Creatinine clearance and/or glomerular filtration rate (GFR) greater than or equal to 60 mL/min/1.73m^2 within 21 days of protocol therapy; kidney function cannot be estimated by other means
Calculated creatinine clearance or radioisotope glomerular filtration rate < 70 mL/min/1.73 m^2
ALT ? 2.5 x ULN f. Estimated glomerular filtration rate of at least 50 mL/min by the Cockcroft Gault formula
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or
Renal dysfunction for which exposure to cisplatin would be unsafe or require cisplatin dose modification (i.e., creatinine [Cre] > 1.5 mg/dl or glomerular filtration rate [GFR] < 60 cc/min)
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2
Glomerular filtration rate (GFR) >= 35 mL/min estimated by Cockcroft-Gault or measured directly by 24 hour urine creatinine within 90 days prior to Step 1 registration
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or
Estimated glomerular filtration rate (eGFR) (using Cockcroft & Gault equation) > 45 mL/min, within 14 days of registration
Serum creatinine =< 1.5 x upper limit of normal (ULN) or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation
Serum creatinine (Scr) =< 1.5mg/dl; if the Scr > 1.5, patients may still be eligible if the calculated glomerular filtration rate (GFR) (Cockroft-Gault) is >= 40ml/minute
End-stage renal disease (estimated glomerular filtration rate [GFR] < 55 ml/min/body surface area [BSA]), unless the estimated creatinine clearance by Cockcroft Gault is >= 55 ml/min prior to randomization
Serum creatinine ? 1.5 X ULN OR calculated glomerular filtration rate (GFR) by Cockcroft-Gault formula ? 50 mL/min
Creatinine clearance ? 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate calculation
Renal function as follows: serum creatinine < 2.0 mg/dL (176.84 umol/L) and estimated glomerular filtration rate > 30 mL/min/1.73 m2.
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or
Estimated glomerular filtration rate (eGFR) >= 45 mL/min/1.73 m^2 as calculated using the modification of diet renal disease equation
Serum creatinine >1.5 x ULN and/or creatinine clearance or estimated glomerular filtration rate <30 mL/min
Serum creatinine =< 1.5 mg/dL or calculated glomerular filtration rate (GFR) >= 60 mL/min
Glomerular Filtration Rate >= 60 mL/min (according to Modification of Diet in Renal Disease [MDRD] formula or Cockroft & Gault formula)
Pulmonary function: a. Pulse oximetry with a baseline O2 saturation of ? 85% b. Diffusing capacity of the lung for carbon monoxide (DLCO) > 40% (corrected for hemoglobin) d. Renal function: Serum creatinine ? 1.5 x the upper limit of normal for age as per local laboratory and 24 hour urine creatinine clearance >70 mL/min; or GFR > 70 mL/min/1.73 m2 by radionuclide Glomerular Filtration Rate (GFR). e. Hepatic function:
Serum creatinine =< 1.5 mg/dL or calculated glomerular filtration rate (GFR) >= 50 mL/min
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 OR
estimated creatinine clearance (CrCl, by Cockcroft-Gault formula) or estimated glomerular filtration rate (eGFR) ? 30 mL/min/1.73 m2
Subject has any of following laboratory abnormalities: WBC < 3000/uL; ANC < 1500/uL; Hemoglobin < 8 g/dL; Estimated glomerular filtration rate < 30 mL/min/1.73 m2; ALT > 3 x ULN ; Bilirubin > 1.5 x ULN
Measured creatinine clearance > 70 ml/min/1.73 m^2 or normal radioisotope glomerular filtration rate (GFR)
Creatinine clearance or radioisotope Glomerular Filtration Rate ? 70millileters/minute/1.73 meters2 or a normal serum creatinine based on age/gender
Serum creatinine =< 1.5 mg/dL or calculated glomerular filtration rate (GFR) >= 60 mL/min
Serum creatinine ? 1.5 mg/dL (or glomerular filtration rate ? 60 ml/min as determined by the Cockcroft-Gault equation)
Glomerular filtration rate (GFR) greater than or equal to 40 ml/min using the Cockcroft-Gault formula or serum creatinine less than or equal to 1.5 x upper limit of normal (ULN)
Estimated glomerular filtration rate (EGFR) >= 30 ml/min
INCLUSION - TREATMENT: Estimated glomerular filtration rate (GFR) > 60 mL/min
if serum creatinine > 3mg/dL, estimated glomerular filtration rate (GFR) ? 20 mL/min
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or
Serum creatinine ?2.0 mg/dL or eGFR (estimated Glomerular Filtration Rate) < 40 mL/min.
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or
Estimated GFR > 45 ml/min using Cockroft-Gault equation
Serum creatinine within normal range, or if serum creatinine outside normal range, then glomerular filtration rate (GFR) > 40 mL/min/1.73m2 as calculated with the Cockcroft-Gault equation with adjustment if total body weight is ? 125% of ideal body weight.
Serum creatinine =< 1.5 mg/dL OR calculated glomerular filtration rate (GFR) >= 60 mL/min
Estimated glomerular filtration rate (eGFR) of > 45 mls/min using Cockcroft and Gault formula
Renal: For patients > 13.0 years of age at the time of enrollment: estimated creatinine clearance > 50 mL/minute (using the Cockcroft-Gault formula and actual body weight). For patients < 13.0 years of age at enrollment: Glomerular Filtration Rate (GFR) estimated by the updated Schwartz formula ? 90 mL/min/1.73 m2. If the estimated GFR is < 90 mL/min/1.73 m^2, then renal function must be measured by 24-hour creatinine clearance or nuclear GFR, and must be > 50 mL/min/1.73 m^2.
Estimated glomerular filtration rate (eGFR) > 45 mL/min (if eGFR is not included on the clinical lab report,\r\nthe chronic kidney disease epidemiology [CKD-EPI] creatinine calculator may be used)
TREATMENT INCLUSION: Estimated glomerular filtration rate (GFR) > 70 mL/min
Adequate renal function (within normal limits or calculated glomerular filtration rate >50)
Glomerular filtration rate (GFR) ? 30 mL/min/1.73 m2 using the MDRD-4 variable formula
Glomerular filtration rate > 40ml/min/1.73m^2 as estimated by the Cockcroft-Gault formula or creatinine clearance > 50ml/min as determined by 24-hour urine collection
Estimated glomerular filtration rate (GFR by Cockroft-Gault equation OR 24 hour urine collection >= 60 ml/min
Serum creatinine: < 1.5 mg/dL or calculated glomerular filtration rate (GFR) >= 75 cc/min; creatinine clearance (CrCl) by Cockcroft Gault will be used to estimate GFR
Creatinine =< 1.5 x IULN or glomerular filtration rate of >= 60 mL/min
Impaired kidney function requiring dialysis or glomerular filtration rate (GFR) < 40mL/min (estimated or calculated)
Glomerular filtration rate ? 60 ml/min
Renal failure; exception: if GFR (glomerular filtration rate) is > 20%, a patient with renal failure can be included in the study
Glomerular filtration rate (GFR) >= 60 ml/min/1.73 m^2 according to the Modified Diet in Renal Disease (MDRD) abbreviated formula
Creatinine =< 1.5 X ULN and estimated glomerular filtration rate (GFR) (eGFR) >= 60 ml/min
Creatinine < 2.0 x ULN or estimated Glomerular Filtration Rate GFR [Cockcroft-Gault] > 30 mL/min
Decreased renal function with a GFR of less than 50ml/1.73m2/min.
Calculated creatinine clearance >= 30 mL/min by the modified Cockcroft and Gault formula OR glomerular filtration rate >= 30 mL/min/body surface area (BSA) by Modification of Diet in Renal Disease or Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula
Estimated glomerular filtration rate (GFR) > 50 mL/min
Glomerular filtration rate (GFR) ? 30 mL/min/1.73 m2 according to the modified diet in renal disease (MDRD) abbreviated formula
Calculated or measured glomerular filtration rate (GFR) < 30 ml/min, dialysis requirement, or prior renal transplant
Glomerular filtration rate (GFR), calculated via I-125 iothalamate clearance, 24-hour creatinine clearance, or Schwartz formula, >= 70 mL/min or >= 50 mL/min/1.73 m^2 done within 4 weeks prior to study entry
Creatinine clearance (CrCl) or estimated glomerular filtration rate (eGFR) >= 60 ml/min; CrCl will be calculated by Cockcroft-Gault method; eGFR will be calculated by either of the following well established formulas: modification of diet in renal disease (MDRD) or the chronic kidney disease (CKD)-epidemiology collaboration (EPI) (institutional standard) equations; if calculated CrCl/eGFR is < 60 mL/min, patient will have a 24 hr urine collection to measure CrCl; the measured CrCl must also be >= 60 ml/min
Creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation.
TREATMENT WITH SJCAR19: Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 50 ml/min/1.73 m^2 (GFR >= 40 ml/min/1.73 m^2 if < 2 years of age)
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70mL/min/1.73 m^2.
