Oxygen saturation >= 92% on room air
No evidence of dyspnea at rest, no exercise intolerance due to pulmonary insufficiency, and a pulse oximetry > 92% while breathing room air
Pulse oximetry > 94% on room air if there is clinical indication for determination (e.g. dyspnea at rest)
Pulse oximetry > 94% on room air if there is clinical indication for determination (e.g. dyspnea at rest)
Subjects who need daily oxygen therapy
Excluded if known active pulmonary disease with hypoxia defined as: \r\n* Oxygen saturation < 85% on room air, or\r\n* Oxygen saturation < 88% despite supplemental oxygen
No evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 94% if there is clinical indication or determination; pulmonary function tests (PFTs) are not required
No evidence of dyspnea at rest, no exercise intolerance, and a resting pulse oximetry reading > 94% on room air if there is clinical indication for determination
No evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 94% at sea level if there is clinical indication for determination
For children who are unable to cooperate for PFTs, the criteria are: no evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry reading of > 92% on room air
Patients with a history of pulmonary dysfunction must have no evidence of dyspnea at rest, no exercise intolerance due to pulmonary insufficiency, and a pulse oximetry > 92% while breathing room air unless current dysfunction is due to the lymphoma in which case the patient is eligible
Pulse oximetry > 94% on room air if there is clinical indication for determination (e.g. dyspnea at rest)
Normal pulmonary function tests (including diffusion capacity of the lung for carbon monoxide [DLCO]) if there is clinical indication for determination (e.g. dyspnea at rest, known requirement for supplemental oxygen); for patients who do not have respiratory symptoms or requirement for supplemental oxygen, pulmonary function tests (PFTs) are NOT required
Patients requiring any daily supplemental oxygen
Requirement for daily supplemental oxygen
Pulse oximetry of > 95% on room air in patients who previously received radiation therapy
Resting baseline oxygen saturation >= 92% at rest - by pulse oximetry, performed within 14 days of treatment initiation
Dependence on continuous supplemental oxygen use
Normal pulmonary functions tests (including carbon monoxide diffusing capability test [DLCO]) if there is a clinical indication for determination (dyspnea at rest, known requirement for supplemental oxygen); for subjects who do not have respiratory symptoms (no dyspnea at rest, oxygen [O2] saturation [sat] >= 93% on room air), full pulmonary function tests (PFTs) are NOT required
TREATMENT: Pulse oximetry of > 95% on room air in patients who previously received radiation therapy
Pulse oximetry of > 90% on room air
Patients with oxygen (O^2) saturations > 93% on room air (measured by pulse oximetry)
Baseline pulse oximetry < 94% or requires oxygen supplementation of any kind
Obtained within 14 days prior to C1D1: Oxygen saturation (O2 Sat.) >= 92% on ambient air
Baseline oxygen saturation > 92% on room air
Carbon monoxide diffusing capability (DLCO) > 60% predicted (in children, oxygen [O2] saturation > 92% on room air)
Pulse oximetry of > 95% on room air
INCLUSION - TREATMENT: Pulse oximetry of > 90% on room air
Subjects must have adequate lung function to permit surgical resection determined by pre-enrollment pulmonary function tests to include diffusion capacity of the lung for carbon monoxide (DLCO) as follows:\r\n* DLCO >= 70% predicted OR DLCO < 70% but >= 55% with an oxygen consumption (VO2) max >= 10 L/min/kg (assessed by cardiopulmonary exercise testing) or 6 minute walk test >= 500 meters\r\n* Subjects with a DLCO < 55% are excluded from this study\r\n* Subjects must have a baseline oxygen (O2) saturation by pulse oximetry that is >= 92% both at rest and while walking, off supplemental oxygen
If clinical indications, pulse oximetry > 94% on room air
Patients must have normal pulmonary function testing for age based on pulse oximetry
Uncontrolled asthma or O2 saturation < 90% by arterial blood gas analysis or pulse oximetry on room air
INCLUSION - INFUSION: Pulse oximetry of > 90% on room air
TREATMENT INCLUSION: Pulse oximetry of > 90% on room air
Pulse oximetry < 92% on room air
Oxygen saturation < 90% measured by pulse oximetry at rest
The patient is oxygen-dependent.
