--- a +++ b/clusters/9knumclustersv2/clust_1006.txt @@ -0,0 +1,28 @@ +Total protein < g/L or substitution dependency +Worsening urinary paraproteinemia will be considered in the context of International Myeloma Working Group (IMWG) disease response criteria on a monthly basis; any patient with urinary protein (otherwise unrelated to urinary myeloma associated monoclonal [M]-protein) with excretion > . g/day will be considered to have developed nephrotic-range proteinuria, and will be taken off study +Within days prior to cycle day of treatment: Urinary albumin excretion < . g/ hours (as estimated by urine protein-creatinine ratio) +Elevated C-reactive protein (CRP) (CRP > mg/L) probably or definitely attributable to KSHV-MCD +Urinary protein excretion =< mg/day +Presence of serum and/or urinary monoclonal protein +Patients must not have a known thrombophilic condition (i.e. protein S, protein C or antithrombin III deficiency, Factor V Leiden, Factor II GA mutation, homocysteinemia or antiphospholipid antibody syndrome); testing is not required in patients without thrombophilic history +Urinary protein is <+. +Have persistent + protein by urinalysis (patients with + proteinuria that have a spot protein:creatinine ratio of less than . may be enrolled) or a history of nephrotic syndrome. +Prior treatment with TRC or axitinib or any agent targeting the endoglin pathway (including a fusion protein that binds bone morphogenic protein) +Total protein > . +mGPS of : C-reactive protein > mg/L and albumin ? g/L +mGPS of : C-reactive protein > mg/L and albumin < g/L +modified Glasgow prognostic score (mGPS) of : CRP > mg/L and albumin ? g/L +mGPS of : C-reactive protein (CRP) > mg/L and albumin < g/L +mGPS of : C-reactive protein (CRP) > mg/L and albumin ? g/L +mGPS of : CRP > mg/L and albumin < g/L +C-reactive protein > mg/L AND albumin ? g/L; Score = +C-reactive protein > mg L AND albumin < g/L; Score = +Have persistent + protein by urinalysis (patients with + proteinuria that have a spot protein:creatinine ratio of less than . may be enrolled) or a history of nephrotic syndrome. +Urinary M-protein excretion at least mg/ hours; or +Subjects must have a C-reactive protein (CRP) > mg/L +C-reactive protein (CRP) must be >= mg/l in the absence of any other more likely cause of increased CRP like an infection or an autoimmune disorder +Total protein within x ULN +Patient must not have a known thrombophilic condition (i.e. protein S, protein C or antithrombin III deficiency, Factor V Leiden, Factor II GA mutation, homocysteinemia, or antiphospholipid antibody syndrome); testing is not required in patients without a thrombophilic history +Urinary M-protein excretion at least mg/ hours; or +C-reactive protein > mg/L +Known protein C, protein S, or anti-thrombin deficiency or other known thrombophilic disorders