Creatinine: glomerular filtration rate (GFR) > 30 as calculated by modification of diet in renal disease (MDRD) equation
Within 28 days prior to treatment start: Serum creatinine glomerular filtration rate (GFR) > 45 mL/min
Glomerular filtration rate (GFR) >= 45 mL/min
STUDY TREATMENT: Creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation within 14 days prior to the first study treatment.
Adequate renal function as evidenced by serum creatinine ?2.0 × ULN or creatinine clearance 40 mL/min based on the Cockcroft-Gault glomerular filtration rate (GFR)
Pediatric population (patients < 18 years): creatinine within normal limits or calculated creatinine clearance >= 90 ml/min/1.73 m^2 as calculated by the Schwartz formula for estimated glomerular filtration rate (GFR)
Adult population (patients >= 18 years): Serum creatinine =< 1.0 mg/dL; if serum creatinine > 1.0 mg/dL, then the estimated glomerular filtration rate (GFR) must be > 60 mL/min/1.73 m^2 as calculated by the Modification of Diet in Renal Disease equation
Serum creatinine < 2.0 ULN OR an estimated glomerular filtration rate ? 30 mL/minute using the Cockroft-Gault formula.
Within two weeks prior to enrollment: Serum creatinine which is less than 1.5 times the upper limit of institutional normal for age or glomerular filtration rate (GFR) > 70 ml/min/1.73m^2
Creatinine clearance or glomerular filtration rate >= 70 ml/min/1.73 m^2 (calculated or measured as appropriate for age and level of concern by treating medical doctor [MD])
Glomerular filtration rate (GFR) greater than or equal to 40 ml/min using the Cockcroft-Gault formula or serum creatinine less than or equal to 1.5 x ULN
Serum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft?Gault glomerular filtration rate estimation
Glomerular filtration rate (GFR) greater than or equal to 40 ml/min using the Cockcroft-Gault formula or serum creatinine less than or equal to 1.5 x upper limit of normal (ULN)
Serum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation.
Serum creatinine =< 1.5 x upper limit of normal (ULN) for age; if the serum creatinine is above these values, the calculated creatinine clearance or radioisotope glomerular filtration rate (GFR) must be >= 70 mL/min/1.73 m^2
Creatinine < 1.5 x ULN or estimated glomerular filtration rate (GFR) >= 50 ml/min by Cockcroft-Gault
Glomerular filtration rate (either estimated or calculated from 24-hour urine collection) ? 45 mL/min
Serum creatinine =< 1.5 x the upper limit of normal for age as per local laboratory and 24 hour urine creatinine clearance > 70 mL/min/1.73 m^2 OR glomerular filtration rate (GFR) > 70 mL/min/1.73 m^2 by radionuclide GFR
Glomerular filtration rate (GFR) > 60 mL/min
Serum creatinine =< 1.5 x ULN OR creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation, obtained within 7 days prior to first study treatment
Within 7-10 days of study drug administration: Renal function\r\n* Adults (age 18 or >): Serum creatinine =< 1.2 mg/dl; if serum creatinine is > 1.2 mg/dL, nuclear glomerular filtration rate (GFR) will be measured\r\n** GFR will need to be >= 80 ml/min/1.73 m^2 for subjects =< 40 years old\r\n** >= 70 ml/min/1.73 m^2 for subjects between 41-50\r\n** >= 60 ml/min/1.73 m^2 for subjects between 51-60\r\n** >= 50 ml/min/1.73 m^2 for subjects > 60 years old\r\n* Children (age < 18): nuclear GFR >= 80 mL/min/1.73 m^2
Estimated GFR >30mL/min/1.73m2
Subject has adequate renal function defined as: Adequate real function with Sserum creatinine based on age/gender calculated using the Schwartz formula as described in protocol, or a 24-hour creatinine clearance or radioisotope glomerular filtration rate (GFR) (radioisotope or iothalamate) ? 70 mL/min/1.73 m2.
A serum creatinine based on age/gender, derived from the Schwartz formula for estimating glomerular filtration rate (GFR), per protocol-specified criteria.
Having an estimated glomerular filtration rate (GFR) < 40 ml/min/1.73 m^2.
Estimated glomerular filtration rate (eGFR) >= 50 mL/min/1.73m^2 per current institutional calculation formula (within 14 days of study registration)
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 60 ml/min/1.73 m^2, OR
Serum creatinine < 3.0 mg/dl or if elevated, a calculated glomerular filtration rate (GFR) of > 30 mL/min/1.73 m^2
Serum creatinine > 1.5 x the ULN or an estimated glomerular filtration rate (eGFR) calculated using the Modification of Diet in Renal Disease (MDRD) equation of < 45 mL/min/1.73 m^2
Serum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation
Serum creatinine =< 1.5 x ULN or estimated glomerular filtration rate (GFR) >= 50 mL/min/m^2
Obtained within 14 days prior to the first study treatment (cycle 1, day 1): serum creatinine =< 1.5 x ULN or creatinine clearance =< 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation
Estimated glomerular filtration rate (eGFR) >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal OR
Estimated creatinine clearance or GFR (glomerular filtration rate) >= 50 mL/min
Ineligible for cisplatin as defined by presence of one or more of the following:\r\n* Impaired renal function (glomerular filtration rate [GFR] >= 30 but =< 60 cc/min); GFR should be assessed by direct measurement (i.e. creatinine clearance or ethylenediaminetetra-acetate) or, if not available, by calculation from serum/plasma creatinine by Cockroft-Gault equation\r\n* Grade >= 2 hearing loss (measured by loss of > 25 dB at two contiguous frequencies in at least one ear)\r\n* Grade >= 2 peripheral neuropathy\r\n* ECOG performance status of 2\r\n* Solitary kidney
Serum creatinine =< 1.5 mg/dL OR calculated glomerular filtration rate (GFR) >= 60 mL/min
Patients will not be eligible if they present with moderate to severe decrease in creatinine clearance (estimated glomerular filtration rate [eGFR] < 45 mL/min/1.73m2)
Glomerular filtration rate (GFR) > 50 ml/min/1.73 m^2 or serum creatinine =< 2.5 x upper limit of normal (ULN) for age
Estimated glomerular filtration rate (eGFR) > 45 mL/min/1.73 m^2
Creatinine < 1.5 mg/dl OR estimated glomerular filtration rate (eGFR) (creatinine clearance) >= 60 mL/min/1.73 m^2
Estimated glomerular filtration rate (eGFR) >= 50 mL/min/1.73m^2 per current institutional calculation formula
Patients with estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m^2
Serum creatinine =< 2 mg/dL and estimated glomerular filtration rate or creatinine clearance >= 20 ml/min
Estimated creatinine clearance >= 30 mL/min (24 hour measured glomerular filtration rate [GFR] or modified Cockcroft Gault)
Estimated glomerular filtration rate (eGFR) >= 60 mL/min/1.73 m^2
Glomerular Filtration Rate (GFR) <40 ml/min
Modification of diet in renal disease (MDRD) calculated glomerular filtration rate (GFR) < 30 mL/min
Severe renal dysfunction (estimated glomerular filtration rate at the Screening visit; calculated by the central laboratory) <30 mL/min/1.73 m^2 or on chronic dialysis
Within 14 days prior to the first study treatment (cycle 1, day 1): Serum creatinine =< 1.25 x ULN or creatinine clearance >= 60 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation
Serum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation
FULL STUDY INCLUSION CRITERIA: Glomerular filtration rate (GFR) >= 30 mL/min/1.73 m^2 according to the Modification of Diet in Renal Disease (MDRD) abbreviated formula
Inadequate renal function at screening as demonstrated by creatinine clearance < 50 mL/min or glomerular filtration rate < 50 mL/min/1.73 m^2
Maximum serum creatinine 1.5 mg/dL OR a creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70ml/min/1.73 m^2
Creatinine ? 1.5 x upper limit of normal (ULN), or calculated glomerular filtration rate (GFR) > 40 mL/min (Cockcroft-Gault) if creatinine > 1.5x ULN
Serum creatinine level =< 1.5 mg/dL or estimated glomerular filtration rate >= 50 mL/min
Serum creatinine ? 1.5 x ULN or creatinine clearance ? 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation within 14 days prior to the first study treatment (cycle 1, day 1)
Creatinine greater than > 2 x ULN for age or creatinine clearance/glomerular filtration rate (GFR) < 40 ml/min/1.73 m^2
Glomerular filtration rate (GFR) >= 45 mL/min
Creatinine > 1.5 x ULN or glomerular filtration rate (GFR) < 45 mL/min
Glomerular filtration rate (GFR) < 50 mL/min, as assessed using the standard methodology at the investigating center (i.e. Cockroft-Gault), or serum creatinine > 1.5 x ULN
Abnormal kidney function (glomerular filtration rate GFR < 45 mL/min)
For patients >= 1.0 year of age but < 13.0 years of age at the time of enrollment: glomerular filtration rate (GFR) estimated by the updated Schwartz formula >= 90 mL/min/1.73 m^2; if the estimated GFR is < 90 mL/min/1.73 m^2, then renal function must be measured by 24-hour creatinine clearance or nuclear GFR, and must be > 50 mL/min/1.73 m^2
Glomerular filtration rate (GFR) adequate for intravenous (IV) contrast delivery for imaging
Creatinine clearance (CrCl) or glomerular filtration rate (GFR) >= 50 ml/min/1.73 m^2
Estimated glomerular filtration rate (eGFR) of at least 50ml/min using the Cockcroft Gault formula will be determined at base line when testing of BUN and creatinine is performed. The combination of eGFR serum creatinine and BUN will be used to evaluate renal function and assure the safety of this patient function.
