General physical condition compatible with the proposed chemotherapy and surgery No history of severe cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity; examples would include unstable angina, recent myocardial infarction, oxygen-dependent pulmonary disease, and osteoarthritis requiring imminent joint replacement; moderate arthritis that does not preclude physical activity is not a reason for ineligibility Patients must have a complete history and physical examination within 28 days prior to registration Patients must have a complete history and physical examination within 28 days prior to registration Prestudy history and physical exam must be obtained within 28 days prior to sub-study registration Patients must have a complete physical examination and medical history within 28 days prior to step 2 randomization Prestudy history and physical must be obtained with 28 days prior to registration Patients must have complete history and physical examination within 28 days prior to registration Patients must have a complete physical examination and medical history within 28 days prior to registration Patients must have complete history and physical examination within 28 days prior to registration History/physical examination (to include at a minimum digital rectal examination of the prostate and examination of the skeletal system and abdomen) within 90 days prior to registration Patients must have a complete history and physical examination within 28 days prior to registration History and physical including a digital rectal exam 60 days prior to registration Patients must have complete history and physical examination within 28 days prior to registration History/physical examination, including neurologic examination within 60 days prior to step 2 registration History/physical examination within 21 days prior to study entry Patients must have complete history and physical examination within 28 days prior to registration Subjects who are compulsorily detained for treatment of either a psychiatric or physical (e.g., infectious disease) illness. Adequate physical function as measured by all of the following: Has difficulty climbing a flight of stairs or walking eight blocks due to physical impairment Ongoing restriction of physical activity with physician documentation Has chest pain brought on by physical activity Patients must be without evidence of visceral or bone involvement with metastatic cancer on physical exam or any diagnostic study; extensive nodal involvement is allowed Patients who have evidence of infection as determined by history, physical exam or laboratory testing (complete blood count and urinalysis) at baseline will be excluded unless otherwise approved by the PI or PI’s designee In addition, patients who develop evidence of infection (as determined by history, physical exam or laboratory testing) during the study will be discontinued from the study unless otherwise approved by the PI or PI’s designee All patients must have measurable disease documented by CT, MRI, or nonmeasurable disease documented by physical exam within 28 days prior to registration History/physical examination with digital rectal examination of the prostate and baseline toxicity assessment within 90 days prior to randomization. Subjects who are compulsorily detained for treatment of either a psychiatric or physical (e.g. infectious disease) illness Prisoners or subjects who are involuntarily incarcerated or compulsorily detained for treatment of either a psychiatric or physical (e.g. infectious disease) illness Must have a pertinent history/physical examination within 90 days prior to registration Participants must have a complete history and physical examination within 45 days of study entry\r\n* Participants must have a digital rectal examination (confirming clinical stage T1c to T2c) of prostate within 180 days of study entry Treatment for ?3 months with inadequate efficacy response defined as <10% spleen volume reduction by MRI or <30% decrease from baseline in spleen length by physical examination or regrowth to these parameters following an initial response; and/or Palpable splenomegaly ?5 cm below the lower costal margin in the midclavicular line as assessed by physical examination Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (eg, infectious) illness Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (e.g., infectious) illness Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (e.g., infectious) illness Is considered medically unfit for the study by the investigator as a result of the medical interview, physical exam, or screening investigations Patients who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness Clinically apparent ascites on physical examination, ascites present on imaging studies is allowed PHYSICAL AND LABORATORY TEST FINDINGS Adequate cardiac function as assessed by history and physical examination Abnormal finding on physical exam (study physician discretion) Physical or psychological condition which would impair study participation; or Participants must not be compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness American Society of Anesthesiologists (ASA) physical status 1, 2, or 3. Any mental or physical condition or disease or past medical history that mitigates against following the protocol Subjects who are compulsorily detained for treatment of either a psychiatric or physical (infection disease) illness. Participant has a cardiovascular disability status of New York Heart Association Class > 2. Class 2 is defined as cardiac disease in which patients are comfortable at rest but ordinary physical activity results in fatigue, palpitations, dyspnea, or anginal pain. American Society of Anesthesiologists physical status (ASA) 1-3. Subjects who are compulsorily detained for treatment of either a psychiatric or physical (infection disease) illness. Abnormalities on screening physical exam judged by study physicians or supervising physical therapist to contraindicate participation in exercise program compliance History/physical examination within 7 days prior to registration Subjects who are compulsorily detained for treatment of either a psychiatric or physical (e.g. infectious disease) illness. Adequate cardiac function as assessed clinically by history and physical examination. Subjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness. General history and physical examination within 8 weeks prior to registration Finished their active cancer treatment (surgery, chemotherapy [chemo] and or radiation) at least 3 months prior to registration; (anti hormonal therapy will not prevent patient from participation as long as he/she can perform mild to moderate physical activities) In good physical condition to perform low-intensity daily steps (walking) Willing to use Fitbit band to monitor physical activities Already doing moderate to high physical activities in their daily life (rapid screener) Already using physical activity tracker or part of a physical activity program Active tuberculosis based on history, symptoms, physical exam, imaging Acute or chronic, clinically significant hematologic, pulmonary, cardiovascular, or hepatic or renal functional abnormality as determined by the investigator based on medical history, physical examination, electrocardiography (EKG), and/or laboratory screening test (Bevacizumab-related exclusion) History or evidence upon physical/neurological examination of central nervous system (CNS) disease (e.g. seizures) unrelated to cancer unless adequately treated with standard medical therapy Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (e.g., infectious) illness Adequate cardiac function as assessed clinically by history and physical examination. Participants must have a complete history and physical examination within 60 days of study entry Acute or chronic, clinically significant hematologic, pulmonary, cardiovascular, hepatic renal, and/or other functional abnormality that would jeopardize the health and safety of the participant as determined by the investigator based on medical history, physical examination, laboratory values, and/or diagnostic studies Subjects who are compulsorily detained for treatment of either a psychiatric or physical (e.g., infectious disease) illness Subjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness Class 2 is defined as cardiac disease which subjects are comfortable at rest but ordinary physical activity results in fatigue, palpitations, dyspnea, or angina pain. Class 3 is defined as cardiac disease which subjects are comfortable at rest but less than ordinary activity causes fatigue, palpitation, or dyspnea. Class 4 is defined as cardiac disease which subjects have an inability to carry on any physical activity without discomfort, symptoms of heart failure at rest, and if any physical activity is undertaken then discomfort increases. Subjects who are compulsorily detained for treatment of either a psychiatric or physical illness Subjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness Palpable spleen of > 10 cm below the left subcostal margin on physical examination at the screening visit OR Any medical co-morbidity, physical examination finding, or metabolic dysfunction, or clinical laboratory abnormality that renders the patient unsuitable General history and physical examination by a radiation oncologist and medical oncologist within 4 weeks prior to enrollment. History or evidence upon physical/neurological examination of central nervous system disease (e.g., seizures) unrelated to cancer unless adequately controlled by medication; Prisoners or subjects who are compulsorily detained for treatment of either a psychiatric or physical (e.g. infectious disease) illness Subjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness Clinically =< 3 cm unifocal lesion by imaging or physical examination Has primary lesion > 3 cm in size radiographically or by physical examination; pathologically proven nodal disease at diagnosis is not allowed Locally advanced breast cancer defined as any of the following per American Joint Committee on Cancer (AJCC) staging criteria:\r\nNote: imaging methods that may be used for tumor measurement to determine eligibility include breast ultrasound and breast magnetic resonance imaging (MRI); mammography may not be used\r\n* T2 based on tumor measurements by physical examination or imaging with clinically positive regional lymph nodes (cN1 or cN2), irrespective of hormone receptor status\r\n* Hormone receptor-negative patients with tumor size of 3-5 cm measured by physical examination or imaging with clinically negative regional lymph nodes (cN0)\r\n* Any T3 based on tumor measurements by physical examination or imaging, irrespective of hormone receptor status\r\n* Any T4 (including inflammatory breast cancer), irrespective of hormone receptor status Prisoners or patients who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (e.g., infectious disease) illness must not be enrolled into this study Appropriate stage for protocol entry including no clinical evidence for distant metastases based upon the following minimum diagnostic workup:\r\n* History/physical examination, documentation of weight and Zubrod performance status 0-2 within 60 days prior to study entry\r\n* Right and left mammography within 90 days of diagnostic biopsy establishing diagnosis Subjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness Adequate cardiac function as assessed by history and physical examination History/physical examination within 30 days prior to registration Prisoners or subjects who are compulsorily detained involuntarily incarcerated) for treatment of either psychiatric or physical (e.g., infectious) illness Are willing to abstain from heterosexual activity or practice physical barrier contraception prior to time of study entry to 6 months after the last day of treatment History/physical examination within 30 days prior to registration Prisoners or subjects who are compulsorily detained for treatment of either a psychiatric or physical (e.g. infectious disease) illness Subjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness Evidence by physical examination or mammography of other suspicious masses, densities, or microcalcifications in either breast, unless biopsied and found to be benign Measurable disease by physical exam Subjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness Subjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness Other disease, metabolic disorder, physical examination anomaly, abnormal laboratory result, or any other condition that investigators suspect may prohibit use of the investigational product, affect interpretation of study results, or put the patient at high risk. History/physical examination by the treating physician within 24 hours prior to registration History/physical examination with digital rectal examination of the prostate within 90 days prior to study enrollment History and physical with neurological examination, height, and weight within 14 days prior to registration DONOR: Medical history and physical examination confirm good health status as defined by institutional standards Absence of abnormal lymphadenopathy suggesting metastatic PTC on physical examination and/or imaging studies History or evidence on physical examination or screening laboratory tests of any systemic disease or any acute or chronic illness that, in the opinion of the investigator, may interfere with the evaluation of the safety or immunogenicity of the study drug Lack of physical integrity of the upper gastrointestinal tract, malabsorption syndrome or inability to swallow Patients must have a complete history and physical examination within 30 days prior to registration Acute or chronic, clinically significant hematologic, pulmonary, cardiovascular, or hepatic or renal functional abnormality as determined by the investigator based on medical history, physical examination, electrocardiogram (EKG), and/or laboratory screening test No evidence of distant metastasis based on a history/physical examination (to include at least digital rectal examination of the prostate and assessment of the abdomen and skeletal system) Patients who have measurable disease must have had X-rays, scans or physical examinations used for tumor measurement completed within 28 days prior to initial administration of drug Any concomitant serious physical illness other than cancer (i.e., immune deficiency disease, bleeding disorder, etc.) within 1 year prior to dosing Within 30 days of registration: patients must have vital signs, history/physical examination, laboratory studies (complete blood count panel [CBCP] with differential, chemistries including liver function tests, creatinine clearance [CrCl] assessment; pregnancy test if needed within 14 days of registration) Prisoners or subjects who are involuntarily incarcerated or compulsorily detained for treatment of either a psychiatric or physical (e.g. infectious disease) illness Acute or chronic, clinically significant hematologic, pulmonary, cardiovascular, or hepatic or renal functional abnormality as determined by the investigator based on medical history, physical examination, electrocardiogram (EKG), and/or laboratory screening test Patient must have a history/physical examination with digital rectal examination of the prostate within 90 days prior to screening History/physical examination (to include at a minimum digital rectal examination of the prostate and examination of the skeletal system and abdomen) within 90 days prior to registration Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (e.g., infectious) illness Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (e.g., infectious) illness History/physical examination with digital rectal examination of the prostate within 90 days prior to registration History and physical including neurological exam, height, weight, cranial skin exam, and Karnofsky performance status >= 70% within 30 days prior to registration Inability to participate in study activities due to physical or mental limitations Tumor measures at least 1 centimeter on imaging or physical exam Inability to participate in study activities due to physical or mental limitations No evidence of distant metastatic disease as documented by history and physical examination (radiographic staging only to be performed as indicated by symptoms or physical findings) History and physical with neurological examination, steroid documentation, height, and weight within 14 days of registration Completion of a comprehensive evaluation, including clinical history and physical examination, to eliminate other causes of their symptoms Subjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness Nutritional and general physical condition must be considered compatible with the proposed radiation +/- chemotherapy treatment Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (e.g., infectious) illness Adequate cardiac function as assessed clinically by history and physical examination Bradycardia as indicated by a heart rate of < 45 beats per minute on the screening electrocardiogram (ECG) and on physical examination History/physical examination within 42 days prior to registration to document cervical tumor size and stage History/physical examination to include, at a minimum, digital rectal examination of the prostate and examination of the skeletal system and abdomen, and formal comorbidity assessment via the Charlson Comorbidity Index within 60 days prior to registration No evidence of other areas worrisome for cancer on physical examination and mammography of the ipsilateral breast History of liver decompensation: ascites noted on a physical exam, imaging or other test; variceal bleeding; hepatic encephalopathy Lack of physical integrity of the upper gastrointestinal tract, malabsorption syndrome, or inability to swallow pills. Normal Cardiac function: as assessed by history and physical exam. Subjects who are compulsorily detained for treatment of either a psychiatric or physical (e.g., infectious disease) illness Appropriate stage for study entry based on the following diagnostic workup:\r\n* History/physical examination within 28 days prior to registration\r\n* Imaging of the chest, abdomen and pelvis within 30 days prior to registration Each patient entered on the study must have disease that is evaluable for response using RECIST 1.1 criteria with a minimum size of 1 cm by CT/MRI or physical examination A cardiovascular disability status of New York Heart Association Class ? 2, defined as cardiac disease in which patients are comfortable at rest but ordinary physical activity results in fatigue, palpitations, dyspnea, or angina pain Patients must have a complete history and physical examination within 30 days prior to registration Patients must be without evidence of visceral or bone involvement with metastatic cancer on physical exam or any diagnostic study; extensive nodal involvement is allowed History/physical examination within 28 days prior to registration Individuals who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness Measurable disease: a mass that can be reproducibly measured by physical examination and/or ultrasound and is at least 1 cm in size Appropriate stage for study entry based on the following diagnostic workup:\r\n* History/physical examination within 28 days prior to registration\r\n* Imaging of target lesion(s) within 28 days prior to registration\r\n* Completion of pre-study protocol specific assessments as required Prestudy history and physical exam must be obtained within 28 days prior to re-registration Patients must not be prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (e.g., infectious) illness Patients with radiographic ascites that is apparent on physical exam or requiring medical intervention (medication or procedures) in the 2 months prior to enrollment Prestudy history and physical exam must be obtained within 28 days prior to re-registration Pre-study history and physical exam must be obtained within 28 days prior to re-registration History and physical examination including weight, performance status, and body surface area within 8 weeks prior to study registration Patients who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness Patients must have complete history and physical examination within 28 days prior to registration Complete history and physical examination noting in detail the exact size and location of any lesions that are detected on examination will be performed within 30 days prior to initiation of chemotherapy History/physical examination, including documentation of weight, within 2 weeks prior to registration History and physical examination within 6 weeks of registration Prestudy history and physical must be obtained with 28 days prior to registration Patients must have a complete history and physical examination within 28 days prior to registration Considered by the investigator to be eligible for high-dose chemotherapy (HDT) and autologous stem cell transplantation (ASCT) according to the institution's criteria based on age, medical history, cardiac and pulmonary status, overall health and condition, co-morbid condition(s), physical examination, and laboratory studies Physical and Laboratory Test Findings Patients must have a complete physical examination and medical history within 28 days prior to registration Prestudy history and physical must be obtained within 28 days prior to registration Has clinically apparent ascites on physical examination. Note: ascites detectable on imaging studies only ARE allowed. Patients must have a complete history and physical examination within 28 days prior to registration Physical examination indicates Tanner Stage 1 Evidence of any other medical conditions (such as psychiatric illness, infectious diseases, neurological conditions, physical examination or laboratory findings) that may interfere with the planned treatment, affect patient compliance or place the patient at high risk from treatment related complications Prestudy history and physical must be obtained within 28 days prior to registration Patients must have a complete physical examination and medical history within 28 days prior to registration Prestudy history and physical exam must be obtained within 28 days prior to RE-TREATMENT registration Any prior (within 1 year) or current clinically significant ascites as measured by physical