The patient has uncontrolled or poorly controlled hypertension despite standard medical management as defined in this protocol
No history of grade 4 hypertension, defined as hypertension resulting in life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis)
Uncontrolled hypertension
Uncontrolled chronic hypertension defined as systolic > 150 or diastolic > 90 despite optimal therapy.
Patients with uncontrolled hypertension (>= 140/90 mmHg) are NOT eligible for participation
Uncontrolled hypertension
Patients with poorly controlled hypertension on multiple antihypertensives
Uncontrolled hypertension (as defined as ? 160/90 despite optimal medical management)
Uncontrolled arterial hypertension >/= 150/ >/= 90 millimeter of mercury (mmHg) despite standard medical management;
Patients with uncontrolled hypertension; patients with a history of hypertension must be well controlled (< 160/90) on a regimen of hypertensive medication
Poorly controlled hypertension. During screening ?2/3 of readings must be < 160/90, regardless of whether on a regimen of anti-hypertensive therapy or not.
History of significant cardiac disease or uncontrolled hypertension
Uncontrolled hypertension or diabetes
Uncontrolled hypertension or uncontrolled diabetes within 14 days prior cycle 1, day 1
Patients with uncontrolled hypertension (> 140/90 mmHg) are NOT eligible for participation
Uncontrolled severe hypertension, according to the judgment of the investigator, or symptomatic hypertension
Uncontrolled hypertension or diabetes
Uncontrolled hypertension
Poorly controlled hypertension despite anti-hypertensive medications
A past medical history of other clinically significant cardiovascular disease (eg, uncontrolled hypertension, history of labile hypertension, history of poor compliance with an antihypertensive regimen).
Subjects with other uncontrolled medical conditions, e.g. myocardial infarction, cerebrovascular accident, diabetes or hypertension.
Uncontrolled hypertension
Uncontrolled hypertension
Uncontrolled hypertension
Pulmonary hypertension
Has uncontrolled or poorly controlled hypertension
Uncontrolled hypertension
Uncontrolled hypertension despite optimal medical management
Uncontrolled hypertension (despite medical therapy); blood pressure should be < 140/90 in accordance with American Heart Association definition of hypertension
Uncontrolled hypertension (> 150/100 mmHg)
Have uncontrolled diabetes or have hypertension requiring more than 3 medications for control of hypertension.
Hypertension that is not controlled by standard medication (to 150/90 mmHg or below),
Uncontrolled hypertension, i.e., blood pressure (BP) of >= 160/95; patients who have a history of hypertension controlled by medication must be on a stable dose (for at least one month) and meet all other inclusion criteria; or
Patients must not have uncontrolled hypertension
Uncontrolled hypertension or diabetes
Uncontrolled hypertension (HTN)
Uncontrolled hypertension
Poorly controlled hypertension, defined as sustained, uncontrolled, non-episodic baseline hypertension consistently above 159/99 mmHg despite optimal medical management
Patients with uncontrolled hypertension
Sustained uncontrolled hypertension (> 150/90 average over 1 week) despite optimal medical management
Hypertension that is unstable or not controlled by medication.
Patient has poorly controlled hypertension and on multiple antihypertensives
Any known uncontrolled cardiovascular disease, pulmonary embolism, hypertension not adequately controlled by standard medications within 3 months prior to enrollment.
Uncontrolled hypertension
Uncontrolled diabetes or hypertension
Patients with uncontrolled hypertension
Patients with uncontrolled hypertension (HTN) (> 160/90) will not be admitted onto the study
FOR ALL PHASES (Ib AND II): Uncontrolled arterial hypertension despite optimal medical management
Criteria for hypertension: Blood pressure greater than 170/90 or 2 standard deviations (SD) from normal based on age and weight nomogram on 3 separate measurements; uncontrolled hypertension (HTN)
Patients must not have symptomatic hypertension
Pulmonary hypertension.
Hypertension requiring 3 or more anti-hypertensive medications to control
Severe or unstable cardiovascular disease or uncontrolled hypertension
Uncontrolled hypertension
Uncontrolled or severe hypertension, or cerebrovascular disease.