Pulse oximetry of > 90% on room air
Pulse oximetry of > 90% on room air
Pulse oximetry > 93% on room air and no evidence of dyspnea at rest
INCLUSION CRITERIA FOR STRATUM C: Pulse oximetry > 93% on room air and no evidence of dyspnea at rest
Patients without respiratory symptoms (e.g. dyspnea at rest, known requirement for supplemental oxygen therapy) and who have an oxygen saturation > 92% on room air, will be eligible; for patients not meeting this criteria, pulmonary function tests will be performed to confirm that the diffusion capacity of the lung for carbon monoxide (DLCO)/alveolar volume (VA)/Adj is 50% of the normal predicted value corrected for hemoglobin and alveolar volume in order to meet eligibility\r\n* (For children who are unable to cooperate for pulmonary function test [PFT]s, the criterion is: No evidence of dyspnea at rest, no exercise intolerance and no requirement for supplemental oxygen therapy)
ELIGIBILITY CRITERIA AT TIME OF TREATMENT: Pulse oximetry of > 90% on room air
Pulse oximetry of > 95% on room air in patients who previously received radiation therapy
DLCO corrected < 50%; patients who are unable to perform pulmonary function tests (for example, due to young age and/or developmental status) will be excluded if the O2 saturation is < 92% on room air; patients with a DLCO 50-60% must also have a partial pressure of oxygen (pO2) of > 80 mmHg
Oxygen saturation >= 90%, no more than 2 liters per minute (LPM) oxygen
Pulse oximetry of > 90% on room air
Adequate respiratory function defined as not requiring supplemental oxygen or mechanical ventilation; oxygen saturation 90% or higher on room air
RETREATMENT WITH MODIFIED T-CELLS INCLUSION CRITERIA: Oxygen saturation 90% or higher on room air
INCLUSION - TREATMENT: Pulse oximetry of ? 90% on room air
Within 4 weeks prior to study enrollment: Pulse oximetry > 94% on room air or oxygen (O2) by nasal cannula
Oxygen saturation >= 90% by pulse oximetry
Patients with baseline respiratory insufficiency severe enough to require supplemental oxygen.
Pulse oximetry >= 94% if there is clinical indication for determination
TREATMENT WITH SJCAR19: Forced vital capacity (FVC) >= 50% of predicted value; or pulse oximetry >= 92% on room air if patient is unable to perform pulmonary function testing
No evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 94%
Pulmonary function\r\n* Baseline oxygen saturation > 92% on room air at rest \r\n* Patients with respiratory symptoms must have a diffusing capacity of the lungs for carbon monoxide (DLCO)/adjusted > 45%; for children who are unable to cooperate for pulmonary function tests (PFTs) they must not have dyspnea at rest or known requirement for supplemental oxygen
Must have an ambulatory oxygen saturation of > 90% on room air
Resting baseline oxygen (O2) saturation by pulse oximetry of ? 92% at rest
Baseline oxygen saturation > 92% on room air
Patients/subjects who need daily oxygen therapy
Must have a minimum level of pulmonary reserve defined as ? grade 1 dyspnea and pulse oximetry of ? 88% on room air
Adequate respiratory function defined as not requiring supplemental oxygen or mechanical ventilation; oxygen saturation 90% or higher on room air
Pulse oximetry > 94% on room air
Patients who have any clinical evidence of hypoxia with O2 saturation less than 92% on room air.
A pulse oximetry ? 93%
Adequate respiratory function defined as not requiring supplemental oxygen or mechanical ventilation; oxygen saturation 90% or higher on room air
Baseline oxygen saturation > 92% on room air
Patients who have a significant history of pulmonary disease that necessitates the use of supplemental oxygen, and patients with resting pulse oximetry < 92% on room air
Pulse oximetry > 94% on room air
Pulse oximetry oxygen (O2) saturation < 90% at rest on room air
Adequate respiratory function defined as not requiring supplemental oxygen or mechanical ventilation; oxygen saturation 90% or higher on room air
Subject does not require supplemental oxygen or mechanical ventilation, and oxygen saturation by pulse oximetry is 94% or higher on room air.