examination and that requires paracentesis for control; Prestudy history and physical must be obtained within 28 days prior to registration Complete history and physical examination including weight and Zubrod status within 31 days of study entry (or within 31 days prior to day 1 of chemotherapy post-surgery for those patients having started chemotherapy prior to first step registration) Clinical evidence of ascites by physical exam Patients must have a complete physical examination and medical history within 28 days prior to registration Patients must have complete history and physical examination within 28 days prior to registration History/physical examination within 30 days prior to registration History/Physical examination by a Radiation Oncologist and Medical oncologist prior to entering the study. Patients must have history and physical examination within 28 days prior to registration Appropriate stage for study entry based on the following diagnostic workup:\r\n* History/physical examination within 42 +/- 5 days of planned surgical procedure (18-21 days from day 1);\r\n* Further protocol-specific assessments History or evidence upon physical/neurological examination of central nervous system (CNS) disease unrelated to cancer, unless adequately treated with standard medical therapy (e.g. uncontrolled seizures) Has clinically apparent ascites on physical examination Palpable splenomegaly or hepatomegaly of more than or equal to 5 cm below left or right, respectively, costal margin on physical exam History/physical examination within 7 days prior to registration History/physical examination within 45 days prior to study registration Patients must have a complete physical examination and medical history within 28 days prior to Step 2 Randomization Subjects who are compulsorily detained for treatment of either a psychiatric or physical (e.g., infectious disease) illness Appropriate stage for protocol entry, including no clinical evidence for distant metastases, based upon the following minimum diagnostic workup:\r\n* History/physical examination, including breast exam and documentation of weight and Karnofsky performance status of 80-100% at study entry Appropriate stage for protocol entry, based upon the following minimum diagnostic workup within 60 days prior to registration:\r\n* History/physical examination including weight, performance data, body surface area History/physical examination (to include, at a minimum, digital rectal examination of the prostate and examination of the skeletal system and abdomen, and formal comorbidity assessment via the ACE-27 instrument) within 60 days prior to registration; Note: the ACE-27 is posted on the 0815 protocol information page on the NRG Oncology/Radiation Therapy Oncology Group (RTOG) web site History/physical examination Physical abnormality or medical condition that limits swallowing multiple pills, or has a history of non-adherence to oral therapies. Patients whose disease is not measurable or cannot be assessed by radiographic imaging or physical examination (e.g., elevated serum tumor marker only) are not eligible Stable physical and mental health Subjects who are compulsorily detained for treatment of either a psychiatric or physical (infection disease) illness A cardiovascular disability status of New York Heart Association class >= 2, defined as cardiac disease in which patients are comfortable at rest but ordinary physical activity results in fatigue, palpitations, dyspnea, or angina pain Subjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness Physical, clinical, radiographic or pathologic evidence of satellite, in-transit, regional, or distant metastatic melanoma. Appropriate stage for study entry based on the following diagnostic workup:\r\n* History/physical examination within 28 days prior to registration Class III or Class IV myocardial disease as described by the New York Heart Association; a recent history (within 6 months) of myocardial infarction, or symptomatic arrhythmia at the time of randomization. Class III: Patients with cardiac disease resulting in marked limitation of physical activity. Such patients are comfortable at rest. Less than ordinary physical activity that causes fatigue, palpitation, dyspnea, or anginal pain. Class IV: Patients with cardiac disease resulting in inability to perform any physical activity without discomfort. Symptoms of cardiac insufficiency or anginal syndrome may be present even at rest. Inability to participate in physical activity because of co-morbidity or disability (e.g., severe arthritic conditions) A history or presence of a comorbid disease for which diet modification and increased physical activity may be contraindicated or complicated Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (e.g., infectious) illness Presence of any clinically significant findings at entry for medical history, laboratory values, or physical examination A cardiovascular disability status of New York Heart Association Class >/=3. Class 3 is defined as cardiac disease in which participants are comfortable at rest but have marked limitation of physical activity due to fatigue, palpitations, dyspnea, or anginal pain Tumor diameter =< 2 cm on physical exam & imaging studies Tumors > 2 cm in diameter on physical exam or imaging studies Subjects who are compulsorily detained for treatment of either a psychiatric or physical illness Patients must have a complete physical examination and medical history within 28 days prior to registration Willingness to change diet, physical activity and weight Lack of physical integrity of the upper gastrointestinal tract or malabsorption syndrome Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either psychiatric or physical (e.g., infectious) illness Cardiovascular disability status of New York Heart Association Class greater than or equal to 2. Class 2 is defined as cardiac disease in which patients are comfortable at rest but ordinary physical activity results in fatigue, palpitations, dyspnea or anginal pain. History/physical examination, including neurologic examination, within 14 days prior to registration Chronic GVHD manifestations that can be followed on physical or laboratory exam\r\n* Skin changes\r\n* Oral mucosa changes\r\n* Hepatic dysfunction\r\n* Diarrhea Subjects who are compulsorily detained for treatment of either a psychiatric or physical (egg, infectious disease) illness Subject has a cardiovascular disability status of New York Heart Association Class greater or equal to 2. Class 2 is defined as cardiac disease in which patients are comfortable at rest but ordinary physical activity, results in fatigue, palpitations, dyspnea or anginal pain. Lack of physical integrity of the upper gastrointestinal tract or malabsorption syndrome Prisoners or patients who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (i.e., infectious) illness Lack of physical integrity of the upper gastrointestinal tract or malabsorption syndrome Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (eg, infectious) illness Subjects who are compulsorily detained for treatment of either a psychiatric or physical (e.g., infectious disease) illness History/physical examination within 28 days prior to registration Cardiac: Left ventricular ejection fraction at rest ? 