The patient has uncontrolled or poorly controlled hypertension despite standard medical management as defined in this protocol

No history of grade 4 hypertension, defined as hypertension resulting in life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis)

Uncontrolled hypertension

Uncontrolled chronic hypertension defined as systolic > 150 or diastolic > 90 despite optimal therapy.

Patients with uncontrolled hypertension (>= 140/90 mmHg) are NOT eligible for participation

Uncontrolled hypertension

Patients with poorly controlled hypertension on multiple antihypertensives

Uncontrolled hypertension (as defined as ? 160/90 despite optimal medical management)

Uncontrolled arterial hypertension >/= 150/ >/= 90 millimeter of mercury (mmHg) despite standard medical management;

Patients with uncontrolled hypertension; patients with a history of hypertension must be well controlled (< 160/90) on a regimen of hypertensive medication

Poorly controlled hypertension. During screening ?2/3 of readings must be < 160/90, regardless of whether on a regimen of anti-hypertensive therapy or not.

History of significant cardiac disease or uncontrolled hypertension

Uncontrolled hypertension or diabetes

Uncontrolled hypertension or uncontrolled diabetes within 14 days prior cycle 1, day 1

Patients with uncontrolled hypertension (> 140/90 mmHg) are NOT eligible for participation

Uncontrolled severe hypertension, according to the judgment of the investigator, or symptomatic hypertension

Uncontrolled hypertension or diabetes

Uncontrolled hypertension

Poorly controlled hypertension despite anti-hypertensive medications

A past medical history of other clinically significant cardiovascular disease (eg, uncontrolled hypertension, history of labile hypertension, history of poor compliance with an antihypertensive regimen).

Subjects with other uncontrolled medical conditions, e.g. myocardial infarction, cerebrovascular accident, diabetes or hypertension.

Uncontrolled hypertension

Uncontrolled hypertension

Uncontrolled hypertension

Pulmonary hypertension

Has uncontrolled or poorly controlled hypertension

Uncontrolled hypertension

Uncontrolled hypertension despite optimal medical management

Uncontrolled hypertension (despite medical therapy); blood pressure should be < 140/90 in accordance with American Heart Association definition of hypertension

Uncontrolled hypertension (> 150/100 mmHg)

Have uncontrolled diabetes or have hypertension requiring more than 3 medications for control of hypertension.

Hypertension that is not controlled by standard medication (to 150/90 mmHg or below),

Uncontrolled hypertension, i.e., blood pressure (BP) of >= 160/95; patients who have a history of hypertension controlled by medication must be on a stable dose (for at least one month) and meet all other inclusion criteria; or

Patients must not have uncontrolled hypertension

Uncontrolled hypertension or diabetes

Uncontrolled hypertension (HTN)

Uncontrolled hypertension

Poorly controlled hypertension, defined as sustained, uncontrolled, non-episodic baseline hypertension consistently above 159/99 mmHg despite optimal medical management

Patients with uncontrolled hypertension

Sustained uncontrolled hypertension (> 150/90 average over 1 week) despite optimal medical management

Hypertension that is unstable or not controlled by medication.

Patient has poorly controlled hypertension and on multiple antihypertensives

Any known uncontrolled cardiovascular disease, pulmonary embolism, hypertension not adequately controlled by standard medications within 3 months prior to enrollment.

Uncontrolled hypertension

Uncontrolled diabetes or hypertension

Patients with uncontrolled hypertension

Patients with uncontrolled hypertension (HTN) (> 160/90) will not be admitted onto the study

FOR ALL PHASES (Ib AND II): Uncontrolled arterial hypertension despite optimal medical management

Criteria for hypertension: Blood pressure greater than 170/90 or 2 standard deviations (SD) from normal based on age and weight nomogram on 3 separate measurements; uncontrolled hypertension (HTN)

Patients must not have symptomatic hypertension

Pulmonary hypertension.

Hypertension requiring 3 or more anti-hypertensive medications to control

Severe or unstable cardiovascular disease or uncontrolled hypertension

Uncontrolled hypertension

Uncontrolled or severe hypertension, or cerebrovascular disease.

