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+Evidence of clinically significant cardiovascular and respiratory conditions
+Clinically significant cardiovascular disease
+Subjects with clinically significant cardiovascular disease, including:
+Clinically significant cardiovascular disease
+Clinically significant cardiovascular disease or condition
+Patients with clinically significant cardiovascular disease, thromboembolic disease, or significant risk of bleeding.
+Clinically significant cardiovascular or pulmonary disease
+History of clinically significant cardiovascular disease
+Clinically significant cardiovascular disease.
+Clinically significant cardiovascular disease or condition
+History of clinically significant cardiovascular disease;
+Clinically significant cardiovascular disease.
+Clinically significant cardiovascular disease
+Clinically significant cardiovascular disease.
+Have clinically significant, uncontrolled, or active cardiovascular disease, specifically including, but not restricted to:
+Clinically significant cardiovascular disease
+Clinically significant cardiovascular disease including:
+Clinically significant cardiovascular disease or condition
+Subjects who developed cardiovascular disease within  weeks prior to study entry, which is deemed to be clinically significant by the Investigator.
+Known clinically significant cardiovascular disease or condition.
+Impaired cardiovascular function or clinically significant cardiovascular disease including any of the following: symptomatic congestive heart failure, clinically significant cardiac arrhythmias and/or conduction abnormalities <  months prior to screening except for atrial fibrillation and paroxysmal supraventricular tachycardia
+Clinically significant, uncontrolled, cardiovascular disease.
+History of clinically-significant cardiovascular disease.
+Clinically significant cardiovascular disease
+Clinically significant cardiovascular risk.
+Clinically significant (i.e., active) cardiovascular disease
+Clinically significant cardiovascular disease
+Subject has clinically significant cardiovascular disease.
+Clinically significant cardiovascular disease;
+Clinically symptomatic and uncontrolled cardiovascular disease
+Patients with clinically significant cardiovascular disease.
+Patients with clinically significant, uncontrolled cardiovascular disease
+Subjects with clinically significant cardiovascular disease.
+Subject has clinically significant cardiovascular disease including:
+Subjects with clinically significant cardiovascular disease. This includes:
+Clinically significant cardiovascular disease;
+Clinically significant cardiovascular disease
+Clinically significant cardiovascular disease
+Clinically significant (that is, active) cardiovascular disease
+Impaired cardiovascular function or clinically significant cardiovascular diseases
+Impaired cardiovascular function or clinically significant cardiovascular diseases.
+Impaired cardiovascular function or clinically significant cardiovascular diseases
+History of clinically significant cardiovascular disease including.
+Clinically significant cardiovascular disease;
+History of clinically significant cardiovascular disease including:
+Clinically significant cardiovascular disease at screening including:
+Clinically significant cardiovascular disease.
+Clinically significant cardiovascular impairment
+Impaired cardiovascular function or clinically significant cardiovascular diseases, including any of the following: symptomatic chronic heart failure; evidence of clinically significant cardiac arrhythmias and/or conduction abnormalities <  months prior to screening except atrial fibrillation and paroxysmal supraventricular tachycardia
+Clinically significant cardiovascular risk
+Clinically significant cardiovascular disease
+Clinically significant cardiovascular disease including:
+Uncontrolled hypertension or clinically significant cardiovascular disease
+Impaired cardiovascular function or clinically significant cardiovascular diseases
+History of clinically-significant cardiovascular disease
+History of clinically significant cardiovascular disease, gastrointestinal disorder, or significant pulmonary compromise.
+History of clinically significant cardiovascular disease
+Clinically severe cardiovascular disease or clinically significant electrocardiogram (ECG) abnormality.
+Clinically significant cardiac/cardiovascular disease, or pulmonary compromise
+Clinically significant cardiovascular disease including: