--- a +++ b/clusters/9knumclustersv2/clust_1370.txt @@ -0,0 +1,42 @@ +Patients with uncontrolled hypertension are ineligible; uncontrolled hypertension is defined as follows:\r\n* Patients aged =< years: greater than th percentile systolic and diastolic blood pressure based on age and height which is not controlled by one anti-hypertensive medication\r\n* Patients aged > years: systolic blood pressure >= mmHg and/or diastolic blood pressure >= mmHg that is not controlled by one anti-hypertensive medication +Patients who are currently receiving more than one anti-hypertensive medication (grade ) or whose blood pressure is not controlled are not eligible for study enrollment +Poorly controlled hypertension. During screening ?/ of readings must be < /, regardless of whether on a regimen of anti-hypertensive therapy or not. +Patients who are currently receiving more than one anti-hypertensive medication (Grade ) or whose blood pressure is not well controlled are not eligible for study enrollment. +Patients who are receiving anti-hypertensive medications for control of blood pressure at the time of enrollment are not eligible for this trial +Presence of any of the following conditions, which are risk factors for RVO: Uncontrolled glaucoma with intraocular pressure > millimetres of mercury (mm Hg); Serum cholesterol >/=Grade ; Hypertriglyceridemia >/=Grade ; Hyperglycemia (fasting) >/=Grade ; Grade >/= uncontrolled hypertension (participants with a history of hypertension controlled with anti-hypertensive medication to Grade </= are eligible) +Uncontrolled or ongoing/active infection; patients with the following history will also not be eligible for the trial: patients with a recent history of hemorrhage or hemoptysis; patients with dehiscence or wound healing complications requiring medical intervention; patients with severe hypertension that cannot be controlled (blood pressure of > systolic or > diastolic mmHg) with anti-hypertensive therapy within days of first dose of therapy +Patients will be excluded from study participation if they currently are known to have any of the following risk factors for RVO: a. Glaucoma with intraocular pressure >= mmHg b. Grade >= serum cholesterol c. Grade >= hypertriglyceridemia d. Grade >= or symptomatic hyperglycemia (fasting) e. Grade >= uncontrolled hypertension (patients with a history of hypertension controlled with anti-hypertensive medication to grade =< are eligible +Hypertension requiring or more anti-hypertensive medications to control +Have uncontrolled hypertension; subjects with a history of hypertension are permitted in the study provided their blood pressure is controlled by anti-hypertensive therapy +PHASE II COLORECTAL CANCER COHORT (MEDI+C ONLY):\r\nAdequately controlled blood pressure (SBP < mm Hg and DBP < mmHg) on a maximum of three anti-hypertensive medications +Patients must have controlled blood pressure with a systolic blood pressure < mmHg and diastolic < mmHg (for patients with an elevated initial blood pressure (BP) reading [hypertensive range], a repeat measurement at least minutes later should be performed, and the two readings should be averaged to obtain a BP reading); any hypertensive at-home blood pressure reading will be confirmed in clinic; patients on anti-hypertensive medications are eligible, if blood pressure is controlled; study drug dosing will be interrupted for any reading >= / +Inadequately controlled hypertension (defined as systolic blood pressure > mmHg and/or diastolic blood pressure > mmHg) despite antihypertensive medication, or prior history of hypertensive crisis or hypertensive encephalopathy +A requirement for a calcium channel blocker for blood pressure control that cannot be switched to an antihypertensive with an alternative mechanism of action; permitted anti-hypertensive medications include: chlorothiazide, hydrochlorothiazide, atenolol, nadolol, enalapril, lisinopril, eprosartan, and irbesartan +Patients who are receiving anti-hypertensive medications for control of blood pressure at the time of enrollment are not eligible for this trial +Hypertensive patients with uncontrolled blood pressure. +Uncontrolled symptomatic hypertension that cannot be controlled with anti-hypertensive agents +History of hypertension not well-controlled (>= /) even though on a regimen of anti-hypertensive therapy +Controlled blood pressure defined as a systolic blood pressure =< mmHg and diastolic blood pressure =< mmHg on no more than