Participants must, in the opinion of the investigator, be capable of complying with the protocol The subject is capable of understanding and complying with protocol requirements. Participants must in the opinion of the investigator be capable of complying with this protocol Patients in whom there is a medical contraindication or potential problem in complying with the requirements of the protocol, in the opinion of the investigator. Capable of understanding and complying with protocol requirements. Participants must, in the opinion of the Investigator, be capable of complying with the requirements of this protocol including self-administration of study treatment mCRPC EXPANSION COHORT: Patient must be capable of understanding and complying with protocol requirements and is willing to give informed consent Participants in whom there is a medical contraindication or potential problem in complying with the requirements of the protocol, in the opinion of the investigator Patient must be capable of understanding and complying with protocol requirements and is willing to give informed consent The subject is capable of understanding and complying with parameters as outlined in the protocol Patient must be capable of understanding and complying with protocol requirements and is willing to give informed consent The subject is capable of understanding and complying with parameters as outlined in the protocol In the opinion of the investigator, the participant or legal guardian is capable of understanding and complying with protocol requirements for the duration of the study. Psychiatric disorders or other conditions rendering the subject incapable of complying with the requirements of the protocol Participants must, in the opinion of the investigator, be capable of complying with the protocol Must in the opinion of the investigator be capable of complying with this protocol Participants must, in the opinion of the investigator, be capable of complying with the protocol Written voluntary informed consent: the patient is capable of complying with the requirements of the written Informed Consent Form and complying with protocol requirements Subjects must in the opinion of the Investigator be capable of complying with this protocol Participants must be capable of understanding and complying with the protocol requirements and signing informed consent Participants must, in the opinion of the investigator, be capable of complying with the requirements of this protocol Capable of complying with study procedures and communicating with study personnel Patient is capable of complying with study procedures Patient is capable of complying with study procedures Patient is capable of complying with study procedures Patient is capable of complying with study procedures Capable of understanding and complying with protocol requirements.