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+History of proximal urethral stricture requiring dilatation.
+Esophageal stenosis/stricture preventing advancement of a therapeutic endoscope (patients may have the stenosis/stricture dilated and then be treated with CryoBalloon ablation under this protocol at a subsequent procedure ? weeks later)
+History of proximal urethral stricture requiring dilatation.
+History of proximal urethral stricture requiring dilatation
+History of urethral stricture disease;
+Patient has ever had confirmed extravesical urothelial disease (upper tract and urethral including prostatic urethral)
+History of proximal urethral stricture requiring dilatation
+A history of prior trans-urethral surgery requires cystoscopy for evaluation before study entry to rule out stricture
+History of urethral and bladder outlet disorders, including urethral stricture disease, urethral diverticulae, bladder neck contracture, urethral fistulae, urethral stenting, urethral sling, urethroplasty or chronic indwelling urethral catheter
+Urethral stricture/bladder neck contracture
+Urethral tumor (prostatic urethra included).
+Prior history of chronic prostatitis or urethral stricture
+history of urethral stent or urethral surgery (urethral dilation, urethroplasty); a Uroflow exam may be conducted at the investigators discretion;
+current bladder cancer, urethral stricture, or bladder neck contracture; a cystoscopy my be performed at the investigator's discretion to rule out these conditions;
+Patients who present for EGD with dilation for dysphagia symptoms thought secondary to either radiation-induced stricture or anastomotic stricture based on history
+Endoscopic finding of a stricture that is not caused by either radiation or anastomotic narrowing
+Prior history of urethral stricture
+Are unable to catheterize due to a urethral stricture disease,
+Known radiographic evidence of a Bismuth-Corlette type  biliary stricture.
+Have a known urethral stricture, colostomy, or inability to urinate requiring chronic urinary catheter; only men who are cleared by their physician to safely participate in a physical exercise program (including walking and lifting weights) will be eligible for this study
+Urethral stricture/bladder neck contracture
+Presence of a biliary stricture
+No stricture
+Significant esophageal stricture requiring dilatation.
+Patient with prior rectal surgery or anal stricture requiring surgical intervention prior to biopsy.
+History of colorectal surgery, or repeated endoscopic examinations/interventions related to anorectal diseases or proximal urethral stricture requiring dilatation