Must be obtained within 14 days prior to registration for protocol therapy: Creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated a creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 30 mL/min for subject with creatinine levels > 1.5 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Within 14 days of treatment initiation: Serum creatinine =< 1.5 x ULN OR measured or calculated creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine =< institutional upper limit normal (ULN), CTCAE v 3.0 grade 0; NOTE: if creatinine > ULN, creatinine clearance must be > 50 mL/min

Creatinine =< 1.5 times institutional upper limit of normal (ULN) OR calculated creatinine clearance >= 60 mL/min

Serum creatinine below the upper limit of the institutional normal range (ULN) or creatinine clearance ? 60 mL/min/1.73 m2 for patients with serum creatinine levels above institutional ULN.

Within 21 days of treatment initiation:\r\nSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl)

Creatinine < 1.5 x institutional upper limit of normal or creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Creatinine =< institutional upper limit or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 50 mL/min for subject with creatinine levels > 1.5 X institutional ULN (within 14 days of treatment initiation)

Measured within 28 days prior to registration: serum or plasma creatinine =< 1.5 x institutional upper limit of normal (ULN) OR creatinine clearance >= 51 mL/min/1.73 m^2 for participants

Creatinine clearance >= 50 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above 1.5 x upper limit of normal

Renal: serum creatinine ?1.5 × ULN or calculated creatinine clearance or glomerular filtration rate >50 mL/min/1.73 m2 for subjects with creatinine levels above institutional normal.

Creatinine =< 1.5 x IULN or >= 60 ml/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subjects with creatinine levels > 1.5 x institutional ULN obtained within 14 days prior to registration

Within 14 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (up to 14 days before treatment initiation)

Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal (using Cockcroft Gault formula)

Within 14 days of treatment initiation:\r\nSerum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Acceptable renal function: o Serum creatinine within normal limits, OR calculated creatinine clearance 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal.

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard

Within 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard

INCLUSION CRITERIA FOR SECOND-LINE THERAPY: Serum creatinine =< 1.5 X upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

INCLUSION CRITERIA FOR THIRD-LINE THERAPY: Serum creatinine =< 1.5 X upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Creatinine < 1.5 mg/dL OR creatinine clearance ? 60 mL/min/1.73 m^2 for patients with creatinine levels > institutional normal within 14 days of registration

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< serum creatinine =< 1.5 x upper limit of normal (ULN) or creatinine clearance (CrCl) >= 40 mL/min (if using the Cockcroft-Gault formula), performed within 10 days of treatment initiation\r\n* Creatinine clearance should be calculated per institutional standard

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Serum creatinine =< 1.5 x institutional upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN, performed within 14 days of treatment initiation\r\n* Creatinine clearance should be calculated per institutional standard

Creatinine =< 1.5 x above institutional normal or >= 60 ml/min/1.73 m^2 for subjects with creatinine levels above institutional normal

COHORT 1: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or corrected creatinine [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 14 days of treatment initiation

COHORT 2: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (GFR can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 14 days of treatment initiation

Creatinine =< 1.5 x the institutional upper limit of normal (ULN), or 24-hr clearance >= 50 mL/min, within 14 days of registration

Creatinine =< 1.5 x the upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x the upper limit of normal

SAFETY RUN-IN: Within 10 days of registration: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

RANDOMIZED PHASE II CLINICAL TRIAL: Within 10 days of registration: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (GFR can also be used in place of CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Serum creatinine =< 1.5 X ULN OR creatinine clearance (measured or calculated) >= 60 mL/min for participants with creatinine levels > 1.5 X ULN (glomerular filtration rate [GFR] can be used in place of creatinine or creatinine clearance), performed within 14 days of treatment initiation

Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 x institutional upper limit of normal or creatinine clearance > 60 mL/min/1.73 m^2 (per 24 hour urine collection or calculated according to the Cockcroft-Gault formula) for subjects with creatinine levels above the institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 50 mL/min for patients with creatinine levels above institutional normal

Serum creatinine < 2 mg/dL OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (unless elevated creatinine or creatinine clearance felt by investigator to be acute and reversible)

Creatinine within normal institutional limits OR creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits or creatinine clearance > 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (using Cockcroft-Gault formula)

Creatinine within institutional normal limits (WNL) OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Patients with a creatinine =< 2 x normal for age

Creatinine =< 1.5 x institutional ULN OR creatinine clearance >= 60 mL/min by Cockcroft-Gault equation for participants with creatinine levels above institutional normal.

Serum creatinine =< 1.5 x institutional ULN, OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with serum creatinine levels above 1.5 x institutional ULN

Creatinine within normal institutional limits OR creatinine clearance ? 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Within 10 (except as noted) days of planned treatment initiation: Serum creatinine =< 1.5 x the upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for patients with creatinine levels > 1.5 x institutional ULN (calculated per institutional standard). (glomerular filtration rate can be used in place of creatinine or creatinine clearance)

Obtained within 21 days prior to study registration: creatinine within normal institutional limits OR creatinine clearance ? 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Creatinine =< 1.5 times the normal upper institutional limit OR creatinine clearance >= 60 mL/min/1.73 m^2 in participants with creatinine levels > 1.5 times the normal upper institutional limit

Serum creatinine or creatinine clearance =< institutional upper limit or >= 60 mL/min creatinine clearance for patients with serum creatinine > institutional upper limit

Serum creatinine =< 1.5 x upper limit of normal or calculated creatinine clearance >= 60 mL/min using Cockcroft-Gault equation for patients with creatinine levels > 1.5 x institutional upper limit of normal (ULN)

Serum creatinine =< 1.5 x institutional upper limit of normal (ULN) OR calculated creatinine clearance >= 50 mL/min for subjects with creatinine levels > 1.5 x institutional ULN within 28 days of treatment initiation and must be independent of hematopoietic growth factor support

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance >= 60 mL/min for patient with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])\r\n* Creatinine clearance should be calculated per institutional standard.

Creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Creatinine ? 1.5 x institutional ULN OR creatinine clearance ? 60 mL/min by Crockoft-Gault for participants with creatinine levels above institutional normal

Creatinine clearance < 1.5 x institutional ULN

Creatinine within upper normal institutional limit OR creatinine clearance >= 50 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Patients with a creatinine normal for age

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 10 days of treatment initiation\r\n* Creatinine clearance should be calculated per institutional standard

Within 14 days of treatment registration: Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard

Creatinine =< 1.5 x within normal institutional ULN OR

Creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional ULN

Creatinine =< 1.5 x within normal institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional ULN

Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 x institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with serum creatinine levels > 1.5 x higher than institutional normal

Creatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with serum creatinine levels above institutional normal (IULN) (calculated by creatinine clearance estimate by Cockcroft-Gault equation)

Creatinine clearance >= 50 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Within 2 weeks prior to initiation of study treatment: Creatinine =< upper limit of institutional normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 x ULN or a creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal, determined within 14 days of registration

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (creatinine clearance should be calculated per institutional standard), performed within 14 days of treatment initiation

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 30 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 14 days of treatment initiation\r\n* Creatinine clearance should be calculated per institutional standard

Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine within normal institutional limits or creatinine clearance >= 40 ml/min

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 14 days of D1 of treatment under LCCC1522

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (performed within 28 days of treatment initiation)

Serum creatinine ?1.5 × institutional upper limit of normal (ULN) or calculated creatinine clearance >30 mL/min.