three anti-hypertensive agents; drug formulations containing two or more anti-hypertensive agents will be counted based on the number of active agents in each formulation +No patients with inadequately controlled hypertension (defined as a blood pressure of >= mmHg systolic and/or >= mmHg diastolic), or any prior history of hypertensive crisis or hypertensive encephalopathy +Controlled blood pressure (systolic blood pressure < and diastolic blood pressure < ) on no more than three anti-hypertensive agents; drug formulations containing two or more anti-hypertensive agents will be counted based on the number of active agents in each formulation +Patients with a history of hypertension should be well controlled (< / mmHg) on a regimen of anti-hypertensive therapy +Inadequately controlled hypertension (systolic blood pressure of > mmHg or diastolic pressure > mmHg on anti-hypertensive medications); Note: history of hypertensive crisis or hypertensive encephalopathy not allowed +Patients with a history of hypertension must be well-controlled (< /) on a regimen of anti-hypertensive therapy +Patients with inadequately controlled hypertension (defined as a blood pressure of > mmHg systolic and/or > mmHg diastolic on medication), or any prior history of hypertensive crisis or hypertensive encephalopathy +Uncontrolled hypertension (home blood pressure readings are permitted) or prior history of hypertensive crisis or hypertensive encephalopathy; however, treatment of hypertension with medications is permitted +Patients receiving anti-hypertensive medicines must be on a stable regimen for at least month +History of hypertensive or diabetic retinopathy +Patients who have persistently elevated systolic blood pressures (BPs) >= or diastolic BPs >= need to have their systolic or diastolic BP controlled with anti-hypertensive agents for at least days prior to the initiation of cell therapy; patients already on anti-hypertensive agents will have their medicine adjusted based on the clinical judgment of the patient care team +Patients with a history of hypertension must be well-controlled (< systolic/< diastolic) on a stable regimen of anti-hypertensive therapy +Recent initiation (within -months) of anti-hypertensive medication (individuals on stable therapy may be enrolled) +Hypertensive medication should be initiated or increased for optimal blood pressure control according to standard public health guidelines prior to starting the ketogenic diet +Hypertensive medication should be initiated or increased for optimal blood pressure control according to standard public health guidelines prior to starting the ketogenic diet +Inadequately controlled hypertension (defined as systolic blood pressure >= and/or diastolic blood pressure >= mmHg on antihypertensive medications), any prior history of hypertensive crisis or hypertensive encephalopathy, and history of myocardial infarction or unstable angina within months prior to study enrollment +Poorly controlled hypertension (defined as requiring changes in any hypertensive regimen within week of study entry) or patients diagnosed with hypertension based on repeat blood pressure measurements of > / mmHg at screening +Blood pressure <=Grade (hypertensive participants are permitted if their blood pressure is controlled to <=Grade by hypertensive medications. +Blood pressure ?Grade (hypertensive participants are permitted if their blood pressure is controlled to ? Grade by hypertensive medications and glycosylated hemoglobin is ?.%). +History of hypertension that is not well-controlled (>= /) on anti-hypertensive therapy +Uncontrolled hypertension (defined as blood pressure in adults > /)\r\n* Patients on anti-hypertensive medications are eligible if blood pressure is controlled +Hypertensive-level readings over three weeks, with at least two of three elevated blood pressure (BP) readings (systolic >= and/or diastolic >= ); OR one hypertensive crisis reading (systolic >= and/or diastolic >= ) (eligible for the study without having to return for second or third readings) OR have a known diagnosis of hypertension and have elevated values at one reading (eligible for the study without having to return for second or third readings) +Normotensive or controlled blood pressure (< /) on a single anti-hypertensive medication +Blood pressure <= Grade (hypertensive participants are permitted if their blood pressure is controlled to <= Grade by hypotensive medications and glycosylated HbAC <= .%).