40% demonstrated by Multi Gated Acquisition Scan (MUGA) or echocardiogram. Patients with known heart disease must have a functional status no worse than American Heart Association Class I defined as patients with cardiac disease but without resulting limitation of physical activity. Ordinary physical activity does not cause undue fatigue, palpitation, dyspnea, or anginal pain. Subject has a cardiovascular disability status of New York Heart Association Class greater or equal to 2. Class 2 is defined as cardiac disease in which patients are comfortable at rest but ordinary physical activity, results in fatigue, palpitations, dyspnea or anginal pain. Patients must have a complete physical examination and medical history within 28 days prior to registration Any physical, social, or psychiatric condition that would prevent effective cooperation or participation in the study Subjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness Physical examination, and scans needed for tumor assessment must be performed within 90 days prior to registration Any new medical contraindication or clinically significant abnormality on physical, neurological, laboratory, vital signs, or electrocardiographic (ECG) examination (e.g., atrial fibrillation; with the exception of subjects for whom the ventricular rate is controlled) that precludes continuation or initiation of treatment with NEOD001 or participation in the study History/physical examination within 60 days prior to registration to document cervical tumor size and stage American Heart Association (AHA) class 1 without significant limitation of physical activity Subjects who are compulsorily detained for treatment of either a psychiatric or physical (e.g., infectious disease) illness Any new medical contraindication or clinically significant abnormality on physical, neurological, laboratory, vital signs, or electrocardiogram (ECG) examination (e.g., atrial fibrillation; with the exception of subjects for whom the ventricular rate is controlled) that precludes continued or initiation of treatment with NEOD001 or participation in the study History/physical examination with digital rectal examination of the prostate within 8 weeks prior to registration Bradycardia as indicated by a heart rate of < 45 beats per minute on the screening electrocardiogram (ECG) and on physical examination; The patient must have a history and physical documented within four weeks of registration and be deemed by a medical oncologist to be ineligible for standard continuous course chemoradiotherapy with cisplatin Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical illness (e.g., infectious disease) must not be enrolled into this study Measurable, non-bony disease (at least one lesion on radiographic or physical exam assessment measuring >= 2 cm in longest axis), as demonstrated by imaging or physical exam performed =< 28 days of study entry, provided no anti-tumor therapies or interventions have occurred in that time period Palpable splenomegaly ? 5 cm on physical examination >= 1 measurable lesion that is palpable, its size can be measured by bi-dimensional tape, ruler or caliper technique, and the minimum size of the largest tumor diameter is greater than 2.0 cm by imaging or physical examination Axillary lymph nodes negative by pre-operative physical examination in all cases and pathologic examination from surgery for invasive disease History/physical examination within 30 days prior to registration Exercise/physical activity contraindicated Palpable primary breast tumor measuring >= 2.0 cm on physical exam or imaging prior to neoadjuvant chemotherapy Patients who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness. Physical or psychological condition which would impair study participation; or Presence of detectable (by physical exam) third-space fluid collections Palpable splenomegaly of more than or equal to 5 cm below left costal margin on physical exam Pre-study history and physical must be obtained with 28 days prior to registration Measurable disease by radiographic or physical examination Patients must have laboratory and physical examination parameters within acceptable limits by standard of practice guidelines prior to surgery as assessed by preoperative anesthesia assessment Be willing to abstain from heterosexual activity or practice physical barrier contraception from study entry to 6 months after the last day of treatment Patients must have a history and physical examination obtained within 28 days prior to registration Measurable tumor by physical or radiographic examination Unstable brain or leptomeningeal disease based on history and physical examination. History and physical examination, including neurologic examination, within 2 weeks prior to registration Physical and Laboratory Test Findings Unable to participate in all necessary study activities due to physical or mental limitations Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (e.g., infectious) illness In good physical health (no unstable medical condition); Is considered medically unfit for the study by the investigator as a result of the medical interview, physical exam, or baseline investigations. History and physical with neurological examination, steroid documentation, height, and weight within 14 days of registration History, physical and performance status of 2 or less within 180 days prior to registration Patients must have a complete physical examination and medical history within 28 days prior to registration History and physical exam, and Karnofsky performance status of >= 70 within 30 days prior to registration Bedridden, or physical debilitation such that study participation would not be feasible or would create undue hardship Sedentary defined as participating in 2 or less days of dedicated physical activity per week Participates in 3 or more days of dedicated physical activity per week Self-reported sexual dysfunction (Derogatis Interview for Sexual Functioning [DISF]-Male [M]-II score =< 20 in the sexual desire domain), and/or fatigue (Functional Assessment of Chronic Illness Therapy [FACIT]-Fatigue [F] score < 30), or physical dysfunction (self-reported difficulty in walking a 1/4 mile or climbing two flights of stairs, and short physical performance battery score [SPPB] between 4 to 9) Approval from their treating physician to engage in moderate-intensity physical activity Patient-assessed ability to walk and engage in moderate physical activity Has physical limitations that would prevent participation (e.g. blindness) Patients who are currently receiving physical therapy or practicing yoga for any reason Has another serious or chronic medical or psychiatric condition that contributes to substantial physical or emotional disability that would detract from participating in either of the intervention programs or from the measurement of intervention outcomes Approval from their treating physician to engage in moderate-intensity physical activity Patient-assessed ability to walk and engage in moderate physical activity Already walking or engaging in other physical activity > 120 minutes per week as documented via subject self-report Unable to walk or engage in moderate-intensity physical activity Patients must have complete physical examination and medical history obtained within 28 days prior to registration History/physical examination within 14 days prior to registration Baseline weight-bearing physical activity less than 150 min·wk^-1 using the Paffenbarger physical activity questionnaire Any other condition that may impede testing of the study hypothesis, make it unsafe to engage in the physical activity program, or make the participant not