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 30 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Serum creatinine =< 1.5 X institutional upper limit of normal (ULN) OR measured or calculated creatinine clearance should be calculated per institutional standard (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 28 days of study registration

COHORT I: Creatinine < 2 x upper limit of normal (ULN) or creatinine clearance >= 45 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above 1.5 x institutional normal

Creatinine =< upper limit of normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 x upper limit of normal (ULN) OR creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (obtained =< 14 days prior to registration)

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 x institutional upper limit of normal (IULN) OR creatinine clearance by Cockcroft-Gault >= 60 mL/min for patients with serum creatinine > 1.5 x IULN

Creatinine < 2 x institution upper limit of normal OR creatinine clearance > 45 mL/min/1.73 m^2, for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits, OR creatinine clearance >= 60 mL/min, based either on Cockcroft-Gault estimate or based on urine collection (12 or 24 hour), for participants with creatinine levels above institutional normal

Creatinine =< 1.5 X institutional upper limit of normal OR measured creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normal

Serum creatinine < 2 x institutional upper limit of normal OR creatinine clearance >= 50 mL/min/for patients with creatinine levels above institutional normal

Creatinine =< 1.5 x institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 mg/dL

Either creatinine < 1.5 x institutional upper limit of normal (ULN) or creatinine clearance > 60 mL/min as calculated by institution’s standard formula

Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Performed within 10 business days of treatment initiation with the exception of beta- HCG (72 hours), if applicable: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine ? 1.5 x upper limit of normal (ULN) OR creatinine clearance ? 50 mL/min/1.73 m^2 (using Cockroft Gault Formula) for patients with creatinine levels above institutional normal

Creatinine clearance >= 60 Ml/min/1.73 m^2 for patients with creatinine levels above institutional normal.

At time of registration and within 4 weeks prior to initiating on-protocol treatment: Creatinine =< 1.5 x upper limit of normal (ULN), OR measured or calculated creatinine clearance (glomerular filtration rate (GFR) can also be used in place of creatinine or CrCl) >= 60 mL/min/1.73m^2 for participants with creatinine levels > 1 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard. For participants with a baseline calculated creatinine clearance below normal institutional laboratory values, a measured baseline creatinine clearance should be determined. Individuals with higher values felt to be consistent with inborn errors of metabolism will be considered on a case-by-case basis.

Creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal.

Within 10 days prior to the start of study treatment: Creatinine =<1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCl) >= 30 mL/min for participant with creatinine levels > 1.5 x institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl)

Creatinine ? 1.5 x IULN OR creatinine clearance ? 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance\r\n(glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 28 days of treatment initiation

Performed within 10 days of treatment initiation: Serum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) ? 40 mL/min for subject with creatinine levels > 2.0 X institutional ULN

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN, should be performed within 10 days of treatment initiation

Creatinine =< 1.5 x IULN or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 x upper limit of normal (ULN) OR creatinine clearance > 50 mL/min/1.73 m2 for patients with creatinine levels =< 1.5 x upper limit above institutional normal

Serum creatinine =< 1.5 x institutional upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCL) >= 50 mL/min (creatinine clearance should be calculated per institutional standard); glomerular filtration rate (GFR) can also be used in place of creatinine of CrCl

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR Measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]), performed within 10 days of treatment

Serum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance ? 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) within 21 days of treatment initiation\r\n* Creatinine clearance should be calculated per institutional standard

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or corrected creatinine [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 21 days of treatment initiation

Performed within 10 days of treatment initiation: serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine < 1.5 x ULN OR creatinine clearance > 50 mL/min for subject with creatinine levels > 1.5 x ULN

Should be performed within 30 days of treatment initiation: Serum creatinine ? 2.0 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) ? 60 mL/min for subject with creatinine levels ? 1.5 X institutional ULN

Creatinine < institutional upper limit of normal (ULN) OR creatinine clearance >= 50 mL/min for patients with creatinine levels greater than ULN

Within 28 days of cycle 1 day 1: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (performed within 10 days of treatment initiation) (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])\r\n* Creatinine clearance should be calculated per institutional standard

Within 5 days prior to the start of study treatment: Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional upper limit of normal (ULN). Creatinine clearance should be calculated per institutional standard.

Serum creatinine =< 1.5 x institutional upper limit of normal (IULN) and creatinine clearance >= 75 mL/min

Serum creatinine =< 1.5 x institutional ULN, OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with serum creatinine levels > 1.5 x higher than institutional normal

Creatinine within normal institutional limits OR creatinine clearance ? 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 14 days of treatment initiation

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance\r\n(glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 28 days of treatment initiation

Serum creatinine =< 1.5 X upper limit of normal (ULN) measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine OR calculated creatinine clearance =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN. Creatinine clearance should be calculated per institutional standard.

Creatinine > 1.5 x within normal institutional ULN OR creatinine clearance >= 40 mL/min (using Cockcroft-Gault formula) for participants with creatinine levels above institutional ULN

Creatinine =< 1.5 times normal institutional limits OR creatinine clearance >= 40 ml/min for patients

To be performed within 14 days of treatment initiation: serum creatinine ? 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) ? 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Serum creatinine ? 2.0 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) ? 60 mL/min for subject with creatinine levels > 2.0 X institutional ULN within 14 days of treatment initiation\r\n* Creatinine clearance should be calculated per institutional standard

Creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< upper limit of normal (ULN) OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above normal within 14 days of treatment initiation

Within 10 days of treatment initiation: Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN. Note: Creatinine clearance should be calculated per institutional standard.

Creatinine clearance >= 45 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal.

Within 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Within 14 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard

Serum creatinine =<1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]), performed within 10 days of treatment initiation\r\n* Creatinine clearance should be calculated per institutional standard

Performed within 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard

Serum creatinine OR measured or calculated creatinine clearance glomerular filtration rate (GFR) can also be used in place of creatinine or creatinine clearance (CrCl) =< 1.5 x upper limit of normal (ULN) OR =< 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN.\r\n* Creatinine clearance should be calculated per institutional standard.

Within 7 days of registration: Creatine =< 1.7 x upper limit of normal (ULN) OR measure or calculateda creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 70.0 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard

Obtained =< 14 days prior to registration: Creatinine =< 1.5 X upper limit of normal (ULN)\r\n* NOTE: measured or calculated (per institutional standard) creatinine clearance is acceptable >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Within 10 days prior to on-study date: Serum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) ? 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Within 28 days prior to enrollment: Serum creatinine OR measured calculated creatinine clearance (glomerular filtration rate [GFR] may also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels >= 1.5 X institutional ULN

Serum creatinine adults: =< 1.5 X upper limit of normal (ULN) children age >= 14: =< 1.5 mg/dL OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) OR >= 30 mL for subject with creatinine levels > 1.5 X institutional ULN (CrCl should be calculated per institutional standard)

Obtained with 21 days of registration: creatinine =< 2 x institutional upper limit of normal OR creatinine clearance > 60 mL/min for patients with creatinine levels greater than institutional upper limit of normal

Within 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine =<1.5 x normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above 1.5 x institutional normal