Creatinine < 2 mg/dl (or a glomerular filtration rate > 60)
Estimated GFR < 40 ml/min
Serum creatinine within normal range, or if serum creatinine outside normal range, then renal function (measured or estimated creatinine clearance or glomerular filtration rate [GFR]) > 40mL/min/1.73 m^2
Glomerular filtration rate (GFR) >= 45 mL/min
Within 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR estimated glomerular filtration rate (GFR) per Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN
Serum creatinine =< 1.5 mg/dl or glomerular filtration rate > 50 ml/min
Creatinine =< 2.0 mg/dl (adults) and estimated glomerular filtration rate (GFR) >= 40 mL/min (pediatrics); adults with a creatinine > 1.2 mg/dl or a history of renal dysfunction must have estimated glomerular filtration rate (GFR) > 40 mL/min
Estimated glomerular filtration rate (GFR) by Modification of Diet in Renal Disease (MDRD) formula > 40 mL/min/1.73 m^2
Glomerular filtration rate (GFR) < 30 ml/min/1.73 m^2 (if receiving contrast for MRI)
Creatinine =< 1.5 x IULN OR glomerular filtration rate (GFR) of >= 50 mL/min
Creatinine clearance or glomerular filtration rate (GFR) > 60 mL/min/1.73 m^2; if a creatinine clearance is performed at end induction and the result is < 100 ml/min/1.73 m^2, a GFR must then be performed using a nuclear blood sampling method or iothalamate clearance method; camera method is NOT allowed as measure of GFR prior to or during consolidation therapy for patients with GFR or creatinine clearance of < 100 ml/min/1.73 m^2
Kidney: estimated glomerular filtration rate (Cockcroft-Gault) ? 50 mL/min.
Within 14 days prior to registration: Serum creatinine < 1.5 X institutional ULN mg/dL OR estimated glomerular filtration rate (eGFR) >= 50 mL/min
Serum creatinine clearance < 60 ml/min on the basis of either 24-hour urine collection or the glomerate filtration rate estimated by Cockraft-Gault equation
Serum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation
An estimated glomerular filtration rate (eGFR) calculated using the Modification of Diet in Renal Disease (MDRD) equation of at least 45 mL/min/1.73 m^2
Within 3 months of registration: Glomerular filtration rate (GFR) >= 45 mL/min; Cockcroft-Gault formula will be used to calculate creatinine clearance
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 60 ml/min/1.73m^2
Estimated glomerular filtration rate (eGFR) of at least 50 mL/min
Estimated glomerular filtration rate (eGFR) (chronic kidney disease [CKD]-epidemiology collaboration [EPI]) >= 50 mL/min/1.73 m^2
Glomerular filtration rate (GFR) > 60 as defined by the Modification of Diet in Renal Disease (MDRD) formula
Serum creatinine =< 2 x ULN or glomerular filtration rate (GFR) >= 50
Serum creatinine concentration =< 3 x the institutional upper limit of normal (ULN) or creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2
TREATMENT: Glomerular filtration rate (GFR) > 30 mL/min (calculated by the Cockcroft-Gault, Modification of Diet in Renal Disease [MDRD] study, or Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] creatinine equations, or equivalent)
Serum creatinine based on age or creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/ml/min/1.73 m^2
Glomerular filtration rate (GFR) > 50 ml/min/1.72 m^2 or creatinine < 2 g/dL, values =< 2 weeks
Estimated or actual glomerular filtration rate (GFR) > 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal; GFR should be corrected for body surface area (BSA)
ELIGIBILITY CRITERIA FOR T-CELL PRODUCT INFUSION: Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a normal serum creatinine based on age/gender
Creatinine < 1.5 mg/dl or glomerular filtration rate > 50 ml/min
For patients who agree to participate in PET/MR imaging:\r\n* Renal insufficiency (glomerular filtration rate [GFR] < 30 mL/min/1.73 m^2) measured within the past 60 days which precludes safe administration of the contrast agent\r\n* On dialysis\r\n* Prior allergic reaction to gadolinium-based MR contrast agents
Creatinine =< 1.5 X institutional upper limit of normal or estimated glomerular filtration rate < 45 mL/min/1.73 m^2
Estimated glomerular filtration rate (GFR) > 30 ml/min
Serum creatinine within normal range for age, or if serum creatinine outside normal range for age, then renal function (creatinine clearance or glomerular filtration rate [GFR]) > 40 mL/min/1.73m^2
Glomerular filtration rate (GFR) > 59
Creatinine < 2 mg/dl (or a glomerular filtration rate > 60 mL/min)
Adequate renal function with glomerular filtration rate equal to or greater than 30 ml/min/1.73 m2
Serum creatinine > 1.8 mg/dL OR glomerular filtration rate (GFR) < 30 mL/min
Renal (glomerular filtration rate [GFR] > 40) contraindications for high dose chemotherapy
Serum creatinine > 1.5 x the upper limit of normal for age, or calculated creatinine clearance or nuclear glomerular filtration rate (GFR) < 70 ml/min/1.73 m^2
Glomerular filtration rate (GFR) >= 45 mL/min
Creatinine clearance or glomerular filtration rate ?30 mL/min as estimated by the Cockroft-Gault (C-G) or other medically acceptable formulas, such as MDRD (Modification of Diet in Renal Disease) or CKD-EPI (the Chronic Kidney Disease Epidemiology Collaboration).
Creatinine clearance or radioisotope glomerular filtration rate (GFR) > 70 ml/min/1.73 m^2 or normal serum creatinine for patient’s age and gender
Glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2
Adequate renal function with creatinine (Cre) =< 1.5; if greater, then glomerular filtration rate (GFR) > 60 mL/min/1.73 m^2 as calculated by the Modification of Diet in Renal Disease equation
Creatinine clearance or glomerular filtration rate (GFR) >= 60 ml/min
Serum creatinine within normal range for age, or if serum creatinine outside normal range for age, then renal function (creatinine clearance or glomerular filtration rate [GFR]) > 40 mL/min/1.73m^2
Serum creatinine =< 1.5 x upper limit of normal (ULN) for age or creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2
Serum Creatinine <~ 1.5 x normal, or creatinine clearance of 70 ml/min/1.73 m^2 or an equivalent glomerular filtration rate (GFR) as determined by the institutional normal range
Glomerular filtration rate > 60 ml/min/1.73 m^2
Either serum creatinine ? 1.5 x ULN or estimated glomerular filtration rate ? 45 mL/min/1.73 m^2
Serum creatinine < 1.5 x upper limit normal (ULN) or estimated glomerular filtration rate (GFR) > 50 mL/min based upon Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation. Patients with estimated GFR between 50 - 60 mL/min at baseline will require a 99mTc-DTPA GFR test and only patients with non-obstructive pathology will be included in the study.
A serum creatinine based on age/gender, derived from the Schwartz formula for estimating glomerular filtration rate (GFR)
Estimated glomerular filtration rate (eGFR) > 40 mL per 1.73 m*2
Adequate renal function defined as normal serum creatinine for the participant's age or creatinine clearance or radioisotope glomerular filtration rate (GFR) 70 milliliter per minute per 1.73 square meter (mL/min/1.73 m^2) at Cycle 1 Day 1 pre-dosing
Renal-calculated or measured glomerular filtration rate (GFR) < 40 ml/min, dialysis requirement, or prior renal transplant
Screening laboratory analyses shows any of the following abnormal laboratory results: Estimated Glomerular filtration (eGFR) rate < 30 mL/min
Glomerular filtration rate (GFR) at Screening < 40 milliliter (mL)/minute (min)
Estimated glomerular filtration rate (GFR) (eGFR) >= 60 ml/min
Glomerular filtration rate (GFR) ?30 ml/min/1.73 m2 (assessed using the Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation)
Glomerular filtration rate (GFR) ? 30 mL/min/1.73 m2 according to the Modification of Diet in Renal Disease (MDRD) formula.