Common Terminology Criteria for Adverse Events (CTCAE) grade =< 1 dyspnea and oxygen saturation (SaO2) >= 92% on room air
Oxyhemoglobin saturation at rest >= 95% (off supplemental oxygen)
Use of continuous oxygen
Adequate pulmonary function as assessed by >= 92% oxygen saturation on room air by pulse oximetry
Adequate pulmonary function as assessed by >= 92% oxygen saturation on room air by pulse oximetry
Oxygen saturation >= 90% on room air
No clinically significant pleural effusion, baseline oxygen saturation > 92% on room air
Pulse oximetry >= 92% on room air at rest
Room air oxygen saturation of 92% or greater
Baseline oxygen saturation > 92% on room air
Pulmonary dysfunction defined as:\r\n* Severe pulmonary dysfunction with (1) a hemoglobin corrected DLCO < 40% of predicted at the Baseline Screening visit, or (3) FVC < 45% of predicted Baseline Screening visit, or\r\n* Partial pressure (pO2) < 70 mmHg or pCO2 >= 45 mmHg without supplemental oxygen, or \r\n* O2 saturation < 92% at rest without supplemental oxygen as measured by forehead pulse oximeter
Patients/subjects who need daily oxygen therapy
Uncontrolled asthma or oxygen saturation < 90% by arterial blood gas analysis or pulse oximetry on room air.
CELL PROCUREMENT: Subjects may not have an oxygen requirement as defined by pulse oximetry of < 90% on room air
LYMPHODEPLETION: Subjects may not have an oxygen requirement as defined by pulse oximetry of < 90% on room air
Must not require supplemental oxygen or have a pulse oximetry < 92% on room air
Patients requiring oxygen therapy
Patients requiring oxygen therapy
The patient has adequate pulmonary function per protocol and oxygen saturation >92% on room air.
Patients requiring continuous supplemental oxygen are excluded to avoid possible complications from pneumonitis
For patients < 8 years of age unable to perform pulmonary function tests (PFTs) due to age or developmental ability: (1) no evidence of dyspnea at rest and (2) no need for supplemental oxygen and (3) oxygen (O2) saturation > 92% on room air
Must have an ambulatory oxygen saturation of > 88% on room air
Must have an ambulatory oxygen saturation of > 90% on room air
Forced vital capacity (FVC) >= 40% of predicted value; or pulse oximetry >= 92% on room air if patient is unable to perform pulmonary function testing
Oxygen saturation >= 90% on room air and adjusted diffusing capacity of the lungs for carbon monoxide (DLCO) of at least 40%
Need for supplemental oxygen
No evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 94%
PRIOR TO INFUSION OF ATLCAR.CD30 CELLS: Pulse oximetry of > 90% on room air
Room air oxygen saturation of 92% or greater
Has a pulse oximetry < 92% on room air
Must have a minimum level of pulmonary reserve defined as =< grade 1 dyspnea, pulse oxygen > 92% on room air, and carbon monoxide diffusing capability test (DLCO) >= 40% (corrected for anemia)
Patient has a pulse oximetry of < 92% on room air
Subjects must have resting baseline oxygen (O2) saturation by pulse oximetry of >= 92% at rest
Pulse Oximetry measurement ? 95% saturation without supplemental oxygen
Oxygen saturation over 90% by pulse oximetry without administration of supplemental oxygen
Baseline oxygen saturation > 92% on room air and no clinically significant pleural effusion
No supplemental oxygen requirement
Pulse oximetry of > 95% on room air
ELIGIBILITY CRITERIA- LYMPHODEPLETION/INFUSION OF tvs-CTL: Pulse oximetry of > 95% on room air
Patient has a pulse oximetry of < 92% on room air
Patient is on supplemental home oxygen
ADDITIONAL CRITERIA FOR STUDY CONTINUATION: Patient has a pulse oximetry of < 92% on room air
ADDITIONAL CRITERIA FOR STUDY CONTINUATION: Patient is on supplemental home oxygen
AT THE TIME OF INFUSION: Pulse oximetry of ? 90% on room air
Adequate pulmonary function as defined as: no evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 94% if there is clinical indication for determination
TREATMENT: Pulse oximetry of > 90% on room air
Patients must have clinically normal lung function as manifested by no dyspnea at rest and no oxygen requirement
No evidence of dyspnea at rest and pulse oximetry > 94%
Not requiring supplemental oxygen or mechanical ventilation; oxygen saturation 90% or higher on room air; no dyspnea at rest
ELIGIBILITY CRITERIA FOR T-CELL PRODUCT INFUSION: Not requiring supplemental oxygen or mechanical ventilation, oxygen saturation 90% or higher on room air and no dyspnea at rest
RETREATMENT WITH MODIFIED T CELLS: Oxygen saturation 90% or higher on room air