available for end of study assessments (determined by the investigative team) Able to initiate a supervised exercise program (free from any cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity) Severe and/or uncontrolled comorbidity precluding safe participation in a physical activity program Myopathic or rheumatologic disease that impacts physical function Medications felt to be clinically contributing to fatigue based on the investigator’s history, physical examination, and assessment; those may include: antidepressants, chronic use of long-acting anxiolytics or neuroleptics No obvious medical conditions or physical handicaps which would preclude an exercise regimen as determined by the radiation oncologist Physical handicap that would prevent participation in program The subject is not participating in regular physical exercise (more than 60 minutes of moderate intensity or 30 minutes of vigorous intensity exercise per week) or weight reduction dieting Impairments in physical function, as defined by a score < 9 on the SPPB pre-screen Medical clearance from an oncologist or primary care physician stating the participant is able to participate in an unsupervised, moderate-intensity physical activity program Report < 150 minutes of weekly moderate-to-vigorous physical activity (MVPA) on the Global Physical Activity Questionnaire (GPAQ) Physically able to engage in physical activity Medical condition contraindicating physical activity participation Participants must consume < 5 servings of fruits and vegetables per day and/or engages in < 150 weekly minutes of moderate to vigorous physical activity Sedentary 6 months before the baseline visit defined as those individuals not participating in a regular exercise program or not meeting the minimal physical activity recommendations from the General Surgeon which is accumulating 30 minutes or more of moderate physical activity on most days of the week American Society of Anesthesiology (ASA) physical status I-III Must have a caregiver or assistance at home who can assist with collecting physical therapy (PT) measures Patients who have difficulty walking or may not be able to complete the physical therapy measures Approval from the treating clinician to engage in moderate-intensity physical activity Patient-assessed ability to walk and engage in moderate physical activity Are willing to attempt increase in physical activity level Survivors must not be performing >= 100 minute (min)/week of moderate-vigorous physical activity Conditions that would interfere with the safety of moderate-to-vigorous intensity physical activity; participants will be screened for safety using the validated Physical Activity Readiness Questionnaire (PAR-Q) Any physical or mental health condition that would interfere with full participation in the study, including individuals who are unable to read consent materials or appear to lack the capacity to consent Has difficulty climbing a flight of stairs due to physical impairment Has chest pain brought on by physical activity Regular participation in moderate- or vigorous-intensity physical activity for >= 30 minutes at least 5 times a week and strength training for >= 2 days Inability to travel to the NIH, for example, due to physical limitations, for the in-person evaluation(s) Primary physician consent to engage in physical activity unsupervised ALS PATIENTS: Must have ALSFRS-R walking score of at least 3 or 4 and forced vital capacity (FVC) at least 50% (to ensure patients are fit enough for ambulation and physical activity) Presence of cardiovascular disease that would make physical activity risky at the discretion of the provider Moderate to highly active level of physical activity (e.g. currently participating in >= 60 minutes of moderate aerobic activity weekly) Phase 2: CRC survivors 6 months or greater post-treatment, who additionally do not follow guidelines for physical activity (PA) (150 minutes of moderate to strenuous exercise weekly), and average, at least 6 hours/day of sedentary behaviors Previous or ongoing physical therapy treatments are acceptable Participants must have a baseline activity level of < 150 minutes/wk of moderate to vigorous activity as calculated using the moderate to vigorous components of the Leisure Time Exercise Questionnaire (LTEQ) for physical activity (completed during screening) SUBJECT: Must be willing to register online and install the software to use an age-appropriate activity monitor and website, which will include sharing some personal identifiable information, to allow the participant to track their physical activity. SUBJECT: Currently engaging in > 3 hours of moderate to vigorous physical activity per week, as reported in the exercise screening questions completed at the pre-study screening evaluation. SUBJECT: Currently on or planning to begin active neoplastic therapy, as the side effects may significantly impair ability to participate in physical activity. Sedentary, as defined as < 60 minutes of recreation or work requiring modest PA/week based on the 7 day physical activity recall questionnaire Physical limitations (e.g., orthopedic, central nervous system) that contraindicate participation in a low to moderate intensity home-based walking program Self-report of a discrepancy between present and optimal level of cognitive, emotional, and/or physical functioning Approval from their treating physician to engage in moderate-intensity physical activity Patient-assessed ability to walk and engage in moderate physical activity Unable to walk or engage in moderate-intensity physical activity Children who meet the above criteria, but whose treating oncologist advises against study participation for physical health, mental health (parent or child) or logistical reasons Physically able to exercise and have physician consent from their treating physician to start a physical activity program Currently physically active (> 90 minutes of moderate or vigorous physical activity per week) as determined by Leisure Score Index of Godin Leisure-Time Exercise Questionnaire [LSI]) Cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity; examples would include unstable angina, recent myocardial infarction, oxygen-dependent pulmonary disease, and osteoarthritis requiring imminent joint replacement; moderate arthritis that does not preclude physical activity is not a reason for ineligibility History/physical examination within 2 weeks prior to registration Have been cleared by their provider to engage low to moderate intensity physical activities Physician permission to engage in moderate-intensity physical activity Patient has physical and mental capabilities to take part in study Patient reported regular participation in moderate- or vigorous-intensity physical activity for at >= 30 minutes at least 5 times a week and strength training for >= 2 days/week Currently enrolled in a physical therapy course Must not have engaged in a regular (> 3x/week, physical activity program in the last 6 months) Have complete history and physical examination documenting no clinical evidence of disease within 8 weeks of registration Any uncontrolled illness or physical disability including, but not limited to, infection, cardiopulmonary disease, musculoskeletal or psychiatric condition that contradicts moderate to vigorous aerobic exercise; not able to walk unassisted Physically capable to do the hula-based physical activity moderate and vigorous physical activity (MVPA) Are able to pass