Serum creatinine ?1.5 mg/dL or estimated glomerular filtration rate (eGFR) ?60 mL/min/1.73 m2
Within 14 days of first dose of study drug: Serum creatinine =< 1.5 x ULN or estimated glomerular filtration rate (GFR) >= 45 mL/min using the Cockcroft Gault formula
Adequate renal function (estimated glomerular filtration rate [GFR] > 40mL/min)
Estimated creatinine clearance of >= 60 ml/min according to the Cockcroft-Gault formula, unless calculated to be < 60 ml/min or borderline in which case glomerular filtration rate (GFR) should be formally measured, e.g. with edetic acid (EDTA) scan
Patients should have serum creatinine < 1.5 x ULN and estimated glomerular filtration rate (GFR) of > 30 mL/min. If serum creatinine is >= 1.5 x ULN, then patient must have creatinine clearance >= 51 mL/min estimated using the Cockcroft-Gault equation.
Within 14 days prior to the first study treatment (cycle 1, day 1): Serum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation.
Creatinine ? 2 x ULN OR creatinine clearance > 30 mL/min based on the Cockroft-Gault glomerular filtration rate (GFR) estimation within 14 days prior to registration
Glomerular filtration rate ? 45 ml/min based on Cockcroft-Gault equation
Patients must not be suitable for concurrent cisplatin as determined by the following:\r\n* Creatinine clearance less than 60ml/min; glomerular filtration rate (GFR) should be assessed by calculation from serum/plasma creatinine (Cockcroft-Gault formula)\r\n* Common Terminology Criteria for Adverse Events (CTCAE) grade (Gr) >= 2 hearing loss\r\n* CTCAE Gr >= 2 neuropathy
Creatinine < 2.0 mg/dl for adults or glomerular filtration rate > 50 ml/min for children
Within 14 days of study registration (30 days for pulmonary and cardiac): estimated glomerular filtration rate (GFR) >= 40 mL/min/1.73m^2
Serum creatinine =< 1.5 x ULN or estimated glomerular filtration rate (GFR) >= 45 mL/min using Cockcroft Gault formula
Renal impairment defined as estimated glomerular filtration rate (EGFR) < 30
Creatinine within institutional normal limits or glomerular filtration rate >= 30 mL/min/1.73 m^2 by chronic kidney disease (CKD) epidemiology collaboration (EPI) equation
Creatinine within institutional normal limits or Glomerular filtration rate (GFR) > 50 mL/min/m^2 (calculated by the Cockcroft-Gault equation), calculated as follows:\r\n* For males = ((140 – age[years]) x (body weight [kg]))/((72) x (serum creatinine [mg/dL]))\r\n* For females = 0.85 x male value
Glomerular filtration rate (GFR) >= 30 ml/min/1.73 m^2 according to the Modified Diet in Renal Disease (MDRD) abbreviated formula
Creatinine within institutional normal limits or glomerular filtration rate (GFR) > 60 mL/min/m^2 (calculated by the Cockcroft-Gault equation)
Creatinine clearance >= 50 mL/min by either measured (using the Cockcroft-Gault, Modification of Diet in Renal Disease [MDRD] or Chronic Kidney Disease Epidemiology [CKD-EPI] formula) or calculated clearance (i.e. glomerular filtration rate [GFR])
Estimated glomerular filtration rate (eGFR) >= 50 ml/min/1.73 m^2 using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, obtained within 14 days prior to the first study treatment (cycle 1, day 1)
Estimated glomerular filtration rate (eGFR) > 30 (milliliter per minute (mL/min) /1.73 square meter (m^2) as assessed by Modification of Diet in Renal Disease (MDRD) formula for subjects >= 18 years of age or Schwartz formula for subjects less than (<) 18 years of age.
Creatinine clearance or glomerular filtration rate ?30 mL/min estimated by the Cockroft-Gault (C-G) or other medically acceptable formulas such as MDRD (Modification of Diet in Renal Disease) or CKD-EPI (the Chronic Kidney Disease Epidemiology Collaboration).
Creatinine clearance < 30 mL/min, not eligible for bisphosphonate; estimated glomerular filtration rate will be calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and/or the Cockcroft-Gault equation
Adequate renal function: Estimated glomerular filtration rate ? 30 mL/minute using the Cockroft-Gault formula or: a serum creatinine based on age/gender as outlined in the protocol
Patients with a serum creatinine > 1 are eligible if they have a calculated glomerular filtration rate (GFR) of >= 60 ml/min (i.e. class I or class II chronic kidney disease ) using the Modification of Diet in Renal Disease (MDRD) formula\r\n* Note: Daily creatinine and MDRD formula are only for the 1st induction cycle
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or
Glomerular filtration rate (GFR) or creatinine clearance (CrCl) (24 hour urine) greater than 30 ml/min corrected for body surface area
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or
Estimated glomerular filtration rate (GFR) ?30 mL/min as assessed by CKD-epi, MDRD or the Cockcroft-Gault Equation
Serum creatinine =< 1.5 x upper limit of normal or a creatinine clearance or glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2
Glomerular filtration rate (GFR) greater than or equal to 40 ml/min using the Cockcroft-Gault formula or serum creatinine less than or equal to 1.5 x upper limit of normal (ULN)
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or
Creatinine clearance estimated glomerular filtration rate (GFR) >= 30 mL/min/1.73 m^2 (Cockcroft-Gault)
Estimated glomerular filtration rate (GFR) of >= 50 ml/min (based on the Fairview Laboratories formula at time of screening)
Patients with severe renal disease (i.e. measured or estimated creatinine clearance or radioisotope glomerular filtration rate [GFR] =< 70 ml/min/1.73 m^2)
Creatinine clearance or radioisotope glomerular filtration rate >= 60 mL/min
Creatinine: =< 3 mg/dl OR if serum creatinine > 3 mg/dl, estimated glomerular filtration rate (GFR) > 30 mL/min/1.73 m^2
Subjects must have adequate kidney function, with serum creatinine < 1.5 x upper limit of normal (ULN) or calculated glomerular filtration rate (GFR) of > 45/mL/min/1.73 m^2
Serum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation
Estimated glomerular filtration rate (eGFR) greater than or equal to 60 ml/min/1.73 m^2
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 or
Serum creatinine =< 1.2 mg/dL or serum creatinine > 1.2 mg/dL and an estimated glomerular filtration rate (GFR) > 60 mL/min/1.73 m^2 as calculated by the modification of diet in renal disease equation
Estimated glomerular filtration rate (GFR) (calculated using Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation) >= 30 mL/min/1.73 sq.m.
Creatinine < 2 mg/dl; glomerular filtration rate (GFR) > 50 mL/min (Cockroft and Gault formula)
Estimated or actual glomerular filtration rate (GFR*) > 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal\r\n* GFR should be corrected for body surface area (BSA)
Serum creatinine =< 1.5 x ULN or 24-hour clearance >= 50 mL/min or calculated glomerular filtration rate (GFR) of 60cc/ml using the formula of Cockcroft and Gault
Serum creatinine ? 1.5 x ULN or an estimated glomerular filtration rate of > 50 mL/min as calculated by the Modification of Diet in Renal Disease equation.
Serum creatinine =< 1.5 mg/dL or estimated glomerular filtration rate (GFR) (by Cockcroft-Gault) >= 50 mL/min or 12 or 24 hour urine creatinine clearance >= 50 mL/min, unless renal insufficiency is due to tumoral ureteral obstruction in which case eligibility will be determined by the national principal investigator (or national co-PI or MSKCC co-PI if the national PI is unavailable) with notification of the MSKCC Institutional Review Board (IRB)
Serum creatinine ?1.5×upper limit of normal (ULN), or glomerular filtration rate >25 mL/min, as calculated with the Cockcroft-Gault formula.
Creatinine clearance calculated using the Schwartz formula, or radioisotope glomerular filtration rate (GFR) > 70 mL/min/1.73 m2.
Subjects must have adequate renal function as evidenced by a serum creatinine ?2.0 × ULN or creatinine clearance >40mL/min based on Cockroft-Gault glomerular filtration rate (GFR)
Patient must have adequate renal function as evidenced by: Serum creatinine ?2.0 × ULN or Creatinine clearance >40 mL/min based on the Cockroft-Gault glomerular filtration rate (GFR) estimated: (140-Age) x (weight in kg) x (0.85 if female)/72 x serum creatinine
Renal function defined as (Calculated creatinine clearance or radioisotope Glomerular Filtration Rate (GFR) > 60 mL/min/1.73 m2 OR serum creatinine based on age/gender
Estimated Glomerular Filtration Rate (eGFR) ? 60 mL/min/1.73 m2
Renal function estimated glomerular filtration rate (eGFR) > 30 mL/min via calculated creatinine clearance
Glomerular filtration rate (GFR) must be greater than or equal to 30 mL/min/1.73 m2 according to the Modified Diet in Renal Disease (MDRD) abbreviated formula.