RETREATMENT WITH MODIFIED T CELLS: Patient requiring supplemental oxygen or mechanical ventilation
TREATMENT: Pulse oximetry of > 93% on room air in patients who previously received radiation therapy
Requirement for FiO2 > 0.5 to maintain arterial oxygen saturation > 90%
Children unable to perform pulmonary function tests (e.g., less than 7 years old) pulse oximetry of >= 92% on room air
Normal lung function as manifested by no dyspnea at rest and no oxygen requirement
ELIGIBILITY CRITERIA TO UNDERGO OPTIONAL T CELL ABLATION\r\n* Research participant has >= 1% CAR T cells in the peripheral blood\r\n* Pulmonary: not requiring supplemental oxygen or mechanical ventilation, oxygen saturation 90% or higher on room air\r\n* Cardiovascular: not requiring pressor support, no symptomatic cardiac arrhythmias, no acute coronary syndrome, or uncontrolled hypertension\r\n* Renal Function: serum creatinine did NOT increase by more than 2.5 fold from baseline (at time of screening)\r\n* Liver Function: adequate liver function defined as total bilirubin =< 3.0 mg/dl \r\n* AST =< 5 x ULN, ALT =< 5 x ULN\r\n* Neurological: research participant without clinically significant encephalopathy/new focal deficits\r\n* Infectious diseases: no clinical evidence of uncontrolled active infectious process
Not requiring supplemental oxygen or mechanical ventilation, oxygen saturation 90% or higher on room air
(ELIGIBILITY CRITERIA AT TIME OF INFUSION OF GENETICALLY MODIFIED AUTOLOGOUS T CELLS): Not requiring supplemental oxygen or mechanical ventilation, oxygen saturation 90% or higher on room air
Not requiring supplemental oxygen or mechanical ventilation, oxygen saturation 90% or higher on room air
Pulmonary: not requiring supplemental oxygen or mechanical ventilation, oxygen saturation 90% or higher on room air
Pulmonary criteria: not requiring supplemental oxygen or mechanical ventilation, oxygen saturation 90% or higher on room air
Receiving supplementary continuous oxygen
Pulse oximetry of > 90% on room air
Normal oxygen saturation at baseline ABG (arterial blood gas) testing
For children who are unable to perform pulmonary function tests but have no evidence of dyspnea at rest nor exercise intolerance nor abnormal chest X-ray (CXR), a pulse oximetry > 94% on room air is acceptable
Baseline oxygen saturation of < 85% or partial pressure of oxygen in arterial blood (PaO2) < 70
Must have a minimum level of pulmonary reserve defined as =< grade 1 dyspnea and pulse oxygen > 92% on room air
Diffusing capacity of the lung for carbon monoxide (DLCO) equal or greater than 50% predicted corrected for hemoglobin; for children =< 7 years of age who are unable to perform pulmonary function tests (PFT), oxygen saturation >= 92% on room air by pulse oximetry
Oxygen saturation >= 90% on room air
Patients must have no evidence of dyspnea at rest and a pulse oximetry > 92% while breathing room air
RANDOMIZED PHASE II (ARMS K AND L): Patients must have no evidence of dyspnea at rest and a pulse oximetry > 92% while breathing room air
Pulse oximetry of > 90% on room air
Normal lung function as manifested by no dyspnea and/or oxygen saturation >= 94% on room air
Forced vital capacity (FVC) >= 50% of predicted value; or pulse oximetry >= 92% on room air if patient is unable to perform pulmonary function testing
Severe chronic obstructive or other pulmonary disease with hypoxemia (requires supplementary oxygen, symptoms due to hypoxemia or oxygen saturation <90% by pulse oximetry after a 2 minute walk) or in the opinion of the investigator any physiological state likely to cause systemic or regional hypoxemia
Pulse oximetry of > 90% on room air
Oxygen saturation >= 90% on room air, measured prior to treatment
Pulse oximetry > 94% if there is clinical indication for determination
Continuous oxygen use
Pulse oximetry of > 90% on room air
Pulse oximetry of >= 90% on room air
For children who are uncooperative for pulmonary function tests and have no evidence of dyspnea at rest or exercise intolerance, pulse oximetry > 94% on room air is considered acceptable, with a normal chest X-ray
Adequate pulmonary function as assessed by >= 92% oxygen saturation on room air by pulse oximetry
Oxygen saturation > 92%
Dyspnea at rest due to complications of advanced malignancy or other disease requiring continuous oxygen therapy.
Evidence of dyspnea at rest or oxygen saturation (<=) 94 percent (%).
Current dyspnea at rest of any origin, or other diseases requiring continuous oxygen therapy.
