STEP I: The following patients will be excluded:\r\n* Pregnant women\r\n* Nursing women STEP II: The following patients will be excluded:\r\n* Pregnant women\r\n* Nursing women No patients that are known to be pregnant or nursing Not pregnant and not nursing Pregnancy and/or nursing females Nursing mothers are excluded Women who are pregnant or nursing Subject is pregnant, nursing or intends to become pregnant during the course of the study. Pregnant or nursing female patients. Female patients who are pregnant or nursing Pregnant and nursing women are excluded from this study Pregnant and nursing females. Pregnant or nursing women Pregnant or nursing women Female patients who are pregnant or nursing are not eligible Pregnant and nursing mothers are excluded from this study. Pregnant or nursing women Pregnant or nursing (lactating) women. Any of the following:\r\n* Pregnant women\r\n* Nursing women Females who are pregnant or nursing Patients who are pregnant or actively nursing an infant are not eligible Nursing women Pregnant or nursing (lactating) women Pregnant or nursing Pregnant or nursing mothers are excluded Pregnant/nursing Pregnant, or nursing female patient Previous treatment Pregnant or nursing. Pregnant or nursing women. Are pregnant and/or nursing Pregnant or nursing women will be excluded from the study Women who are pregnant or nursing a child may not take part in this study Pregnant or nursing females Women who are pregnant or nursing Pregnant or nursing women will be excluded from the study Pregnant women are excluded from this study; nursing mothers should stop breastfeeding to be eligible For female subjects of childbearing potential: Is pregnant or nursing Female patients who are pregnant or nursing are not eligible Pregnant or nursing Pregnant or nursing Pregnant and nursing subjects are excluded Nursing women Pregnant/nursing female Pregnant or nursing Pregnant or nursing women are excluded Patients who are pregnant or nursing Pregnant or nursing females. Pregnant or nursing female patients Pregnant or nursing women Pregnant or nursing women Nursing women Pregnant or nursing female subjects Pregnant or nursing women Female subjects who are pregnant, intend to become pregnant or are nursing Pregnant or nursing women Pregnant or nursing female participants Patients who are pregnant or nursing. Pregnant and nursing women Pregnant or nursing women Pregnant or nursing women Women who are pregnant or nursing are not eligible as treatment involves unforeseeable risks to the fetus or child Nursing or pregnant women Patient is pregnant or nursing Nursing or pregnant women Pregnant or nursing female subjects Pregnant or nursing female participants Women who are pregnant or nursing. Pregnant or nursing Patients must not be pregnant or nursing Pregnant or nursing female participants Females who are pregnant or nursing Pregnant or nursing women Female patients who are pregnant or nursing are not eligible Women who are pregnant or nursing or plan to become pregnant or nurse during the course of the study Female patients will not be eligible for this study if she is either pregnant or nursing at the time of enrollment Female patients who are pregnant or nursing. Subjects must not be pregnant or nursing due to the potential for congenital abnormalities and the potential of this regimen to harm nursing infants. Pregnant and nursing women are excluded because of the potential teratogenic effects and potential unknown effects on nursing newborns (please see above paragraph under inclusion criteria regarding WOCBP) Pregnant or nursing women Pregnant and nursing women are excluded from this study Female patients who are pregnant or nursing are not eligible Pregnant or nursing women Subjects must not be pregnant or nursing due to the potential for congenital abnormalities and the potential of this regimen to harm nursing infants Women who are pregnant or nursing. Nursing or pregnant women Any of the following:\r\n* Pregnant women\r\n* Nursing women May not be pregnant or nursing Be female and pregnant or nursing. Pregnant or nursing women Pregnant or nursing (lactating) women; breastfeeding should be discontinued Pregnant or nursing women Women who are pregnant, nursing, or who plan to become pregnant while in the trial Pregnant or nursing female participants Pregnant or nursing female participants Non-pregnant and non-nursing; pregnant and nursing patients may not be enrolled; women and men of reproductive potential must agree to use acceptable