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+++ b/clusters/9knumclustersv2/clust_1226.txt
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+Presence of a non-healing wound, or non-healing ulcer, (that is not tumor related) or bone fracture
+Presence of any non-healing wound, fracture, or ulcer within  days prior to study registration.
+Presence of non-healing wound, non-healing ulcer, or bone fracture
+Presence of a non-healing wound, non-healing ulcer, or bone fracture
+Presence of a non-healing wound, non-healing ulcer, or bone fracture
+Non-healing wound(s) or ulcer(s) except for ulcerative lesions caused by the underlying neoplasm;
+Serious non-healing or dehiscing wound, active ulcer, or untreated or non-healing bone fracture
+FOR ALL PHASES (Ib AND II): Non-healing wound or ulcer
+Presence of a non-healing wound, non-healing ulcer, or bone fracture
+Presence of a non-healing wound, non-healing ulcer or bone fracture
+Serious, non-healing or dehiscing wound or active ulcer
+Presence of a non-healing wound, non-healing ulcer, or bone fracture
+Serious, non-healing or dehiscing wound
+REGORAFENIB EXCLUSION CRITERIA: Presence of a non-healing wound, non-healing ulcer, or bone fracture
+Presence of a non-healing wound, non-healing ulcer, or benign bone fracture (patients with stress insufficiency fractures e.g. from osteoporosis or pathological fracture from tumor are eligible for study)
+Presence of any non-healing wound, fracture, or ulcer
+Serious non-healing wound, non-healing ulcer, or bone fracture
+Non-healing wound(s) or ulcer(s) except for ulcerative lesions caused by the underlying neoplasm;
+Presence of a non-healing wound, non-healing ulcer, or bone fracture
+Presence of a non-healing wound, non-healing ulcer, or bone fracture
+Prior major surgery within the previous  days of study registration and/or presence of any non-healing wound, fracture, or ulcer
+Presence of a non-healing wound, non-healing ulcer, or bone fracture
+Presence of any non-healing wound, fracture, or ulcer, or presence of symptomatic peripheral vascular disease
+Patients are excluded if they have a non-healing wound or ulcer
+Presence of non-healing wound, non-healing ulcer, or bone fracture.
+Presence of a non-healing wound, non-healing ulcer, or bone fracture
+Presence of a non-healing wound, non-healing ulcer, or bone fracture.
+Presence of a non-healing wound or non-healing ulcer that is not tumor related
+Presence of any non-healing wound, fracture, or ulcer within  days prior to the first dose of study drug.
+Presence of a non-healing wound, non-healing ulcer, or bone fracture
+Presence of any non-healing wound, fracture, or ulcer within  days prior to study registration.
+Presence of a non-healing wound, non-healing ulcer, or bone fracture
+Presence of a non-healing wound or non-healing ulcer that is not tumor related
+Presence of a non-healing wound, non-healing ulcer, or bone fracture
+Presence of a non-healing wound, non-healing ulcer, or bone fracture
+Presence of a non-healing wound, non-healing ulcer, or bone fracture
+Serious, non-healing wound
+Serious non-healing wound or ulcer on scalp
+Severe acute infection; serious non-healing wound or ulcer on scalp
+Presence of a non-healing wound, non-healing ulcer, or bone fracture
+Presence of a non-healing wound, non-healing skin ulcer, or bone fracture
+Presence of a non-healing wound or bone fracture
+Patients must not have a non-healing wound or fracture
+Presence of any non-healing wound, fracture, or ulcer
+Presence of a non-healing wound, non-healing ulcer, or bone fracture
+No history of serious non-healing wound, ulcer, or bone fractures
+Serious, non-healing or dehiscing wound or active ulcer
+Presence of a non-healing wound, non-healing ulcer, or bone fracture
+Serious, non-healing or dehiscing wound or active ulcer