Normal lung oxygen saturation by pulse oximeter, as determined by the Principal Investigator based on patient history and status.
Respiratory failure (defined as oxygen saturation [SaO2] < 90% on room air; partial pressure of carbon dioxide [PCO2] > 45mmHg; or forced expiratory volume in one second [FEV1] <1.0 liter).
No clinically significant pleural effusion, baseline oxygen saturation > 92% on room air
No clinically significant pleural effusion, baseline oxygen saturation > 92% on room air.
Oxygen saturation (Sp02) of less than 95% on room air
ENROLLMENT: Pulmonary symptoms controlled by medication and pulse oximetry >= 92% on room air.
Within 14 days of study registration: No oxygen requirement on room air or requiring =< 2L supplemental oxygen (O2)
Within 14 days of study registration (30 days for pulmonary and cardiac): oxygen saturation >= 90% on room air with no symptomatic pulmonary disease. If symptomatic or prior known impairment single breath carbon monoxide diffusing capacity (DLCOc) or >= 40%.
Current use of supplemental oxygen
Oxygen saturation as measured by pulse oximetry is > 93% on room air and no evidence of dyspnea at rest
No evidence of dyspnea at rest, no history of exercise intolerance, and a pulse oximetry > 94%
Any patient requiring supplemental oxygen therapy
Resting baseline oxygen (O2) saturation by pulse oximetry of >= 92% at rest
Resting oxygen saturation (O2 sat) must be >= 92%
Within 30 days of registration: Oxygen saturation >= 90% on room air
Patients must not require daily supplemental oxygen
Pulse oximetry > 94% on room air
Oxygen saturation >= 92% on room air
Oxygen saturation on room air > 92 % by pulse oximetry; (patients on intermittent or continuous supplemental oxygen are not allowed)
Known severely impaired lung function (spirometry and diffusing capacity of the lung for carbon monoxide [DLCO] 50% or less of normal and oxygen [O2] saturation 88% or less at rest on room air)
Uncontrolled asthma or oxygen (O2) saturation < 90% by ABG (arterial blood gas) analysis or pulse oximetry on room air
No requirement for supplemental oxygen therapy
With impaired pulmonary function as evidenced by partial pressure of oxygen (pO2) < 70 mm Hg and carbon monoxide diffusing capability test (DLCO) < 70% of predicted or pO2 < 80 mm Hg and DLCO < 60% of predicted; (or, for pediatric patients unable to perform pulmonary function tests, then oxygen (O2) saturation < 92% on room air), or receiving supplementary continuous oxygen
Pulse oxygen (Ox) >= 90% on room air
Severely impaired lung function as defined as spirometry and DLCO (corrected for Hgb)\n             that is <50% of the normal predicted value and/or O2 saturation <88% at rest on room\n             air.
Severe hypoxemia with room air pulmonary arterial oxygen tension (PaO2) < 70, supplemental oxygen dependence, or DLCO < 50% predicted
Pulse oximetry of >= 90% on room air
Pulse oximetry of > 90% on room air
Patients requiring supplemental oxygen
Must have a minimum level of pulmonary reserve defined as ?Grade 1 dyspnea and pulse oxygenation > 91% on room air
Must have a minimum level of pulmonary reserve defined as ? Grade 1 dyspnea and pulse oxygenation > 91% on room air
Subject has resting baseline oxygen saturation by pulse oximetry of ? 92% at rest.
The patient is oxygen-dependent.
Participants requiring any daily supplemental oxygen
Must have a minimum level of pulmonary reserve as ? Grade 1 dyspnea and pulse oxygenation > 91% on room air.
O2 saturation < 92% (on room air).