Within 10 days of treatment initiation: Serum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) ? 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Serum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) ? 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine =< 1.6 mg/ml OR creatinine clearance (estimated glomerular filtration rate [eGFR]) >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal at the time DAC-THU and pembrolizumab treatment commences

Serum creatinine =< 1.5 x upper limit of normal (ULN) or >= 60 mL/minute for subjects with creatinine levels > 1.5 x the institutional ULN

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance >= 50 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) (performed within 10 days of treatment initiation)

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Performed within 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine within institutional normal limits or, clearance > 60 mL/ minute if serum creatinine is elevated above institution upper limit (UL)

Serum creatinine OR measured or calculated creatinine clearance (creatinine clearance should be calculated per institutional standard) (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN, performed within 10 days of treatment initiation

Creatinine < 1.5 X institution upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2, for patients with creatinine levels above institutional normal

Serum creatinine within the institutional normal limits, OR if the creatinine is elevated

Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (by the Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation)

Performed within 7 days of treatment initiation: Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Creatinine up to 1.5 upper institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Performed within 14 days of treatment initiation: Serum creatinine =< 1.5 upper limit of normal (ULN) OR measured calculated creatinine clearance (glomerular filtration rate [GFR] may also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels >= 1.5 X institutional ULN

Creatinine =< 2.0 x the institutional upper limit of normal (ULN) OR creatinine clearance > 30 ml/min within 14 days of cycle 1 day 1

Serum creatinine =< 2.0 X institutional upper limit of normal or creatinine clearance >= 50 mL/min (according to the Cockroft and Gault equation)

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal 14 days or fewer from registration

Serum creatinine =< 2.0 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject

Serum creatinine OR measured or calculated a creatinine clearance (GFR can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN, performed within 14 days of treatment initiation

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN, performed within 10 days of treatment initiation

Creatinine within normal institutional limits or creatinine clearance (estimated glomerular filtration rate [eGFR]) >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normal

Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels >= 1.5 x upper limit of normal (after the HDT/ASCT)

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) OR serum creatinine clearance (CL) > 40 mL/min by the Cockcroft-Gault formula or by 24-hour urine collection for determination of creatinine clearance

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine < 1.5 X institution upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 2.0 OR creatinine clearance > 30 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]); serum creatinine =< 1.5 x upper limit of normal (ULN) or creatinine clearance >= 40 mL/min (if using Cockcroft-Gault formula), performed within 14 days of protocol registration

Performed within 10 days of treatment initiation: Serum creatinine or measured or calculated creatine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrcL]) =< 2.0 x upper limit of normal (ULN) or >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN. Creatinine clearance should be calculated per institutional standard

Serum creatinine >= 1.5 x upper limit of normal (ULN) OR calculated creatinine clearance =< 30 mL/min for patients with creatinine levels > 1.5 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard

Creatinine =< 1.5 x ULN OR measured or calculated creatinine clearance >= 50 mL/min for subject with creatinine levels > 1.5 x institutional ULN; (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])

Within 28 days prior to registration for protocol therapy: Creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Performed within 10 days of treatment initiation: Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])\r\n* Creatinine clearance should be calculated per Cockcroft-Gault equation

Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (creatinine clearance should be calculated per institutional standard)

Determined within 3 weeks of treatment initiation: Serum creatinine =< 1.5 x ULN or a measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (Note: creatinine clearance need not be determined if the baseline serum creatinine is within normal limits; glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])\r\n* Creatinine clearance should be calculated per institutional standard

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN; creatinine clearance should be calculated per institutional standard

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 14 days of treatment initiation; creatinine clearance should be calculated per institutional standard

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR calculated creatinine clearance (CrCL) per institutional standard (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Within 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine levels within normal institutional limits; or, creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal; unless decreased due to renal involvement by lymphoma

Serum creatinine below institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with serum creatinine levels above institutional ULN

Within 14 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine =< 1.5 ULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine OR measured or calculated creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) =< 1.5 X institutional upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 14 days of registration

Creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine level =< upper limit of normal (ULN): if creatinine > ULN, creatinine clearance must be > 60 ml/min

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 40 mL/min creatinine clearance

Creatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

OR creatinine clearance >= 60 mL/min for patients with creatinine levels above 1.5 X institutional upper limit of normal

Performed within 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard

Serum creatinine within normal institutional limits or creatinine clearance > 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal, assessed within 14 days prior to registration

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Serum creatinine =< 1.5 X upper limit of normal (ULN) Or measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Serum creatinine =< 1.5 x upper normal limit of institution's normal range or creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance\r\n(glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (performed within 28 days of registration)

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) or >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN performed within 10 days of treatment initiation

Creatinine =< 2 x normal institutional limits OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal as defined by the Cockcroft-Gault equation

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Serum creatinine =< 1.5 X upper limit of normal (ULN) or measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (within 10-15 days of treatment initiation)

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 50 mL/min for patient with creatinine levels > 1.5 x institutional ULN

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 16 days of treatment initiation

Creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance) =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN; Note: creatinine clearance should be calculated per institutional standard performed within 7 days of treatment initiation

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN, during screening and on cycle 1, day 1

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 14 days of treatment initiation

Creatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine OR measured or calculated creatinine clearance (should be calculated per institutional standard) (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels =< 1.5 X institutional ULN (performed within 10 days of treatment initiation)

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Creatinine within normal institutional limits; OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Creatinine clearance > 60 mL/min for patients with creatinine levels above institutional normal

Within 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN; creatinine clearance should be calculated per institutional standard

Serum creatinine within normal institutional limits OR measured creatinine clearance >= 50 mL/min/for patients with creatinine levels above institutional normal

Serum creatinine: =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for participant with creatinine levels > 1.5 X institutional ULN; glomerular filtration rate (GFR) can also be used in place of creatinine or creatinine clearance (CrCl)

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Completed within 10 days of SBRT treatment initiation: Measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Serum creatinine =< 1.5 x ULN OR creatinine clearance (if measured or calculated per institutional standard) >= 60 mL/min if creatinine levels > 1.5 x ULN\r\n* Glomerular filtration rate (GFR) can also be used in place of creatinine or creatinine clearance (CrCl)

Creatinine < 1.5 x institution upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2, for patients with creatinine levels above institutional normal

Measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subjects with creatinine levels > 1.5 x ULN within 14 days of treatment initiation

Creatinine =< 2.0 x ULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for participants with creatinine levels above 2.0 x ULN

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 14 days prior to registration

Creatinine < 1.5 mg/dL OR creatinine clearance >= 50 mL/min for patients with creatinine levels above institutional normal

Creatinine 1.5 x the normal institutional limits OR creatinine clearance >= 40 mL/min/1.73 m^2

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/ per Cockroft-Gault equation\r\nfor patients with creatinine levels above institutional normal

Creatinine =< institutional upper limit of normal OR creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or calculated creatinine clearance [CrCl]) creatinine clearance >= 60 mL/min (for subject with creatinine levels > 1.5 X institutional ULN) determined by 24-hour collection or estimated by Cockcroft-Gault formula

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min/1.73 m^2 for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]), performed within 10 days of treatment initiation

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl)

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 30mL/min for subject with creatinine levels > 1.5 X institutional upper limit of normal (ULN)