forms of contraception during the study Pregnant or nursing Female patients who are pregnant or nursing are not eligible Patients who are pregnant or nursing Pregnant or nursing women Nursing women Pregnant and nursing women are excluded from this study Pregnant or nursing Female patients who are pregnant or nursing are not eligible Pregnant or nursing women Pregnant or nursing women Subjects who are pregnant or nursing Pregnant or nursing women are excluded from this study Patients who are pregnant or nursing Female subjects who are pregnant, intend to become pregnant or are nursing Pregnant or nursing Subjects must not be pregnant or nursing Pregnant or nursing patients Pregnant and nursing women are excluded Pregnant or nursing Patients who are pregnant or nursing are excluded Pregnant or nursing (lactating) women Pregnant or nursing PHASE I: Patients must not be pregnant or nursing as the potential of this regimen to harm nursing infants has not been evaluated PHASE II: Patients must not be pregnant or nursing as the potential of this regimen to harm nursing infants has not been evaluated Subjects must not be pregnant or nursing due to the potential for congenital abnormalities and the potential of this regimen to harm nursing infants. Female patients who are pregnant or nursing are not eligible Pregnant or nursing women Pregnant or nursing (lactating) women Nursing women Patients who are pregnant or nursing Pregnant or nursing women Patients who are pregnant or nursing Pregnant or nursing women. Pregnant or nursing women Pregnant or nursing patients Pregnant women or nursing mothers Pregnant and nursing mothers are excluded from this study Female patients who are either pregnant or nursing. Pregnant or nursing women Pregnant or nursing women Pregnant or nursing women Nursing women may participate only if nursing is discontinued Women who are pregnant or nursing Subjects must not be pregnant or nursing Pregnant or nursing women Pregnant or nursing Study drug must not be administered to pregnant women or nursing mothers Patients who are pregnant or nursing Subjects must not be pregnant or nursing Pregnant or nursing (lactating) women Pregnant women or nursing mothers Not pregnant and not nursing Pregnant or nursing (lactating) women Women who are pregnant or nursing Patients who are pregnant or nursing (Turnstile I) Women who are pregnant or nursing. Subjects who are pregnant or nursing Pregnant or nursing female subjects Pregnant women or nursing mothers Women who are pregnant or nursing Subjects must not be pregnant or nursing Females who are pregnant, intend to become pregnant, or are nursing at the time of randomization. Pregnant or nursing female patients Patients who are pregnant or nursing (Turnstile I) Pregnant women or nursing mothers Patients who are pregnant or nursing Are pregnant and/or nursing Pregnant or nursing women are excluded from this study EXCLUSION CRITERIA FOR REGISTRATION: pregnant or nursing women are excluded from this study Patient must not be pregnant because of the risk of harm to the fetus; nursing women may participate only if nursing is discontinued, due to the possibility of harm to nursing infants from the treatment regimen; women/men of reproductive potential must agree to use an effective contraception method Pregnant or nursing (lactating) women Pregnant or nursing women Pregnancy or nursing patients will be excluded from the study Pregnant or nursing women Pregnancy or nursing Not pregnant or nursing Pregnant and nursing women. Pregnant or nursing female participants Pregnancy or nursing Women who are pregnant or nursing Female subjects who are pregnant or nursing Women who are pregnant or nursing Pregnant or nursing at the time of signing informed consent Lactating females must agree to discontinue nursing Pregnant or nursing women Pregnant or nursing females. Nursing or pregnant females or females who plan pregnancy during the duration of the study. Pregnant or nursing women. Nursing women Are not pregnant or nursing; Patients must not be pregnant or nursing due to the potential for congenital abnormalities and the potential of this regimen to harm nursing infants Pregnant or nursing Pregnant or nursing Female patients who are pregnant or nursing are not eligible Patients must not be nursing due to the potential for congenital abnormalities and the potential of this regimen to harm nursing infants Patients must not be pregnant or nursing May not be pregnant or nursing Patients must not be pregnant or nursing