Oxygen saturation on room air > 92 % by pulse oximetry; (subjects on intermittent or continuous supplemental oxygen are excluded)
> 90% oxygen saturation on room air by pulse oximetry
Uncontrolled asthma or oxygen saturation <90% by arterial blood gas analysis or pulse oximetry on room air;
Adequate oxygen saturation via pulse oximeter within 28 days prior to registration (i.e., patient can NOT have CTCAE hypoxia grade 2 or greater)
Resting baseline oxygen (O2) saturation by pulse oximetry of >= 92% at rest
Must have a minimum level of pulmonary reserve defined as =< grade 1 dyspnea and pulse oxygen > 92% on room air
Known severely impaired lung function, including: • CTCAE grade 2 (or greater) hypoxia (decreased oxygen saturation with exercise [e.g., pulse oximeter <88%]; intermittent supplemental oxygen)
Patients requiring supplemental oxygen therapy
Severe chronic obstructive or other pulmonary disease with hypoxemia (requires supplementary oxygen, symptoms due to hypoxemia or oxygen [O2] saturation < 90% by pulse oximetry after a 2 minute walk or in the opinion of the investigator any physiological state likely to cause systemic or regional hypoxemia)
Oxygen saturation >= 90% on room air
Adequate pulmonary function defined as:\r\n* No evidence of dyspnea at rest, no exercise intolerance, no chronic oxygen requirement, and room air pulse oximetry > 94% if there is a clinical indication for pulse oximetry; normal pulmonary function tests in patients who are capable of cooperating with testing (including diffusion capacity of the lung of carbon monoxide [DLCO]) are required if there is a clinical indication for determination; for patients who do not have respiratory symptoms, full pulmonary function tests (PFTs) are NOT required
Pulse oximetry of > 90% on room air
Pulse oximetry of > 90% on room air
Normal pulmonary function tests (including diffusing capacity of the lungs for carbon monoxide [DLCO]) if there is clinical indication for determination (e.g. dyspnea at rest, known requirement for supplemental oxygen); Note: for patients who do not have respiratory symptoms or requirement for supplemental oxygen, pulmonary function tests (PFTs) are NOT required
The patient is oxygen-dependent.
Baseline oxygen saturation > 92% on room air
Resting and ambulatory oxygen saturation >= 94% on room air
Oxygen saturation as measured by pulse oximetry must be >= 93% on room air
Severe chronic obstructive or other pulmonary disease with hypoxemia (requires supplementary oxygen, symptoms due to hypoxemia or oxygen saturation < 90% by pulse oximetry after a 2 minute walk) or in the opinion of the investigator any physiological state likely to cause normal tissue hypoxia
Patient has a pulse oximetry of < 92% on room air
Patient is on supplemental home oxygen
Patients must not have any known uncontrolled underlying pulmonary disease or severely impaired lung function (spirometry and diffusing capacity of the lung for carbon monoxide [DLCO] 50% or less of normal and oxygen [O2] saturation 88% or less at rest on room air)
Dyspnea at rest or other diseases that require continuous oxygen therapy
AT THE TIME OF INFUSION: Pulse oximetry of > 90% on room air
Patients must have adequate lung function, as defined by oxygen saturation greater than or equal to 90% by pulse oximetry
Not requiring supplemental oxygen or mechanical ventilation, oxygen saturation 90% or higher on room air
Resting and walking oxygen (O2) saturation must remain above 90% at the time of screening
Patients with a pulse oximetry of < 92% on room air
Patients on supplemental home oxygen
Continuous oxygen use
Patients on oxygen
No evidence of dyspnea at rest, no exercise intolerance due to pulmonary insufficiency, and a pulse oximetry > 92% while breathing room air
Patients must demonstrate a respiratory rate that is within normal limits for age, measured when afebrile and at rest (measured for a full minute) and pulse oximetry >= 93% on room air
For pediatric patients unable to perform pulmonary function tests, oxygen (O2) saturation > 92% on room air
May not be on supplemental oxygen
Patient must not have a requirement for supplemental oxygen
Pulse oximetry greater than or equal to 92% on room air
Oxygen (O2) saturation at rest >= 90% (off supplementary oxygen)
No evidence of dyspnea at rest and a pulse oximetry > 94% if there is clinical indication for determination
Individuals with active lung disease as defined by presence of pulmonary infiltrates on screening chest x-ray or baseline room air oxygen saturation of < 92%
The patient must not be dependent on supplemental oxygen
Pulmonary function test (PFT) demonstrating a diffusion capacity of least 50% predicted; for children =< 7 years of age who are unable to perform PFT, oxygen saturation >= 92% on room air by pulse oximetry
Pulse oximetry of > 88%
Adequate pulmonary function as assessed by >= 92% oxygen saturation on room air by pulse oximetry
Oxygen saturation >= 95% on room air
Oxygen saturation >= 90% on room air
Oxygen saturation >= 90% on room air and diffusing capacity of the lung for carbon monoxide corrected (DLCOcor) >= 40%
Use of formalin or hyperbaric oxygen treatment
Significant lung disease (oxygen [O2] saturation less than 88% in room air)
Adequate pulmonary function as assessed by >= 92% oxygen saturation on room air by pulse oximetry
Pulmonary function - diffusion capacity of at least 50% predicted; children unable to perform pulmonary function tests (e.g. less than 7 years old) pulse oximetry of >= 92% on room air
Pulse oximetry of > 90% on room air
Pulmonary function test demonstrating a diffusion capacity of least 50% predicted (myeloablative regimen 4, reduced intensity regimen 3) or at least 40% predicted (nonmyeloablative regimen 2); for children < 7 years of age who are unable to perform pulmonary function test (PFT), oxygen saturation > 92% on room air by pulse oximetry
Patients must not have any evidence of dyspnea at rest, exercise intolerance, and must have a pulse oximetry > 94% at sea level
Hypoxia (oxygen saturation < 90% on room air) or in the opinion of the investigator any pulmonary compromise leading to hypoxia, at the time of study entry
Severe pulmonary dysfunction with a hemoglobin corrected DLCO < 30% or FVC < 40% of predicted or O2 saturation < 92% at rest without supplemental oxygen
A pulse oximetry ? 94% at sea level (? 90% at altitude ? 5000 feet) if there is clinical indication for determination.