the Physical Activity Readiness Questionnaire or participant provides a letter from their physician or nurse practitioner clearing them for study participation No contradictions to exercise based on the Physical Activity Readiness Questionnaire (PAR-Q) Sedentary: < 90 minutes/week of moderate-intensity (not exhausting, light perspiration, e.g. fast walking, tennis, easy bicycling, easy swimming, popular and folk dancing) physical activity during the preceding 2 months, and < 30 minutes/month of any high-intensity activity (heart beats rapidly, sweating, e.g. running, aerobics classes, cross country skiing, vigorous swimming, vigorous bicycling) in the past 2 months Myopathic or rheumatologic disease that impacts physical function Suspected or confirmed physical closure of salivary gland ducts on either side CANCER PATIENT GROUP: Sedentary defined as < 60 minutes of recreation or work requiring modest physical activity (PA)/week CANCER PATIENT GROUP: Ability to perform the level of physical activity assessed by the Physical Activity Readiness Questionnaire (PAR-Q) NON-CANCER PATIENT GROUP: Ability to perform the level of physical activity assessed by the Physical Activity Readiness Questionnaire (PAR-Q) Any physical, psychological illness, and/or medical problems that restricted them from exercise Less than 120 minutes/week of physical activity Approval from member of the treatment team to engage in moderate-intensity physical activity Patient-assessed ability to walk and engage in moderate physical activity Unable to walk or engage in moderate-intensity physical activity Report more than 120 minutes/week of physical activity Absence of tumors:\r\n* Patients must undergo thorough physical examination of the leg undergoing surgery; if physical exam is equivocal for presence of tumors, then a normal magnetic resonance imaging (MRI) of the lower extremity will be required before eligibility is met\r\n* If there is evidence of plexiform neurofibroma or nodular neurofibroma of > 3 cm diameter on the ipsilateral leg, then they are ineligible for the study Subjects who are compulsorily detained for treatment of either a psychiatric or physical (e.g., infectious disease) illness Patient cannot comfortably be set up in the prone position (i.e. physical disability) Lymphedema of the upper extremities, as detected on history and physical Completed medically indicated physical therapy Prestudy history and physical must be obtained within 180 days prior to registration Suspected or confirmed physical closure of salivary gland ducts on either side History/physical examination within 30 days prior to registration Pathologically proven diagnosis of cancer any stage, based upon the following minimum diagnostic workup:\r\n* History & physical examination, including documentation of Karnofsky performance status of 70-100% for at least 60 days prior to study entry Individuals with a physical or mental impairment which would preclude their ability\n to perform the intervention. Physical deformities that could interfere with accurate acupuncture point location Individuals unable to complete art therapy activities independently due to physical and/or mental impairment Be inactive at baseline (< 150 minutes [min]/week of moderate physical activity) Patients who have any condition that contradicts moderate to vigorous exercise; are unable to walk unassisted; or are already meeting the physical activity guidelines of 150 min/week (wk) of moderate physical activity American Society of Anesthesiologists (ASA) physical status 4 or 5 Medications felt to be clinically contributing to fatigue based on the investigator’s history, physical examination, and assessment; those may include: antidepressants, chronic use of long-acting anxiolytics or neuroleptics Able to participate occasionally in mildly strenuous physical effort Physical deformities that could interfere with accurate acupuncture point location Participants answering ‘Yes’ to one or more of the questions on the physical activity readiness questionnaire (PAR-Q) will need to obtain approval from a physician before they can participate in the intervention Patients must not be currently enrolled in an ongoing (participating for 6 months or longer) medically prescribed diet or physical activity regimen Patients who have participated in a marathon, triathlon, or other endurance-related physical activity within the previous 24 months At the time of consent, patient or parent/guardian reports less than 420 minutes of moderate to vigorous physical activity over the last week < 30 minutes per day of self-reported moderate or vigorous physical activity (PA) Physical impairments (bad hip, knees, feet, peripheral neuropathy) that would prohibit performing moderate intensity exercise at least 5 days per week Physical impairments (bad hip, knees, feet, peripheral neuropathy) that would prohibit performing moderate intensity exercise at least 5 days per week Answer “no” to all questions on the Physical Activity Readiness Questionnaire (PAR-Q) Patients with a current dependence on alcohol (characterized by a physical addiction to alcohol that interferes with physical or mental health, and social, family or job responsibilities) Willingness to change diet, physical activity, and weight Individuals who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness Are currently enrolled in a physical activity and/or dietary clinical trial Able mentally and physically to participate in interventions in this study (Note: If there are one or more positive responses to the Physical Activity Readiness Questionnaire [PARQ], then a physician-release for exercise is required prior to obtaining consent) Not adherent to the standard for > five servings of fruits and vegetable and 150 minutes of physical activity Has physical limitations and cannot participate in physical activity A medical condition that precludes moderate-vigorous physical activity as determined by health care provider Currently physically inactive; using the international physical activity questionnaire (IPAQ) short form physically inactive will be defined as scoring a 0 in both the moderate and vigorous activity questions, and engaging in walking that is =< 420 minutes per week Cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity Subjects who are noted (upon initial online screening) to do 150 minutes or more of moderate level physical activity each week, get less than 8% of their calories from saturated fat, and eat more than 5 fruit and vegetable servings per day will not be eligible Documented splenomegaly of at least 5 cm below the costal margin as measured on inspiration by physical exam. Any physical or mental limitation that would prevent participation in study activities (Including but not limited to grade 4 neuropathy or inability to ambulate) Able to communicate dietary and physical activity data via telephone Any condition that, in the investigators’ judgment, would contraindicate diet modification, increased physical activity, use of metformin, or otherwise interfere with participation in the trial Medical, surgical or radiation oncologist agrees to subject participation in a diet and physical activity program. Cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity. Moderate arthritis that does not preclude physical activity is not a reason for ineligibility. Stable physical/mental health Stable physical/mental health In stable physical/mental health Significant pulmonary, cardiovascular, orthopedic, or