Subjects known to be pregnant or nursing. Pregnant or nursing Pregnant or nursing females Nursing women who are unwilling to discontinue nursing Female patients who are pregnant or nursing are not eligible Pregnant or nursing female patients are excluded from this study ARM A: Pregnant or nursing women ARM B: Pregnant or nursing women DOSE ESCALATION COHORT: Pregnant or nursing DOSE EXPANSION COHORT: Pregnant or nursing Any of the following:\r\n* Pregnant women\r\n* Nursing women Pregnant or nursing women Pregnant or nursing women Pregnant women are excluded from this study; nursing women are excluded from this study Nursing woman Pregnant women are excluded from this study; nursing women are excluded from this study Any of the following:\r\n* Pregnant women\r\n* Nursing women Pregnant or nursing. Women who are pregnant or nursing Pregnant or nursing women Pregnant or nursing Pregnant or nursing mothers Pregnant or nursing women Women who are pregnant or are nursing Pregnant or nursing female patients Women who are pregnant or nursing Patients who are pregnant or nursing are excluded Pregnancy or nursing Mother Patients who are pregnant or nursing are excluded Pregnant/nursing women are excluded from this study because oxaliplatin is an agent with the potential for teratogenic or abortifacient effects Pregnant and nursing women are excluded from this study Not pregnant or nursing Pregnant women or nursing mothers Pregnant or nursing Pregnant or nursing Patients who are pregnant or nursing Patients of childbearing potential, not practicing adequate contraception, patients who are pregnant or patients who are nursing are not eligible for this trial; bevacizumab should not be administered to nursing women Pregnant and nursing females. Patients who are pregnant or nursing Is a female who is pregnant, nursing, or breastfeeding, or who intends to become pregnant during the participation in the study Pregnant or nursing (lactating) women Pregnant, planning to become pregnant, or nursing Pregnant or nursing (lactating) women Pregnant or nursing women Non-pregnant and non-nursing Pregnant or nursing Females who are pregnant, nursing or breastfeeding, or intend to become pregnant during the participation to the study Pregnant or nursing women. Pregnant, planning to become pregnant, or nursing Pregnant or nursing women Is pregnant or nursing Women who are pregnant, nursing, or who plan to become pregnant while in the trial Is a female who is pregnant, nursing, or breastfeeding, or who intends to become pregnant during the participation in the study Pregnant or nursing Pregnant or nursing female participants Women who are pregnant or nursing. No women who are pregnant or nursing Currently pregnant, nursing, or wishing to become pregnant during the study Pregnant or nursing female participants Pregnant women or nursing women Women who are pregnant or nursing (lactating). Patients must be non-pregnant and non-nursing Pregnant women and/or nursing patients will be excluded from the study Females who are nursing must agree to discontinue nursing before the first dose of GS-5829 Pregnant or nursing; or Women who are pregnant or nursing Patient is pregnant or nursing or physiologically capable of becoming pregnant and not using highly effective contraception Patients who are pregnant or nursing Nursing and pregnant females Pregnant or nursing (lactating) women. Pregnancy or nursing Pregnant or nursing Females who are nursing must agree to discontinue nursing before the first dose of study drug Women who are pregnant or nursing/breastfeeding Pregnant or nursing women Pregnant or nursing females. Women who are pregnant or nursing (lactating) women Female patients who are pregnant or nursing (lactating) are not eligible Pregnant or nursing women will be excluded from the study Female patients who are pregnant or nursing are not eligible Female patients who are pregnant or nursing are not eligible Participants who are pregnant or nursing Subjects must not be pregnant or nursing Pregnant or nursing Women that are pregnant or nursing Pregnant or nursing. Pregnant and nursing women Pregnant or nursing patients will be excluded from the study Any of the following\r\n* Pregnant women\r\n* Nursing women Pregnant or nursing women will be excluded from the study Patients who are pregnant or nursing Pregnant women and nursing mothers Pregnant or nursing (lactating) women Pregnant or nursing women Pregnant or nursing females Pregnant and nursing women are excluded from this