--- a +++ b/clusters/9knumclustersv2/clust_1183.txt @@ -0,0 +1,72 @@ +Patients who are receiving dexamethasone must be on a stable or decreasing dose for at least week prior to enrollment +Stable dose of corticosteroids for at least days +If patients are on corticosteroids, they must have been on a stable or decreasing dose >= days prior to obtaining their baseline gadolinium (Gd)-magnetic resonance imaging (MRI) of brain; this MRI is to be obtained within days of registration; NOTE: If patient needs escalation of steroids prior to therapy, or are on unstable doses of steroids they are not eligible +For subjects on corticosteroids for endocrine deficiencies or tumor-associated symptoms, must be on a stable (or decreasing) dose for at least days before first dose of study treatment. +Patients who are on dexamethasone must be on a stable or decreasing dose for at least one week prior to registration +Participants must have bi-dimensionally measurable disease with a minimum measurement of cm per dimension on MRI performed within days prior to registration; if receiving corticosteroids, participants must be on a stable or decreasing dose of corticosteroids for at least days prior to baseline MRI +Steroid regimen stable or decreasing for at least days prior to inoculation +Corticosteroids: patients who are receiving dexamethasone must be on a stable or decreasing dose for at least week prior to registration +Stable or decreasing steroid dose within weeks of first dose of study drug if patient is taking steroids. No steroid use is also acceptable. +For patients with HGG and receiving glucocorticoid therapy, must be on stable or decreasing equivalent daily dose of glucocorticoids for weeks ( days) prior to dose assignment +Patients receiving unstable or increasing doses of corticosteroids; if patients are on corticosteroids for endocrine deficiencies or tumor-associated symptoms other than CNS related, dose must have been stabilized (or decreasing) for at least days before first dose of INC +Corticosteroids: patients who are receiving dexamethasone or other corticosteroids must be on a stable or decreasing dose for at least week prior to enrollment; it is recommended that patients be off all steroid therapy or receive the least dose that will control their neurologic symptoms +Patients enrolling in the medical arm (Arms C and D) must be on a stable or decreasing dose of corticosteroids (or none) for at least days prior to the baseline MRI; +If on corticosteroids for mass effect and/or edema related to the tumor, patient must be on a stable or decreasing dose for at least weeks prior to study entry +Corticosteroids: Patients who are receiving dexamethasone must be on a stable or decreasing dose for at least week prior to registration. +STRATUM A: Participants who are receiving corticosteroids must be on a stable or decreasing dose for at least week prior to study enrollment with no plans for escalation +STRATUM B: Participants who are receiving corticosteroids must be on a stable or decreasing dose for at least week prior to study enrollment with no plans for escalation +STRATUM C: Participants who are receiving corticosteroids must be on a stable or decreasing dose for at least week prior to study enrollment with no plans for escalation +Corticosteroids: patients who are receiving dexamethasone must be on a stable or decreasing dose for at least week prior to registration +Patients requiring steroids must be at a stable or decreasing dose for at least week prior to enrollment +Patients who are receiving dexamethasone must be on a stable or decreasing dose for at least week prior to registration +Stable or decreasing steroid dose (=< mg/day) at time of post-external beam radiation therapy (XRT) adjuvant TMZ initiation; if patients are decreasing steroid use, once they are at mg/day, they may be supplemented with hydrocortisone, at the discretion of the treating oncologist +Patients must be on a stable or decreasing dose of corticosteroids within days prior to CT scan or MRI (which is done to determine eligibility); patients must be on no more than mg a day but an attempt should be made to keep the dose at mg or less; please contact the PI if doses of > mg are needed +If receiving corticosteroids, patients must be on a stable or decreasing dose of corticosteroids for ? days prior to baseline MRI. +Stable and/or decreasing dose of corticosteroids for greater than or equal to days. +CAPMATINIB EXCLUSION CRITERIA: Patients on unstable or increasing doses of corticosteroids; if patients are on corticosteroids for endocrine deficiencies or tumor-associated symptoms other than CNS related, dose must have been stabilized or decreasing for at least days before first dose of capmatinib +Subjects who are receiving corticosteroids must be on a stable or decreasing dose for at least weeks before first dose of study treatment. +Steroids: patients who are receiving corticosteroids must be on a stable or decreasing dose for at least week prior enrollment in the study +Fixed or decreasing dose of corticosteroids (or no corticosteroids) for at least week prior to cycle day +If patient is on corticosteroids, the dose must be stable or decreasing for at least days prior to enrollment +Have brain metastases that are neurologically unstable or require an increasing dose of corticosteroids. Patients must be on a stable or decreasing dose of corticosteroids for days prior to first dose of AP. +If receiving concomitant corticosteroids, must be on a stable or decreasing dose for at least days prior to the baseline Gd-MRI. +Patients who are receiving corticosteroids must be on a stable or decreasing dose for at least week prior to registration +Corticosteroids: Participants receiving