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+Subjects with other uncontrolled medical conditions, e.g. myocardial infarction, cerebrovascular accident, diabetes or hypertension.
+Patients with arterial thrombotic events, such as cerebrovascular accident or myocardial infarction, within  months of enrollment
+History of myocardial infarction or cerebrovascular accident within  months of enrollment date
+A history of events such as myocardial infarction, cerebrovascular accident or acute hepatitis within  months of randomization or treatment of a major active infection within one month of randomization, or any other significant event that in the opinion of the Investigator would preclude protocol therapy.
+Known history of cerebrovascular accident, myocardial infarction, or intracranial hemorrhage within  months of enrollment.
+History of cerebrovascular accident, myocardial infarction or unstable angina within the previous  months before starting therapy
+Clinically significant cardiomyopathy or cardiac complications, including recent myocardial infarction or cerebrovascular accident within one year, and/or unstable or uncontrolled angina
+Patients with a known history of myocardial infarction or cerebrovascular accident are not eligible
+Patients with a history of myocardial infarction, unstable angina, or cerebrovascular accident <  months prior to registration
+Myocardial infarction or cerebrovascular accident within  months prior to study registration
+History of documented myocardial infarction or cerebrovascular accident
+Subject has history of severe/unstable angina, myocardial infarction or cerebrovascular accident within  months prior to the planned first dose of study drug.
+Subject has history of severe/unstable angina, myocardial infarction or cerebrovascular accident within  months prior to the planned first dose of study drug.
+Subject has history of severe/unstable angina, myocardial infarction or cerebrovascular accident within  months prior to the first dose of study drug.
+History of myocardial infarction or cerebrovascular accident within  months of enrollment date.
+Subject has history of severe/unstable angina, myocardial infarction, or cerebrovascular accident within  months prior to the first dose of study drug.