musculoskeletal problems that would, in their oncologist's judgment, limit their ability to participate in physical activity Any confirmed or suspected immunosuppressive or immunodeficient condition, based on medical history and physical examination. Acute or chronic, clinically significant pulmonary, cardiovascular, hepatic or renal functional abnormality, as determined by physical examination or laboratory screening tests. stable physical/mental health, interested in increasing their physical activity, Contraindications to increasing physical activity including, but not limited to, Patients presenting to surgery clinic after receipt of NAC at outside hospital with documentation of cT4 or cN2/3 disease on initial outside physical exam and imaging studies Patients receiving NAC and having a nodal complete clinical response as assessed by physical exam Patients with persistent palpable axillary nodes after NAC, as assessed by physical exam Clinically detectable disease either by physical examination or radiographic studies Physical limitation that would limit compliance with the study requirements Physical limitation that would limit compliance with the study requirements Any patient who is unable (either because of physical or psychological factors) to undergo imaging studies without sedation but is not considered an anesthesia candidate Evidence of distant disease on physical exam or initial imaging Inability to lie comfortably on a bed inside the scanner for 60 minutes as assessed by physical examination and medical history (e.g. back pain, arthritis) Patients currently receiving trastuzumab therapy with or without other types of systemic therapy can participate if their disease progresses (development of new lesion[s] or worsening of known lesion(s) based on imaging modalities or physical examination Subjects must have either primary or recurrent papillary thyroid cancer (PTC) or medullary thyroid carcinoma (MTC) with nodal metastases detected through physical examination and/or standard imaging techniques Patients with a grade 1/2 tumors and evidence of deep myometrial invasion or cervical involvement on preoperative imaging or physical exam Subjects with a pathologically-proven diagnosis of classic HL or DLBCL with measurable disease by any imaging technique or physical examination Clinical evidence of T1-4N1-2, T3-4N0 disease; this can be either by imaging studies or by physical exam findings Medical history, physical exam, and vital signs within 30 days of enrollment Good physical health (no unstable medical or mental health condition) A history or presence of a comorbid disease for which diet modification and increased physical activity may be contraindicated Patients must not have signs of bowel perforation necessitating surgery or “acute” abdomen evidenced by peritonitis on physical exam within 2 days prior to registration Prestudy history and physical must be obtained within 3 days prior to registration AIM 1: Not meeting national guidelines for aerobic physical activity (i.e., at least 150 minutes per week of moderate intensity aerobic physical activity) AIM 2: Not meeting national guidelines for aerobic physical activity (i.e., at least 150 minutes per week of moderate intensity aerobic physical activity) Has not seen a doctor for an annual physical within the last year, not including an annual required physical for work, at baseline Myopathic or rheumatologic disease that impacts physical function (PCS study) Unable to provide consent due to a mental, emotional, or physical handicap, that keep them from understanding the consent information Patients who are considered to be in severe physical or emotional distress based on the assessment by the research staff DISEASE CHARACTERISTICS:\n\n - Completely resected histologically confirmed adenocarcinoma of the colon\n\n - High-risk stage II disease, including one of the following:\n\n - T4 lesions\n\n - Less than 12 sampled lymph nodes\n\n - Poorly differentiated histology\n\n - Stage III disease, defined as having at least one pathologically confirmed\n positive lymph node or one pathologically confirmed positive tumour deposit.\n\n - Synchronous primary colon cancer allowed\n\n - Adjuvant chemotherapy treatment for colon cancer with a 5-fluorouracil- based regimen\n received with an intent to provide a complete course of treatment. While one current\n standard is 24 weeks of treatment, patients who are pre-planned to receive a shorter\n duration of chemotherapy, including as part of a research study will also be\n permitted. The actual treatment received may be less than 24 weeks; participants must\n have received a minimum of one treatment cycle.\n\n - Chemotherapy must have been completed (i.e. last dose received) a minimum of 60 days\n and a maximum of 180 days prior to registration.\n\n - Carcinoembryonic antigen (CEA) ? 5 ?g/L\n\n - Current physical activity levels do not meet the recommended guidelines (? 150 minutes\n of moderate-to-vigorous or ? 75 minutes of vigorous physical activity/week) as\n calculated using the Leisure Time Exercise Questionnaire (LTEQ)\n\n - Completion of chest x-ray or CT, and CT, MRI or ultrasound of abdomen within 60 days\n of registration; these imaging tests must not show evidence of metastatic or\n locally-recurrent colon cancer.\n\n - No rectal cancer\n\n PATIENT CHARACTERISTICS:\n\n - ECOG performance status 0-1\n\n - Absolute granulocyte count ? 1,000/mm³\n\n - Platelet count ? 100,000/mm³\n\n - Hemoglobin ? 100 g/L\n\n - Serum creatinine ? 1.5 times upper limit of normal (ULN)\n\n - Total bilirubin ? 1.5 times upper limit of normal (ULN)\n\n - Alkaline phosphatase < 2.5 times ULN\n\n - ALT < 2 times ULN\n\n - Not pregnant or planning to become pregnant within the next 3 years\n\n - Able (i.e., sufficiently fluent) and willing to effectively communicate with the\n physical activity consultant affiliated with the originating cancer center\n\n - Able (i.e., sufficiently fluent in English or French) and willing to complete the\n patient-reported outcome questionnaires, social determinants of exercise measurement,\n health economics, and physical activity questionnaires and logs\n\n - Able to complete the baseline exercise test\n\n - No significant comorbid conditions precluding participation in a physical activity\n program as determined by the investigator\n\n - Likely to participate in a physical activity program, as assessed by the investigator\n\n - No history of other malignancies, except adequately treated nonmelanoma skin cancer,\n curatively treated in situ cancer of the cervix, other solid tumors, Hodgkin lymphoma,\n or non-Hodgkin lymphoma curatively treated with no evidence of disease for > 5 years\n\n PRIOR CONCURRENT THERAPY:\n\n - See Disease Characteristics\n\n - No prior radiotherapy as a component of treatment for primary tumor\n\n - No concurrent treatment with additional chemotherapy or radiation\n\n - No concurrent treatment with any medications deemed by the investigator as likely to\n preclude participation in a physical activity program\n\n - No concurrent anticancer treatment including chemotherapy, biological, or targeted\n agents Major physical disability which would prevent subject from transferring from a chair to a bed and sitting in an upright position Any concomitant serious physical illness other than cancer (e.g., immune deficiency disease, bleeding disorder, etc.) within 1 year prior to dosing. No history of autoimmune disease.