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+Participants with stage IV-V chronic kidney disease or end stage renal disease
+Participants with stage V chronic kidney disease or end stage renal disease
+History of end-stage renal disease requiring dialysis
+Subjects with end-stage kidney disease and/or grade II liver dysfunction
+End-stage renal disease (i.e., any patient requiring or advised to undergo dialysis)
+Moderate to end-stage kidney disease and a history of severe asthma or allergies
+Has hepatic dysfunction defined as Model for End-Stage Liver Disease (MELD) Score >.
+Ineligible for liver transplantation per institutional criteria:\r\n* Age >  \r\n* Biologic model for end-stage liver disease (MELD) score > \r\n* Evidence of extrahepatic disease \r\n* Vascular invasion on imaging
+End-stage liver disease unrelated to tumor
+Major concomitant medical illness inclusive of severe chronic obstructive pulmonary disease, multiple sclerosis, symptomatic coronary artery disease, heart failure, recent major cerebrovascular accident, brittle diabetes, renal dialysis, end stage liver disease, labile hypertension, or any autoimmune disorder
+End-stage renal disease: requiring hemodialysis
+Patients with acute hepatitis or end stage liver disease
+Subject has end stage renal disease and requires chronic dialysis
+Patients with end-stage renal disease defined as creatinine clearance of < mL/min and/or diagnosed with stage  chronic kidney disease
+End stage renal disease (ESRD)
+Participants with end-stage liver disease (cirrhosis)
+Have end stage renal disease
+Patients with end stage renal disease (ESRD) and/or on dialysis
+Have end-stage renal disease
+End Stage Renal Disease (ESRD)
+Model for end-stage liver disease (MELD) > 
+End stage renal disease with hemodialysis
+Has end-stage renal impairment
+End-stage liver disease unrelated to tumor
+End-stage renal disease (ESRD) on hemodialysis or CrCl ?  mL/min
+Current diagnosis of cancer, unstable cardiovascular disease, end-stage liver or kidney disease, or other major medical illness