Have uncontrolled hypertension; subjects with a history of hypertension are permitted in the study provided their blood pressure is controlled by anti-hypertensive therapy

Patients with diagnosed uncontrolled hypertension (> 150/90 mmHg) are to be excluded

Patients with hypertension controlled with medications are allowed

Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to start of treatment

Uncontrolled hypertension (refer to World Health Organization [WHO]-International Society of Hypertension [ISH] guidelines)

Uncontrolled hypertension despite optimal medical management (per investigator´s assessment)

Uncontrolled hypertension, i.e., blood pressure (BP) of >= 160/95; patients who have a history of hypertension controlled by medication must be on a stable dose and meet all other inclusion criteria; or

Uncontrolled hypertension defined as > 140/90 and not cleared for surgery at the time of consent

Uncontrolled diabetes or hypertension

Subjects with a history of pulmonary hypertension is excluded

Poorly controlled hypertension despite multiple antihypertensive medication or

Uncontrolled hypertension, uncontrolled pulmonary hypertension or uncontrolled diabetes within 14 days prior to enrollment

Uncontrolled diabetes, hypertension or other medical conditions that may interfere with assessment of toxicity

Uncontrolled hypertension

Uncontrolled hypertension or uncontrolled diabetes

Uncontrolled arterial hypertension despite appropriate medical therapy

Have uncontrolled severe hypertension

Must not have any uncontrolled hypertension or uncontrolled diabetes within 14 days prior to enrollment.

Uncontrolled hypertension

DONOR: Current uncontrolled hypertension

Uncontrolled hypertension

Have a known history of uncontrolled hypertension. Patients with hypertension should be under treatment on study entry to control blood pressure.

Patients with >= grade 2 uncontrolled hypertension

Patient with poorly controlled hypertension despite multiple antihypertensives

Uncontrolled arterial hypertension despite optimal medical management (per institutional guidelines).

Uncontrolled hypertension or unstable angina.

Uncontrolled hypertension during screening

Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to randomization

Patients who exhibit uncontrolled hypertension (>= 140/90 mmHg) or uncontrolled diabetes within 14 days prior to registration are NOT eligible for participation

Current uncontrolled hypertension

Uncontrolled arterial hypertension despite appropriate medical therapy

Part 2: tachycardia and/or uncontrolled hypertension

Uncontrolled hypertension at study entry; patients with a history of uncontrolled hypertension are allowed provided blood pressure is controlled by antihypertensive treatment

Uncontrolled hypertension

Uncontrolled diabetes, heart disease, hypertension

Uncontrolled hypertension

Uncontrolled hypertension or diabetes.

Hypertension that is not controlled by standard medication (to 150/90 mmHg or below)

Uncontrolled hypertension, major bleeding, HIV infection, or recent acute\n             cardiovascular event

A past medical history of other clinically significant cardiovascular disease - e.g., uncontrolled hypertension, history of labile hypertension or history of poor compliance with an antihypertensive regimen

History of pulmonary hypertension

Uncontrolled hypertension or uncontrolled diabetes mellitus

Pulmonary hypertension

Uncontrolled hypertension (> 150/90 mmHg)

Hypertension not adequately controlled by 3 or less medications

Hypertension not adequately controlled by 3 or less medications

Poorly controlled hypertension despite anti-hypertensive medications

The participant has uncontrolled hypertension, despite antihypertensive intervention.

History of uncontrolled intercurrent illness including hypertension, active infection, diabetes

Uncontrolled hypertension defined as > 140/90 and not cleared for surgery at the time of consent

Cirrhosis or portal hypertension

Uncontrolled hypertension (> 150/100 mmHg despite optimal medical therapy)

Uncontrolled diabetes or uncontrolled hypertension within 14 days prior to first dose

Uncontrolled hypertension

Unstable angina pectoris, uncontrolled hypertension, uncontrolled asthma or other pulmonary disease

Uncontrolled hypertension.

Poorly controlled hypertension

Patients must not have a diagnosis of uncontrolled seizure or uncontrolled hypertension

Have uncontrolled hypertension.

Any other serious cardiac illness or medical conditions such as unstable angina, pulmonary embolism, or uncontrolled hypertension.

Any other serious cardiac illness or medical conditions such as unstable angina, pulmonary embolism, or uncontrolled hypertension

Patients with poorly controlled hypertension and on multiple antihypertensives

uncontrolled cardiovascular disease or uncontrolled hypertension

have uncontrolled hypertension

Pulmonary hypertension.

Hypertension defined below:

Uncontrolled hypertension, or uncontrolled diabetes mellitus

Uncontrolled hypertension

Have uncontrolled hypertension prior to initiating study treatment, despite antihypertensive intervention.

