--- a
+++ b/clusters/3009knumclusters/clust_189.txt
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+The patient has uncontrolled or poorly controlled hypertension despite standard medical management as defined in this protocol
+No history of grade 4 hypertension, defined as hypertension resulting in life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis)
+Uncontrolled hypertension
+Uncontrolled chronic hypertension defined as systolic > 150 or diastolic > 90 despite optimal therapy.
+Patients with uncontrolled hypertension (>= 140/90 mmHg) are NOT eligible for participation
+Uncontrolled hypertension
+Patients with poorly controlled hypertension on multiple antihypertensives
+Uncontrolled hypertension (as defined as ? 160/90 despite optimal medical management)
+Uncontrolled arterial hypertension >/= 150/ >/= 90 millimeter of mercury (mmHg) despite standard medical management;
+Patients with uncontrolled hypertension; patients with a history of hypertension must be well controlled (< 160/90) on a regimen of hypertensive medication
+Poorly controlled hypertension. During screening ?2/3 of readings must be < 160/90, regardless of whether on a regimen of anti-hypertensive therapy or not.
+History of significant cardiac disease or uncontrolled hypertension
+Uncontrolled hypertension or diabetes
+Uncontrolled hypertension or uncontrolled diabetes within 14 days prior cycle 1, day 1
+Patients with uncontrolled hypertension (> 140/90 mmHg) are NOT eligible for participation
+Uncontrolled severe hypertension, according to the judgment of the investigator, or symptomatic hypertension
+Uncontrolled hypertension or diabetes
+Uncontrolled hypertension
+Poorly controlled hypertension despite anti-hypertensive medications
+A past medical history of other clinically significant cardiovascular disease (eg, uncontrolled hypertension, history of labile hypertension, history of poor compliance with an antihypertensive regimen).
+Subjects with other uncontrolled medical conditions, e.g. myocardial infarction, cerebrovascular accident, diabetes or hypertension.
+Uncontrolled hypertension
+Uncontrolled hypertension
+Uncontrolled hypertension
+Pulmonary hypertension
+Has uncontrolled or poorly controlled hypertension
+Uncontrolled hypertension
+Uncontrolled hypertension despite optimal medical management
+Uncontrolled hypertension (despite medical therapy); blood pressure should be < 140/90 in accordance with American Heart Association definition of hypertension
+Uncontrolled hypertension (> 150/100 mmHg)
+Have uncontrolled diabetes or have hypertension requiring more than 3 medications for control of hypertension.
+Hypertension that is not controlled by standard medication (to 150/90 mmHg or below),
+Uncontrolled hypertension, i.e., blood pressure (BP) of >= 160/95; patients who have a history of hypertension controlled by medication must be on a stable dose (for at least one month) and meet all other inclusion criteria; or
+Patients must not have uncontrolled hypertension
+Uncontrolled hypertension or diabetes
+Uncontrolled hypertension (HTN)
+Uncontrolled hypertension
+Poorly controlled hypertension, defined as sustained, uncontrolled, non-episodic baseline hypertension consistently above 159/99 mmHg despite optimal medical management
+Patients with uncontrolled hypertension
+Sustained uncontrolled hypertension (> 150/90 average over 1 week) despite optimal medical management
+Hypertension that is unstable or not controlled by medication.
+Patient has poorly controlled hypertension and on multiple antihypertensives
+Any known uncontrolled cardiovascular disease, pulmonary embolism, hypertension not adequately controlled by standard medications within 3 months prior to enrollment.
+Uncontrolled hypertension
+Uncontrolled diabetes or hypertension
+Patients with uncontrolled hypertension
+Patients with uncontrolled hypertension (HTN) (> 160/90) will not be admitted onto the study
+FOR ALL PHASES (Ib AND II): Uncontrolled arterial hypertension despite optimal medical management
+Criteria for hypertension: Blood pressure greater than 170/90 or 2 standard deviations (SD) from normal based on age and weight nomogram on 3 separate measurements; uncontrolled hypertension (HTN)
+Patients must not have symptomatic hypertension
+Pulmonary hypertension.
+Hypertension requiring 3 or more anti-hypertensive medications to control
+Severe or unstable cardiovascular disease or uncontrolled hypertension
+Uncontrolled hypertension
+Uncontrolled or severe hypertension, or cerebrovascular disease.