corticosteroids who have not been on a stable or decreasing dose of corticosteroid for at least days prior to study drug administration (except when indicated for Central Nervous System [CNS] metastases, then participants must not have received corticosteroids for at least days) +If patient is receiving steroids, must be on stable or decreasing steroid dose within days prior to treatment initiation with SGT-. +Stable or decreasing dose of steroids for at least days at the time of baseline brain MRI. +Fixed or decreasing dose of corticosteroids (or no corticosteroids) >= days prior to registration +Baseline MRI within days of Day & on steroid dosage that has been stable or decreasing for at least days +Patients who were receiving corticosteroids have to receive a stable or decreasing dose for at least days before study entry +If corticosteroids are required for controlling cerebral edema, patients must be on a stable dose of at least week prior to enrollment +Documentation of steroid doses - days prior to study registration and stable or decreasing steroid dose over the week prior to registration +Stable or decreasing dose of corticosteroids within days prior to study . enrollment. +Concurrent use of iron-chelating agents, (except for subjects on a stable or decreasing dose for at least weeks ( days) prior to randomization), corticosteroid (except for subjects on a stable or decreasing dose for ? week prior to randomization for medical conditions other than MDS) +If receiving corticosteroids, patients must be on a stable or decreasing dose of corticosteroids for ? days prior to baseline MRI. +Stable or decreasing dose of corticosteroids prior to treatment with a goal of mg or less of dexamethasone +Patients must be on a stable or decreasing dose of corticosteroids for a minimum of days before the baseline MRI/CT; if the corticosteroid dose is increased between the date of imaging and the initiation of study treatment, a new baseline MRI/CT is required; definition of stable steroids includes patients on no steroids +For those patients in which steroids are clinically indicated, there must be a stable or decreasing dose of steroid medication for >= one week prior to the start of infusion +Fixed or decreasing dose of corticosteroids (or no corticosteroids) >= days prior to registration +Patients must have been on a stable dose of corticosteroids >= days prior to obtaining their baseline gadolinium (Gd)-MRI of brain +Patients must be on a stable or decreasing dexamethasone dosage for at least week prior to baseline MRI +Neurological deficits must be stable on a fixed or decreasing dose of dexamethasone for >= days before study enrollment +Steroids: patients who are receiving corticosteroids must be on a stable or decreasing dose for at least week prior to baseline MRI +Patients must be on a stable or decreasing dose of steroids for at least two weeks prior to randomization +Subjects who are receiving concomitant corticosteroids must be on a stable or decreasing dose for at least weeks prior to first dose of study treatment and off all anticonvulsants for at least weeks prior to study entry. +Baseline MRI must be performed after subject signs informed consent form (ICF), within days of Day , & on steroid dosage that has been stable or decreasing for at least days +Patients must have no residual neurologic symptoms while taking no steroids, a stable or decreasing dose of steroids, or a stable dose of anti-seizure medication for the weeks prior to enrollment. +Patients who are not on a stable or decreasing steroid dose for the previous week prior to the first dose of study enrollment +If receiving corticosteroids, patients must have been on a stable or decreasing dose of corticosteroids and no more than mg dexamethasone (or equivalent) for at least days prior to date of enrollment. +Stable or decreasing dose of corticosteroids for at least days prior to randomization. +Neurological symptoms related to brain metastasis that are not controlled with a stable or decreasing dose of oral steroids for at least days prior to starting GSK +Patients receiving unstable or increasing doses of corticosteroids. If patients are on corticosteroids for endocrine deficiencies or tumor-associated symptoms, dose must have been stabilized (or decreasing) for at least days before first dose of study treatment. +Fixed or decreasing dose of corticosteroids (or no corticosteroids) >= days prior to registration +Patients must be on a steroid dose that has been stable or decreasing for at least days; if the steroid dose is increased between the date of imaging and registration, a new baseline MRI is required +if receiving corticosteroids, dose is stable or decreasing for past days +Unstable or increasing doses of corticosteroids; if patients are on corticosteroids for endocrine deficiencies or tumor-associated symptoms (non-CNS), dose must have been stabilized (or decreasing) for at least days before first dose of study treatment\r\n* Topical and inhaled steroids are allowed +Must have been taking a stable dose of corticosteroids for symptom management for at least week before baseline MRI +Patients must have adequate seizure control and be on a stable, or decreasing, dose of anti-epileptics +Stable dose of corticosteroids for weeks prior to enrollment +Concurrent use of corticosteroids unless the subject is on a stable or decreasing dose for ? week prior to enrollment for medical conditions other than MDS (MYELODYSPLASTIC SYNDROMES) +On a stable or decreasing dose of dexamethasone for the previous days +Patients receiving corticosteroids are eligible provided the dose is stable or decreasing for at least days +Stable or decreasing dose of corticosteroids over days prior to first MRZ dose