Serum creatinine =< 1.5 X upper limit of normal (ULN) or measured or calculated creatinine clearance (CrCl) (Glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 40 mL/min CrCl using the Cockroft-Gault formula

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (IULN); creatinine clearance should be calculated per institutional standard

Performed 28 days prior to study registration up to the first dose of study drug: serum creatinine or measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) or >= 40 mL/min CrCl using the Cockroft-Gault formula

Creatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance\r\n(glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]), performed within 10 days of treatment initiation

Creatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine not greater than upper institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) or measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN; glomerular filtration rate (GFR) can also be used in place of creatinine or creatinine clearance (CrCl) (within 28 days of treatment initiation)\r\n* Creatinine clearance should be calculated per institutional standard

Creatinine =< 2.0 x upper limit normal (ULN) or measured creatinine clearance (CrCl) of >= 50ml/m^2/1.73 m^2

Performed within 14 days (+3 working days) of treatment initiation: Serum creatinine OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine within normal institutional limits or creatinine clearance >= 45 mL/min/1.73 m^2 as estimated by either Cockcroft-Gault or 24-hour urine collection for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN\r\n* Note: creatinine clearance should be estimated per institutional standard

Creatinine clearance: > 60 ml/min for patients with creatinine levels above institutional normal

Creatinine =< 1.5 x institutional upper limits of normal OR creatinine clearance of >= 50 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal by 24-hour urine

Serum creatinine =< 1.5 X upper limit of normal (institutional upper limit of normal, IULN) OR measured or calculated creatinine clearance (GFR can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine clearance >= 60 mL/min/1.73m^2 for patients with creatinine >= 1.5 x upper limit of normal

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Creatinine clearance >= 60 Ml/min/1.73 m^2 for patients with creatinine levels above institutional normal

Performed within 14 days of treatment initiation: Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) OR >= 50 mL/min for subject with creatinine levels > 1.5 x institutional ULN

CAPMATINIB INCLUSION CRITERIA: Creatinine OR creatinine clearance within normal limits > 40 mL/min (calculated by Cockgraft-Gault) for patients with creatinine levels above ULN

ENTRECTINIB INCLUSION CRITERIA: Creatinine OR creatinine clearance within normal limits; > 40 mL/min (calculated by Cockgraft-Gault) for patients with creatinine levels above ULN

Creatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal; creatinine clearance should be calculated using the actual weight from day 1 of the cycle

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance rate [CrCl]) >= 35 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine within normal institutional limits OR creatinine clearance > 50 mL/min for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 ml/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])

Creatinine level within normal institutional limit, or creatinine clearance > 15 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal, calculated using the Cockcroft-Gault formula)

Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine clearance < 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance rate [CrCl])\r\n* Creatinine clearance should be calculated per institutional standard

Creatinine =< 1.5 x ULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (Cockcroft formula)

Creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine ? 1.5 x upper limit of normal (ULN) or Creatinine clearance ? 50%

Creatinine below institutional ULN or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Serum creatinine =< 1.5 X ULN OR calculated creatinine clearance >= 60 mL/min for patients with creatinine levels > 1.5 X institutional ULN

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

PHASE I STUDY ELIGIBILITY CRITERIA:\r\nCreatinine =< 1.5 X within normal institutional limits OR measured creatinine clearance >= 50 mL/min/1.73 m^2

Calculated creatinine clearance ? 60 mL/min /1.73 m2 for subjects with serum creatinine levels > 1.5 x institutional ULN

Creatinine =< the institutional upper limit of normal (ULN) OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Performed within 28 days prior to study registration up to the first dose of study drug: Serum creatinine or measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or calculated creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) or >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (creatinine clearance should be calculated per institutional standard)

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated* creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN; (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])\r\n* Creatinine clearance should be calculated per institutional standard

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 50 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min

Serum creatinine or measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) or >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (creatinine clearance should be calculated per institutional standard), performed within 10 days of treatment initiation

Serum creatinine ? 1.5 × ULN OR creatinine clearance ? 50mL/min/1.73 m2 for subjects with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine below ULN (males 0.7-1.30 mg/dl; females 0.6-1.10 mg/dl) OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard

Performed within 10 days of treatment initiation; serum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) ? 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN \r\n* Creatinine clearance should be calculated per institutional standard

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated* creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional upper limit of normal (ULN) (glomerular filtration rate [GR] can also be used in place of creatinine or creatinine clearance [CrCl])\r\n* Creatinine clearance should be calculated per institutional standard

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal, determined within 14 days of registration

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) =< 1.5 X upper limit of normal (ULN) OR >= 50 mL/min for subject with creatinine levels > 1.5 X institutional ULN; creatinine clearance should be calculated per institutional standard

Serum creatinine OR measured or calculated creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine within normal institutional limits OR creatinine clearance > 45 mL/min for patients with creatinine levels above institutional normal

Measured OR estimated creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above normal

Creatinine within normal institutional limits (< 1.5) OR creatinine clearance >= 50 mL/min/1.73m^2 (for creatinine level above normal)

Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine above institutional upper limit of normal (IULN) obtained no more than 28 days prior to the start of neoadjuvant endocrine therapy

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min for patients with creatinine levels above institutional normal

Creatinine < 1.5 x institutional upper limit of normal (ULN), OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels greater than 1.5 x ULN

Serum creatinine =< 1.5 x upper limit of normal or creatinine clearance >= 60 ml/min for patients with creatinine levels above institutional normal

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Note: creatinine clearance should be calculated per institutional standard

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 x institutional upper limit of normal or creatinine clearance >= 50 mL/min/1.73 m^2

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (within 2 weeks prior to radiotherapy)

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR calculated creatinine clearance >= 60 mL/min for patients with creatinine levels > 1.5 x institutional ULN

Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR calculated creatinine clearance >= 60 mL/min for patients with creatinine levels > 1.5 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard

Serum creatinine =< 1.5 × upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Within 4 weeks of preregistration: Creatinine =< institutional upper limit of normal (ULN) OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

ELIGIBILITY CRITERIA FOR REGISTRATION: creatinine =< institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (within one week of registration if patient postop, otherwise within two weeks of registration)

Creatinine > 3x normal

The patient must have a corrected creatinine clearance >= 50% of normal

Serum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) ? 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Serum creatinine ? 1.5 x Upper Limit of Normal (ULN) OR o glomerular filtration rate (GFR) ?30mL/min if serum creatinine > 1.5 x ULN, creatinine clearance may be calculated using the institutional/laboratory standard method

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearnace [CrCl]) >= 40 mL/min for subject with creatinine levels > 2.0 X institutional ULN, should be performed within 10 days of treatment initiation

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Serum creatinine =< 1.5 x institutional upper limit normal (ULN) and calculated creatinine clearance of >= 60mL/min

Renal: serum creatinine within normal limits (WNL), defined as within 10% of the institution's stated reference range, or a calculated creatinine clearance >60 mL/min/1.73 m2 for patients with abnormal, increased, creatinine levels. Patients with Multiple Myeloma (only): serum creatinine ? 2.5 the institutional upper limit of the normal range and a calculated creatinine clearance > 40 mL/min/1.73 m2.