+Have uncontrolled hypertension; subjects with a history of hypertension are permitted in the study provided their blood pressure is controlled by anti-hypertensive therapy
+Patients with diagnosed uncontrolled hypertension (> 150/90 mmHg) are to be excluded
+Patients with hypertension controlled with medications are allowed
+Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to start of treatment
+Uncontrolled hypertension (refer to World Health Organization [WHO]-International Society of Hypertension [ISH] guidelines)
+Uncontrolled hypertension despite optimal medical management (per investigator´s assessment)
+Uncontrolled hypertension, i.e., blood pressure (BP) of >= 160/95; patients who have a history of hypertension controlled by medication must be on a stable dose and meet all other inclusion criteria; or
+Uncontrolled hypertension defined as > 140/90 and not cleared for surgery at the time of consent
+Uncontrolled diabetes or hypertension
+Subjects with a history of pulmonary hypertension is excluded
+Poorly controlled hypertension despite multiple antihypertensive medication or
+Uncontrolled hypertension, uncontrolled pulmonary hypertension or uncontrolled diabetes within 14 days prior to enrollment
+Uncontrolled diabetes, hypertension or other medical conditions that may interfere with assessment of toxicity
+Uncontrolled hypertension
+Uncontrolled hypertension or uncontrolled diabetes
+Uncontrolled arterial hypertension despite appropriate medical therapy
+Have uncontrolled severe hypertension
+Must not have any uncontrolled hypertension or uncontrolled diabetes within 14 days prior to enrollment.
+Uncontrolled hypertension
+DONOR: Current uncontrolled hypertension
+Uncontrolled hypertension
+Have a known history of uncontrolled hypertension. Patients with hypertension should be under treatment on study entry to control blood pressure.
+Patients with >= grade 2 uncontrolled hypertension
+Patient with poorly controlled hypertension despite multiple antihypertensives
+Uncontrolled arterial hypertension despite optimal medical management (per institutional guidelines).
+Uncontrolled hypertension or unstable angina.
+Uncontrolled hypertension during screening
+Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to randomization
+Patients who exhibit uncontrolled hypertension (>= 140/90 mmHg) or uncontrolled diabetes within 14 days prior to registration are NOT eligible for participation
+Current uncontrolled hypertension
+Uncontrolled arterial hypertension despite appropriate medical therapy
+Part 2: tachycardia and/or uncontrolled hypertension
+Uncontrolled hypertension at study entry; patients with a history of uncontrolled hypertension are allowed provided blood pressure is controlled by antihypertensive treatment
+Uncontrolled hypertension
+Uncontrolled diabetes, heart disease, hypertension
+Uncontrolled hypertension
+Uncontrolled hypertension or diabetes.
+Hypertension that is not controlled by standard medication (to 150/90 mmHg or below)
+Uncontrolled hypertension, major bleeding, HIV infection, or recent acute\n             cardiovascular event
+A past medical history of other clinically significant cardiovascular disease - e.g., uncontrolled hypertension, history of labile hypertension or history of poor compliance with an antihypertensive regimen
+History of pulmonary hypertension
+Uncontrolled hypertension or uncontrolled diabetes mellitus
+Pulmonary hypertension
+Uncontrolled hypertension (> 150/90 mmHg)
+Hypertension not adequately controlled by 3 or less medications
+Hypertension not adequately controlled by 3 or less medications
+Poorly controlled hypertension despite anti-hypertensive medications
+The participant has uncontrolled hypertension, despite antihypertensive intervention.
+History of uncontrolled intercurrent illness including hypertension, active infection, diabetes
+Uncontrolled hypertension defined as > 140/90 and not cleared for surgery at the time of consent
+Cirrhosis or portal hypertension
+Uncontrolled hypertension (> 150/100 mmHg despite optimal medical therapy)
+Uncontrolled diabetes or uncontrolled hypertension within 14 days prior to first dose
+Uncontrolled hypertension
+Unstable angina pectoris, uncontrolled hypertension, uncontrolled asthma or other pulmonary disease
+Uncontrolled hypertension.
+Poorly controlled hypertension
+Patients must not have a diagnosis of uncontrolled seizure or uncontrolled hypertension
+Have uncontrolled hypertension.
+Any other serious cardiac illness or medical conditions such as unstable angina, pulmonary embolism, or uncontrolled hypertension.
+Any other serious cardiac illness or medical conditions such as unstable angina, pulmonary embolism, or uncontrolled hypertension
+Patients with poorly controlled hypertension and on multiple antihypertensives
+uncontrolled cardiovascular disease or uncontrolled hypertension
+have uncontrolled hypertension
+Pulmonary hypertension.
+Hypertension defined below:
+Uncontrolled hypertension, or uncontrolled diabetes mellitus
+Uncontrolled hypertension
+Have uncontrolled hypertension prior to initiating study treatment, despite antihypertensive intervention.