FEV1, FVC > 50% of predicted; Note: If unable to perform pulmonary tests, then O2 saturation > 92% on room air.
Requirement of supplemental oxygen.
Oxygen saturation at rest or with exercise > 88% as measured by pulse oximeter or PaO2 > 55 mm Hg without need for supplemental oxygen at rest or with activity
Oxygen saturation of greater than or equal to 90% on room air
Oxygen saturation at rest by pulse oximetry less than 88% or partial pressure of oxygen (PaO2) less than or equal to 55 mm Hg
Severe chronic obstructive or other pulmonary disease with hypoxemia (requires supplementary oxygen, symptoms due to hypoxemia or oxygen saturation less than 90% by pulse oximetry after a 2 minute walk) or in the opinion of the investigator any physiological state likely to cause hypoxia of normal tissue.
Oxygen partial pressure (pO2) < 60% or carbon dioxide partial pressure (pCO2) >= 50 on room air arterial blood gas
Subjects must have a resting baseline oxygen (O2) saturation by pulse oximetry of >= 92% at rest
Baseline oxygen saturation >92% on room air
Requiring supplemental oxygen at more than 2 L/min
Oxygen saturation (Sp02) of less than 95% on room air.
Pulse oximetry of > 90% on room air
Dyspnea of any cause requiring supplemental oxygen therapy;
Participants requiring any daily supplemental oxygen
Pulse oximetry greater than or equal to 92% on room air
Patients with history of lung disease currently requiring any pharmacologic or supplemental oxygen treatment
Adequate pulmonary function defined as:\r\n* No dyspnea at rest\r\n* No known requirement for supplemental oxygen\r\n* No known active pneumonitis
Pulmonary function test (PFT) demonstrating a diffusion capacity of least 50% predicted; for children =< 7 years of age who are unable to perform PFT, oxygen saturation >= 92% on room air by pulse oximetry
Patients must have baseline pulse oximetry > 90% on room air
Pulse > 45 or < 120
Forced vital capacity (FVC) >= 40% of predicted value; or pulse oximetry >= 92% on room air if patient is unable to perform pulmonary function testing
Forced vital capacity (FVC) >= 50% of predicted value or pulse oximetry (Pox) >= 92% on room air
Patients must have baseline pulse oximetry > 90% on room air
O2 saturation < 92% (on room air), evidence of TLS > grade 2 (according to the Cairo-Bishop criteria (3)) or leukostasis (2).
The patient is oxygen-dependent.
Cohort A: Continuous oxygen use
Forced vital capacity (FVC) >= 40% of predicted value; or pulse oximetry >= 92% on room air if patient is unable to perform pulmonary function testing
Patient currently requiring supplemental oxygen for his/her daily life
Requirement for supplemental oxygen to carry out activities of daily living
If unable to perform pulmonary function tests due to young age, oxygen saturation > 92% on room air
Oxygen saturation <95% on room air by trans-cutaneous method or need for any supplemental oxygenation or ventilatory support, or increase in oxygen supplementation requirement of ?2 litres for subjects with chronic oxygen dependency. For those subjects with a history of chronic hypoxia (without supplemental oxygen), an oxygen saturation of at least 3% below the patient's historical baseline oxygen saturation will satisfy this criterion.
persistent arterial oxygen desaturation, arterial partial pressure of oxygen (PaO2) < 50 or oxygen saturation (SaO2) saturation < 80%,
Pulse oximetry >= 93% at room air
Impaired lung function: O2 saturation 88% or less at rest on room air by pulse oximetry; if O2 saturation is =< 88% at rest, further pulmonary function tests (PFTs) should be ordered to confirm normal pulmonary function and eligibility
No evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 94% in room air, if there is clinical indication for determination
Oxygen saturation >= 90% on room air
Room air oxygen saturation of > 94%
Pulse > 45 and < 120
Current dyspnea at rest, owing to complications of advanced malignancy or any requirement for supplemental oxygen to perform activities of daily living
Oxygen saturation < 90% despite supplemental oxygen > 6 L/minute.