Creatinine ?1.5 times the upper limit of normal (ULN) and/or creatinine clearance ?60 mL/min

creatinine clearance greater than or equal to 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal

Serum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) ? 60 ml/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 40 mL/min for subject with creatinine levels > 1.5 X institutional ULN; creatinine clearance should be calculated by Cockcroft-Gault

Creatinine =< 1.5 x institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 mg/dL

Creatinine =< 1.5 x institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 mg/dL

REGISTRATION TO TREATMENT (STEP 1): Serum creatinine =< 1.5 X upper limit of normal (ULN) OR creatinine clearance (per institutional standards) >= 60 mL/min for patient with creatinine levels > 1.5 X ULN, within 14 days prior to first dose of pembrolizumab

REGISTRATION TO TREATMENT (STEP 2): Serum creatinine =< 1.5 X upper limit of normal (ULN) OR creatinine clearance (per institutional standards) >= 60 mL/min for patient with creatinine levels > 1.5 X ULN, within 14 days prior to first dose of pembrolizumab

Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 x IULN OR creatinine clearance >= 40 mL/min by Cockcroft-Gault for patients with creatinine levels above institutional normal

Serum creatinine ? 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCl) ? 50 mL/min for subject with creatinine levels > 1.5 X institutional ULN within 7 days of treatment initiation\r\n* Glomerular filtration rate (GFR) can also be used in place of creatinine or CrCl

All screening labs should be performed within 14 days (+3 working days) of treatment initiation: serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN;

Within 10 days of treatment initiation: If serum creatinine concentration >= 1.5 x upper limit of normal (ULN), then estimated creatinine clearance must be >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Creatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (GFR can also be used in place of creatinine or creatinine clearance [CrCl]) >= 30 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 28 days of treatment initiation

Serum creatinine =< 1.5 X upper normal limit of institution's normal range OR creatinine clearance >= 40 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal; creatinine clearance should be determined by the Cockcroft-Gault formula or by 24-hour urine collection for determination of creatinine clearance

Within 10 days of treatment initiation: Serum creatinine within upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > institutional ULN

Creatinine level within normal institutional limit, or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine level above institutional normal

Creatinine < 1.5x institutional upper limits of normal (ULN) or creatinine clearance ? 60 mL/(min 1.73 m^2) for patients with elevated creatinine levels (? 21d of study day 1)

Creatinine clearance > 50 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal limits

EXCLUSION CRITERIA FOR TREATMENT: Creatinine clearance > 50 ml/min/1.73m^2 for patients with creatinine levels above institutional normal limits

Creatinine < 1.5 x institutional upper limit of normal (ULN) OR creatinine clearance (CrCl) >= 50 mL/min/1.73 m^2 for subjects with creatinine levels greater than 1.5 x ULN

Creatinine or measured/calculated creatinine clearance (as calculated by institutional standard) =< 1.5 X institutional upper limit of normal (ULN) OR >= 60 mL/min for subjects with creatinine levels > 1.5 x institutional ULN

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine levels =< upper limit of institutional normal; or creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance must be >= 60 mL/min for subjects with creatinine levels > 1.5 X ULN using the Cockcroft-Gault formula (glomerular filtration rate [GFR] >= 60 mL/min [1.0 mL/s/m^2] can also be used in place of creatinine or creatinine clearance [CrCl]) obtained =< 28 days prior to registration

Creatinine =< the institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine =< 1.5 x ULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance >= 60 mL/min for patient with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])

TUMOR BIOPSY SEQUENCING: Creatinine < 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min for patients with creatinine levels >= 1.5 x institutional upper limit of normal

TREATMENT: Creatinine < 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min for patients with creatinine levels >= 1.5 x institutional upper limit of normal

Creatinine within normal institutional limits OR calculated creatinine clearance >= 60 mL/min/1.73 m^2 (Cockroft-Gault formula) for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Creatinine =< 1.5 x ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN, performed within 10 days of treatment initiation

Serum creatinine <= 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Serum creatinine =< 1.5 X ULN or measured or calculated creatinine clearance (CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl); creatinine clearance should be calculated per institutional standard

Serum creatinine =< 1.5 x institutional upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard

Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance rate [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine < 1.5 x ULN OR creatinine clearance measured >= 60 mL/minute for patients with creatinine levels >= 1.5 x upper limit of normal

Creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 50 mL/min for participant with creatinine levels > 1.5 x institutional ULN, specimens must be collected within 10 days prior to the start of study treatment\r\n* Creatinine clearance (CrCl) should be calculated per institutional standard

Within 30 days prior to treatment initiation: Serum creatinine =< 1.5 X institutional upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 30 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])\r\n* Creatinine clearance should be calculated per institutional standard

Creatinine < 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 × upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 mg/dL or creatinine clearance (Cockcroft-Gault) >= 60 mL/min for patients with creatinine levels above institutional upper limit of normal (ULN)

PHASE II: Creatinine =< 1.5 mg/dL or creatinine clearance (Cockcroft-Gault) >= 60 mL/min for patients with creatinine levels above institutional upper limit of normal (ULN)

Creatinine within normal institutional limits OR calculated creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine within normal institutional limits or creatinine clearance must be at least 60 ml/min

Creatinine < 1.5 x normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine level above institutional normal based either on Cockroft-Gault estimate or based on urine collection (12 or 24 hour)

Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above 1.5 X institutional upper limit of normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 times the upper limit of normal (ULN) OR creatinine clearance >= 60 mL/min/1.73 m^2

Creatinine < 1.5 x institutional upper limit of normal OR creatinine clearance > 60 ml/min OR > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< institutional upper limit normal (ULN); note: if creatinine > ULN, creatinine clearance must be > 50 mL/min

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine within normal institutional limits or a creatinine clearance >= 60 mL/min for patients with creatinine levels above institutional normal

Creatinine =< 1.5 X ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x ULN

PHASE II: Creatinine =< 1.5 X ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x ULN

Creatinine =< 1.5 x IULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine within normal institutional limits or a creatinine clearance >= 60 ml/min within 2 weeks prior to registration

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine < 2.5 X institutional ULN OR measured or calculated* creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 30 mL/min for subject with creatinine levels > 2.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard

Creatinine within normal institutional limits for age OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above ULN

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 x IULN OR calculated creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 x institutional ULN OR creatinine clearance >= 45 mL/min/ 1.73 m^2 for participants with creatinine levels above institutional ULN

Creatinine =< 1.5 × institutional upper limit of normal OR creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above 1.5 x institutional limit of normal

Creatinine =< 1.5 x ULN OR calculated or measured creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine above institutional normal

Measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 50 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Renal function: Creatinine ?1.5x ULN OR measured or calculated creatinine clearance (Glomerular filtration rate [GFR]) can also be used in place of creatinine or CrCl) > 60 mL/min for subjects with creatinine levels > 1.5x institutional ULN

Creatinine ? 1.5 × ULN or, for patients with creatinine levels above institutional upper limit of normal, creatinine clearance must be > 60 mL/min/1.73 m^2.

Creatinine clearance >60 mL/min/1.73 m2 for subjects with creatinine levels above institutional normal

Creatinine clearance >= 60 Ml/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional limits

Creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional upper limit of normal (ULN)

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated* creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrC])\r\n* Creatinine clearance should be calculated per institutional standard

Creatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine ? 1.5 × ULN or, for patients with creatinine levels above institutional upper limit of normal, creatinine clearance must be > 60 mL/min/1.73 m^2.

Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal limits (creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal)

Serum creatinine =< 1.5 X upper limit of normal (ULN) or measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or calculated creatinine clearance [CrCl])

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine less than institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 x University of Iowa Hospitals and Clinics (UIHC) upper limit of normal or creatinine clearance of at least 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine clearance > 60 mL/min for patients with creatinine levels above institutional normal

Obtained within 30 days of registration: Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 x institutional upper limits of normal or for patients with creatinine levels above 1.5 x institutional normal: creatinine clearance >= 50 mL/min/1.73 m^2 by 24 hour urine collection or estimated creatinine clearance of >= 50 mL/min; for creatinine clearance estimation, the Cockcroft and Gault equation should be used

Serum creatinine =< 1.5 x ULN OR creatinine clearance (if measured or calculated per institutional standard; glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min if creatinine levels > 1.5 x ULN (within 14 days prior to day 1 of protocol therapy)

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (performed within 10 days of treatment initiation)\r\n* Creatinine clearance should be calculated per institutional standard

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN, performed within 10 days of treatment initiation

Creatinine =< 1.5 mg/dL, or creatinine clearance >= 30 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Within 14 days prior to registration: serum creatinine less than or equal to the institutional upper limit of normal (ULN) or creatinine clearance (CrCl) >= 60 mL/min (calculated using the Cockcroft-Gault formula) for participants with serum creatinine levels above institutional ULN

Creatinine clearance > 45 mL/min/1.73 m^2, for patients with creatinine levels above institutional normal

Measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for participant with creatinine levels > 1.5 x institutional ULN (within 14 days of treatment initiation)

Serum creatinine =< 1.5 x institutional upper limit of normal concurrent with creatinine clearance >= 50 mL/min (measured or calculated by Cockcroft and Gault equation), confirmation of creatinine clearance is only required when creatinine is > 1.5 x upper limit of normal (ULN), within 14 days of study registration

Within 72 h of initiating study treatment: Creatinine =< 1.5 x upper limit of normal (ULN) OR calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x ULN (Cockcroft and Gault)

Measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN; creatinine clearance should be calculated per institutional standard, should be performed within 28 days of treatment initiation, unless otherwise indicated

Creatinine =< IULN OR creatinine clearance >= 40 mL/min for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]); creatinine clearance should be calculated per institutional standard

Creatinine within normal institutional limits, OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional upper limit of normal (ULN)

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) (creatinine clearance will be calculated per institutional standard) =< 1.5 × upper limit of normal (ULN) OR >= 60 mL/min GFR or CrCl for subjects with creatinine levels > 1.5 × institutional ULN, performed within 28 days of treatment initiation

Serum creatinine =< 1.5 x ULN OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN\r\n* Glomerular filtration rate (GFR) can also be used in place of creatinine or creatinine clearance (CrCl)\r\n* Creatinine clearance should be calculated per institutional standard

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN; creatinine clearance should be calculated per institutional standard

Serum creatinine < 2.0 mg/dL or creatinine clearance (Cockcroft) >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 50 mL/min for subject with creatinine levels > 1.5 X institutional ULN; creatinine clearance should be calculated per institutional standard

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN; creatinine clearance should be calculated per institutional standard

Serum creatinine =< 1.5 x IULN OR creatinine clearance > 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine within normal institutional limits, or creatinine clearance (calculated by Cockcroft-Gault) >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine less than or equal to the institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Serum creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 14 days prior to registration

Within 14 days of treatment initiation: Serum creatinine =< 1.5 X institutional upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine below institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Performed within 28 days of radiation therapy: Serum creatinine =< 1.8 x upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 50 mL/min for subject with creatinine levels > 1.8 x institutional ULN; (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl])

Creatinine within normal institutional limits for age OR creatinine clearance >= 70 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< institutional ULN or creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Creatinine less than or equal to 1.5 times the ULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]); creatinine clearance should be calculated per institutional standard, performed within 28 days of treatment initiation

Creatinine within institutional limits of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal obtained =<14 days prior to randomization

Serum creatinine within normal institutional limits or creatinine clearance at least 60 ml/min within 30 days prior to registration

Serum creatinine =< 1.5 upper limit of normal (ULN) OR measured calculated creatinine clearance >= 60 mL/min for subject with creatinine levels >= 1.5 X institutional ULN (glomerular filtration rate [GFR] may also be used in place of creatinine or creatinine clearance [CrCl])

Serum creatinine =< 2.5 x ULN OR measured or calculated* creatinine clearance (CrCl) (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 30 mL/min for subject with creatinine levels > 2.5 x institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard (labs should be performed within 14 days of treatment initiation)

Creatinine clearance >= 30 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Within 14 days of registration: Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 x the institutional upper limits of normal or corrected creatinine clearance of >= 50 mg/ml/hr/1.73 m^2 body surface area (BSA)

Creatinine =< institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

PHASE I: Creatinine between 0-1.3 mg/dL or creatinine clearance > 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normal

PHASE II: Creatinine between 0-1.3 mg/dL or creatinine clearance > 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normal

Creatinine =< institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Creatinine < 1.5 X institutional upper limit of normal OR creatinine clearance >= 30 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine up to 1.5 X ULN or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normal

Creatinine ?1.5 x ULN or creatinine clearance >60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (as determined by Cockcroft-Gault equation).

Serum creatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/for patients with creatinine levels above institutional normal

Creatinine < 1.5 X institutional upper limit of normal OR calculated creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< institutional ULN or creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal or >= 50 mL/min 24-hour creatinine clearance

Subjects must have a serum creatinine level that is ? 1.5 × institutional upper limit of normal (ULN) according to age. If serum creatinine level is > 1.5 × ULN, the subject must have a calculated creatinine clearance or radioisotope glomerular filtration rate (GFR) ? 70 mL/min/1.73 m2.

Creatinine within normal institutional limits OR creatinine clearance >= 40 mL/min for patients with creatinine levels above institutional normal

Creatinine < 1.5 X institutional upper limit of normal OR creatinine clearance >= 60 mL/min for patients with creatinine levels above 1.5 X institutional upper limit of normal

Creatinine within 1.5 x upper limit of normal, OR creatinine clearance > 60 mL/min for patients with creatinine levels above institutional normal

PART B: Creatinine =< 1.5 X ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 times institutional upper limit of normal OR creatinine clearance >= 60ml/min/1.73m^2 measured by 24-hour urine collection

Creatinine =< 1.5 times institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 measured by 24-hour urine collection

Creatinine within 1.5 X normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal by Cockcroft-Gault equation

Creatinine < 1.5 x institution upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< upper limit of normal (ULN) or creatinine clearance (either estimated or calculated) >= 60 mL/min/1.73 m for patients with creatinine levels above institutional normal

Creatinine < or equal to 1.5 x ULN or creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

REGISTRATION INCLUSION CRITERIA: Creatinine =< 1.5 institutional upper limits of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine ? 1.5 × ULN or creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal.