+Has prior history of uncontrolled hypertension, hypertensive crisis or hypertensive encephalopathy
+Uncontrolled or poorly controlled hypertension.
+Severe or uncontrolled systemic diseases including uncontrolled hypertension
+Uncontrolled symptomatic hypertension that cannot be controlled with anti-hypertensive agents
+Uncontrolled hypertension.
+Uncontrolled hypertension or diabetes
+Resisted hypertension
+Uncontrolled hypertension or uncontrolled diabetes despite medication
+Uncontrolled arterial hypertension despite optimal medical management (per investigator's assessment).
+Uncontrolled hypertension, i.e., blood pressure (BP) of >= 170/95; patients who have a history of hypertension controlled by medication must be on a stable dose (for at least one month) and meet all other inclusion criteria
+History of hypertension not well-controlled (>= 160/90) even though on a regimen of anti-hypertensive therapy
+Known history of pulmonary hypertension
+Controlled hypertension
+Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to the first day of treatment
+Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to randomization
+Current uncontrolled hypertension as well as prior history of hypertensive crisis or hypertensive encephalopathy
+Current uncontrolled hypertension
+No uncontrolled hypertension or uncontrolled diabetes (as determined by the treating physician) within 14 days prior to cycle 1 day 1
+Known history of malignant hypertension
+Uncontrolled hypertension
+Uncontrolled hypertension or diabetes
+Uncontrolled hypertension or diabetes.
+Inadequately controlled arterial hypertension
+Uncontrolled hypertension or diabetes
+Pulmonary hypertension
+Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to signing consent
+Uncontrolled arterial hypertension despite medical treatment
+Patients must not have uncontrolled diabetes, uncontrolled infection despite antibiotics or uncontrolled hypertension within 30 days prior to registration
+Patients with a history of hypertension should be well controlled (< 140/90 mmHg) on a regimen of anti-hypertensive therapy
+Uncontrolled hypertension
+Uncontrolled hypertension or diabetes
+History or evidence of poorly controlled hypertension
+Uncontrolled arterial hypertension despite medical treatment
+Patients with known pulmonary hypertension
+Patients with uncontrolled hypertension (i.e., persistent grade 3 while undergoing treatment)
+Patients with a history of hypertension must be well-controlled (< 150/90) on a regimen of anti-hypertensive therapy
+Patients with uncontrolled hypertension (>= 145/90 mmHg) are NOT eligible for participation
+Poorly controlled hypertension
+Other clinically significant heart disease (e.g. uncontrolled hypertension, or history of labile hypertension)
+Uncontrolled hypertension (home blood pressure readings are permitted) or prior history of hypertensive crisis or hypertensive encephalopathy; however, treatment of hypertension with medications is permitted
+Hypertension
+Uncontrolled diabetes, hypertension or other medical conditions at the time of transition to this study that may interfere with assessment of toxicity
+Patient has poorly controlled hypertension and on multiple antihypertensives
+Uncontrolled heart failure or hypertension or uncontrolled diabetes mellitus
+Uncontrolled heart failure or hypertension or uncontrolled diabetes mellitus
+Uncontrolled hypertension (BP ?150/95 mmHg despite medical therapy)
+Other clinically significant heart disease (i.e., Grade ?3 hypertension, history of labile hypertension, or poor compliance with an anti-hypertensive regimen)
+Uncontrolled hypertension or diabetes
+Patients with poorly controlled hypertension despite multiple antihypertensive medications
+Patients with poorly controlled hypertension despite hypertensive medication
+Patients with poorly controlled hypertension
+A past history of, or current uncontrolled hypertension. Blood pressure must be adequately controlled prior to dosing with VS-5584.
+Subject has uncontrolled hypertension.
+Uncontrolled arterial hypertension despite optimal medical management (per investigator's assessment) (modified by amendment 1)
+Uncontrolled hypertension defined as systolic greater than 180 and diastolic greater than 100
+Known history of malignant hypertension.
+Uncontrolled arterial hypertension despite medical treatment
+Uncontrolled hypertension despite optimal medical management
+Uncontrolled hypertension
+Uncontrolled hypertension
+Uncontrolled arterial hypertension despite appropriate medical therapy
+12 Known history of malignant hypertension.
+Inadequately controlled hypertension
+Any uncontrolled hypertension, arrhythmia, or active angina pectoris
+Patients with a history of hypertension must be well-controlled (< 150 systolic/< 100 diastolic) on a stable regimen of anti-hypertensive therapy
+Uncontrolled hypertension or diabetes
+7. Uncontrolled congestive heart failure or uncontrolled hypertension.
+Uncontrolled hypertension
+Uncontrolled seizures or uncontrolled hypertension
+Other clinically significant heart disease (e.g., CHF NY Heart Association class III or IV, uncontrolled hypertension, history of labile hypertension, or history of poor compliance with an antihypertensive regimen).
+Hypertension uncontrolled by medication
+Uncontrolled hypertension
+Known history of malignant hypertension (severe hypertension >180/120 mmHg with end organ involvement.
+Uncontrolled hypertension, i.e., blood pressure (BP) of >= 160/95; patients who have a history of hypertension controlled by medication must be on a stable dose (for at least one month) and meet all other inclusion criteria
+Uncontrolled hypertension (per the Investigator's discretion)
+Uncontrolled concurrent medical illness including uncontrolled hypertension
+Uncontrolled arterial hypertension despite medical treatment
+Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to randomization
+Presence of predisposing factors to RVO or CSR (e.g., uncontrolled glaucoma or ocular hypertension, uncontrolled hypertension, uncontrolled diabetes mellitus, or a history of hyperviscosity or hypercoagulability syndromes), or
+Uncontrolled hypertension
+Uncontrolled hypertension (per Investigator's discretion)
+Uncontrolled hypertension
+Patients may not be on medical therapy for hypertension at time of enrollment.
+Uncontrolled hypertension, defined as systolic BP >140 or diastolic >90 despite therapy.
+Poorly-controlled hypertension
+Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to randomization
+Uncontrolled diabetes, hypertension or other medical conditions that may interfere with assessment of toxicity.
+No uncontrolled hypertension (BP >150/100mmHg despite full doses of 1 anti-hypertensive medication).
+Uncontrolled hypertension or cardiomyopathy
+Have >= Grade 2 uncontrolled hypertension
+Pulmonary hypertension,
+Known pulmonary hypertension
+Patients with uncontrolled hypertension (systolic > 140, diastolic > 90) despite antihypertensive therapy
+Uncontrolled arterial hypertension despite medical treatment
+Uncontrolled hypertension or chronic renal disease
+Uncontrolled hypertension;
+Have uncontrolled diabetes or have hypertension requiring more than 3 medications for control of hypertension.
+History of hypertension that is not well-controlled (>= 160/90) on anti-hypertensive therapy
+Uncontrolled hypertension or other uncontrolled chronic disease (e.g. diabetes mellitus, thyroid disease, pulmonary disease, etc.)
+Diagnosis of pulmonary hypertension
+Current and past history of hypertension
+Known cardiovascular disease, uncontrolled hypertension, or new cardiac event within the past 6 months
+Hypertension other than mild essential hypertension controlled with medication
+Patients with uncontrolled hypertension.
+Uncontrolled hypertension.
+Diagnosis of pulmonary hypertension
+Have tachycardia and/or uncontrolled hypertension
+Uncontrolled hypertension, i.e., blood pressure (BP) of >= 160/95; patients who have a history of hypertension controlled by medication must be on a stable dose (for at least one month) and meet all other inclusion criteria; or
+Has untreated hypertension or has hypertension under treatment that meets protocol definitions.
+uncontrolled hypertension
+severe pulmonary hypertension
+Uncontrolled hypertension (defined as 3 consecutive readings over the past year of over 160 systolic, and over 100 diastolic)
+Severe pulmonary hypertension
+Major co-morbidities (e.g., uncontrolled diabetes, hypertension, etc.)
+Patient has uncontrolled hypertension
+History of Uncontrolled hypertension
+History of chronic disease including diabetes, uncontrolled hypertension or thyroid disease
+Well-controlled hypertension
+Uncontrolled hypertension
+Known pulmonary hypertension
+Uncontrolled chronic illness such as hypertension, diabetes, or heart failure
+Patients with known pulmonary hypertension
+Severe pulmonary hypertension or uncontrolled systemic hypertension or respiratory distress syndrome
+recent history of cardiovascular distress (heart attack in past year; arrhythmia; uncontrolled hypertension)
+Uncontrolled hypertension.
+Clinically uncontrolled hypertension in the investigator's opinion (e.g., blood pressure >160/100 mmHg; note that isolated elevated readings considered to not be indicative of uncontrolled hypertension are allowed). The following within 6 months prior to Cycle 1 Day 1:
+Uncontrolled chronic hypertension defined as systolic > 150 or diastolic > 90 despite optimal therapy