Have uncontrolled hypertension; subjects with a history of hypertension are permitted in the study provided their blood pressure is controlled by anti-hypertensive therapy
Patients with diagnosed uncontrolled hypertension (> 150/90 mmHg) are to be excluded
Patients with hypertension controlled with medications are allowed
Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to start of treatment
Uncontrolled hypertension (refer to World Health Organization [WHO]-International Society of Hypertension [ISH] guidelines)
Uncontrolled hypertension despite optimal medical management (per investigator´s assessment)
Uncontrolled hypertension, i.e., blood pressure (BP) of >= 160/95; patients who have a history of hypertension controlled by medication must be on a stable dose and meet all other inclusion criteria; or
Uncontrolled hypertension defined as > 140/90 and not cleared for surgery at the time of consent
Uncontrolled diabetes or hypertension
Subjects with a history of pulmonary hypertension is excluded
Poorly controlled hypertension despite multiple antihypertensive medication or
Uncontrolled hypertension, uncontrolled pulmonary hypertension or uncontrolled diabetes within 14 days prior to enrollment
Uncontrolled diabetes, hypertension or other medical conditions that may interfere with assessment of toxicity
Uncontrolled hypertension
Uncontrolled hypertension or uncontrolled diabetes
Uncontrolled arterial hypertension despite appropriate medical therapy
Have uncontrolled severe hypertension
Must not have any uncontrolled hypertension or uncontrolled diabetes within 14 days prior to enrollment.
Uncontrolled hypertension
DONOR: Current uncontrolled hypertension
Uncontrolled hypertension
Have a known history of uncontrolled hypertension. Patients with hypertension should be under treatment on study entry to control blood pressure.
Patients with >= grade 2 uncontrolled hypertension
Patient with poorly controlled hypertension despite multiple antihypertensives
Uncontrolled arterial hypertension despite optimal medical management (per institutional guidelines).
Uncontrolled hypertension or unstable angina.
Uncontrolled hypertension during screening
Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to randomization
Patients who exhibit uncontrolled hypertension (>= 140/90 mmHg) or uncontrolled diabetes within 14 days prior to registration are NOT eligible for participation
Current uncontrolled hypertension
Uncontrolled arterial hypertension despite appropriate medical therapy
Part 2: tachycardia and/or uncontrolled hypertension
Uncontrolled hypertension at study entry; patients with a history of uncontrolled hypertension are allowed provided blood pressure is controlled by antihypertensive treatment
Uncontrolled hypertension
Uncontrolled diabetes, heart disease, hypertension
Uncontrolled hypertension
Uncontrolled hypertension or diabetes.
Hypertension that is not controlled by standard medication (to 150/90 mmHg or below)
Uncontrolled hypertension, major bleeding, HIV infection, or recent acute\n             cardiovascular event
A past medical history of other clinically significant cardiovascular disease - e.g., uncontrolled hypertension, history of labile hypertension or history of poor compliance with an antihypertensive regimen
History of pulmonary hypertension
Uncontrolled hypertension or uncontrolled diabetes mellitus
Pulmonary hypertension
Uncontrolled hypertension (> 150/90 mmHg)
Hypertension not adequately controlled by 3 or less medications
Hypertension not adequately controlled by 3 or less medications
Poorly controlled hypertension despite anti-hypertensive medications
The participant has uncontrolled hypertension, despite antihypertensive intervention.
History of uncontrolled intercurrent illness including hypertension, active infection, diabetes
Uncontrolled hypertension defined as > 140/90 and not cleared for surgery at the time of consent
Cirrhosis or portal hypertension
Uncontrolled hypertension (> 150/100 mmHg despite optimal medical therapy)
Uncontrolled diabetes or uncontrolled hypertension within 14 days prior to first dose
Uncontrolled hypertension
Unstable angina pectoris, uncontrolled hypertension, uncontrolled asthma or other pulmonary disease
Uncontrolled hypertension.
Poorly controlled hypertension
Patients must not have a diagnosis of uncontrolled seizure or uncontrolled hypertension
Have uncontrolled hypertension.
Any other serious cardiac illness or medical conditions such as unstable angina, pulmonary embolism, or uncontrolled hypertension.
Any other serious cardiac illness or medical conditions such as unstable angina, pulmonary embolism, or uncontrolled hypertension
Patients with poorly controlled hypertension and on multiple antihypertensives
uncontrolled cardiovascular disease or uncontrolled hypertension
have uncontrolled hypertension
Pulmonary hypertension.
Hypertension defined below:
Uncontrolled hypertension, or uncontrolled diabetes mellitus
Uncontrolled hypertension
Have uncontrolled hypertension prior to initiating study treatment, despite antihypertensive intervention.