Serum creatinine =< the institutional upper limit of normal or creatinine clearance >= 40 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Serum creatinine ? 1.5 x ULN or creatinine clearance > 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Creatinine < 1.5 x institutional upper limit of normal or creatinine clearance >= 50 mL/min/1.73 m^2

Creatinine =< 1.5 x upper limit of normal OR creatinine clearance >= 60 mL/min/1.73m^2 for patients with creatinine >= 1.5 x upper limit of normal

Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 x institutional upper limits of normal OR creatinine clearance of >= 50 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal by 24 hour urine

Creatinine within normal institutional limits OR creatinine clearance >= 50mL/min for patients with creatinine levels above institutional normal

Creatinine =< 1.5 x institutional ULN or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional ULN

Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 x upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x upper limit of normal

Obtained within 14 days prior to registration: Serum creatinine =< 1.5 x the institutional upper limits of normal or corrected creatinine clearance of >= 50 mg/ml/hr/1.73 m^2 body surface area (BSA)

creatinine clearance > 60 mL/min for patients with creatinine levels above institutional normal

Serum creatinine levels =< 1.5 x upper limit of normal (ULN) OR creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Creatinine less than the institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Serum creatinine =< 1.5 × upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Within 14 days after subjects signed the treatment consent: Serum creatinine =< 1.5 mg/dl OR creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Creatinine =< 1.2 x normal prior to biopsy

Creatinine =< 1.5 x normal institutional limits or creatinine clearance > 50mL/min

Creatinine ? 2.0 mg/dl Or Creatinine clearance ? 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal

Creatinine less than institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above the institutional normal

Creatinine < 1.5 x upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels >= 1.5 x upper limit of normal

Creatinine less than or equal to 1.5 x institutional upper limit of normal (ULN) or measured or calculated creatinine clearance greater than or equal to 50 mL/min for subject with creatinine levels greater than 1.5 x institutional ULN; (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) (creatinine clearance should be calculated per institutional standard)

Serum creatinine clearance =< 1.5 x ULN or >= 60 mL/minute for subjects with creatinine levels > 1.5 x the institutional upper limit of normal (ULN)

Creatinine =< 1.5 mg/dL or creatinine clearance >= 50 mL/min for subjects with creatinine levels about institutional normal

EXPANSION COHORT ONLY: Creatinine =< 1.5 mg/dL or creatinine clearance >= 50 mL/min for subjects with creatinine levels about institutional normal

Creatinine =< institutional ULN or creatinine clearance >= 30 mL/min/1.73 m^2 for subjects with creatinine levels above institutional ULN

Serum creatinine OR measured or calculated (creatinine clearance should be calculated per institutional standard) creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x institutional upper limit of normal (ULN) OR (measured via 24-hour urine collection) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Creatinine =< the institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Creatinine below or within the upper institutional limits of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Creatinine clearance >= 60 mL/min for patients with creatinine levels above 1.5 x institutional upper limit of normal

Normal creatinine for age

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN\r\n* Creatinine clearance should be calculated per institutional standard

Creatinine < 1.5 x upper limit of normal OR measured creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x upper limit of normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) or measured or calculated creatinine clearance\r\n(glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 x upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Patient's serum creatinine must be ? 1.5 x institutional upper limit of normal (ULN) according to age. If the serum creatinine is greater than 1.5 times normal, the patient must have a calculated creatinine clearance or radioisotope GRF ? 70mL/min/1.73m2.

Creatinine =< 1.5 X normal institutional limits or creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above normal institutional limit (a calculated one may be used)

Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance > 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine OR creatinine clearance within normal institutional limits OR > 60 Ml/min/1.73 m^2 for patients with creatinine levels above institutional normal

creatinine clearance* >45 mL/min/1.73 m2 for patients with creatinine levels above institutional normal

Serum creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (as calculated by Cockcroft-Gault)

Creatinine within normal limits for the laboratory OR creatinine clearance >= 60 mL/min/1.73 m^2 (estimated glomerular filtration rate [eGFR]) for patients with creatinine levels above the ULN for the laboratory

Serum creatinine =< 1.5 X upper limits of normal or creatinine clearance > 60 mg/min for subjects with creatinine levels >= 1.5 X upper limits of normal

Serum creatinine within normal limits or calculated clearance ? 50 mL/min/1.73 m2 for subjects with serum creatinine levels above or below the institutional normal value. If using creatinine clearance, actual body weight should be used for calculating creatinine clearance (eg, using the Cockroft-Gault formula). For subjects with a body mass index (BMI) > 30 kg/m2, lean body weight should be used instead.

Creatinine within normal institutional limits or creatinine clearance >= 60mL/min/1.73 m^2 for subject with creatinine levels above institutional normal

Creatinine within normal institutional limits OR calculated creatinine clearance >= 60 mL/min/1.73 m^2 for patients with levels above institutional normal using modified Cockcroft-Gault

Creatinine =< 1.2 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine:\r\n* Creatinine levels within normal institutional limits (< 1.5 x ULN); or,\r\n* Creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Acceptable renal function: • Serum creatinine ? 1.5 times the ULN, or calculated creatinine clearance ? 60 mL/min/1.73 m2 for patients with creatinine levels above 1.5 times the institutional normal

Creatinine =< ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine above institutional normal

Creatinine =< 1.5 x institutional ULN or creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal, obtained through calculated or measured creatinine clearance

Creatinine > 2.0 times upper normal limit and creatinine clearance < 30 ml/min/m^2; patients with creatinine > 2 times upper limit of normal will have creatinine clearance estimated; at the discretion of treating physician, creatinine clearance can be measured and that value can be used instead of calculated creatinine clearance

Creatinine =< 1.5 x institutional upper limits of normal OR creatinine clearance > 50 mL/min/1.73 m^2 for patients with creatinine levels above 1.5 x institutional normal

Creatinine within normal institutional limit for the reference lab OR creatinine clearance >= 60 mL/min/1.73 m^2 as calculated by Cockcroft-Gault formula for participants with creatinine levels above institutional normal

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN within 7 days of treatment initiation; (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]); creatinine clearance should be calculated per institutional standard

Creatinine within 1.5 x upper limit of normal OR creatinine clearance > 60 mL/min for patients with creatinine levels above institutional normal

Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min for patients with creatinine levels above institutional normal, as determined by a measured 24-hour creatinine clearance

Creatinine =< 1.5 x upper limits of normal (ULN); if creatinine (Cr.) > 1.5 x ULN, then calculated creatinine clearance > 40 cc/min

Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Creatinine not to be above IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine < institutional upper limit of normal (ULN) OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels greater than ULN

Patient's serum creatinine must be ? 1.5 x institutional upper limit of normal (ULN) according to age. If the serum creatinine is greater than 1.5 times normal, the patient must have a calculated creatinine clearance or radioisotope GRF ? 70mL/min/1.73m2.