Glomerular Filtration Rate (GFR) > 40mL (milliliter)/min; Creatinine ? 1.5 x ULN (Upper limit of Normal)
Creatinine clearance estimated (est.) glomerular filtration rate (GFR) >= 30 mL/min/1.73 m^2 (Cockcroft-Gault)
Glomerular filtration rate (GFR) > 30 mL/min (by standard Cockcroft and Gault formula or measured via 24 hour urine collection)
Serum creatinine =< 2 mg/dL (or glomerular filtration rate >= 40 ml/min)
Serum creatinine =< 1.2 mg/dL for subjects age 18 or >; if serum creatinine is > 1.2 mg/dL, nuclear glomerular filtration rate (GFR) will be measured; GFR will need to be >= 80 ml/min/1.73 m^2 for subjects =< 40 years old; children (age < 18): nuclear GFR >= 80 mL/min/1.73 m^2
Renal function\r\n* >= 70 ml/min/1.73 m^2 for subjects between 41-50\r\n* >= 60 ml/min/1.73 m^2 for subjects between 51-60\r\n* >= 50 ml/min/1.73 m^2 for subjects > 60 years old\r\n** Renal function criteria based on our previous experience with 90Y-DOTATOC therapy and known changes in GFR with age
Glomerular filtration rate (GFR) ? 60 mL/min/1.73 m2 according to the Modified Diet in Renal Disease (MDRD) abbreviated formula.
Serum creatinine =< 2 x ULN or glomerular filtration rate (GFR) >= 50
Serum creatinine < 1.5 x institutional Upper Limit of Normal (ULN) or an estimated glomerular filtration rate (eGFR) of > 50 ml/min as calculated by the Modification of Diet in Renal Disease (MDRD) equation
Creatinine < 2 mg/dl (or a glomerular filtration rate > 60)
Calculated creatinine clearance (estimated glomerular filtration rate [eGFR]) < 60 ml/min; EGFR values can be determined by either Modification of Diet in Renal Disease (MDRD) or Cockcroft-Gault equation based on the investigator’s discretion
Creatinine clearance or estimated radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or
Glomerular filtration rate (GFR) > 25 ml/min (for patients receiving cisplatin, GFR >= 60 ml/min)
Creatinine < 2 mg/dl (or a glomerular filtration rate > 60)
Serum creatinine ? 1.5 x ULN or creatinine clearance ? 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation:
Estimated glomerular filtration rate >= 60 ml/min/1.73m^2 using the chronic kidney disease (CKD)-epidemiology (EPI) equation
Estimated glomerular filtration rate (eGFR) >= 50 ml/min/1.73m^2 using the CKD-EPI equation
Renal: serum creatinine (SCr) within normal range for age (see table 2.3). If SCr is outside normal range for age, creatinine clearance (CrCl) > 40 mL/min/1.73m2 must be obtained (measured by 24-hour (hr) urine specimen or nuclear glomerular filtration rate (GFR), or calculated GFR (by Cockcroft-Gault formula for those aged ? 18 years; by Original Schwartz estimate for those < 18 years))
Creatinine clearance >= 50 mL/min/1.73 m^2 (calculated by estimated glomerular filtration rate [eGFR] from EPIC)
Creatinine > 1.5 ULN or glomerular filtration rate (GFR) < 45 ml/min
Serum creatinine =< 2 mg/dL (or glomerular filtration rate >= 50 ml/min as determined by the Cockcroft-Gault equation)
Within 14 days prior to the first study treatment (cycle 1, day 1): Serum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation
Creatinine =< 1.5 times ULN for age OR a creatinine clearance or glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2; obtained =< 7 days prior to registration
Creatinine =< 1.5 or glomerular filtration rate (GFR) >= 60 mL/min/1.73m^2
Adequate renal function with estimated glomerular filtration rate (GFR) by Cockcroft Gault of greater than 40 ML per minute
OR if serum creatinine > 3 mg/dL, estimated glomerular filtration rate (GFR) ? 20 mL/min
Serum creatinine =< 1.5 x upper limit of normal (ULN) (or glomerular filtration rate [GFR] >= 60 ml/min for patients with creatinine > 1.5 x ULN)
Estimated glomerular filtration rate (eGFR) of at least 50 mL/min
The standard Cockcroft and Gault formula or the measured glomerular filtration rate must be used to calculate creatinine clearance (CrCl) for enrollment or dosing
Calculated creatinine clearance >= 60 mL/min (Cockcroft-Gault formula) or serum creatinine (Cr) less than institution ULN (the elderly will often have < 60 glomerular filtration rate [GFR])
Creatinine < 1.5 x the ULN or glomerular filtration rate (GFR) < 45 ml/min
Glomerular filtration rate (GFR) >= 30 ml/min/1.73 m^2 according to the MDRD (modified diet in renal disease) abbreviated formula
Adequate renal function defined as glomerular filtration rate ? 40 mL/min,
Maximum serum creatinine 1.5 mg/dL OR a creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2
Glomerular filtration rate (GFR) > 50 mL/min
Patients with renal failure (GFR < 50 mL/min) are excluded
Patients with >= grade 3 chronic kidney disease at enrollment (estimated glomerular filtration rate [eGFR] or creatinine clearance [CrCl] < 30 ml/min/1.73m^2)
Subjects must have adequate renal function as evidenced by: a. Serum creatinine ?2.0 × ULN OR b. Creatinine clearance >40 mL/min based on the Cockroft-Gault glomerular filtration rate (GFR) estimation: (140 - Age) x (weight in kg) x (0.85 if female)/72 x serum creatinine
Glomerular filtration rate ? 50 mL/min;
Glomerular filtration rate (GFR) > 40 mL/minute as calculated by the Cockcroft-Gault formula
Serum creatinine ? 1.5 x institutional ULN or an estimated glomerular filtration rate (eGFR) of > 50 ml/min as calculated by the Modification of Diet in Renal Disease (MDRD) equation.
Subjects with end stage renal function (creatinine clearance [CrCl] < 15 mL/min or glomerular filtration rate [GFR] <15 mL/min) regardless of whether hemodialysis is required
Obtained within 14 days prior to the first study treatment (cycle 1, day 1); serum creatinine ? 1.5 x ULN or creatinine clearance ? 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation
Subjects must have adequate renal function as evidenced by: • Serum creatinine ?2.0 × ULN OR • Creatinine clearance greater than 40 mL/min based on the Cockroft-Gault glomerular filtration rate (GFR) estimation: (140 - Age) x (weight in kg) x (0.85 if female)/72 x serum creatinine
Creatinine < 2.0 x ULN or creatinine clearance (estimated [est.] glomerular filtration rate [GFR] [Cockcroft-Gault]) >= 30 mL/min
Creatinine =< 1.5 times upper limit of normal (ULN*) OR corrected glomerular filtration rate >= 70 ml/min\r\n* NOTE: *of institutional norms
All patients must be able to undergo MRI with and without contrast with a glomerular filtration rate (eGFR) greater than or equal to 30 mg/min/1.72 m^2
Participants must have a creatinine < 3 mg/dl and a glomerular filtration rate (GFR) > 30 mL/min/1.73m^2
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 OR
Glomerular filtration rate >/= 30 ml/min/1.73 m2 according to the Modification of diet in renal disease study equation.