Has prior history of uncontrolled hypertension, hypertensive crisis or hypertensive encephalopathy
Uncontrolled or poorly controlled hypertension.
Severe or uncontrolled systemic diseases including uncontrolled hypertension
Uncontrolled symptomatic hypertension that cannot be controlled with anti-hypertensive agents
Uncontrolled hypertension.
Uncontrolled hypertension or diabetes
Resisted hypertension
Uncontrolled hypertension or uncontrolled diabetes despite medication
Uncontrolled arterial hypertension despite optimal medical management (per investigator's assessment).
Uncontrolled hypertension, i.e., blood pressure (BP) of >= 170/95; patients who have a history of hypertension controlled by medication must be on a stable dose (for at least one month) and meet all other inclusion criteria
History of hypertension not well-controlled (>= 160/90) even though on a regimen of anti-hypertensive therapy
Known history of pulmonary hypertension
Controlled hypertension
Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to the first day of treatment
Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to randomization
Current uncontrolled hypertension as well as prior history of hypertensive crisis or hypertensive encephalopathy
Current uncontrolled hypertension
No uncontrolled hypertension or uncontrolled diabetes (as determined by the treating physician) within 14 days prior to cycle 1 day 1
Known history of malignant hypertension
Uncontrolled hypertension
Uncontrolled hypertension or diabetes
Uncontrolled hypertension or diabetes.
Inadequately controlled arterial hypertension
Uncontrolled hypertension or diabetes
Pulmonary hypertension
Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to signing consent
Uncontrolled arterial hypertension despite medical treatment
Patients must not have uncontrolled diabetes, uncontrolled infection despite antibiotics or uncontrolled hypertension within 30 days prior to registration
Patients with a history of hypertension should be well controlled (< 140/90 mmHg) on a regimen of anti-hypertensive therapy
Uncontrolled hypertension
Uncontrolled hypertension or diabetes
History or evidence of poorly controlled hypertension
Uncontrolled arterial hypertension despite medical treatment
Patients with known pulmonary hypertension
Patients with uncontrolled hypertension (i.e., persistent grade 3 while undergoing treatment)
Patients with a history of hypertension must be well-controlled (< 150/90) on a regimen of anti-hypertensive therapy
Patients with uncontrolled hypertension (>= 145/90 mmHg) are NOT eligible for participation
Poorly controlled hypertension
Other clinically significant heart disease (e.g. uncontrolled hypertension, or history of labile hypertension)
Uncontrolled hypertension (home blood pressure readings are permitted) or prior history of hypertensive crisis or hypertensive encephalopathy; however, treatment of hypertension with medications is permitted
Hypertension
Uncontrolled diabetes, hypertension or other medical conditions at the time of transition to this study that may interfere with assessment of toxicity
Patient has poorly controlled hypertension and on multiple antihypertensives
Uncontrolled heart failure or hypertension or uncontrolled diabetes mellitus
Uncontrolled heart failure or hypertension or uncontrolled diabetes mellitus
Uncontrolled hypertension (BP ?150/95 mmHg despite medical therapy)
Other clinically significant heart disease (i.e., Grade ?3 hypertension, history of labile hypertension, or poor compliance with an anti-hypertensive regimen)
Uncontrolled hypertension or diabetes
Patients with poorly controlled hypertension despite multiple antihypertensive medications
Patients with poorly controlled hypertension despite hypertensive medication
Patients with poorly controlled hypertension
A past history of, or current uncontrolled hypertension. Blood pressure must be adequately controlled prior to dosing with VS-5584.
Subject has uncontrolled hypertension.
Uncontrolled arterial hypertension despite optimal medical management (per investigator's assessment) (modified by amendment 1)
Uncontrolled hypertension defined as systolic greater than 180 and diastolic greater than 100
Known history of malignant hypertension.
Uncontrolled arterial hypertension despite medical treatment
Uncontrolled hypertension despite optimal medical management
Uncontrolled hypertension
Uncontrolled hypertension
Uncontrolled arterial hypertension despite appropriate medical therapy
12 Known history of malignant hypertension.
Inadequately controlled hypertension
Any uncontrolled hypertension, arrhythmia, or active angina pectoris
Patients with a history of hypertension must be well-controlled (< 150 systolic/< 100 diastolic) on a stable regimen of anti-hypertensive therapy
Uncontrolled hypertension or diabetes
7. Uncontrolled congestive heart failure or uncontrolled hypertension.
Uncontrolled hypertension
Uncontrolled seizures or uncontrolled hypertension
Other clinically significant heart disease (e.g., CHF NY Heart Association class III or IV, uncontrolled hypertension, history of labile hypertension, or history of poor compliance with an antihypertensive regimen).