study Pregnant or nursing (lactating) women Patients who are pregnant or nursing Females who are nursing must agree to discontinue nursing before the first dose of MMB Pregnant or nursing female subjects Patients who are pregnant or nursing are not eligible Pregnant or nursing Nursing women Pregnant and nursing women are excluded from this study Women who are pregnant or nursing/breastfeeding. Pregnant or nursing (lactating) women Pregnant or nursing (lactating) women Pregnant or nursing within past 6 months, or plans to become pregnant in the next year Pregnant or nursing (lactating) women Pregnant or nursing women Pregnant women and nursing women are excluded from this study Patient must not be pregnant or nursing Are pregnant or nursing, or intending to become pregnant within the duration of the study Pregnant or nursing Pregnant or nursing Patients pregnant or nursing Pregnant or nursing (lactating) women. Pregnant or nursing women Pregnant or nursing within past 6 months Non-pregnant and non-nursing; pregnant or nursing patients may not be enrolled; women and men of reproductive potential should agree to use an effective means of birth control Pregnant or nursing women Patients who are pregnant or nursing Pregnant or nursing (lactating) women. Nursing female. Pregnant or nursing women Pregnant or nursing females Nursing women Pregnant women and nursing patients will be excluded Patient is pregnant or nursing not pregnant or nursing; Female participants must not breastfeed during the study and for a period of 30 days following the last dose. Pregnant or nursing Patients who are pregnant or nursing. Nursing women Not pregnant or nursing Nursing women. Pregnant or nursing women Pregnancy and/or nursing mothers Pregnant or nursing (lactating) women Subject is nursing or intends to begin nursing during the course of the study Pregnant or nursing Pregnant or nursing (lactating) women Pregnancy or nursing Pregnant or nursing female patients Nursing or pregnant. Pregnant or nursing women may not participate in this trial Pregnant or nursing female subjects Pregnant and nursing patients will be excluded from the study Pregnant or nursing patients will be excluded from the study Pregnant, nursing or planning to become pregnant Pregnant or nursing women. Patients who are pregnant, nursing, or who wish to become pregnant during the study Nursing women Patients who are pregnant or nursing Is, within 2 weeks prior to Day 1, nursing. Pregnant and nursing women are excluded from this study Females who are pregnant or nursing. Pregnant or nursing female patients. Pregnant or nursing women Pregnant or nursing female patients Pregnant or nursing women Pregnant or nursing Is nursing or pregnant Females who are pregnant or currently nursing. Pregnant or nursing women. Pregnant or nursing women Pregnant or nursing (lactating) women Pregnant or nursing females Women who are pregnant and/or nursing Pregnant women or nursing women Currently pregnant or nursing. Is nursing or pregnant Pregnant or nursing females; patient was pregnant or nursing at the time of entry Pregnant or nursing women; breastfeeding must be discontinued prior to treatment Pregnant or nursing females. Females who are nursing. Pregnant or nursing Patients must not be pregnant or nursing Pregnant or nursing female patients Patients must not be pregnant or nursing Participant is nursing or intends to begin nursing during the course of the study Subject is pregnant or nursing an infant Are pregnant or nursing Pregnant or nursing women Pregnant or nursing Pregnant or nursing females. Women who are pregnant or nursing. Pregnant or nursing women Pregnant or nursing mothers Pregnant or nursing women. Pregnant and nursing patients are excluded because the effects of CWP232291 on a fetus or nursing child are unknown. Pregnant or nursing Participants who are pregnant or nursing Pregnant or nursing women Part 3 Exclusion Criteria: Pregnant or nursing women Part 4 Exclusion Criteria: Pregnant or nursing women Pregnant or nursing women Female subjects cannot be pregnant or nursing. Pregnant or nursing Pregnant or nursing women will be excluded from study. Not pregnant or nursing Pregnant or nursing women are excluded Women who are pregnant or nursing (pregnancy test to be performed within 24 hours prior to HIFU treatment) Pregnant and nursing women Female patients who are pregnant or nursing are not eligible Pregnant or nursing female patients Patients who are pregnant or nursing Women who are pregnant or nursing (pregnancy test to be performed within 24 hours prior to HIFU treatment) Patients who are pregnant or nursing are ineligible Pregnant or nursing female patients Pregnant or nursing female patients Females who are nursing Pregnant or nursing Pregnant or nursing Patient is pregnant or nursing Subject is pregnant, nursing, or planning to get pregnant during study duration. Female patients who are pregnant or nursing are not eligible. Known pregnancy or nursing Patient is pregnant or nursing Pregnant or nursing women Pregnant or nursing female subjects; may be determined in the preoperative evaluation Pregnant or nursing female participants Pregnant or nursing women Participant is pregnant or nursing Pregnant or nursing women Women who are pregnant, lactating/nursing or plan to become pregnant Currently pregnant, nursing or planning to become pregnant Pregnant women will be excluded; nursing patients will be included Pregnant or nursing women Pregnant and nursing women Pregnant or nursing female patients Women who are known to be pregnant or nursing Nursing women Pregnant or nursing female patients Subject is pregnant or nursing Nursing women Pregnant or nursing (lactating) women Women who are pregnant or nursing; pregnancy will be confirmed by urine test Female participants who are pregnant or lactating/nursing Women who are nursing Women who are nursing Not pregnant or nursing Pregnant or nursing patients will not be included in the study Females of childbearing potential who are pregnant or nursing Currently pregnant, nursing, or wishing to become pregnant during the study Women who are pregnant, nursing, or who may become pregnant in the next 3 months Pregnant women or nursing women Women who are pregnant or nursing Pregnant or nursing female participants Women who are pregnant or nursing, or intend to be/do so during the course of the study Women who are pregnant or nursing Non-pregnant and non-nursing Pregnant or nursing women Pregnancy or nursing women Nursing women Pregnant or nursing women Pregnant or nursing (lactating) women Nursing or pregnant females Subject is pregnant or nursing Nursing or pregnant females Pregnant or nursing (lactating) women. Pregnant or nursing Pregnant or nursing If a woman is or becomes pregnant or is nursing at any time before or during the treatment period, she will be excluded from the study Women who are pregnant or nursing except when the indication is an abnormal cell-free DNA test Females who are pregnant or nursing Females who are pregnant or nursing Women who are pregnant or nursing Pregnant or nursing participants Pregnant or nursing Pregnant or nursing Nursing female subjects Females who are pregnant or nursing Pregnant or nursing (lactating) women Patient is pregnant or nursing Pregnant or nursing Pregnant or nursing Pregnant or nursing females The patient must not be pregnant or nursing Pregnant and/or nursing women Patients who are pregnant or nursing HEALTHY VOLUNTEER: Females who are pregnant or nursing or are actively lactating PATIENT: Females who are pregnant or nursing Pregnant or nursing female Female patients who are pregnant or nursing Female participants/volunteers who are pregnant or nursing Female patients who are pregnant or nursing Pregnancy or nursing patients Pregnant or nursing Women who are pregnant or nursing Pregnant or nursing females. Pregnant or nursing (lactating) Pregnant or nursing female Pregnant or nursing female Pregnant or nursing female Pregnant or nursing female Pregnant or nursing females Pregnant or nursing female Pregnant or nursing females Pregnant or nursing women Patient is pregnant or nursing; Females who are pregnant or nursing. Patient is pregnant or nursing Females who are pregnant or nursing Pregnancy or nursing mothers Pregnant or nursing patients will be excluded from the study Patient is pregnant or nursing Pregnant or nursing female subjects Women who are pregnant or nursing Subjects must not be pregnant or nursing Pregnant or nursing female Pregnant or nursing Are pregnant or nursing Females who are pregnant or nursing Pregnant or nursing Known pregnant or nursing patients Subjects who are pregnant or nursing Pregnant or nursing patients will be excluded from the study Females who are pregnant or nursing Pregnant or nursing women Pregnant or nursing Pregnant and nursing women Pregnant or nursing women Pregnant or nursing Pregnant or nursing Pregnant or nursing Pregnant or nursing female patients Pregnant or nursing patients will be excluded from the study