % of predicted\r\n* AND evidence of alveolitis/interstitial lung disease by high-resolution chest CT scan and/or by BAL (interstitial lung disease may be nonspecific interstitial pneumonia [NSIP] or usual interstitial pneumonia [UIP]; A bronchoalveolar lavage [BAL] should be done to confirm the findings of alveolitis only if the high resolution CT scan [HRCT] fails to show findings typically associated with systemic sclerosis changes [ground glass, NSIP, UIP, SSc related interstitial lung disease])\r\n* Alveolitis by BAL cell count will be defined based on a BAL cell differential count (> % neutrophils and/or > % eosinophils) from any lavaged lobe +History of extensive interstitial lung disease, e.g., pneumonitis or pulmonary fibrosis or any evidence of extensive interstitial lung disease on baseline chest computed tomography (CT) scan +No interstitial pneumonia or extensive and symptomatic interstitial fibrosis of the lung +Interstitial pneumonia or interstitial fibrosis of the lung, which in the opinion of the site investigator could compromise the subject or the study +History of interstitial lung disease e.g. pneumonitis or pulmonary fibrosis, or any evidence of interstitial lung disease on baseline chest CT scan\r\n* For the NSCLC expanded cohort only: scarring from previous radiation therapy or pneumonia allowed +Known history of, or any evidence of interstitial lung disease, non-infectious pneumonitis, pulmonary fibrosis diagnosed based on imaging or clinical findings, or uncontrolled systemic diseases, including diabetes, hypertension, acute lung diseases, etc +Interstitial lung disease or pulmonary fibrosis +Known history of active pneumonia, pneumonitis, symptomatic interstitial lung disease, or definitive evidence of interstitial lung disease described on CT scan, MRI, or chest x-ray in asymptomatic patients; dyspnea at rest requiring current continuous oxygen therapy. +Idiopathic pulmonary fibrosis or other severe interstitial lung disease that requires oxygen therapy or is thought to require oxygen therapy within year prior to step registration +Patients with known interstitial fibrosis or interstitial lung disease are not eligible +Patients with known interstitial fibrosis or interstitial lung disease. +History of extensive, disseminated, bilateral or presence of Grade or interstitial fibrosis or interstitial lung disease including a history of pneumonitis, hypersensitivity pneumonitis, interstitial pneumonia, interstitial lung disease, obliterative bronchiolitis and pulmonary fibrosis. +History of interstitial lung disease (e.g. pneumonitis or pulmonary fibrosis) or evidence of interstitial lung disease on baseline chest CT scan +Known interstitial lung disease, interstitial fibrosis, or history of tyrosine kinase inhibitor-induced pneumonitis. +No symptomatic pulmonary fibrosis or interstitial pneumonitis >= grade +Symptomatic interstitial lung disease or definitive evidence of interstitial lung disease described on CT scan, MRI, or chest x-ray in asymptomatic patients; dyspnea at rest requiring current continuous oxygen. +Interstitial pneumonia or extensive and symptomatic interstitial fibrosis of the lung. +History of interstitial lung disease (e.g. pneumonitis or pulmonary fibrosis) or evidence of interstitial lung disease on baseline chest computed tomography (CT) scan +Patients must not have interstitial pneumonia or extensive symptomatic interstitial fibrosis of the lung +Presence of interstitial lung disease, pulmonary fibrosis, or pulmonary hypersensitivity reaction +Symptomatic interstitial lung disease or definitive evidence of interstitial lung disease described on CT scan, MRI, or chest x-ray in asymptomatic patients; dyspnea at rest requiring current continuous oxygen therapy. +History of interstitial lung disease e.g. pneumonitis or pulmonary fibrosis or evidence of interstitial lung disease on baseline chest computed tomography (CT) scan +Interstitial pneumonia or extensive and symptomatic interstitial fibrosis of the lung +History of interstitial lung disease e.g. pneumonitis or pulmonary fibrosis or evidence of interstitial lung disease on baseline chest computed tomography (CT) scan +History of extensive interstitial lung disease e.g. pneumonitis or pulmonary fibrosis or any evidence of extensive interstitial lung disease on baseline chest computed tomography (CT) scan +Has a history of pneumonitis or idiopathic pulmonary fibrosis, or evidence of interstitial lung disease. +History of extensive disseminated interstitial fibrosis or any grade of interstitial lung disease. +Patients with a prior diagnosis of interstitial lung disease or pulmonary fibrosis +History of interstitial lung disease e.g. pneumonitis or pulmonary fibrosis or evidence of interstitial lung disease on baseline chest computed tomography (CT) scan +Known preexisting interstitial lung disease, interstitial pulmonary fibrosis, or connective tissue disorder associated lung disease +History of or known presence of extensive, disseminated/bilateral or Grade or interstitial fibrosis or interstitial lung disease, including a history of pneumonitis, hypersensitivity pneumonitis, interstitial pneumonia, interstitial lung disease, obliterative bronchiolitis, or pulmonary fibrosis, but not including a history of prior radiation pneumonitis. Patients with clinically significant lung disease requiring oxygen therapy (eg, COPD). +History of interstitial lung disease e.g. pneumonitis or pulmonary fibrosis or evidence of interstitial lung disease on baseline chest computed tomography (CT) scan +Clinically significant lung disease (including pneumonitis, interstitial lung disease, idiopathic pulmonary fibrosis, cystic fibrosis, active infection/ history of opportunistic infections) +Patients with specific contraindications to the use of anti-EGFR therapy such as pulmonary fibrosis, interstitial pneumonia history +Patients with a documented history of interstitial lung disease or pulmonary fibrosis +Subjects with a history or evidence of interstitial pneumonitis or pulmonary fibrosis +Patients with a history or evidence of interstitial pneumonitis or pulmonary fibrosis +Has any history of interstitial lung disease (pulmonary fibrosis or severe radiation pneumonitis) or is suspected to have such disease by imaging during screening +History of extensive, disseminated, bilateral or presence of grade or interstitial fibrosis or interstitial lung disease including pneumonitis, hypersensitivity pneumonitis, interstitial pneumonia, interstitial lung disease, obliterative bronchiolitis and pulmonary fibrosis; patients with history of prior radiation pneumonitis are not excluded +History of extensive disseminated/bilateral or known presence of interstitial fibrosis or interstitial lung disease, including a history of pneumonitis, hypersensitivity pneumonitis, interstitial pneumonia, interstitial lung disease, obliterative bronchiolitis, and pulmonary fibrosis, but not history of prior radiation pneumonitis.