Serum creatinine within normal range for age, or if serum creatinine outside normal range, then renal function (estimated glomerular filtration rate [GFR] by modification of diet in renal disease [MDRD] formula) > 40 mL/min/1.73 m^2
Glomerular filtration rate (GFR) =< 50
Estimated glomerular filtration rate (GFR) > 50 ml/min
Serum creatinine < 2.0 mg/dl or glomerular filtration rate (GFR) > 40 mL/min/1.73m^2; patients with a creatinine > 1.2 mg/dl or a history of renal dysfunction must have glomerular filtration rate (GFR) > 40 mL/min/1.73 m^2
Creatinine clearance or glomerular filtration rate (GFR) greater than or equal to 50 mL/min/1.73 m^2
Estimated glomerular filtration rate >= 60 ml/min/1.73 m^2 using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation
Calculated glomerular filtration rate (GFR) > 45 mL/min
Serum creatinine =< upper limit of normal (ULN) for age; if serum creatinine above these values, the calculated creatinine clearance or radioisotope glomerular filtration rate (GFR) must be >= 60 ml/min/1.73 m^2
Acute or chronic severe renal insufficiency (Glomerular filtration rate (GFR) <30ml/min/1.73 sq.meters)
Estimated glomerular filtration rate (GFR) must be >= 50 mL/min
Estimated glomerular filtration rate (GFR) >= 50 mL/min/1.73m^2
Creatinine clearance > 60 ml/min/1.73 m^2; glomerular filtration rate (GFR) may also demonstrate adequate renal function
Glomerular filtration rate (GFR) >= 30 ml/min/1.73m^2
Serum creatinine =< 1.5 x ULN or glomerular filtration rate (GFR) of 60 cc/ml using the formula of Cockcroft and Gault
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2
Serum creatinine which is less than 1.5 x the upper limit of institutional normal for age or glomerular filtration rate (GFR) > 70 ml/min/1.73 m^2 within two weeks prior to enrollment
Serum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation (obtained within 14 days prior to the first study treatment [course 1, day 1])
Glomerular filtration rate > 30ml/min/1.73 m2 according to the Modified Diet in Renal Disease abbreviated formula or creatinine clearance (CrCL) > 60 ml/min (Cockcroft and Gault)
Serum creatinine ? 2.0 x upper limit of normal (ULN) or an estimated glomerular filtration rate (eGFR) of > 50 mL/min as calculated by the Cockcroft Gault Method
Estimated glomerular filtration rate (eGFR) ?25 mL/min/1.73 m2 as estimated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, or measured GFR ?25 mL/min/1.73 m2
Patients will have an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m^2
Must have estimated glomerular filtration rate (eGFR) by Modification of Diet in Renal Disease (MDRD) formula or Cockroft-Gault formula of 50 mL/min or higher
Creatinine =< 1.5 times upper limit of normal (ULN) OR glomerular filtration rate >= 70 ml/min
Serum creatinine <2.0 x upper limit of normal (ULN) or estimated glomerular filtration rate of > 50 mL/min as calculated by the Cockcroft Gault Method
Alkaline phosphatase 2.5 ULN with the following exception: Patients with liver or bone inv ULN or creatinine clearance 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation: (140 age) (weight in kg) (0.85 if female) 72 (serum creatinine in mg/dL)
Adequate renal function (creatinine ? 1.5×ULN [upper limit of normal]) or glomerular filtration rate of ? 60 mL/min
Estimated glomerular filtration rate ?30 mL/minute
Adequate renal function, defined as serum creatinine ?2.0 times ULN and creatinine clearance >50 mL/min or estimated glomerular filtration rate (eGFR) >50 mL/min/1.73 m^2
Subjects must have adequate kidney function, as assessed by the estimated glomerular filtration rate (eGFR) >=60 mL/min per 1.73 m*2 [Common Terminology Criteria for Adverse Events(CTCAE Grade <=1)] calculated by the Modification of Diet in Renal Disease Study Group (MDRD) formula
Glomerular filtration rate (GFR) > 30 using Cockcroft–Gault formula
Creatinine >= 1.5 x upper limit of normal (ULN) or glomerular filtration rate (GFR) < 45 ml/min
Adequate renal function (creatinine ? 1.5x upper limit of normal [ULN]) and/or glomerular filtration rate (GFR) of ?50 mL/min.
Estimated glomerular filtration rate (eGFR) ? 60 mL/min per 1.73 m2 according to the Modification of Diet in Renal Disease Study Group (MDRD) formula (see Section 14.6)
Estimated glomerular filtration rate (GFR) > 45 mL/min/1.73 m^2
Estimated GFR > 45 mL/min/1.73 m^2
Creatinine clearance (Cockcroft-Gault) greater than or equal to 30 mL/min or estimated (est) glomerular filtration rate (GFR) greater than or equal to 30 mL/min/1.73 m^2
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age and gender as follows:\r\n* Age >= 16 years: maximum serum creatinine (mg/dL): 1.7 for male and 1.4 for female
Glomerular filtration rate > 60 ml/min
Glomerular filtration rate>/=30 mL/min/1.73 m2 according to the Modified Diet in Renal Disease abbreviated formula
Cisplatin ineligibility based on one or more of the following criteria:\r\n* Estimated glomerular filtration rate (eGFR) 30-59 ml/min/1.73^2\r\n* >= Grade 2 sensory neuropathy\r\n* >= Grade 2 hearing loss
13. Adequate renal function (creatinine ? 1.5 x ULN [upper limit of normal] or glomerular filtration rate of ? 50mL/min).
Estimated glomerular filtration rate (eGFR) < 60 within 6 weeks prior to registration
Creatinine within institutional normal limits or glomerular filtration rate >= 50 mL/min/1.73 m^2 by Chronic Kidney Disease Epidemiology Collaboration (CKD EPI) equation
Serum creatinine ? 1.5 x upper limit of normal (ULN) or, if serum creatinine > 1.5 x ULN, estimated glomerular filtration rate (eGFR) ? 30 mL/min
Glomerular Filtration Rate ? 60 mL/min (according to Modification of the Diet in Renal Disease (MDRD) formula or cockroft & Gault formula)
Calculated glomerular filtration rate (GFR) > 50 ml/min
Calculated creatinine clearance (CRCL) ?40 mL/min. Glomerular Filtration Rate (GFR) is calculated based on Cockcroft-Gault method.
Within 14 days prior to first study treatment: Serum creatinine =< 1.5 x ULN OR creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation
Glomerular filtration rate > 60 ml/min/1.73 m^2
Calculated creatinine clearance > 50 ml/min/1.73m^2 as calculated by the Schwartz formula for estimated glomerular filtration rate
Serum creatinine ? 1.25 x ULN; or if serum creatinine > 1.25 ULN, then calculated (Cockcroft-Gault formula, glomerular filtration rate (GFR) ? 60 mL/min;
Glomerular filtration rate (GFR) of 50 ml/minute or greater (if elevated serum creatinine level > 1.5 x ULN)
Glomerular filtration rate (GFR) of 50 mL/min or greater
Creatinine clearance or glomerular filtration rate greater than or equal to 50 mL/min/1.73 m^2
Pediatric Population (age <18): Calculated creatinine clearance ? 90 ml/min/1.73m2 as calculated by the Schwartz formula for estimated glomerular filtration rate (GFR)
Adult Population (age >18): Serum creatinine <1.0 mg/dL; if serum creatinine >1.0 mg/dL, then the estimated glomerular filtration rate (GFR) must be >60 mL/min/1.73 m2
Glomerular filtration rate (GFR) < 60 mL/min/1.73 m^2 or calculated GFR < 60 mL/min/m^2 per Schwartz formula
Creatinine of =< 2 mg/dl and a calculated glomerular filtration rate (GFR) of > 50 mL/min/1.73 m^2
Subject has an estimated glomerular filtration rate (eGFr) of < 60ml/min as calculated by the modification of diet Renal disease (MDRD) Equation.
Estimated glomerular filtration rate (eGFR) >/=50 mL/min per 1.73 m2 according to the Modification of Diet in Renal Disease Study Group (MDRD) formula
Creatinine clearance (CrCl) or glomerular filtration rate (GFR) >= 50 ml/min/1.73m^2
Calculated glomerular filtration rate (GFR) >= 60 ml/min
Creatinine clearance (CrCL) or glomerular filtration rate (GFR) >= 50 ml/min/1.73 m^2
Estimated (calculated) or measured glomerular filtration rate >= 45 mL/min (or 45 mL/min/1.73 m^2); creatinine (mg/dl) used in calculation (Cockroft-Gault) must be obtained within 28 days prior to registration
CROSSOVER (STEP 2) REGISTRATION: Estimated (calculated) or measured glomerular filtration rate >= 45 mL/min (or 45 mL/min/1.73 m^2) within 28 days prior to registration; creatinine (mg/dl) used in calculation (Cockroft-Gault) must be obtained within 28 days prior to registration
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or
Renal: estimated glomerular filtration rate (eGFR) using the modification of diet in renal disease (MDRD) formula ? 50 mL/min;
Serum creatinine < 1.5 x institutional ULN or an estimated glomerular filtration rate (eGFR) of > 50 ml/min as calculated by the Modification of Diet in Renal Disease (MDRD) equation.
Glomerular filtration rate >= 50 mL/min (calculated according to the formula of Cockcroft and Gault)
Does the subject have an estimated glomerular filtration rate of at least 50 mL/min (inclusive) by the Cockcroft-Gault formula?
Serum creatinine < 1.5 X institutional ULN mg/dL OR glomerular filtration rate (GFR) >= 50 mL/min
Heart: presence of mean left ventricular wall thickness on echocardiogram greater than 12 mm in the absence of hypertension or valvular heart disease, or unexplained low voltage (< 0.5 mV) on ECG, or NT-proBNP > 332 ng/L in the absence of impaired renal function [estimated glomerular filtration rate (eGFR) < 45 mL/min]
creatinine ? 1.5 x upper limit of normal (ULN), or calculated glomerular filtration rate (GFR) > 50 mL/min if creatinine > 1.5x ULN
Calculated glomerular filtration rate (GFR) must be >= 60 ml/min; GFR will be calculated as needed per institutional guidelines
Estimated creatinine clearance (CrCl) or estimated glomerular filtration rate (eGFR) ? 30 mL/min/1.73 m2
Glomerular filtration rate (GFR) > 45 mL/min/1.73m^2 according to the Cockcroft-Gault estimation.
Glomerular filtration rate (GFR) >= 50 ml/minute using Cockroft-Gault formula
Must have adequate organ function as defined by the following values: renal function - 24 hr creatinine clearance (revised Schwartz formula), or radioisotope glomerular filtration rate (GFR) >=60 milliliter (mL) per minute per 1.73 meter square (mL/min/1.73m^2); or a serum creatinine <=upper limit of normal (ULN) for age and gender; liver functions as bilirubin (sum of conjugated + unconjugated) <=1.5 x ULN for age, alanine aminotransferase (ALT) <=2.5 x ULN; for the purposes of enrollment and toxicity monitoring the ULN for ALT will be 45 unit per liter (U/L); cardiac function - corrected QT (QTcB) interval <480 milliseconds (msec), left ventricular ejection fraction (LVEF) >=lower limit of normal (LLN) by ECHO.