Has prior history of uncontrolled hypertension, hypertensive crisis or hypertensive encephalopathy

Uncontrolled or poorly controlled hypertension.

Severe or uncontrolled systemic diseases including uncontrolled hypertension

Uncontrolled symptomatic hypertension that cannot be controlled with anti-hypertensive agents

Uncontrolled hypertension.

Uncontrolled hypertension or diabetes

Resisted hypertension

Uncontrolled hypertension or uncontrolled diabetes despite medication

Uncontrolled arterial hypertension despite optimal medical management (per investigator's assessment).

Uncontrolled hypertension, i.e., blood pressure (BP) of >= 170/95; patients who have a history of hypertension controlled by medication must be on a stable dose (for at least one month) and meet all other inclusion criteria

History of hypertension not well-controlled (>= 160/90) even though on a regimen of anti-hypertensive therapy

Known history of pulmonary hypertension

Controlled hypertension

Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to the first day of treatment

Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to randomization

Current uncontrolled hypertension as well as prior history of hypertensive crisis or hypertensive encephalopathy

Current uncontrolled hypertension

No uncontrolled hypertension or uncontrolled diabetes (as determined by the treating physician) within 14 days prior to cycle 1 day 1

Known history of malignant hypertension

Uncontrolled hypertension

Uncontrolled hypertension or diabetes

Uncontrolled hypertension or diabetes.

Inadequately controlled arterial hypertension

Uncontrolled hypertension or diabetes

Pulmonary hypertension

Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to signing consent

Uncontrolled arterial hypertension despite medical treatment

Patients must not have uncontrolled diabetes, uncontrolled infection despite antibiotics or uncontrolled hypertension within 30 days prior to registration

Patients with a history of hypertension should be well controlled (< 140/90 mmHg) on a regimen of anti-hypertensive therapy

Uncontrolled hypertension

Uncontrolled hypertension or diabetes

History or evidence of poorly controlled hypertension

Uncontrolled arterial hypertension despite medical treatment

Patients with known pulmonary hypertension

Patients with uncontrolled hypertension (i.e., persistent grade 3 while undergoing treatment)

Patients with a history of hypertension must be well-controlled (< 150/90) on a regimen of anti-hypertensive therapy

Patients with uncontrolled hypertension (>= 145/90 mmHg) are NOT eligible for participation

Poorly controlled hypertension

Other clinically significant heart disease (e.g. uncontrolled hypertension, or history of labile hypertension)

Uncontrolled hypertension (home blood pressure readings are permitted) or prior history of hypertensive crisis or hypertensive encephalopathy; however, treatment of hypertension with medications is permitted

Hypertension

Uncontrolled diabetes, hypertension or other medical conditions at the time of transition to this study that may interfere with assessment of toxicity

Patient has poorly controlled hypertension and on multiple antihypertensives

Uncontrolled heart failure or hypertension or uncontrolled diabetes mellitus

Uncontrolled heart failure or hypertension or uncontrolled diabetes mellitus

Uncontrolled hypertension (BP ?150/95 mmHg despite medical therapy)

Other clinically significant heart disease (i.e., Grade ?3 hypertension, history of labile hypertension, or poor compliance with an anti-hypertensive regimen)

Uncontrolled hypertension or diabetes

Patients with poorly controlled hypertension despite multiple antihypertensive medications

Patients with poorly controlled hypertension despite hypertensive medication

Patients with poorly controlled hypertension

A past history of, or current uncontrolled hypertension. Blood pressure must be adequately controlled prior to dosing with VS-5584.

Subject has uncontrolled hypertension.

Uncontrolled arterial hypertension despite optimal medical management (per investigator's assessment) (modified by amendment 1)

Uncontrolled hypertension defined as systolic greater than 180 and diastolic greater than 100

Known history of malignant hypertension.

Uncontrolled arterial hypertension despite medical treatment

Uncontrolled hypertension despite optimal medical management

Uncontrolled hypertension

Uncontrolled hypertension

Uncontrolled arterial hypertension despite appropriate medical therapy

12 Known history of malignant hypertension.

Inadequately controlled hypertension

Any uncontrolled hypertension, arrhythmia, or active angina pectoris

Patients with a history of hypertension must be well-controlled (< 150 systolic/< 100 diastolic) on a stable regimen of anti-hypertensive therapy

Uncontrolled hypertension or diabetes

7. Uncontrolled congestive heart failure or uncontrolled hypertension.

Uncontrolled hypertension

Uncontrolled seizures or uncontrolled hypertension

Other clinically significant heart disease (e.g., CHF NY Heart Association class III or IV, uncontrolled hypertension, history of labile hypertension, or history of poor compliance with an antihypertensive regimen).

