--- a +++ b/clusters/9knumclustersv2/clust_1307.txt @@ -0,0 +1,34 @@ +Primary immunodeficiency disorder or other nonmalignant inherited disease (except Fanconi anemia) treatable by allogeneic HCT +Fanconi anemia +Inherited bone marrow failure syndromes. At minimum, the diagnosis of Fanconi anemia must be excluded by diepoxybutane (DEB) or equivalent testing on peripheral blood or marrow. +Patients with idiopathic aplastic anemia and Fanconi anemia; (patients with aplastic anemia associated with paroxysmal nocturnal hemoglobinuria [PNH] or inherited marrow failure syndromes, except Fanconi anemia, will be allowed) +Bone marrow failure syndromes, except for Fanconi anemia +Patients with Fanconi anemia; at a minimum, the diagnosis of Fanconi anemia must be excluded by diepoxybutane (DEB) or equivalent testing on peripheral blood or marrow in patients younger than years of age; (additional mutational testing may have been performed in a clinical or research capacity on a per patient basis but is not considered an exclusion criteria) +Acquired bone marrow failure syndromes, except for Fanconi anemia +Fanconi Anemia or other underlying bone marrow failure syndrome +Diagnosis of Fanconi anemia must be excluded by mitomycin C or diepoxybutane chromosomal breakage testing on peripheral blood at a CLIA-approved laboratory (not required for patients with a genetic mutation consistent with DC) +Diagnosis of Fanconi anemia +Patients with Fanconi anemia (FA) must have aplastic anemia (AA), myelodysplastic syndrome without excess blasts, or high risk genotype as defined below\r\n* Aplastic anemia is defined as having at least one of the following when not receiving growth factors or transfusions:\r\n** Platelet count < x ^ IL\r\n** Absolute neutrophil count (ANC) < x ^/L\r\n** Hemoglobin (Hgb) < g/dL\r\n* Myelodysplastic syndrome with multilineage dysplasia with or without chromosomal anomalies\r\n* High risk genotype (e.g. IVS- or exon FANCC mutations, or BRCA or mutations) +Bone marrow failure syndromes, except for Fanconi anemia +Acquired bone marrow failure syndromes except for Fanconi anemia or dyskeratosis congenita +Diamond Blackfan anemia; +Fanconi anemia (FA) +Patients with Fanconi anemia, Kostmann syndrome, Shwachman syndrome, or other inherited bone marrow failure syndromes are not eligible +Fanconi anemia +Primary immunodeficiency disorder or other nonmalignant inherited disease (except aplastic anemia and Fanconi anemia) treatable by allogeneic HCT +Patients with Aplastic anemia and Fanconi anemia +Non-malignant disorders deemed curable by allogeneic transplantation: a. primary immune deficiencies, b. severe aplastic anemia not responding to immune suppressive therapy, c. osteopetrosis d. selected cases of erythroid disorders such as ? ? thalassemia major, sickle cell disease, Diamond-Blackfan anemia. e. congenital/hereditary cytopenia, including Fanconi Anemia before any clonal malignant evolution (MDS, AML). Note: Subjects will be eligible if they meet either item OR item . +Is undergoing transplant for the treatment of nonmalignant hematological disorders (for example: aplastic anemia, sickle cell anemia, thalassemias, Fanconi anemia). +Fanconi Anemia +Patients with Fanconi anemia or other cancer-predisposition syndromes +Patients with history of Down's syndrome, Fanconi anemia or other known marrow failure condition +Fanconi anemia (FA) +Patients with Down syndrome and deoxyribonucleic acid (DNA) fragility syndromes (such as Fanconi anemia, Bloom syndrome) are excluded +Anemia below lower limit of normal or anemia requiring transfusion support as per center standard +Anemia +Diagnosis of Fanconi anemia must be excluded in patients younger than years of age by diepoxybutane testing on peripheral blood or comparable testing on marrow. +Other indications for HCT, including Fanconi anemia, other form of inherited bone marrow failure diseases, metabolic disorder, hemoglobinopathy, or immune deficiency +Have hypothyroidism and anemia +Patient with aplastic anemia will be excluded +Persons with any other condition (such as lichen planus, Fanconi anemia, heavy tobacco use, etc) making them at higher risk for oral cancer development +Subjects at increased risk for radiation toxicities, such as known collagen vascular disease (example, scleroderma, Sjogren's disease, etc) or other inherited radiation hypersensitivity syndromes (example, Gorlin syndrome, Fanconi anemia, ataxia-telangiectasia, etc.)