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2
Adequate renal and metabolic function defined as: calculated glomerular filtration rate (eGFR) (Schwartz formula), or radioisotope GFR >=90 milliliters/minutes (mL/min)/1.73 meter square (m^2); or a serum creatinine within the institutional reference range upper limit of normal (for age/gender, if available).
Measured or calculated creatinine clearance >=50 milliliters per minute (mL/min) on the basis of the Cockcroft-Gault glomerular filtration rate estimation Cancer-Specific Inclusion Criteria:
Creatinine clearance or glomerular filtration rate of >= 70 ml/min/1.73m^2
Calculated creatinine clearance (estimated glomerular filtration rate [eGFR]) > 50 ml/min
Estimated Glomerular Filtration Rate <45 mL/min.
estimated glomerular filtration rate > 50 mL/min
Calculated creatinine, glomerular filtration rate (GFR) >= 30 cc/minute
Normal creatinine for age or glomerular filtration rate (GFR) >= 70/ml/min/1.73m^2
Glomerular filtration rate (GFR) > 40 ml/min/1.73m^2 or
Serum creatinine < 2.0 mg/dl (provided they also have a glomerular filtration rate of at least 55 ml/min)
Estimated glomerular filtration rate (GFR) > 30 ml/min
Creatinine 2 x ULN or glomerular filtration rate (GFR) > 50
Estimated glomerular filtration rate (eGFR) of > 50 ml/min as calculated by the Cockcroft-Gault Method
Calculated glomerular filtration rate (GFR) > 50 ml/minute
Serum creatinine > 1.6 mg/dL or glomerular filtration rate < 50
Glomerular filtration rate > 60ml/min; OR =< ULN creatinine per institution normals
Glomerular filtration rate (GFR) < 45 ml/min
Glomerular filtration rate (GFR) greater than or equal to 30 ml/min/1.73 m^2 by modification of diet in renal disease (MDRD)
Unless felt due to underlying disease and approved by the overall principal investigator (PI): Creatinine < 2.0 mg/dl, and estimated glomerular filtration rate (eGFR) >= 60 mL/min
Calculated Glomerular filtration rate ? 50 mL/min;
Serum creatinine =< 1.5 mg/dL or calculated glomerular filtration rate (GFR) >= 60 mL/min
Glomerular filtration rate (GFR) >= 30 ml/min
Subjects with severe renal failure or end stage renal disease (estimated GFR [glomerular filtration rate] of < 30 mL/min) as estimated by the Cockcroft-Gault formula
Glomerular filtration rate (GFR) of >= 50 mL/min/1.73 m^2
Glomerular filtration rate (GFR) < 55 mL/min
Estimated glomerular filtration rate (GFR) of < 50 mL/min/1.73 m^2
Modification of diet in renal disease (MDRD) calculated glomerular filtration rate (GFR) < 30 mL/min
Creatinine clearance or glomerular filtration rate (GFR) which is greater than or equal to 70 ml/min/1.73 m^2
Serum creatinine within normal range, or if serum creatinine is outside normal range, then renal function (measured or estimated creatinine clearance or glomerular filtration rate [GFR]) >= 40 mL/min/1.73 m^2
Chronic kidney disease with glomerular filtration rate < 30 ml/min
Estimated glomerular filtration rate (GFR) >15 mL/min/1.73m2
Glomerular Filtration Rate (GFR) ? 30% (? 30 ml/min/1.73 m2)
Serum creatinine =< 1.5 x upper limit of normal (ULN) (or glomerular filtration rate >= 40 mL/min), obtained within 14 days of the first dose of study drug
Renal function defined as a calculated or measured glomerular filtration rate (GFR) >= 30 mL/min; for Arm F carboplatin and pemetrexed, GFR >= 45 mL/min
Estimated glomerular filtration rate (eGFR) < 60 within 6 weeks prior to registration
Estimated glomerular filtration rate (eGFR) >= 60 mL/min/1.73m^2, as evidenced in laboratory values =< 3 months old
Serum creatinine ? 2 times upper limits of normal or estimated glomerular filtration rate ? 60 mL/min/1.73 meter squared per Modification of Diet in Renal Disease equation (MDRD)
Glomerular filtration rate (GFR) < 30
Decreased glomerular filtration rate (GFR) (< 60 ml/min/1.73 m^2 as estimated by the revised Schwartz equation)
Creatinine < 2.0 mg/dL, for patient with a creatinine > 1.2 mg/dL or a history of renal dysfunction an estimated glomerular filtration rate > 40 mL/min/1.73 m^2 is required
Participants must have normal organ and marrow function as defined by a glomerular filtration rate (GFR) >= 60 mL/min/1.73 m^2 to be performed per clinical protocol.
Participants with renal insufficiency or failure, as determined by glomerular filtration rate (GFR) < 60 mL/min/1.73 m^2, performed for all patients within 24 hours of the imaging exams
Glomerular filtration rate (GFR) > 40
Contraindication to contrast CMR including estimated glomerular filtration rate (eGFR) < 30 mls/min/1.73 m^2
Estimated creatinine clearance (for patients > 12 years) greater than 50.0 mL/minute (using the Cockcroft-Gault formula and actual body weight); for pediatric patients (> 1 year to 12 years), Glomerular Filtration Rate (GFR) estimated by the updated Schwartz formula ? 90.0 mL/min/1.73 m^2. If the estimated creatinine clearance is < 90 mL/min/1.73 m^2, then renal function must be measured by 24-hour creatinine clearance or nuclear GFR, and must be > 70.0 mL/min/1.73 m^2.
Estimated glomerular filtration rate (eGFR) >= 45 mL/min
Have significant renal disease or dysfunction defined as estimated glomerular filtration rate (eGFR) < 45
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 100 ml/min/1.73 m^2
Creatinine =< 2.0 mg/dL, for patient with a creatinine > 1.2 mg/dL or a history of renal dysfunction an estimated glomerular filtration rate >= 40 mL/min/1.73 m^2 is required
Creatinine =< 1.5 x institutional upper limit of normal (ULN) (OR glomerular filtration rate [GFR] > 30 ml/min/1.73 m^2)
OR glomerular filtration rate (GFR) > 30 ml/min/1.73 m^2 obtained =< 45 days prior to randomization
Glomerular filtration rate (GFR) >= 60 ml/min
Estimated glomerular filtration rate (GFR) < 35 ml/min/1.73 m^2
Patients must have adequate renal function: glomerular filtration rate (GFR) > 30 mL/min/1.73 m^2; for the test-retest sub-study MRI, patients must have a GFR of > 60 mL/min/1.73m^2
Glomerular filtration rate < 60 ml/min/1.73 m^2
Patient must have adequate bone marrow, coagulation, renal, and hepatic function; estimated glomerular filtration rate (eGFR) calculation >= 60 mL/min/1.73 m^2 (within 28 days of screening CT submission)
Severe renal insufficiency, estimated glomerular filtration rate (EGFR) < 30
Adequate renal function to tolerate intravenous gadolinium contrast injection (estimated glomerular filtration rate >= 45 mL/min/1.73 m^2 prior to initial DCE-MRI and estimated glomerular filtration rate >= 30 mL/min/1.73 m^2 for subsequent DCE-MRI scans)
Contraindications to receiving intravenous gadolinium contrast injection including prior allergic reaction and/or chronic renal insufficiency (estimated glomerular filtration rate < 45 mL/min/1.73 m^2 prior to initial DCE-MRI and estimated glomerular filtration rate < 30 mL/min/1.73 m^2 for subsequent DCE-MRI scans)
Patient has a glomerular filtration rate (GFR) > 60. In patients with moderate renal failure (GFR 30-60), an alternate injection with 2 times half-dose multihance (gadobenate dimeglumine) or gadovist (gadobutrol) will be considered, if a contrast exam is deemed clinically necessary.