Hypertension uncontrolled by medication
Uncontrolled hypertension
Known history of malignant hypertension (severe hypertension >180/120 mmHg with end organ involvement.
Uncontrolled hypertension, i.e., blood pressure (BP) of >= 160/95; patients who have a history of hypertension controlled by medication must be on a stable dose (for at least one month) and meet all other inclusion criteria
Uncontrolled hypertension (per the Investigator's discretion)
Uncontrolled concurrent medical illness including uncontrolled hypertension
Uncontrolled arterial hypertension despite medical treatment
Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to randomization
Presence of predisposing factors to RVO or CSR (e.g., uncontrolled glaucoma or ocular hypertension, uncontrolled hypertension, uncontrolled diabetes mellitus, or a history of hyperviscosity or hypercoagulability syndromes), or
Uncontrolled hypertension
Uncontrolled hypertension (per Investigator's discretion)
Uncontrolled hypertension
Patients may not be on medical therapy for hypertension at time of enrollment.
Uncontrolled hypertension, defined as systolic BP >140 or diastolic >90 despite therapy.
Poorly-controlled hypertension
Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to randomization
Uncontrolled diabetes, hypertension or other medical conditions that may interfere with assessment of toxicity.
No uncontrolled hypertension (BP >150/100mmHg despite full doses of 1 anti-hypertensive medication).
Uncontrolled hypertension or cardiomyopathy
Have >= Grade 2 uncontrolled hypertension
Pulmonary hypertension,
Known pulmonary hypertension
Patients with uncontrolled hypertension (systolic > 140, diastolic > 90) despite antihypertensive therapy
Uncontrolled arterial hypertension despite medical treatment
Uncontrolled hypertension or chronic renal disease
Uncontrolled hypertension;
Have uncontrolled diabetes or have hypertension requiring more than 3 medications for control of hypertension.
History of hypertension that is not well-controlled (>= 160/90) on anti-hypertensive therapy
Uncontrolled hypertension or other uncontrolled chronic disease (e.g. diabetes mellitus, thyroid disease, pulmonary disease, etc.)
Diagnosis of pulmonary hypertension
Current and past history of hypertension
Known cardiovascular disease, uncontrolled hypertension, or new cardiac event within the past 6 months
Hypertension other than mild essential hypertension controlled with medication
Patients with uncontrolled hypertension.
Uncontrolled hypertension.
Diagnosis of pulmonary hypertension
Have tachycardia and/or uncontrolled hypertension
Uncontrolled hypertension, i.e., blood pressure (BP) of >= 160/95; patients who have a history of hypertension controlled by medication must be on a stable dose (for at least one month) and meet all other inclusion criteria; or
Has untreated hypertension or has hypertension under treatment that meets protocol definitions.
uncontrolled hypertension
severe pulmonary hypertension
Uncontrolled hypertension (defined as 3 consecutive readings over the past year of over 160 systolic, and over 100 diastolic)
Severe pulmonary hypertension
Major co-morbidities (e.g., uncontrolled diabetes, hypertension, etc.)
Patient has uncontrolled hypertension
History of Uncontrolled hypertension
History of chronic disease including diabetes, uncontrolled hypertension or thyroid disease
Well-controlled hypertension
Uncontrolled hypertension
Known pulmonary hypertension
Uncontrolled chronic illness such as hypertension, diabetes, or heart failure
Patients with known pulmonary hypertension
Severe pulmonary hypertension or uncontrolled systemic hypertension or respiratory distress syndrome
recent history of cardiovascular distress (heart attack in past year; arrhythmia; uncontrolled hypertension)
Uncontrolled hypertension.
Clinically uncontrolled hypertension in the investigator's opinion (e.g., blood pressure >160/100 mmHg; note that isolated elevated readings considered to not be indicative of uncontrolled hypertension are allowed). The following within 6 months prior to Cycle 1 Day 1:
Uncontrolled chronic hypertension defined as systolic > 150 or diastolic > 90 despite optimal therapy