Are receiving chronic oxygen therapy
Daily supplemental oxygen
Subjects currently on supplemental oxygen support
Patients with history of lung disease currently requiring any pharmacologic or supplemental oxygen treatment
Chronic supplemental oxygen requirement or hypoxemia < 92% blood oxygen saturation (SpO2)
Any patients requiring oxygen at baseline
Non-hypoxemic (i.e. oxygen saturation > 90% on ambient air)
Able to tolerate high-flow oxygen/air
Supplemental oxygen dependency
Tracheotomy or oxygen dependence at time of MBS
Partial pressure of arterial oxygen (PaO2):fraction of inspired oxygen (FiO2) ratio =< 300 mmHg OR a peripheral capillary oxygen saturation (SaO2):FiO2 =< 357
Oxygen saturation > 90% on ambient air at time of assessment
Patients who are oxygen dependent
Room air desaturation at rest =< 85%
Room air desaturation at rest =< 85%
Supplemental oxygen requirement > 6 L per minute
Patients requiring oxygen more than 2 liters
Adequate pulmonary function defined as:\r\n* Room air oxygen saturation of > 90% at altitude > 5000 feet, or > 93% < 5000 feet
No requirement for supplemental oxygen (O2)
Oxygen saturation during exertion is maintained at >= 88% on room air
Patients with history of lung disease currently requiring any supplemental oxygen treatment
Adequate pulmonary function as assessed by oxygen saturation >= 90% when ambulating and not requiring supplemental oxygen
Respiratory disease requiring continuous supplemental oxygen
Supplemental oxygen requirement > 6 L per minute
Supplemental oxygen requirement > 6 L per minute
Oxygen saturation < 90% despite supplemental oxygen > 6 L/min
Patients with RSV infection limited to the URT as documented by negative chest radiographic findings within the last 48 hours of enrollment and pulse oxygenation of more than 90 mm of Hg on room air
Patients with evidence of RSV LRI as documented by a positive rapid RSV antigen testing and/or culture on nasal washes AND new or progressive infiltrates on chest radiographic studies suggestive of viral etiology and/or pulse oxygen less than 90 mm of Hg on room air
Oxygen dependent
Oxygen saturation below 92% on room air
Adequate respiratory function with a room air oxygen saturation of at least 92%
Pulse oximetry of > 90% on room air
On chronic oxygen
Carbon monoxide diffusing capability test (DLCO) > 60% predicted and in children- room air oxygen saturation > 92%
Severe hypoxemia with room air partial pressure of oxygen (PaO2) < 70, supplemental oxygen dependence, or DLCO < 50% predicted
Required prior to infusion of ATLCAR.CD30 cells: Pulse oximetry of > 90% on room air
Room air desaturation at rest =< 85%
For children who are unable to perform pulmonary function testing, no evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 94% on room air
For children who are unable to perform pulmonary function testing, no evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 92% in room air
Pulse oximetry of hemoglobin saturation ?92% on room air
Oxygen saturation >= 90% on room air
Hypoxemia (less than 90% saturation with supplemental oxygen)
Current use of supplemental oxygen
Known severely impaired lung function (spirometry and DLCO 50% or less of normal and O2 saturation 88% or less at rest on room air)
Respiratory failure requiring greater than 6 Lpm supplemental oxygen (O2) by nasal cannula or mechanical ventilation within the past six weeks
Baseline oxygen saturation > 92% on room air
Patients must have documented pulse oximetry >= 92% on room air
Patients that require supplemental oxygen are excluded
Patients requiring continuous supplemental oxygen due to the requirement of spirometry during all imaging studies
Oxygen saturation < 90% on room air
Patients with history of lung disease currently requiring any pharmacologic or supplemental oxygen treatment
Requires daily supplemental oxygen.
Patients that require supplemental oxygen are excluded
Oxygen saturation >= 90% when ambulating and not requiring supplemental oxygen