- Serum Cr < 1.5 x ULN or estimated GFR > 60 ml/min based upon Cockroft-Gault equation
Patients with a glomerular filtration rate (GFR) < 30 ml/min are ineligible to receive intravenous contrast per standard magnetic resonance (MR) exclusion criteria
Severe kidney dysfunction (glomerular filtration rate [GFR] < 30 mL/min/1.73m^2)
Subjects with a calculated glomerular filtration rate (GFR) >= 60 mL/min/1.73 m^2
Subjects with a calculated glomerular filtration rate (GFR) > 60 mL/min/1.73 m^2
Subject has impaired renal function (estimated glomerular filtration rate [eGFR]< 30 mL/min)
For patients with known history of allergic reaction to MR contrast material or abnormal kidney function (glomerular filtration rate [GFR] < 30 mL/min), a contrast enhanced exam will not be performed; however, a non-contrast exam may be performed in these patients
Renal dysfunction with estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m^2
Abnormal renal function with estimated glomerular filtration rate (eGFR) less than 30 mL/min/m^2 based on creatinine obtained within last 30 days
Elevated creatinine and/or glomerular filtration rate (GFR) < 40 ml/min/1.7 sqm (exclusion criterion only for contrast enhanced MRI)
Patients with an estimated glomerular filtration rate (eGFR) =< 30 will be excluded to avoid issues related to contrast administration in such patients; this glomerular filtration rate (GFR) threshold cutoff level is chosen per institutional policy, because below that level other measures would be required (hydration or no contrast administration); in order to keep the imaging information as uniform as possible in such a small study group, patients with a low GFR will not be enrolled in the study
Have a calculated glomerular filtration rate (GFR) =< 30 mL/min/1.73 m^2
Are receiving any form of renal replacement therapy or have a calculated glomerular filtration rate (GFR) < 30 mL/min/1.75 m²; results of serum creatinine testing will be reviewed for calculation of glomerular filtration rate (GFR); patients without a serum creatinine level drawn within the prior 3 months will have this drawn upon enrollment
Patients with moderate to end-stage renal (kidney) disease, defined as a glomerular filtration rate (GFR) less than 30 mL/day/1.73m^2
Patients with renal failure, defined as glomerular filtration rate (GFR) < 60 at the time of the radiation treatment-planning (RTP) scan, will be excluded
Severe renal function impairment (estimated glomerular filtration rate [eGFR] < 45 mL/min/1.73 m^2) would make the patient inappropriate for enrollment due to the increased risk of nephrogenic systemic fibrosis (NSF) with higher dose of IV gadolinium-based contrast agents (GBCA) administration
Subjects with estimated glomerular filtration rate (eGFR) =< 30 mL/min/1.73 m^2 will not participate in the gadolinium (Gd) contrast-enhanced MRI
Patients with estimated glomerular filtration rate (eGFR) < 30 are not eligible
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 30 mL/min/1.73 m^2
Patients with severe chronic renal insufficiency (glomerular filtration rate < 30 mL/min/1.73 m^2), hepatorenal syndrome or post-liver transplantation
Patients with renal function (estimated glomerular filtration rate [eGFR] >= 30)
Glomerular filtration rate (GFR) >= 40
Late stage renal failure with estimated glomerular filtration rate (eGFR) of less than 30 mL/min/1.73 m^2 based on patient's serum creatinine; (‘past’ 3 months timeframe will be used to calculate the eGFR)
Renal insufficiency: glomerular filtration rate (GFR) < 40ml/min/1.73) and following European Society of Urogenital Radiology (ESUR) guidelines (exclusion criterion only for contrast enhanced MRI)
Participants with diagnosis of renal insufficiency or glomerular filtration rate (GFR) < 60 ml/min/1.73m^2
Estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73m^2
Contraindications for MRI with contrast or PET/CT including:\r\n* Cardiac pacemaker, implanted cardiac defibrillator, pacing wires, internal electrodes\r\n* Aneurysm clips\r\n* Cochlear, otologic, or other ear implant\r\n* Tissue expander\r\n* Swan-Ganz or thermodilution\r\n* Moderate renal insufficiency (estimated glomerular filtration rate [GFR] less than 60 mL/min/1.73 m^2) to end stage renal disease (estimated GFR less than 15 mL/min/1.73 m^2 or a serum creatinine more than 3 mg/dL), who are not on dialysis, and patients with renal failure on chronic dialysis\r\n* Severe claustrophobia
Patients with renal insufficiency with a glomerular filtration rate (GFR) < 30
Creatinine serum level >= 2 mg/dL or glomerular filtration rate (GFR) =< 30 mL/min/1.73 m^2 (contraindication for intravenous [i.v.] gadolinium only)
Patients must have an estimated glomerular filtration rate of >= 30 mL/min/1.73m^2 within six weeks of the MRI to be included in the study
Subjects with an estimated glomerular filtration rate of < 30 mL/min/1.73m^2 within six weeks of the MRI
Acute or chronic severe renal insufficiency (estimated glomerular filtration rate < 30 mL/min/1.73m^2)
Subjects must have a serum creatinine < 2.0 mg/dL and/or calculated glomerular filtration rate (GFR) 50 ml/min/1.73 m^2 (Modification of Diet in Renal Disease [MDRD] formula) or greater
Patient with significant renal insufficiency, i.e. an estimated glomerular filtration rate (eGRF) less than 30 mL/min/1.73m^2
Subjects with glomerular filtration rate (GFR) < 50
Creatinine > 1.8 mg/dL OR glomerular filtration rate (GFR) < 30 mL/min
Glomerular filtration rate (GFR) > 30 ml/min
Patients with renal insufficiency; glomerular filtration rate (GFR) < 60
Patients with renal insufficiency; glomerular filtration rate (GFR) < 60
Normal creatinine and estimated glomerular filtration rate (GFR) within 30 days under the following circumstances:\r\n* Had abnormal creatinine in the last 60 days\r\n* Are over 60 years of age\r\n* Has received chemotherapy within the past 30 days\r\n* Has diabetes, human immunodeficiency virus (HIV), renal disease or history (hx) of renal cancer
Renal dysfunction as defined as a glomerular filtration rate (GFR) < 70
Baseline glomerular filtration rate (GFR) < 50 mL/min/1.73m^2
If agreeing to MRI contrast, participant must not have renal insufficiency (glomerular filtration rate [GFR] < 30 mL/min/1.73 m^2) measured within the past 60 days
Glomerular filtration rate (GFR) < 50
Patient must not have an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m^2
In addition, patients with glomerular filtration rate (GFR) < 15 ml/min/1.73m^2 or who are on dialysis will be excluded from the study
Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 OR
Serum creatinine =< 1.5 x the upper limit of normal (ULN) or an estimated glomerular filtration rate (eGFR) calculated using the modification of diet in renal disease (MDRD) equation of at least 45 mL/min/1.73 m^2
Serum creatinine ? 1.5 x institutional upper limit of normal (ULN), or if serum creatinine outside normal range, then glomerular filtration rate (GFR) > 40 mL/min/1.73m^2 as calculated with the 4-parameter Modification of Diet in Renal Disease (MDRD) equation.
Estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m^2
Patients with glomerular filtration rate (GFR) < 15 ml/min/1.73 m^2 or who are on dialysis will be excluded from the study
Renal failure, as determined by estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m^2 by the Modification of Diet in Renal Disease (MDRD) model based on a serum creatinine level obtained within 28 days prior to enrollment
Subjects with renal insufficiency; glomerular filtration rate (GFR) < 50
Impaired renal function (chronic kidney disease [CKD] 4 or 5: estimated glomerular filtration rate [eGFR] < 30 mLs/min), which is a contraindication to gadolinium containing contrast
Estimated glomerular filtration rate (GFR) >= 30 mL/min/1.73 m^2
Estimated glomerular filtration rate (eGFR) < 30 mL/min
Patients with inadequate renal function (creatinine >= 1.5 times upper limit of normal) or acute or chronic renal insufficiency (glomerular filtration rate < 20 ml/min)
Estimated glomerular filtration rate < 30 mL/min
Subject presenting with acute or chronic Grade III (at least) renal insufficiency, defined as an estimated Glomerular Filtration Rate (eGFR) <60 mL/min/1.73m² based on two eGFR assessments, one within 7 days before the first study MRI and on the day of the MRI (if any of the eGFR result is <60 mL/min/1.73m², the subject is not eligible).
Contraindication to MRI (e.g. claustrophobia, pacemaker, estimated glomerular filtration rate ? 50mls/min)
Serum creatinine within 3 weeks prior to Eovist MRI =< 1.8 mg/dl and estimated glomerular filtration rate (eGFR) must be > 30 ml/min/1.73 m^2
- Serum Cr < 1.5 x ULN or estimated GFR > 60 ml/min based upon Cockroft-Gault equation
GFR (glomerular filtration rate) < 30 on labs drawn within 6 weeks of imaging
Renal insufficiency (defined as glomerular filtration rate [GFR] < 30 mL/min/1.73 m^2) measured no more than 60 days before the first research scan) which precludes safe administration of the contrast agent
Patients with glomerular filtration rates < 30 mL/min/1.73m^2
Estimated glomerular filtration rate (GFR) (using Cockcroft formula) less than 30 ml/min/1.73 m^2
Compromised renal function with estimated glomerular filtration rate (GFR) of < 30 ml/min/1.73m^2
Estimated glomerular filtration rate (eGFR) >= GFR 70 mL/min/1.73 m^2
Estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m^2 or estimated creatinine clearance (eCrCL) > 60 mL/min
Serum creatinine > 1.5 mg/dL or glomerular filtration rate < 50
Have an estimated glomerular filtration rate (eGFR) (using the Cockcroft-Gault equation) of more than 60 mL/min
Estimated glomerular filtration rate (eGFR) ? 40 mL/min per 1.73 m^2 according to the Modification of Diet in Renal Disease Study Group (MDRD) formula