Hypertension uncontrolled by medication

Uncontrolled hypertension

Known history of malignant hypertension (severe hypertension >180/120 mmHg with end organ involvement.

Uncontrolled hypertension, i.e., blood pressure (BP) of >= 160/95; patients who have a history of hypertension controlled by medication must be on a stable dose (for at least one month) and meet all other inclusion criteria

Uncontrolled hypertension (per the Investigator's discretion)

Uncontrolled concurrent medical illness including uncontrolled hypertension

Uncontrolled arterial hypertension despite medical treatment

Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to randomization

Presence of predisposing factors to RVO or CSR (e.g., uncontrolled glaucoma or ocular hypertension, uncontrolled hypertension, uncontrolled diabetes mellitus, or a history of hyperviscosity or hypercoagulability syndromes), or

Uncontrolled hypertension

Uncontrolled hypertension (per Investigator's discretion)

Uncontrolled hypertension

Patients may not be on medical therapy for hypertension at time of enrollment.

Uncontrolled hypertension, defined as systolic BP >140 or diastolic >90 despite therapy.

Poorly-controlled hypertension

Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to randomization

Uncontrolled diabetes, hypertension or other medical conditions that may interfere with assessment of toxicity.

No uncontrolled hypertension (BP >150/100mmHg despite full doses of 1 anti-hypertensive medication).

Uncontrolled hypertension or cardiomyopathy

Have >= Grade 2 uncontrolled hypertension

Pulmonary hypertension,

Known pulmonary hypertension

Patients with uncontrolled hypertension (systolic > 140, diastolic > 90) despite antihypertensive therapy

Uncontrolled arterial hypertension despite medical treatment

Uncontrolled hypertension or chronic renal disease

Uncontrolled hypertension;

Have uncontrolled diabetes or have hypertension requiring more than 3 medications for control of hypertension.

History of hypertension that is not well-controlled (>= 160/90) on anti-hypertensive therapy

Uncontrolled hypertension or other uncontrolled chronic disease (e.g. diabetes mellitus, thyroid disease, pulmonary disease, etc.)

Diagnosis of pulmonary hypertension

Current and past history of hypertension

Known cardiovascular disease, uncontrolled hypertension, or new cardiac event within the past 6 months

Hypertension other than mild essential hypertension controlled with medication

Patients with uncontrolled hypertension.

Uncontrolled hypertension.

Diagnosis of pulmonary hypertension

Have tachycardia and/or uncontrolled hypertension

Uncontrolled hypertension, i.e., blood pressure (BP) of >= 160/95; patients who have a history of hypertension controlled by medication must be on a stable dose (for at least one month) and meet all other inclusion criteria; or

Has untreated hypertension or has hypertension under treatment that meets protocol definitions.

uncontrolled hypertension

severe pulmonary hypertension

Uncontrolled hypertension (defined as 3 consecutive readings over the past year of over 160 systolic, and over 100 diastolic)

Severe pulmonary hypertension

Major co-morbidities (e.g., uncontrolled diabetes, hypertension, etc.)

Patient has uncontrolled hypertension

History of Uncontrolled hypertension

History of chronic disease including diabetes, uncontrolled hypertension or thyroid disease

Well-controlled hypertension

Uncontrolled hypertension

Known pulmonary hypertension

Uncontrolled chronic illness such as hypertension, diabetes, or heart failure

Patients with known pulmonary hypertension

Severe pulmonary hypertension or uncontrolled systemic hypertension or respiratory distress syndrome

recent history of cardiovascular distress (heart attack in past year; arrhythmia; uncontrolled hypertension)

Uncontrolled hypertension.

Clinically uncontrolled hypertension in the investigator's opinion (e.g., blood pressure >160/100 mmHg; note that isolated elevated readings considered to not be indicative of uncontrolled hypertension are allowed). The following within 6 months prior to Cycle 1 Day 1:

Uncontrolled chronic hypertension defined as systolic > 150 or diastolic > 90 despite optimal therapy