Creatinine =< 1.5 x upper limit of normal (ULN) or creatinine clearance >= 60 ml for patients with creatinine levels 1.5 times above institutional ULN (calculated based on age, weight and sex)

Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 x upper limit of normal or creatinine clearance >= 60ml/min for patients with creatinine levels above institutional normal

Creatinine < 1.5 X institution upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Performed within 10 days of treatment initiation: Serum creatinine =< 1.5 x ULN OR measured or calculated creatinine clearance >= 60 mL/min for subject with creatinine clearance (CrCl) levels > 1.5 x institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or CrCl)

Creatinine within normal institutional limits OR creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (unless due to lymphoma)

Creatinine within normal institutional limits OR creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 x ULN OR calculated or measured creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine above institutional normal

Creatinine less than the institutional upper limit of normal OR creatinine clearance >= 50 mL/min/1.73 m^2

Renal: serum creatinine WNL or calculated creatinine clearance ? 50 mL/min/1.73m2 for patients with creatinine levels above institutional normal

Creatinine < 1.5 x institutional upper limit or normal OR creatinine clearance >= 60 mL/min for patients with creatinine levels above 1.5 x institutional upper limit of normal

Creatinine =< institution upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine < 1.5 x ULN or creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min for patients with creatinine levels above institutional normal

Serum creatinine ? 1.5 × upper limit of normal (ULN) or calculated creatinine clearance ? 50 mL/min using Cockcroft-Gault equation for patients with creatinine levels > 1.5× institutional ULN

Serum creatinine =< institutional upper limit of normal or creatinine clearance (either estimated or calculated) >= 60 mL/min/1.73 m for patients with creatinine levels above institutional normal

Creatinine below 1.5 X upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normal

Creatinine =< 2 X institutional ULN OR creatinine clearance >= 30 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 x ULN OR creatinine clearance >= 60 ml/min for patients with creatinine levels above institutional normal

Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine < 1.5 X institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine < 1.5 X institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 x upper normal limits OR creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal, as calculated by the Cockcroft Gault formula

Creatinine within 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine level above institutional normal

Creatinine =< 1.5 X institutional upper limit of normal or creatinine clearance less than 60 ml/min

Creatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within institutional limits of normal or creatinine clearance >= 60 ml/min/m^2 if elevated creatinine

Creatinine clearance 24 hour urine creatinine clearance > 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (may use creatinine clearance Cockcroft-Gault equation)

The participant has adequate renal function as defined by serum creatinine ? 1.5 x the institutional ULN or creatinine clearance ? 60 milliliter/minute (mL/min) for participants with creatinine levels above the ULN

Serum creatinine less than 1.5 x upper limit of normal (ULN), OR 24-hour creatinine clearance = or 60 mL/min for subject with creatinine levels more than 1.5 x ULN; (Note: creatinine clearance need not be determined if the\r\nbaseline serum creatinine is within normal limits; creatinine clearance should be determined per institutional standard)

Measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Serum creatinine > 1.5 x upper limit of normal (ULN) or creatinine clearance < 60 mL/minute

Creatinine < 1.5 x upper limit of normal (ULN) or creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Creatinine =< IULN OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance or calculated >= 60 mL/min/1.73 m^2 for patients with creatinine clearance or estimated creatinine levels above institutional glomerular filtration rate (eGFR) normal

Creatinine clearance ? 15 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Creatinine =< 2.0 or creatinine clearance > 30 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Creatinine OR Measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 x upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Performed within 10 days of treatment initiation: Measured or calculated creatinine clearance >= 60 mL/min for patient with creatinine levels > 1.5 x institutional ULN\r\n* Creatinine clearance (CrCl) should be calculated per institutional standard; glomerular filtration rate (GFR) can also be used in place of creatinine or CrCl

Creatinine =< institutional upper limit of normal OR creatinine clearance >= 30 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Creatinine clearance >= 70 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate (GFR) can also be used in place of creatinine or creatinine clearance [CrCl]) =< 2.0 x upper limit of normal (ULN) OR >= 40 mL/min for subject with creatinine levels > 2.0 x institutional ULN (performed within 10 days of treatment initiation)

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 x institutional upper limit of normal (ULN) for age; if the serum creatinine is above these values, the calculated creatinine clearance or radioisotope glomerular filtration rate (GFR) must be >= 60 mL/min/1.73m^2

Creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional upper limit of normal (ULN)

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine less than upper limit of normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine OR measured or calculated creatinine clearance within normal institutional limits; glomerular filtration rate (GFR) can also be used in place of creatinine or creatinine clearance (CrCl) within normal institutional limits as adjusted for age and sex

Serum creatinine within normal institutional limits or less than the lower limit of normal institutional limits; or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 if serum creatinine > institutional normal

Creatinine within normal institutional limits OR creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine clearance >= 50 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine =< 1.5 times institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2

Creatinine £ 1.5 ´ ULN or creatinine clearance > 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal

Patients with a creatinine =< 2 x normal for age

Creatinine within normal institutional limits OR creatinine clearance >= 55 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, performed within 10 days of treatment initiation

Creatinine within normal institutional limits or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normal

Serum creatinine: =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance >= 60 mL/min for participant with creatinine levels > 1.5 X institutional ULN (using Cockcroft-Gault equation), glomerular filtration rate (GFR) can also be used in place of creatinine or creatinine clearance (CrCl)

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min using the Cockcroft-Gault formula for subject with creatinine levels > 1.5 x institutional upper limits of normal (ULN), obtained within 14 days prior to C11-AMT PET scan

Creatinine within normal institutional limits OR creatinine clearance >= 30 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal; (calculated via Cockcroft-Gault equation)

SURGICAL ARM: creatinine within normal institutional limits or creatinine clearance > 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normal limit

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Serum creatinine =< 1.5 x institutional upper limit of normal concurrent with creatinine clearance >= 50 mL/min (measured or calculated by Cockcroft and Gault equation), confirmation of creatinine clearance is only required when creatinine is > 1.5 x upper limit of normal (ULN) (within 14 days of study registration)

Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN, obtained =< 30 days prior to registration

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCL]); creatinine clearance should be calculated per institutional standard, performed within 10 days of treatment initiation

Creatinine within normal institutional limits or\r\n* Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine below upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Subject must have adequate renal function with creatinine within normal institutional limits or creatinine clearance > 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal

Creatinine within normal institutional limits or creatinine clearance ? 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (calculated via Cockcroft-Gault equation)

Creatinine within 1.5 x upper limit of normal (ULN) OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine ? 1.5 x ULN or CrCl > 60 mL/min/1.73 m2 for patients with serum creatinine levels above institutional 1.5 x ULN

Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Creatinine within normal institutional limits OR creatinine clearance >= 30 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (calculated via Cockcroft-Gault equation)

Creatinine ? 1.5 mg/dL or creatinine clearance > 60 mL/min/1.73 m2 for subjects with creatinine levels above institutional normal.

Creatinine within normal institutional limits or creatinine clearance > 60 mL/min/1.73 m2 for subjects with creatinine levels above institutional normal.

The participant has adequate renal function as defined by serum creatinine less than or equal to 1.5 x the institutional ULN or creatinine clearance greater than or equal to 60 mL/min for participants with creatinine levels above the ULN.

The participant has adequate renal function as defined by serum creatinine less than or equal to 1.5 x the institutional ULN or creatinine clearance greater than or equal to 60 mL/min for participants with creatinine levels above the ULN.

Creatinine within normal institutional limits or creatinine clearance > 60 mL/min/1.73 m2 for subjects with creatinine levels above institutional normal.

Serum creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >= 60 mL/min for subject with creatinine levels > 1.5 x institutional ULN

Creatinine =< 1.5 X institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

Serum creatinine =< 1.5 x ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (calculated with the Cockcroft-Gault Equation in EPIC)

Serum creatinine OR measured or calculated creatinine clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) =< 1.5 X upper limit of normal (ULN) OR >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN